Establishment of an inducible expression system of chimeric MLL-LTG9 protein and inhibition of Hox a7, Hox b7 and Hox c9 expression by MLL-LTG9 in 32Dcl3 cells.

abstract：:Nuclear Foxc2 is a transcriptional regulator of mesenchymal transformation during developmental epithelial-mesenchymal transition (EMT) and has been associated with EMT in malignant epithelia. Our laboratory has shown that in normal epithelial cells Foxc2 is maintained in the cytoplasm where it promotes an epithelial ...

journal_title：Oncogene

authors： Golden D,Cantley LG

更新日期：2015-09-03 00:00:00

abstract：:The p53 protein is a multifunctional transcription factor which orchestrates cellular responses to DNA damage, so helping to conserve genomic stability. It may also regulate genes involved in intercellular signalling, such as thrombospondin, a negative regulator of angiogenesis and metastatic spread. Activation of p53...

journal_title：Oncogene

authors： Rolley N,Butcher S,Milner J

更新日期：1995-08-17 00:00:00

abstract：:As leukemic transformation of myeloproliferative neoplasms (MPNs) worsens the clinical outcome, reducing the inherent risk of the critical event in MPN cases could be beneficial. Among genetic alterations concerning the transformation, the frequent one is TP53 mutation. Here we show that retroviral overexpression of J...

journal_title：Oncogene

authors： Tsuruta-Kishino T,Koya J,Kataoka K,Narukawa K,Sumitomo Y,Kobayashi H,Sato T,Kurokawa M

更新日期：2017-06-08 00:00:00

abstract：:Mammalian Stanniocalcin-1 (STC1) is a glycoprotein that has been implicated in various biological processes including angiogenesis. Aberrant STC1 expression has been reported in breast, ovarian and prostate cancers, but the significance of this is not well understood. Here, we report that oxidative stress caused a 40-...

journal_title：Oncogene

authors： Nguyen A,Chang AC,Reddel RR

更新日期：2009-05-07 00:00:00

abstract：:The CD4 T-cell surface antigen and the lymphocyte-specific tyrosine-protein kinase p56lck form a stable noncovalent complex in CD4+ T-lymphocytes. In this report, we demonstrate that these two gene products can also associate when co-expressed in NIH3T3 fibroblasts, therefore implying that other lymphoid specific comp...

journal_title：Oncogene

authors： Simpson SC,Bolen JB,Veillette A

更新日期：1989-09-01 00:00:00

abstract：:The HER-2/neu proto-oncogene is frequently amplified or overexpressed in many different types of human cancers, a phenomenon that has been shown to correlate with shorter survival time and lower survival rate in ovarian cancer patients. We previously reported that increased HER-2/neu expression led to more severe mali...

journal_title：Oncogene

authors： Yu D,Matin A,Xia W,Sorgi F,Huang L,Hung MC

更新日期：1995-10-05 00:00:00

abstract：:Cell migration is an integral component of metastatic disease. The ability of cells to transit between mesenchymal and amoeboid modes of migration has complicated the development of successful therapies designed to target cell migration as a means of inhibiting metastasis. Therefore, investigations of the mechanisms t...

journal_title：Oncogene

authors： Lees JG,Bach CT,Bradbury P,Paul A,Gunning PW,O'Neill GM

更新日期：2011-03-10 00:00:00

abstract：:Triple-negative breast cancers (TNBCs) are characterized by a poor prognosis and lack of targeted treatments, and thus, new therapeutic strategies are urgently needed. Inhibitors against programmed death-1 (PD-1)/PD-1 ligand (PD-L1) have shown significant efficacy in various solid cancers, but their activity against T...

journal_title：Oncogene

authors： Castagnoli L,Cancila V,Cordoba-Romero SL,Faraci S,Talarico G,Belmonte B,Iorio MV,Milani M,Volpari T,Chiodoni C,Hidalgo-Miranda A,Tagliabue E,Tripodo C,Sangaletti S,Di Nicola M,Pupa SM

更新日期：2019-05-01 00:00:00

abstract：:The Mucin 1 (MUC1) protein is overexpressed in various cancers and mediates chemotherapy resistance. However, the mechanism is not fully understood. Given that most chemotherapeutic drugs disrupt ER homeostasis as part of their toxicity, and MUC1 expression is regulated by proteins involved in ER homeostasis, we inves...

journal_title：Oncogene

authors： Olou AA,King RJ,Yu F,Singh PK

更新日期：2020-04-01 00:00:00

abstract：:Stimulation of the c-Kit receptor tyrosine kinase has a critical role in the development and migration of melanocytes, and oncogenic c-Kit mutants contribute to the progression of some melanomas. c-Kit signalling activates the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways an...

journal_title：Oncogene

authors： Todd JR,Scurr LL,Becker TM,Kefford RF,Rizos H

更新日期：2014-01-09 00:00:00

abstract：:High Mobility Group AT-hook 2 (HMGA2) is a chromatin modifier and its overexpression has been found in patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Level of Hmga2 expression is fine-tuned by Lin28b-Let-7 axis and Polycomb Repressive Complex 2, in which deletion of Ezh2 leads to activa...

journal_title：Oncogene

authors： Bai J,Yokomizo-Nakano T,Kubota S,Sun Y,Kanai A,Iimori M,Harada H,Iwama A,Sashida G

更新日期：2021-01-15 00:00:00

abstract：:Gastric cancer (GC) is one of the most common tumors and the molecular mechanism underlying its metastasis is still largely unclear. Here, we show that miR-25 was overexpressed in plasma and primary tumor tissues of GC patients with tumor node metastasis stage (III or IV) or lymph node metastasis. MiR-25 inhibition si...

journal_title：Oncogene

authors： Li BS,Zuo QF,Zhao YL,Xiao B,Zhuang Y,Mao XH,Wu C,Yang SM,Zeng H,Zou QM,Guo G

更新日期：2015-05-14 00:00:00

abstract：:Activating mutations of K-ras are frequent in colon tumors and aberrant crypt foci, and may play important roles in colon carcinogenesis. Here, we investigated the effects of a K-ras codon 12 mutation on inducible nitric oxide synthase (iNOS) expression. When rat intestinal epithelial cells (IEC-6) were transfected wi...

journal_title：Oncogene

authors： Takahashi M,Mutoh M,Shoji Y,Kamanaka Y,Naka M,Maruyama T,Sugimura T,Wakabayashi K

更新日期：2003-10-23 00:00:00

abstract：:Chromosome 1p36.23 is frequently deleted in glioblastoma multiforme (GBM). miR-34a localizes in this region. Our experiments found that miR-34a was often deleted and epidermal growth factor receptor (EGFR) was frequently amplified in genomic DNA of 55 GBMs using single-nucleotide polymorphism DNA microarray. Notably, ...

journal_title：Oncogene

authors： Yin D,Ogawa S,Kawamata N,Leiter A,Ham M,Li D,Doan NB,Said JW,Black KL,Phillip Koeffler H

更新日期：2013-02-28 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) K13/vFLIP (viral Flice-inhibitory protein) induces transcription of numerous genes through NF-κB activation, including pro-inflammatory cytokines, which contribute to the pathogenesis of Kaposi's sarcoma (KS). In this study, we report that KSHV vFLIP induces the expressio...

journal_title：Oncogene

authors： Sakakibara S,Espigol-Frigole G,Gasperini P,Uldrick TS,Yarchoan R,Tosato G

更新日期：2013-03-07 00:00:00

abstract：:Ki-1 lymphoma is a subtype of human malignant lymphoma characterized by the expression of CD30 (Ki-1) and a peculiar morphology. It is occasionally accompanied by a unique reciprocal chromosomal translocation t(2;5)(p23;q35). A Ki-1 lymphoma cell line, AMS3, was established by maintaining biopsied tumor cells in SCID ...

journal_title：Oncogene

authors： Shiota M,Fujimoto J,Semba T,Satoh H,Yamamoto T,Mori S

更新日期：1994-06-01 00:00:00

abstract：:Checkpoint kinase 2 (Chk2) is known to mediate diverse cellular responses to genotoxic stress. The fundamental role of Chk2 is to regulate the network of genome-surveillance pathways that coordinate cell-cycle progression with DNA repair and cell survival or death. Defects in Chk2 contribute to the development of both...

journal_title：Oncogene

authors： Park HU,Jeong SJ,Jeong JH,Chung JH,Brady JN

更新日期：2006-01-19 00:00:00

abstract：:The extracellular matrix glycoprotein, fibronectin, influences a variety of cellular functions including adhesion, migration, survival, differentiation, and growth. Fibronectin has also been shown to increase the migration and proliferation of human lung carcinoma cells. However, the role of fibronectin in controlling...

journal_title：Oncogene

authors： Han SW,Roman J

更新日期：2006-07-20 00:00:00

abstract：:Based on observations suggesting a role for the tumor suppressor protein p53 in regulating expression of the 67-kDa laminin receptor precursor, 37LRP, we analysed the 37LRP promoter activity in a wild-type p53 (wt p53) ovarian carcinoma cell line and in a cisplatin-resistant subline with mutated p53. We observed an in...

journal_title：Oncogene

authors： Modugno M,Tagliabue E,Ardini E,Berno V,Galmozzi E,De Bortoli M,Castronovo V,Ménard S

更新日期：2002-10-24 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are known to play an important role in melanoma development and progression. However, the downstream targets of BMPs have not been investigated thus far. Therefore, we treated melanoma cell lines with the Smad-specific BMP inhibitor Dorsomorphin and performed a cDNA microarray. We id...

journal_title：Oncogene

authors： Braig S,Bosserhoff AK

更新日期：2013-02-14 00:00:00

abstract：:Exposure of cells to DNA damaging agents results in a G2 arrest. Exposure of HeLa cells to camptothecin, etoposide or nitrogen mustard for 1 h in S phase resulted in delayed expression of cyclin B1 mRNA during the G2 arrest. Initially the levels of cyclin B1 protein were low as well; however, with extended time the ce...

journal_title：Oncogene

authors： Maity A,Hwang A,Janss A,Phillips P,McKenna WG,Muschel RJ

更新日期：1996-10-17 00:00:00

abstract：:Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein that is part of the carcinoembryonic antigen and the immunoglobulin superfamilies. We have shown that it functions as a tumor suppressor and that this function depends upon the presence of the longer CEACAM1 cytoplasmic domain. In th...

journal_title：Oncogene

authors： Leung N,Turbide C,Olson M,Marcus V,Jothy S,Beauchemin N

更新日期：2006-09-07 00:00:00

abstract：:Beta-transducin repeats-containing proteins (beta-TrCP) serve as the substrate recognition subunits for the SCFbeta-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylated substrates and play a pivotal role in the regulation of cell division and various signal transduction pathways, which, in...

journal_title：Oncogene

authors： Fuchs SY,Spiegelman VS,Kumar KG

更新日期：2004-03-15 00:00:00

abstract：:Dasatinib, a dual Src family kinase and Abl inhibitor, is being tested clinically for the treatment of prostate cancer bone metastasis. Bidirectional interactions between osteoblasts and prostate cancer cells are critical in the progression of prostate cancer in bone, but the effect of dasatinib on osteoblasts is unkn...

journal_title：Oncogene

authors： Lee YC,Huang CF,Murshed M,Chu K,Araujo JC,Ye X,deCrombrugghe B,Yu-Lee LY,Gallick GE,Lin SH

更新日期：2010-06-03 00:00:00

abstract：:The tumor suppressor gene p53 is a potent transcriptional regulator of genes which are involved in many cellular activities including cell cycle arrest, apoptosis, and angiogenesis. Recent studies have demonstrated that the activation of the transcriptional factor nuclear factor kappaB (NF-kappaB) plays an essential r...

journal_title：Oncogene

authors： Shao J,Fujiwara T,Kadowaki Y,Fukazawa T,Waku T,Itoshima T,Yamatsuji T,Nishizaki M,Roth JA,Tanaka N

更新日期：2000-02-10 00:00:00

abstract：:The mouse mammary epithelial cell hierarchy contains both multipotent stem cell as well as lineage-limited duct and lobular progenitor cell functions. The latter-also termed parity-identified mammary epithelial cells (PI-MECs)-are marked by beta-galactosidase (β Gal) expression following pregnancy and involution in wh...

journal_title：Oncogene

authors： Bruno RD,Boulanger CA,Smith GH

更新日期：2012-01-05 00:00:00

abstract：:Treatment of cells with insulin and protein tyrosine phosphatase inhibitors such as vanadate and pervanadate resulted in the tyrosine phosphorylation of Grb10, a Src homology 2 (SH2) and pleckstrin homology domain-containing adaptor protein which binds to a number of receptor tyrosine kinases including the insulin rec...

journal_title：Oncogene

authors： Langlais P,Dong LQ,Hu D,Liu F

更新日期：2000-06-08 00:00:00

abstract：:The regulation of cell adhesion and motility in human prostate is not well understood. We have previously shown that the endoglin gene is differently expressed during changes in prostate cell adhesion. Endoglin is a transmembrane transforming growth factor beta binding protein typically expressed by endothelial cells....

journal_title：Oncogene

authors： Liu Y,Jovanovic B,Pins M,Lee C,Bergan RC

更新日期：2002-11-28 00:00:00

abstract：:Expression of polyomavirus middle-T antigen (middle-T) is involved in the formation of various tumors in vivo, e.g. hemangiomas and mammary gland tumors. Several genes have been shown to be activated in middle-T-expressing cells, but the underlying mechanisms have only been partially elucidated. Among the genes regula...

journal_title：Oncogene

authors： Besser D,Urich M,Sakaue M,Messerschmitt A,Ballmer-Hofer K,Nagamine Y

更新日期：1995-12-07 00:00:00

abstract：:Gastrin and its precursors promote proliferation in different gastrointestinal cells. Since mature, amidated gastrin (G-17) can induce cyclin D1, we determined whether G-17-mediated induction of cyclin D1 transcription involved Wnt signaling and CRE-binding protein (CREB) pathways. Our studies indicate that G-17 induc...

journal_title：Oncogene

authors： Pradeep A,Sharma C,Sathyanarayana P,Albanese C,Fleming JV,Wang TC,Wolfe MM,Baker KM,Pestell RG,Rana B

更新日期：2004-04-29 00:00:00