Facilitation of adenoviral wild-type p53-induced apoptotic cell death by overexpression of p33(ING1) in T.Tn human esophageal carcinoma cells.

abstract：:TGF-beta/Smads regulate a wide variety of biological responses through transcriptional regulation of target genes. ELF, a beta-spectrin, plays a key role in the transmission of TGF-beta-mediated transcriptional response through Smads. ELF was originally identified as a key protein involved in endodermal stem/progenito...

journal_title：Oncogene

authors： Katuri V,Tang Y,Marshall B,Rashid A,Jogunoori W,Volpe EA,Sidawy AN,Evans S,Blay J,Gallicano GI,Premkumar Reddy E,Mishra L,Mishra B

更新日期：2005-12-01 00:00:00

abstract：:The cdk2 gene has been identified as a human cdc2/CDC28-related gene that encodes a protein kinase essential for the G1/S transition in mammalian cells, but not for the G2/M transition, which requires Cdk1, another p34cdc2/CDC28 homolog. Novel potential functions of Cdk2 have been uncovered by using two potent and spe...

journal_title：Oncogene

authors： David-Pfeuty T

更新日期：1999-12-09 00:00:00

abstract：:Accumulating evidences have shown the association between aberrantly expressed microRNAs (miRs) and cancer, where these small regulatory RNAs appear to dictate the cell fate by regulating all the main biological processes. We demonstrated the responsibility of the circuitry connecting the oncomiR-221&222 with the tumo...

journal_title：Oncogene

authors： Felli N,Errico MC,Pedini F,Petrini M,Puglisi R,Bellenghi M,Boe A,Felicetti F,Mattia G,De Feo A,Bottero L,Tripodo C,Carè A

更新日期：2016-06-09 00:00:00

abstract：:Colorectal cancer (CRC) is a heterogeneous disease posing a challenge for accurate classification and treatment of this malignancy. There is no common genetic molecular feature that would allow for the identification of patients at risk for developing recurrences and thus selecting patients who would benefit from more...

journal_title：Oncogene

authors： Fessler E,Jansen M,De Sousa E Melo F,Zhao L,Prasetyanti PR,Rodermond H,Kandimalla R,Linnekamp JF,Franitza M,van Hooff SR,de Jong JH,Oppeneer SC,van Noesel CJ,Dekker E,Stassi G,Wang X,Medema JP,Vermeulen L

更新日期：2016-11-17 00:00:00

abstract：:In addition to breast and ovarian cancer in women, recent evidence suggests that germ-line mutations of the breast cancer susceptibility gene-1 (BRCA1) also confer an increased life-time risk for prostate cancer in male probands. However, it is not known if and how BRCA1 functions in prostate cancer. We stably express...

journal_title：Oncogene

authors： Fan S,Wang JA,Yuan RQ,Ma YX,Meng Q,Erdos MR,Brody LC,Goldberg ID,Rosen EM

更新日期：1998-06-11 00:00:00

abstract：:The essential role of prolactin (PRL) in normal mammary gland growth and differentiation has implicated this hormone in the development and progression of breast cancer. Although Stat5 is the best-characterized mediator of PRL signals, PRL also activates multiple other signals, whose roles in normal and pathologic pro...

journal_title：Oncogene

authors： Gutzman JH,Rugowski DE,Nikolai SE,Schuler LA

更新日期：2007-09-20 00:00:00

abstract：:Adenovirus contains two nuclear oncogenes, the EIA and EIB genes, which cooperatively can transform cells through mechanisms that are not understood. The transcriptional activities of the E1A gene (transactivation and repression) are well studied. Using transient expression assays, we show here that the 19,000-Da E1B ...

journal_title：Oncogene

authors： Herrmann CH,Dery CV,Mathews MB

更新日期：1987-01-01 00:00:00

abstract：:The effect of p53-dependent cell-cycle arrest and senescence on Emu-myc-induced B-cell lymphoma development remains controversial. To address this question, we crossed Emu-myc mice with the p53(515C) mutant mouse, encoding the mutant p53R172P protein that retains the ability to activate the cell-cycle inhibitor and se...

journal_title：Oncogene

authors： Post SM,Quintás-Cardama A,Terzian T,Smith C,Eischen CM,Lozano G

更新日期：2010-03-04 00:00:00

abstract：:Over 70% of human breast cancers are estrogen receptor-positive (ER+), most of which express MYB. In these and other cell types, the MYB transcription factor regulates the expression of many genes involved in cell proliferation, differentiation, tumorigenesis, and apoptosis. So far, no clear link has been established ...

journal_title：Oncogene

authors： Yang RM,Nanayakkara D,Kalimutho M,Mitra P,Khanna KK,Dray E,Gonda TJ

更新日期：2019-06-01 00:00:00

abstract：:The c-Myc oncoprotein is a basic-helix-loop-helix-leucine zipper (b-HLH-LZ) transcription factor involved in regulating cell proliferation and differentiation. We have used retrovirus-mediated gene transfer to investigate the effect of ectopic c-Myc expression on the spontaneous differentiation of primary quail myobla...

journal_title：Oncogene

authors： La Rocca SA,Crouch DH,Gillespie DA

更新日期：1994-12-01 00:00:00

abstract：:Low oxygen tension (hypoxia) is a common feature of solid tumors and stimulates the expressions of a variety of genes including those related to angiogenesis, apoptosis and endoplasmic reticulum (ER) stress response. Here we show a close correlation between metastatic potential and the resistance to hypoxia- and ER st...

journal_title：Oncogene

authors： Koshikawa N,Maejima C,Miyazaki K,Nakagawara A,Takenaga K

更新日期：2006-02-09 00:00:00

abstract：:The NF2 gene product, merlin/schwannomin, is a cytoskeleton organizer with unique growth-inhibiting activity in specific cell types. A narrow spectrum of tumors is associated with NF2 deficiency, mainly schwannomas and meningiomas, suggesting cell-specific mechanisms of growth control. We have investigated merlin func...

journal_title：Oncogene

authors： Lallemand D,Manent J,Couvelard A,Watilliaux A,Siena M,Chareyre F,Lampin A,Niwa-Kawakita M,Kalamarides M,Giovannini M

更新日期：2009-02-12 00:00:00

abstract：:Atypical protein kinase C (aPKC) and Lethal giant larvae (Lgl) regulate apical-basal polarity in Drosophila and mammalian epithelia. At the apical domain, aPKC phosphorylates and displaces Lgl that, in turn, maintains aPKC inactive at the basolateral region. The mutual exclusion of these two proteins seems to be cruci...

journal_title：Oncogene

authors： Grifoni D,Garoia F,Bellosta P,Parisi F,De Biase D,Collina G,Strand D,Cavicchi S,Pession A

更新日期：2007-08-30 00:00:00

abstract：:The post-translational modifications ubiquitination and sumoylation have been implicated in regulating many critical cellular pathways. Like ubiquitination, sumoylation is a multistep process involving maturation, activation, conjugation and deconjugation. Ubc9 is a sole E2-conjugating enzyme essential for sumoylation...

journal_title：Oncogene

authors： Mo YY,Yu Y,Theodosiou E,Ee PL,Beck WT

更新日期：2005-04-14 00:00:00

abstract：:A Rho GTPase-activating protein (RhoGAP), deleted in liver cancer 1 (DLC1), is known to function as a tumor suppressor in various cancer types; however, whether DLC1 is a tumor-suppressor gene or an oncogene in melanoma remains to be clarified. Here we revealed that high DLC1 expression was detected in most of the mel...

journal_title：Oncogene

authors： Yang X,Hu F,Liu JA,Yu S,Cheung MPL,Liu X,Ng IO,Guan XY,Wong KKW,Sharma R,Lung HL,Jiao Y,Lee LTO,Cheung M

更新日期：2020-05-01 00:00:00

abstract：:Urothelial carcinoma (UC) carcinogenesis has been hypothesized to occur through epigenetic repression of tumor-suppressor genes (TSGs). By quantitative real-time polymerase chain reaction array, we found that one potential TSG, angiopoietin-like 4 (ANGPTL4), was expressed at very low levels in all bladder cancer cell ...

journal_title：Oncogene

authors： Hsieh HY,Jou YC,Tung CL,Tsai YS,Wang YH,Chi CL,Lin RI,Hung SK,Chuang YM,Wu SF,Li C,Shen CH,Chan MWY,Hsu CD

更新日期：2018-02-01 00:00:00

abstract：:The etiology of cancers appears to be complex and multifactorial. Peyton Rous and others demonstrated the process of co-carcinogenesis by exposing rabbits to a virus and tars. Epidemiologists have proposed virus-chemical interactions to cause several cancers. For example, one might propose that the etiology of cervica...

journal_title：Oncogene

authors： Haverkos HW

更新日期：2004-08-23 00:00:00

abstract：:Tumor cells are characterized by deregulated proliferation and resistance to proapoptotic stimuli. The Bcl-2 family of antiapoptotic proteins is overexpressed in a large number of chemoresistant tumors. Downregulation or inhibition of antiapoptotic proteins might result in the sensitization of cancer cells to chemothe...

journal_title：Oncogene

authors： Nouvion AL,Thibaut J,Lohez OD,Venet S,Colas P,Gillet G,Lalle P

更新日期：2007-02-01 00:00:00

abstract：:The clonality of lymphomas that originate in myc/pim-1 bitransgenic mice due to synergistic action of both oncogenes indicates the requirement of additional events for progression to full malignancy. To isolate genes that cooperate with both myc and pim-1, we have used provirus tagging with E mu L-myc/pim-1 double tra...

journal_title：Oncogene

authors： Zörnig M,Schmidt T,Karsunky H,Grzeschiczek A,Möröy T

更新日期：1996-04-18 00:00:00

abstract：:The onset of human lung cancer occurs through sequential mutations in oncogenes and tumor suppressor genes. Mutations in K-Ras play a prominent role in human non-small cell lung cancer. We have developed a mouse lung tumor model in which K-Ras can be sporadically activated through Cre-lox mediated somatic recombinatio...

journal_title：Oncogene

authors： Meuwissen R,Linn SC,van der Valk M,Mooi WJ,Berns A

更新日期：2001-10-04 00:00:00

abstract：:The membrane-anchored MMP-regulator RECK is down regulated in many solid tumors; the extent of RECK down regulation correlates with poor prognosis. Forced expression of RECK in tumor cells results in suppression of angiogenesis, invasion, and metastasis. Studies on the roles and the mechanisms of regulation of the REC...

journal_title：Oncogene

authors： Echizenya M,Kondo S,Takahashi R,Oh J,Kawashima S,Kitayama H,Takahashi C,Noda M

更新日期：2005-09-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human cancers, with 5-year patient survival rates of <5%. Activating mutations in KRAS are the predominant oncogenic drivers of PDAC but are accompanied by additional lower frequency genetic alterations. Our group previously identified the guanine ...

journal_title：Oncogene

authors： Joseph J,Radulovich N,Wang T,Raghavan V,Zhu CQ,Tsao MS

更新日期：2020-01-01 00:00:00

abstract：:The IGF2 gene, which encodes a growth factor, is subject to genomic imprinting. The frequently observed loss of IGF2 imprinting in a variety of tumors has been suggested to contribute to neoplasia. Since these reports have not documented the imprinting status of IGF2 at the cellular level, it cannot be excluded that t...

journal_title：Oncogene

authors： He L,Cui H,Walsh C,Mattsson R,Lin W,Anneren G,Pfeifer-Ohlsson S,Ohlsson R

更新日期：1998-01-08 00:00:00

abstract：:Castration-resistant prostate cancer (CRPC) continues to be a major clinical problem and the mechanisms behind it remain unclear. Thioredoxin domain-containing protein 5 (TXNDC5) is involved in protein folding and chaperone activity, and its overexpression has been reported in multiple malignancies. In the current stu...

journal_title：Oncogene

authors： Wang L,Song G,Chang X,Tan W,Pan J,Zhu X,Liu Z,Qi M,Yu J,Han B

更新日期：2015-09-03 00:00:00

abstract：:The human MSH2/6 complex is essential for mismatch recognition during the repair of replication errors. Although mismatch repair components have been implicated in DNA homologous recombination repair, the exact function of hMSH2/6 in this pathway is unclear. Here, we show that the recombinant hMSH2/6 protein complex s...

journal_title：Oncogene

authors： Yang Q,Zhang R,Wang XW,Linke SP,Sengupta S,Hickson ID,Pedrazzi G,Perrera C,Stagljar I,Littman SJ,Modrich P,Harris CC

更新日期：2004-05-06 00:00:00

abstract：:Mice transgenic for the leukemia oncogene E2A-PBX1 invariably develop lethal, high-grade T-cell lymphomas by 5 months of age. In this study, retroviral insertional mutagenesis was employed to identify oncogenes that cooperate with the E2A-PBX1 transgene in lymphomagenesis. Neonatal retroviral infection substantially r...

journal_title：Oncogene

authors： Feldman BJ,Reid TR,Cleary ML

更新日期：1997-11-27 00:00:00

abstract：:We have isolated a candidate tumor suppressor gene from a 600-kb region on chromosome 8p21.3-p22 that is commonly deleted in sporadic hepatocellular carcinomas (HCC), colorectal cancers (CRC), and non-small cell lung cancers (NSCLC). As this gene encodes a protein of 375 amino acids that bears significant sequence sim...

journal_title：Oncogene

authors： Fujiwara Y,Ohata H,Kuroki T,Koyama K,Tsuchiya E,Monden M,Nakamura Y

更新日期：1995-03-02 00:00:00

abstract：:Keratinocytes undergo a dramatic phenotypic conversion during reepithelialization of skin wounds to become hyperproliferative, migratory, and invasive. This transient healing response phenotypically resembles malignant transformation of keratinocytes during squamous cell carcinoma progression. Here we present the firs...

journal_title：Oncogene

authors： Pedersen TX,Leethanakul C,Patel V,Mitola D,Lund LR,Danø K,Johnsen M,Gutkind JS,Bugge TH

更新日期：2003-06-19 00:00:00

abstract：:GRIM-19 (Gene associated with Retinoid-Interferon-induced Mortality 19) is a novel tumor suppressor regulated by interferon/retinoid combination. We have recently shown that GRIM-19 inhibits v-Src-induced oncogenic transformation and metastatic behavior of cells. Oncogenic v-Src induces cell motility by cytoskeletal r...

journal_title：Oncogene

authors： Sun P,Nallar SC,Kalakonda S,Lindner DJ,Martin SS,Kalvakolanu DV

更新日期：2009-03-12 00:00:00

abstract：:The DNA-binding, transcriptional activation and transforming activities of the Myc protein require dimerization with Max. Max can form also homodimers which are able to bind the same DNA sequence as Myc/Max heterodimers and suppress Myc-induced transcription and transformation. We have recently identified a naturally ...

journal_title：Oncogene

authors： Västrik I,Mäkelä TP,Koskinen PJ,Alitalo K

更新日期：1995-08-03 00:00:00