Casein kinase 2 prevents mesenchymal transformation by maintaining Foxc2 in the cytoplasm.

abstract：:A transgenic mouse family expressing the middle T antigen of polyoma virus under control of the immunoglobulin heavy chain (IgE) enhancer showed the frequent occurrence of carcinomas in various organs, predominantly in females. Most frequently affected were the salivary and thyroid glands, but mammary tumours, liver h...

journal_title：Oncogene

authors： Rassoulzadegan M,Courtneidge SA,Loubière R,el Baze P,Cuzin F

更新日期：1990-10-01 00:00:00

abstract：:To investigate the tumorigenic potential of mutant p53 when selectively expressed in lung tissue, a transgenic mouse model was developed in which a mutant form of p53 (p53-273H) was placed under the transcriptional control of the lung-specific human surfactant protein C (SP-C) promoter. Two founder mice were identifie...

journal_title：Oncogene

authors： Duan W,Ding H,Subler MA,Zhu WG,Zhang H,Stoner GD,Windle JJ,Otterson GA,Villalona-Calero MA

更新日期：2002-11-07 00:00:00

abstract：:Prostate carcinoma (PCA) is the most frequently diagnosed malignancy in American men. PCA at advanced stages can both proliferate abnormally and resist apoptosis. Among the many known signal transduction pathways, phosphatidylinositide-3'OH kinase (PI3-kinase) has been shown to play an important role in cell survival ...

journal_title：Oncogene

authors： Xue LY,Qiu Y,He J,Kung HJ,Oleinick NL

更新日期：1999-06-03 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of critical cell processes such as apoptosis, cell proliferation and differentiation. A small set of miRNAs is differentially expressed in hematopoietic cells and seemingly has an important role in granulopoiesis and lineage differentiation. In th...

journal_title：Oncogene

authors： Careccia S,Mainardi S,Pelosi A,Gurtner A,Diverio D,Riccioni R,Testa U,Pelosi E,Piaggio G,Sacchi A,Lavorgna S,Lo-Coco F,Blandino G,Levrero M,Rizzo MG

更新日期：2009-11-12 00:00:00

abstract：:ETS is a family of transcription factors that contain a highly conserved ETS DNA binding domain. Various members of the ETS family are expressed in cells of hematopoietic lineage. ETS-1, ETS-2 and ERGB/FLI-1 are expressed at high levels in T-lymphocytes. HIV-1 infects T-cells and it has been shown that its LTR contain...

journal_title：Oncogene

authors： Hodge DR,Robinson L,Watson D,Lautenberger J,Zhang XK,Venanzoni M,Seth A

更新日期：1996-01-04 00:00:00

abstract：:Ovarian cancer (OvCa) exhibits a specific predilection for metastasis to the omentum. Our earlier studies highlighted the tumour-suppressor effect of secreted protein acidic and rich in cysteine (SPARC) in OvCa through multi-faceted roles inhibiting cancer cell interactions within the peritoneal milieu. The goal of th...

journal_title：Oncogene

authors： John B,Naczki C,Patel C,Ghoneum A,Qasem S,Salih Z,Said N

更新日期：2019-05-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) causes fibrosis, cancer progression and metastasis. Integrin-linked kinase (ILK) is a focal adhesion adaptor and a serine/threonine protein kinase that regulates cell proliferation, survival and EMT. Elucidating the molecular mechanisms necessary for development and progressi...

journal_title：Oncogene

authors： Serrano I,McDonald PC,Lock FE,Dedhar S

更新日期：2013-01-03 00:00:00

abstract：:MicroRNAs (miRNAs) have been shown to have an important role in various cellular processes, such as apoptosis, differentiation and development. Recent studies have shown that miRNAs are mis-expressed in human cancers where they can exert their effect as oncogenes or tumor suppressors. Here, we review the potential for...

journal_title：Oncogene

authors： Trang P,Weidhaas JB,Slack FJ

更新日期：2008-12-01 00:00:00

abstract：:Snail1 is a master regulator of the epithelial-mesenchymal transition (EMT) and has been implicated in key tumor biological processes such as invasion and metastasis. It has been previously shown that poly(ADP-ribose) polymerase-1 (PARP-1) knockdown, but not PARP inhibition, downregulates the expression of Snail1. In ...

journal_title：Oncogene

authors： Rodríguez MI,González-Flores A,Dantzer F,Collard J,de Herreros AG,Oliver FJ

更新日期：2011-10-20 00:00:00

abstract：:An altered protein expression of Ca(2+)-dependent protein kinase C (PKC) isoforms and a point mutation in the PKC alpha cDNA (position 908 of the nucleotide sequence, position 294 of the amino acid sequence, substitution of an aspartic acid by a glycine) have been previously described in a subpopulation of human pitui...

journal_title：Oncogene

authors： Prévostel C,Alvaro V,de Boisvilliers F,Martin A,Jaffiol C,Joubert D

更新日期：1995-08-17 00:00:00

abstract：:The transcript encoding endonuclein, the human homolog of yeast PWP1, was previously found up-regulated in pancreatic cancer tissue. By immunohistochemistry we detected a ubiquitous presence in several tissues examined: skin, liver, thyroid gland, heart muscle, neurons, kidney, bladder, pancreas, adrenal gland, ovary,...

journal_title：Oncogene

authors： Honoré B,Baandrup U,Nielsen S,Vorum H

更新日期：2002-02-07 00:00:00

abstract：:The SCL/TAL1 gene was originally identified by virtue of its rearrangement and transcriptional activation in patients with T cell acute lymphoblastic leukaemia. It encodes a helix-loop-helix transcription factor, is not normally expressed in T cells, but is expressed in erythroid, mast, megakaryocytic and progenitor c...

journal_title：Oncogene

authors： Murrell AM,Bockamp EO,Göttgens B,Chan YS,Cross MA,Heyworth CM,Green AR

更新日期：1995-07-06 00:00:00

abstract：:Expression of viral proteins may result in susceptibility of cells to the cytotoxic effect of Tumor Necrosis Factor Alpha (TNF). While murine C127 cells containing the bovine papillomavirus type 1 (BPV-1) genome were reported to exhibit increased TNF sensitivity, the gene(s) responsible was not identified. The BPV-1 E...

journal_title：Oncogene

authors： Rapp L,Liu Y,Hong Y,Androphy EJ,Chen JJ

更新日期：1999-01-21 00:00:00

abstract：:The stress-activated pathways leading to activation of p38 MAP kinase (p38 MAPK) and c-jun N-terminal kinases (JNK) have been shown to be activated by pro-inflammatory cytokines, physical and chemical stresses as well as a variety of hematopoietic growth factors. One exception is interleukin (IL)-4, which does not act...

journal_title：Oncogene

authors： Wery-Zennaro S,Zugaza JL,Letourneur M,Bertoglio J,Pierre J

更新日期：2000-03-16 00:00:00

abstract：:Basal cell carcinoma (BCC) is one of the most common skin neoplasms in humans and is usually characterized by local aggressiveness with little metastatic potential, although deep invasion, recurrence, and regional and distant metastases may occur. Here, we studied the mechanism of BCC invasion. We found that human BCC...

journal_title：Oncogene

authors： Chu CY,Cha ST,Chang CC,Hsiao CH,Tan CT,Lu YC,Jee SH,Kuo ML

更新日期：2007-04-12 00:00:00

abstract：:Proliferating cells need to produce a large amount of energy and, at the same time, need to maintain a constant supply of biosynthetic precursors of macromolecules that are used as building blocks for generating new cells. Indeed, many cancer cells undergo a switch from mitochondrial to glycolytic metabolism and displ...

journal_title：Oncogene

authors： Deblois G,St-Pierre J,Giguère V

更新日期：2013-07-25 00:00:00

abstract：:c-Abl is a nuclear and cytoplasmic tyrosine kinase involved in a variety of cellular growth and differentiation processes. In contrast to its oncogenic counterparts, like BCR-Abl, c-Abl is not constitutively tyrosine phosphorylated and its catalytic activity is very low. Here we report tyrosine phosphorylation of endo...

journal_title：Oncogene

authors： Dorey K,Engen JR,Kretzschmar J,Wilm M,Neubauer G,Schindler T,Superti-Furga G

更新日期：2001-12-06 00:00:00

abstract：:The REL gene, encoding the NF-κB subunit c-Rel, is frequently amplified in B-cell lymphoma and functions as a tumour-promoting transcription factor. Here we report the surprising result that c-rel-/- mice display significantly earlier lymphomagenesis in the c-Myc driven, Eμ-Myc model of B-cell lymphoma. c-Rel loss als...

journal_title：Oncogene

authors： Hunter JE,Butterworth JA,Zhao B,Sellier H,Campbell KJ,Thomas HD,Bacon CM,Cockell SJ,Gewurz BE,Perkins ND

更新日期：2016-06-30 00:00:00

abstract：:Reovirus is a naturally oncolytic virus that preferentially replicates in Ras-transformed cells and is currently undergoing clinical trials as a cancer therapeutic. Ras transformation promotes reovirus oncolysis by enhancing virion disassembly during entry, viral progeny production, and virus release through apoptosis...

journal_title：Oncogene

authors： Garant KA,Shmulevitz M,Pan L,Daigle RM,Ahn DG,Gujar SA,Lee PW

更新日期：2016-02-11 00:00:00

abstract：:Tamoxifen (Tam), besides its action as an anti-estrogen, also inhibits cell proliferation of estrogen receptor (ER)-negative cancer cells by an unknown mechanism. In this study, we used ER-negative lung cancer cells to clarify such ER-independent inhibitory effect of Tam. We found that Tam induced G1 growth arrest in ...

journal_title：Oncogene

authors： Lee TH,Chuang LY,Hung WC

更新日期：1999-07-22 00:00:00

abstract：:Intrachromosomal rearrangements involving the RET and the adjacent H4 or ELE1 gene are very frequent events in thyroid cancer of children from Belarus after the Chernobyl reactor accident (Klugbauer et al., 1995). The fusion product between ELE1 and RET (RET/ PTC3) seems to be the prevailing type of rearrangement as s...

journal_title：Oncogene

authors： Klugbauer S,Lengfelder E,Demidchik EP,Rabes HM

更新日期：1996-09-05 00:00:00

abstract：:In the G2 phase cell cycle checkpoint arrest, the cdc25-dependent activation of cyclin B/cdc2, a critical step in regulating entry into mitosis, is blocked. Studies in yeast have demonstrated that the inhibition of cdc25 function involves 14-3-3 binding to cdc25. In humans, two cdc25 isoforms have roles in G2/M progre...

journal_title：Oncogene

authors： Forrest A,Gabrielli B

更新日期：2001-07-19 00:00:00

abstract：:We evaluated the effect of nitric oxide (NO) on vascular endothelial growth factor (VEGF) gene expression in human A-172 glioblastoma cells and human HepG2 hepatocellular carcinoma cells. The mRNA level of VEGF increased in response to S-Nitroso-N-acetyl-D,L-penicillamine (SNAP) in both cell lines, and increased in mR...

journal_title：Oncogene

authors： Chin K,Kurashima Y,Ogura T,Tajiri H,Yoshida S,Esumi H

更新日期：1997-07-24 00:00:00

abstract：:Detachment of non-malignant epithelial cells from the extracellular matrix causes their apoptosis, a phenomenon called anoikis. By contrast, carcinoma cells are anoikis-resistant, and this resistance is thought to be critical for tumor progression. Many oncogenes trigger not only anti- but also pr-apoptotic signals. T...

journal_title：Oncogene

authors： Yoo BH,Masson O,Li Y,Khan IA,Gowda PS,Rosen KV

更新日期：2015-09-17 00:00:00

abstract：:The p21WAF1/CIP1/SDI1 gene is an important regulator of crucial cellular processes, including cell cycle control, cellular differentiation, and the response to genotoxic stress. Induction of p21 gene expression upon DNA damage is widely believed to be p53-dependent. In the present study we analysed the expression of p...

journal_title：Oncogene

authors： Butz K,Geisen C,Ullmann A,Zentgraf H,Hoppe-Seyler F

更新日期：1998-08-13 00:00:00

abstract：:Oncogenic Ras is known to drive both the Rac and Raf-MAP-kinase pathways, which act in concert to cause cell transformation. Unlike the Raf-MAP-kinase cascade, however, the downstream elements of Rac pathway are not fully understood. Previously, we showed that cytosolic phospholipase A2 (cPLA2) and subsequent metaboli...

journal_title：Oncogene

authors： Yoo MH,Song H,Woo CH,Kim H,Kim JH

更新日期：2004-12-09 00:00:00

abstract：:Activating mutations of the ALK receptor occur in a subset of neuroblastoma tumors. We previously demonstrated that Alk mutations cooperate with MYCN overexpression to induce neuroblastoma in mice and identified Ret as being strongly upregulated in MYCN/Alkmut tumors. By a genetic approach in vivo, we now document an ...

journal_title：Oncogene

authors： Lopez-Delisle L,Pierre-Eugène C,Louis-Brennetot C,Surdez D,Raynal V,Baulande S,Boeva V,Grossetête-Lalami S,Combaret V,Peuchmaur M,Delattre O,Janoueix-Lerosey I

更新日期：2018-03-01 00:00:00

abstract：:Amplified segments of the long arm of chromosome 12 are frequently observed in human sarcomas. In most cases there are separate amplified regions around the MDM2 and CDK4 genes. Here we show recurrent amplification of a third region encompassing HMGIC, a human architectural transcription factor gene. Reduced amplifica...

journal_title：Oncogene

authors： Berner JM,Meza-Zepeda LA,Kools PF,Forus A,Schoenmakers EF,Van de Ven WJ,Fodstad O,Myklebost O

更新日期：1997-06-19 00:00:00

abstract：:The Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) has a significant role in initiating EBV-associated lymphoproliferative disease and EBV-related malignancies. In view of clinical features related to the type of EBV latency, LMP1 may influence invasiveness of EBV associated tumors categorized as ty...

journal_title：Oncogene

authors： Kim KR,Yoshizaki T,Miyamori H,Hasegawa K,Horikawa T,Furukawa M,Harada S,Seiki M,Sato H

更新日期：2000-03-30 00:00:00

abstract：:The precise genetic mechanism of malignant transformation in DNA mismatch repair deficient, microsatellite-unstable colorectal cancer (CRC) has yet to be elucidated. We employed cDNA microarray to identify patterns of gene expression among CRC cell lines and to compare directly lines with and without microsatellite in...

journal_title：Oncogene

authors： Yuan Z,Sotsky Kent T,Weber TK

更新日期：2003-09-18 00:00:00