Abstract:
:The onset of human lung cancer occurs through sequential mutations in oncogenes and tumor suppressor genes. Mutations in K-Ras play a prominent role in human non-small cell lung cancer. We have developed a mouse lung tumor model in which K-Ras can be sporadically activated through Cre-lox mediated somatic recombination. Adenoviral mediated delivery of Cre recombinase in lung epithelial cells gave rise to rapid onset of tumorigenesis, yielding pulmonary adenocarcinomas with 100% incidence after a short latency. The lung tumor lesions shared many features with human non-small cell lung cancer. Our data show that sporadic expression of the K-Ras oncogene is sufficient to elicit lung tumorigenesis. Therefore this model has many advantages over conventional transgenic models used thus far.
journal_name
Oncogenejournal_title
Oncogeneauthors
Meuwissen R,Linn SC,van der Valk M,Mooi WJ,Berns Adoi
10.1038/sj.onc.1204837subject
Has Abstractpub_date
2001-10-04 00:00:00pages
6551-8issue
45eissn
0950-9232issn
1476-5594journal_volume
20pub_type
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