Abstract:
:Since it is reported that adrenomedullin (AM) upregulated by hypoxia inhibits hypoxic cell death, we examined the effects of AM antagonist (AM C-terminal fragment; AM(22-52)) on the growth of pancreatic cancer cells. We, for the first time, demonstrated that AM antagonist significantly reduced the in vivo growth of the pancreatic cancer cell line. Immunohistochemical analysis demonstrated that the mean diameter of blood vessels was significantly smaller in the tumor tissues treated with AM antagonist than in those treated with AM N-terminal fragment (AM(1-25)), and that the PCNA-labeling index was lower in the former than in the latter. Then we demonstrated that AM antagonist showed no effect on the in vitro growth of the pancreatic cancer cell line. These results showed that AM played an important role in the growth of pancreatic cancer cells in vivo, suggesting that AM antagonist might be a useful tool for treating pancreatic cancers.
journal_name
Oncogenejournal_title
Oncogeneauthors
Ishikawa T,Chen J,Wang J,Okada F,Sugiyama T,Kobayashi T,Shindo M,Higashino F,Katoh H,Asaka M,Kondo T,Hosokawa M,Kobayashi Mdoi
10.1038/sj.onc.1206207subject
Has Abstractpub_date
2003-02-27 00:00:00pages
1238-42issue
8eissn
0950-9232issn
1476-5594pii
1206207journal_volume
22pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::The ets-related transcription factors PEA3 and ER81 have recently been isolated and characterized in the mouse. They share 95% identity in a 85 amino acid (AA) domain termed the ETS domain which is responsible for DNA binding, and therefore they form an Ets family group. By screening a human testis cDNA library with a...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::An improved understanding of the biochemical alterations that accompany tumor progression and metastasis is necessary to inform the next generation of diagnostic tools and targeted therapies. Metabolic reprogramming is known to occur during the epithelial-mesenchymal transition (EMT), a process that promotes metastasi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0885-4
更新日期:2020-04-01 00:00:00
abstract::An elevated proteasome activity contributes to tumorigenesis, particularly by providing cancer cells with antiapoptotic protection and efficient clearance from irregular proteins. Still, the underlying mechanisms are poorly known. In this study, we report that in colon cancer patients, higher proteasome activity was d...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.264
更新日期:2009-11-12 00:00:00
abstract::Here we describe the identification of a novel vertebrate-specific centrosome/spindle pole-associated protein (CSPP) involved in cell-cycle regulation. The protein is predicted to have a tripartite domain structure, where the N- and C-terminal domains are linked through a coiled-coil mid-domain. Experimental analysis ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208267
更新日期:2005-02-10 00:00:00
abstract::Understanding the molecular mechanisms that underlie the aggressive behavior and relapse of breast cancer may help in the development of novel therapeutic interventions. CUB-domain-containing protein 1 (CDCP1), a transmembrane adaptor protein, is highly maintained and required in the context of cellular metastatic pot...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0372-3
更新日期:2018-10-01 00:00:00
abstract::The transcription factor E2F activates genes required for S phase, such as cyclin E and cyclin A. We show that, contrary to long term effects of E2F-1 overexpression, short ectopic overexpression of this transcription factor in logarithmically growing cells does neither affect the cell cycle distribution nor the cell ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201061
更新日期:1997-05-15 00:00:00
abstract::The stress-activated protein kinases (SAPKs), also known as c-Jun amino-terminal kinases (JNKs), are activated in response to diverse stimuli including DNA damage, heat shock, interleukin-1, tumor necrosis factor-alpha and Fas. Although all these inducers cause apoptosis, whether SAPK/JNK activation is required for ap...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201253
更新日期:1997-08-14 00:00:00
abstract::Cancer cells are known to adopt aerobic glycolysis in order to fuel tumor growth, but the molecular basis of this metabolic shift remains largely undefined. O-GlcNAcase (OGA) is an enzyme harboring O-linked β-N-acetylglucosamine (O-GlcNAc) hydrolase and cryptic lysine acetyltransferase activities. Here, we report that...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0975-3
更新日期:2020-01-01 00:00:00
abstract::While advances in laboratory automation has dramatically increased throughout of compound screening efforts, development of robust cell-based assays in relevant disease models remain resource-intensive and time-consuming, presenting a bottleneck to drug discovery campaigns. To address this issue, we present a modified...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0274-4
更新日期:2018-08-01 00:00:00
abstract::c-Abl is a nuclear and cytoplasmic tyrosine kinase involved in a variety of cellular growth and differentiation processes. In contrast to its oncogenic counterparts, like BCR-Abl, c-Abl is not constitutively tyrosine phosphorylated and its catalytic activity is very low. Here we report tyrosine phosphorylation of endo...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205017
更新日期:2001-12-06 00:00:00
abstract::Cancer-Associated Fibroblasts (CAFs) are the most prominent stromal cell type in breast tumors. CAFs promote tumor growth and metastasis by multiple mechanisms, including by mediating tumor-promoting inflammation. Immune modulation in the tumor microenvironment plays a central role in determining disease outcome. Howe...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.65
更新日期:2017-08-01 00:00:00
abstract::The transcriptional activity of the androgen receptor (AR) is regulated by both ligand binding and post-translational modifications, including acetylation and small ubiquitin-like modifier (SUMO)ylation. Histone deacetylases (HDACs) are known to catalyze the removal of acetyl groups from both histones and non-histone ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.600
更新日期:2011-05-12 00:00:00
abstract::The neu oncogene encodes a 185,000 dalton transmembrane glycoprotein, p185. The current study examined the effects of p185-specific monoclonal antibody administration on the tumorigenic growth of neu-transformed NIH3T3 cells implanted into nude mice. Treatment with anti-p185 monoclonal antibodies of the IgG1, IgG2a, I...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1988-03-01 00:00:00
abstract::Snail1 is a master regulator of the epithelial-mesenchymal transition (EMT) and has been implicated in key tumor biological processes such as invasion and metastasis. It has been previously shown that poly(ADP-ribose) polymerase-1 (PARP-1) knockdown, but not PARP inhibition, downregulates the expression of Snail1. In ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.153
更新日期:2011-10-20 00:00:00
abstract::Gads is a member of the family of SH2 and SH3 domain containing adaptor proteins that is expressed specifically in hematopoietic cells and functions in the coordination of tyrosine kinase mediated signal transduction. Gads plays a critical role in signalling from the T cell receptor by promoting the formation of a com...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1204771
更新日期:2001-10-01 00:00:00
abstract::Src family kinases are prototypical modular signaling proteins. Their conserved domain organization includes a myristoylated N-terminal segment followed by SH3, SH2, and tyrosine kinase domains, and a short C-terminal tail. Structural dissection of Src kinases has elucidated the canonical mechanisms of phosphotyrosine...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1208081
更新日期:2004-10-18 00:00:00
abstract::Although ErbB2 is known to enhance breast cancer metastasis, the signaling events responsible for this remain elusive. Alpha-isozyme of protein kinase C (PKCalpha), which is involved in cancer development and progression, has been suggested to be activated by ErbB2 without direct evidence. In addition, the roles of PK...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209361
更新日期:2006-06-01 00:00:00
abstract::Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer and frequently diagnosed at an advanced stage. It is prone to develop unpredictable metastases even with proper treatment. Antiangiogenic therapy is the most effective medical treatment for metastatic ccRCC. Thus, exploration of novel approaches t...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-01428-3
更新日期:2020-09-01 00:00:00
abstract::In mammalian cells, the p53 protein is a key regulator of the cell cycle following DNA damage. In the present study, we investigated the function of p53 in the A6 amphibian cell line. Using various specific Xenopus p53 monoclonal antibodies, we showed that Xenopus p53 accumulates after DNA damage, including gamma and ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204492
更新日期:2001-06-28 00:00:00
abstract::Transcription from the rat TGF alpha promoter initiates at two predominant sites (-188 and -58) in a G+C-rich region that does not contain TATA or CAAT motifs. Previous studies using transfected reporter constructs implicated the transcription factor Sp1 in active expression from the promoter, particularly from the -5...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a unique head and neck cancer with highly aggressive and metastatic potential in which distant metastasis is the main reason for treatment failure. Till present, the underlying molecular mechanisms of NPC metastasis remains poorly understood. Here, we identified S100 calcium-binding p...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-1363-8
更新日期:2020-07-01 00:00:00
abstract::Paxillin (PXN), a key component of the focal adhesion complex, has been associated with cancer progression, but the underlying mechanisms are poorly understood. The purpose of this study was to elucidate mechanisms by which PXN affects cancer growth and progression, which we addressed using cancer patient data, cell l...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-01517-3
更新日期:2021-01-01 00:00:00
abstract::The E2F1 transcription factor plays a pivotal role in driving cells out of a quiescent state and into the S phase of the cell cycle, in part by transactivating genes needed for DNA replication including DHFR, thymidine kinase, and DNA Polymerase alpha. E2F1 has also been implicated in regulating an S phase checkpoint,...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205473
更新日期:2002-05-23 00:00:00
abstract::Ewing sarcoma is characterized by the expression of the chimeric EWSR1-FLI1 transcription factor. Proteomic analyses indicate that the decrease of EWSR1-FLI1 expression leads to major changes in effectors of the dynamics of the actin cytoskeleton and the adhesion processes with a shift from cell-to-cell to cell-matrix...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.498
更新日期:2017-06-22 00:00:00
abstract::Oncogenesis results from changes in kinetics or in abundance of proteins in signal transduction networks. Recently, it was shown that control of signalling cannot reside in a single gene product, and might well be dispersed over many components. Which of the reactions in these complex networks are most important, and ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208817
更新日期:2005-08-25 00:00:00
abstract::The management of pain and morbidity due to the spreading and growth of cancer within bone remains to be a paramount problem in clinical care. Cancer cells actively transform bone, however, the molecular requirements and mechanisms of this process remain unclear. This study shows that functional modulation of the alph...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210429
更新日期:2007-09-13 00:00:00
abstract::Normal function of the p53 gene is integral to the cellular response to genotoxic stress. One prediction arising from this is that p53 deficiency results in an increased mutation frequency. However, limited evidence has been produced in support of this idea. In order to further investigate the in vivo role of p53 in s...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201040
更新日期:1997-05-01 00:00:00
abstract::Defects in a developmental signaling pathway involving the mammalian homologue of the Drosophila segment polarity gene, patched are associated with human tumors such as basal cell carcinoma, medulloblastoma and squamous cell carcinoma. Loss of heterozygosity (LOH) in some of these tumor cells suggests that patched fun...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205370
更新日期:2002-04-18 00:00:00
abstract::This study addresses the question of whether loss of p16INK4 expression contributes to the immortalization of human cells. In vitro immortalization usually proceeds through two phases. In the first phase (lifespan extension), cells continue proliferating and their telomeres continue shortening beyond the point at whic...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-09-19 00:00:00
abstract::Mcl-1 is a critical antiapoptotic survival factor for human multiple myeloma (MM). We examined the importance of IL-6 for Mcl-1 expression in five MM cell lines and in primary MM cells from 14 patients. While culture of MM.1S cells in IL-6 did induce Mcl-1 expression, four other MM cell lines exhibited high levels of ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206358
更新日期:2003-03-27 00:00:00