Abstract:
:MET, the receptor tyrosine kinase (RTK) for hepatocyte growth factor, is a proto-oncogene involved in embryonic development and throughout life in homeostasis and tissue regeneration. Deregulation of MET signaling has been reported in numerous malignancies, prompting great interest in MET targeting for cancer therapy. The present review offers a summary of the biology of MET and its known functions in normal physiology and carcinogenesis, followed by an overview of the most relevant MET-targeting strategies and corresponding clinical trials, highlighting both past setbacks and promising future prospects. By placing their efforts on a more precise stratification strategy through the genetic analysis of tumors, modern trials such as the NCI-MATCH trial could revive the past enthusiasm for MET-targeted therapy.
journal_name
Oncogenejournal_title
Oncogeneauthors
Koch JP,Aebersold DM,Zimmer Y,Medová Mdoi
10.1038/s41388-020-1193-8subject
Has Abstractpub_date
2020-04-01 00:00:00pages
2845-2862issue
14eissn
0950-9232issn
1476-5594pii
10.1038/s41388-020-1193-8journal_volume
39pub_type
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