WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma.

abstract：:The translational efficiency of chloramphenicol acetyltransferase (CAT) mRNA containing 5' untranslated region (UTR) sequences of Xenopus c-myc I mRNA was examined in the Xenopus oocyte and early embryo. In contrast to their reduced translation in the oocyte, CAT mRNAs containing 5' UTR sequences located between the c...

journal_title：Oncogene

authors： Lazarus P

更新日期：1992-05-01 00:00:00

abstract：:The NAD-dependent deacetylase sirtuin 1 (SIRT1), a member of the mammalian sirtuin family, plays a pivotal role in deacetylating histone and nonhistone proteins. Recently, it has been reported that SIRT1 is upregulated in various kinds of tumors and is associated with cell growth and metastasis. However, the factors a...

journal_title：Oncogene

authors： Yu L,Dong L,Li H,Liu Z,Luo Z,Duan G,Dai X,Lin Z

更新日期：2020-05-01 00:00:00

abstract：:With the development of a specific anti-rab2 antiserum, p23rab2, a ras-like GTPase with a -GGGCC C-terminus, has been localized mainly to the particulate (P100) fraction in NIH3T3 cells, although a small amount of this protein also appears in the soluble fraction. The endogenous p23rab2 is isoprenylated in intact cell...

journal_title：Oncogene

authors： Wei C,Lutz R,Sinensky M,Macara IG

更新日期：1992-03-01 00:00:00

abstract：:Maf b-Zip transcription factors are involved in both terminal differentiation and oncogenesis. To investigate this apparent contradiction, we used two different primary cell types and performed an extensive analysis of transformation parameters induced by Maf proteins. We show that MafA and c-Maf are potent oncogenes ...

journal_title：Oncogene

authors： Pouponnot C,Sii-Felice K,Hmitou I,Rocques N,Lecoin L,Druillennec S,Felder-Schmittbuhl MP,Eychène A

更新日期：2006-03-02 00:00:00

abstract：:Protein arginine methyltransferase 5 (PRMT5) complexed with MEP50/WDR77 catalyzes arginine methylation on histones and other proteins. PRMT5-MEP50 activity is elevated in cancer cells and its expression is highly correlated with poor prognosis in many human tumors. We demonstrate that PRMT5-MEP50 is essential for tran...

journal_title：Oncogene

authors： Chen H,Lorton B,Gupta V,Shechter D

更新日期：2017-01-19 00:00:00

abstract：:Ataxia telangiectasia (AT) is a human hereditary syndrome whose underlying gene product, ataxia telangiectasia mutated (ATM) protein kinase, is involved in multiple intracellular signaling pathways. We demonstrated previously that AT fibroblasts are defective in intracellular Ca(2+) mobilization in response to both st...

journal_title：Oncogene

authors： Famulski KS,Al-Hijailan RS,Dobler K,Pienkowska M,Al-Mohanna F,Paterson MC

更新日期：2003-01-23 00:00:00

abstract：:Only humans and higher primates have high uric acid blood levels. Although high uric acid causes gout, it has been linked with human longevity because of its hypothetical antioxidant function. Recent studies reveal that p53 has significant roles in cellular metabolism. One example of this is an antioxidant function th...

journal_title：Oncogene

authors： Itahana Y,Han R,Barbier S,Lei Z,Rozen S,Itahana K

更新日期：2015-04-02 00:00:00

abstract：:The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLr). Ubiquitin-dependent degradation of the PRLr that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLr on Ser349 followed by the recruitment of the beta-transducin ...

journal_title：Oncogene

authors： Li Y,Clevenger CV,Minkovsky N,Kumar KG,Raghunath PN,Tomaszewski JE,Spiegelman VS,Fuchs SY

更新日期：2006-03-23 00:00:00

abstract：:Alu sequences are the most abundant short interspersed repeated elements in the human genome. Here we show that in a cell culture model of colorectal cancer (CRC) progression, we observe accumulation of Alu RNA that is associated with reduced DICER1 levels. Alu RNA induces epithelial-to-mesenchymal transition (EMT) by...

journal_title：Oncogene

authors： Di Ruocco F,Basso V,Rivoire M,Mehlen P,Ambati J,De Falco S,Tarallo V

更新日期：2018-02-01 00:00:00

abstract：:p27Kip1 is a regulator of the mammalian cell cycle and a putative tumor suppressor. Distinct altered patterns of p27Kip1 protein expression are found in a variety of human carcinomas, and p27Kip1 expression levels usually correlate directly with disease-free survival. The mechanism(s) by which p27Kip1 expression is re...

journal_title：Oncogene

authors： Worm J,Bartkova J,Kirkin AF,Straten P,Zeuthen J,Bartek J,Guldberg P

更新日期：2000-10-19 00:00:00

abstract：:The FoxO family of Forkhead transcription factors plays an important role in longevity and tumor suppression by upregulating target genes involved in stress resistance, metabolism, cell cycle arrest and apoptosis. FoxO transcription factors translate a variety of environmental stimuli, including insulin, growth factor...

journal_title：Oncogene

authors： Calnan DR,Brunet A

更新日期：2008-04-07 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasm. While ATL cells in peripheral blood (PB-ATL) are sensitive to anti-CC chemokine receptor 4 treatment, non-PB-ATLs, including lymph node ATLs (LN-ATLs), are more aggressive and resistant. We examined characteristic cytokines and growth factors that ...

journal_title：Oncogene

authors： Totani H,Shinjo K,Suzuki M,Katsushima K,Mase S,Masaki A,Ito A,Ri M,Kusumoto S,Komatsu H,Ishida T,Inagaki H,Iida S,Kondo Y

更新日期：2020-08-01 00:00:00

abstract：:Members of the Myc proto-oncogene family encode transcription factors that function in multiple aspects of cell behavior, including proliferation, differentiation, transformation and apoptosis. Recent studies have shown that MYC activities are modulated by a network of nuclear bHLH-Zip proteins. The MAX protein is at ...

journal_title：Oncogene

authors： Quéva C,Hurlin PJ,Foley KP,Eisenman RN

更新日期：1998-02-26 00:00:00

abstract：:The cellular and molecular mechanisms of tumor progression following chemotherapy are largely unknown. Here, we demonstrate that cisplatin (CDDP) treatment upregulates VEGF and Flt1 expression leading to the survival and expansion of a highly tumorigenic fraction of side-population (SP) cells in osteosarcoma (HOS), ne...

journal_title：Oncogene

authors： Tsuchida R,Das B,Yeger H,Koren G,Shibuya M,Thorner PS,Baruchel S,Malkin D

更新日期：2008-06-26 00:00:00

abstract：:Several lines of evidence suggest that gastrin and the CCK-2 receptor (CCK2R) could contribute to pancreatic carcinogenesis by modulating processes such as proliferation, cell adhesion or migration. In the current study, we used a 'cancer gene array' and identified beta1-integrin subunit as a new gastrin-regulated gen...

journal_title：Oncogene

authors： Cayrol C,Clerc P,Bertrand C,Gigoux V,Portolan G,Fourmy D,Dufresne M,Seva C

更新日期：2006-07-27 00:00:00

abstract：:Constitutive activation of the JAK/STAT3 pathway is a major contributor to oncogenesis. In the present study, structure-activity relationship (SAR) studies with five cucurbitacin (Cuc) analogs, A, B, E, I, and Q, led to the discovery of Cuc Q, which inhibits the activation of STAT3 but not JAK2; Cuc A which inhibits J...

journal_title：Oncogene

authors： Sun J,Blaskovich MA,Jove R,Livingston SK,Coppola D,Sebti SM

更新日期：2005-05-05 00:00:00

abstract：:Mutations in mismatch repair (MMR) genes result in microsatellite instability (MSI) and early onset of colorectal cancer. To get mechanistic insights into the time scale, sequence and frequency of intestinal stem cell (ISC) transformation, we quantified MSI and growth characteristics of organoids of Msh2-deficient and...

journal_title：Oncogene

authors： Keysselt K,Kreutzmann T,Rother K,Kerner C,Krohn K,Przybilla J,Buske P,Löffler-Wirth H,Loeffler M,Galle J,Aust G

更新日期：2017-05-11 00:00:00

abstract：:The Rel/NF-kappaB transcription factors regulate the expression of many genes. The activity of RelA, a member of the Rel/NF-kappaB transcription factor family, is constitutively activated in the majority of pancreatic adenocarcinomas and cell lines. We report that the urokinase-type plasminogen activator (uPA), one of...

journal_title：Oncogene

authors： Wang W,Abbruzzese JL,Evans DB,Chiao PJ

更新日期：1999-08-12 00:00:00

abstract：:An early event of cell migration is characterized as the rapid reorganization of the actin cytoskeleton. Recently, we have demonstrated that rapamycin inhibits tumor cell motility. To understand the underlying mechanism, this study was set to determine whether rapamycin inhibition of cell motility is related to its pr...

journal_title：Oncogene

authors： Liu L,Chen L,Chung J,Huang S

更新日期：2008-08-28 00:00:00

abstract：:Functional alterations or loss of tumor-suppressor genes are an important feature of neoplastic progression in humans. The employment of suitable animal model systems would greatly facilitate the detection and manipulation of such genes. We describe here an experimental approach to this problem based on the analysis o...

journal_title：Oncogene

authors： Burns PA,Kemp CJ,Gannon JV,Lane DP,Bremner R,Balmain A

更新日期：1991-12-01 00:00:00

abstract：:Heregulins are a group of growth factors that play diverse and critical roles in the signaling network of the human epidermal growth factor receptor (HER or EGFR) superfamily. Our earlier studies have shown that recombinant heregulinbeta1 (HRG) induces apoptosis in SKBr3 breast cancer cells that overexpress HER2. Here...

journal_title：Oncogene

authors： Le XF,Marcelli M,McWatters A,Nan B,Mills GB,O'Brian CA,Bast RC Jr

更新日期：2001-12-13 00:00:00

abstract：:Triple-negative breast cancers (TNBCs) are characterized by a poor prognosis and lack of targeted treatments, and thus, new therapeutic strategies are urgently needed. Inhibitors against programmed death-1 (PD-1)/PD-1 ligand (PD-L1) have shown significant efficacy in various solid cancers, but their activity against T...

journal_title：Oncogene

authors： Castagnoli L,Cancila V,Cordoba-Romero SL,Faraci S,Talarico G,Belmonte B,Iorio MV,Milani M,Volpari T,Chiodoni C,Hidalgo-Miranda A,Tagliabue E,Tripodo C,Sangaletti S,Di Nicola M,Pupa SM

更新日期：2019-05-01 00:00:00

abstract：:Normal human melanocytes are interspersed singly among keratinocytes along the basement membrane of the epidermis, whereas melanoma cells readily adhere to each other during invasion of the dermis or distant organs. The tumorigenic and metastatic phenotype of melanoma cells often correlates with increased expression o...

journal_title：Oncogene

authors： Satyamoorthy K,Muyrers J,Meier F,Patel D,Herlyn M

更新日期：2001-08-02 00:00:00

abstract：:The transcription factor Cdx1 regulates intestine-specific gene expression and enterocyte differentiation. It has been hypothesized to play a role in regulating intestinal cell proliferation; however, the mechanism for this effect remains elusive. In a prior study, we demonstrated that Cdx1 expression reduced the prol...

journal_title：Oncogene

authors： Lynch J,Keller M,Guo RJ,Yang D,Traber P

更新日期：2003-09-25 00:00:00

abstract：:PTEN, encoding a lipid phosphatase, is a tumor suppressor gene and is mutated in various types of cancers. It is reported to regulate G1 to S phase transition of the cell cycle by influencing the expression, protein stability and subcellular location of cyclin D1. Here, we provide evidence that PTEN modulates the tran...

journal_title：Oncogene

authors： Huang W,Chang HY,Fei T,Wu H,Chen YG

更新日期：2007-04-12 00:00:00

abstract：:B-RAF is a serine/threonine-specific protein kinase that is mutated in approximately 70% of human melanomas. However, the role of this signalling molecule in cancer is unclear. Here, we show that ERK is constitutively activated in melanoma cells expressing oncogenic B-RAF and that this activity is required for prolife...

journal_title：Oncogene

authors： Karasarides M,Chiloeches A,Hayward R,Niculescu-Duvaz D,Scanlon I,Friedlos F,Ogilvie L,Hedley D,Martin J,Marshall CJ,Springer CJ,Marais R

更新日期：2004-08-19 00:00:00

abstract：:B-Myb, a highly conserved member of the Myb oncoprotein family, is a 110 kDa sequence-specific DNA binding protein expressed in virtually all proliferating cells. B-myb expression reaches its maximum at the G1/S phase boundary and during the S phase of the cell cycle. We have previously shown that B-Myb activity is ce...

journal_title：Oncogene

authors： Charrasse S,Carena I,Brondani V,Klempnauer KH,Ferrari S

更新日期：2000-06-15 00:00:00

abstract：:We described previously the characterization of a novel oncogene, cph, activated in primary Syrian hamster embryo fibroblasts by exposure to 3-methylcholanthrene (Velasco et al., Oncogene 9:2065-2069, 1994). The present report describes the participation in the neoplastic conversion of cph-expressing (81C39) hamster f...

journal_title：Oncogene

authors： Avila MA,Velasco JA,Cho C,Lupu R,Wen D,Notario V

更新日期：1995-03-02 00:00:00

abstract：:The RAS/RAF mitogen-activated protein kinase pathway (MAPK) is highly active in many tumor types including the majority of high-grade gliomas and expression of activated RAS or RAF in neural progenitor cells combined with either AKT activation or Ink4a/Arf loss leads to the development of high-grade gliomas in vivo. T...

journal_title：Oncogene

authors： Robinson JP,Vanbrocklin MW,Lastwika KJ,McKinney AJ,Brandner S,Holmen SL

更新日期：2011-03-17 00:00:00

abstract：:Prostate carcinoma (PCA) is the most frequently diagnosed malignancy in American men. PCA at advanced stages can both proliferate abnormally and resist apoptosis. Among the many known signal transduction pathways, phosphatidylinositide-3'OH kinase (PI3-kinase) has been shown to play an important role in cell survival ...

journal_title：Oncogene

authors： Xue LY,Qiu Y,He J,Kung HJ,Oleinick NL

更新日期：1999-06-03 00:00:00