MET targeting: time for a rematch.

Abstract:

:MET, the receptor tyrosine kinase (RTK) for hepatocyte growth factor, is a proto-oncogene involved in embryonic development and throughout life in homeostasis and tissue regeneration. Deregulation of MET signaling has been reported in numerous malignancies, prompting great interest in MET targeting for cancer therapy. The present review offers a summary of the biology of MET and its known functions in normal physiology and carcinogenesis, followed by an overview of the most relevant MET-targeting strategies and corresponding clinical trials, highlighting both past setbacks and promising future prospects. By placing their efforts on a more precise stratification strategy through the genetic analysis of tumors, modern trials such as the NCI-MATCH trial could revive the past enthusiasm for MET-targeted therapy.

journal_name

Oncogene

journal_title

Oncogene

authors

Koch JP,Aebersold DM,Zimmer Y,Medová M

doi

10.1038/s41388-020-1193-8

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

2845-2862

issue

14

eissn

0950-9232

issn

1476-5594

pii

10.1038/s41388-020-1193-8

journal_volume

39

pub_type

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