当前位置： SCI文献检索 > ONCOGENE期刊下所有文献 > HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.

HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.

Abstract：

:Growth factor receptor-mediated signal transduction has been implicated in conferring resistance to conventional chemotherapy on cancer cells. In this study, we delineated a pathway that involves HER2/PI-3K/Akt in mediating multidrug resistance in human breast cancer cells. We found that the cell lines that express both HER2 and HER3 appear to have a higher phosphorylation level of Akt (activated Akt). Transfection of HER2 in MCF7 breast cancer cells that express HER3 caused a phosphoinoside-3 kinase (PI-3K)-dependent activation of Akt, and was associated with an increased resistance of the cells to multiple chemotherapeutic agents (paclitaxel, doxorubicin, 5-fluorouracil, etoposide, and camptothecin). Selective inhibition of PI-3K or Akt activity with their respective dominant-negative expression vectors sensitized the cells to the induction of apoptosis by the chemotherapeutic agents. We further demonstrated that MCF7 cells expressing a constitutively active Akt, in which the phospholipid-interactive PH domain of Akt was replaced by a farnesylation sequence for constitutive membrane anchorage (DeltaPH-Akt1-farn), showed a similar increased resistance to the chemotherapeutic agents. Our results suggest that activation of Akt1 by HER2/PI-3K plays an important role in conferring a broad-spectrum chemoresistance on breast cancer cells and that Akt may therefore be a novel molecular target for therapies that would improve the outcome of patients with breast cancer.

journal_name

Oncogene

journal_title

Oncogene

authors

Knuefermann C,Lu Y,Liu B,Jin W,Liang K,Wu L,Schmidt M,Mills GB,Mendelsohn J,Fan Z

doi

10.1038/sj.onc.1206394

subject

Has Abstract

pub_date

2003-05-22 00:00:00

pages

3205-12

issue

21

eissn

0950-9232

issn

1476-5594

pii

1206394

journal_volume

22

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • Overexpression of the wild-type p53 gene inhibits NF-kappaB activity and synergizes with aspirin to induce apoptosis in human colon cancer cells.

    abstract：:The tumor suppressor gene p53 is a potent transcriptional regulator of genes which are involved in many cellular activities including cell cycle arrest, apoptosis, and angiogenesis. Recent studies have demonstrated that the activation of the transcriptional factor nuclear factor kappaB (NF-kappaB) plays an essential r...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203383

    authors： Shao J,Fujiwara T,Kadowaki Y,Fukazawa T,Waku T,Itoshima T,Yamatsuji T,Nishizaki M,Roth JA,Tanaka N

    更新日期：2000-02-10 00:00:00

  • A functional analysis of PCNA-binding peptides derived from protein sequence, interaction screening and rational design.

    abstract：:Proliferating cell nuclear antigen (PCNA) has no intrinsic enzymatic function, but functions as a sliding platform to mediate protein interactions with the DNA strand. Many proteins interact with PCNA through a small conserved motif with consensus QxxLxxFF. This work uses Schizosaccharomyces pombe and human cells to a...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209320

    authors： Warbrick E

    更新日期：2006-05-11 00:00:00

  • Down-regulation of MHC class I antigens is not a general mechanism for the increased tumorigenicity caused by c-myc amplification.

    abstract：:Previous studies have shown that increased expression of oncogenes from the myc-family can down-regulate the level of MHC class I antigens in tumor cells. This has suggested a mechanism by which amplification/overexpression of myc-genes may contribute to the malignancy development of certain tumors. Earlier published ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Dahllöf B

    更新日期：1990-03-01 00:00:00

  • Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function.

    abstract：:Loss of von Hippel Lindau (VHL) protein function is a key driver of VHL diseases, including sporadic and inherited clear cell renal cell carcinoma. Modulation of the proteostasis of VHL, especially missense point-mutated VHL, is a promising approach to augmenting VHL levels and function. VHL proteostasis is regulated ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2016.40

    authors： German P,Bai S,Liu XD,Sun M,Zhou L,Kalra S,Zhang X,Minelli R,Scott KL,Mills GB,Jonasch E,Ding Z

    更新日期：2016-09-22 00:00:00

  • Role of the BLT2, a leukotriene B4 receptor, in Ras transformation.

    abstract：:Oncogenic Ras is known to drive both the Rac and Raf-MAP-kinase pathways, which act in concert to cause cell transformation. Unlike the Raf-MAP-kinase cascade, however, the downstream elements of Rac pathway are not fully understood. Previously, we showed that cytosolic phospholipase A2 (cPLA2) and subsequent metaboli...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208151

    authors： Yoo MH,Song H,Woo CH,Kim H,Kim JH

    更新日期：2004-12-09 00:00:00

  • Correlation of Snail expression with histological grade and lymph node status in breast carcinomas.

    abstract：:Snail is a zinc finger transcription factor that triggers the epithelial-mesenchymal transition (EMT) by directly repressing E-cadherin expression. Snail is required for mesoderm and neural crest formation during embryonic development and has recently been implicated in the EMT associated with tumour progression. In a...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205416

    authors： Blanco MJ,Moreno-Bueno G,Sarrio D,Locascio A,Cano A,Palacios J,Nieto MA

    更新日期：2002-05-09 00:00:00

  • tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.

    abstract：:A search for protein tyrosine kinases expressed during murine cardiogenesis resulted in the isolation of a novel tyrosine kinase, designated tek, which maps to mouse chromosome 4 between the brown and pmv-23 loci. The deduced amino acid sequence of tek predicts that it encodes a putative receptor tyrosine kinase that ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Dumont DJ,Yamaguchi TP,Conlon RA,Rossant J,Breitman ML

    更新日期：1992-08-01 00:00:00

  • v-Myb represses the transcription of Ets-2.

    abstract：:The v-Myb oncogene causes monoblastic leukemia and transforms only myelomonocytic cells in culture. The v-Myb protein is nuclear and binds to specific DNA sequences. To identify genes regulated by v-Myb, we utilized primary cells transformed by a retrovirus encoding a v-Myb-estrogen receptor (ER) fusion protein. The E...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209868

    authors： Wang DM,Sevcikova S,Wen H,Roberts S,Lipsick JS

    更新日期：2007-02-22 00:00:00

  • Analysis of mammalian fibroblast transformation by normal and mutated human EGF receptors.

    abstract：:Activation of the EGF receptor (c-erbB) tyrosine kinase has been implicated in tumorigenesis, either by overexpression of the normal receptor in the presence of EGF, or through expression of a truncated receptor lacking the EGF binding domain as in the viral oncogene v-erbB. Here, normal and truncated human EGF recept...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Haley JD,Hsuan JJ,Waterfield MD

    更新日期：1989-03-01 00:00:00

  • MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways.

    abstract：:MicroRNAs (miRNAs) as modulators of gene expression have been described to display both tumor-promoting and tumor-suppressive functions. Although their role has been studied in different tumor types, little is known about how they regulate nuclear factor κB (NF-κB) signaling in breast cancer. Here, we performed an unb...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.571

    authors： Keklikoglou I,Koerner C,Schmidt C,Zhang JD,Heckmann D,Shavinskaya A,Allgayer H,Gückel B,Fehm T,Schneeweiss A,Sahin O,Wiemann S,Tschulena U

    更新日期：2012-09-13 00:00:00

  • Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells.

    abstract：:A potential role for 1-oleoyl-sn-glycero-3-phosphate or lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) in the regulation of malignant diseases has been widely considered. In this study, we found that in transformed astroglial cells, the expression profile of lysophospholipid receptor mRNA and the action...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208805

    authors： Malchinkhuu E,Sato K,Horiuchi Y,Mogi C,Ohwada S,Ishiuchi S,Saito N,Kurose H,Tomura H,Okajima F

    更新日期：2005-10-06 00:00:00

  • Methyltransferase inhibition induces p53-dependent apoptosis and a novel form of cell death.

    abstract：:We have analysed the importance of proper substrate methylation by S-adenosylmethionine-dependent methyltransferases for cell survival and cell cycle progression. We show that treatment of cells with the methyltransferase inhibitor adenosine dialdehyde (AdOx) causes cell cycle arrest and death in different cell types....

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208855

    authors： Schwerk C,Schulze-Osthoff K

    更新日期：2005-10-27 00:00:00

  • An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein.

    abstract：:RING-finger proteins play crucial roles in ubiquitination events involved in diverse cellular processes including signal transduction, differentiation and apoptosis. Most of the RING-finger proteins have E3-ubiquitin ligase activity. RNF11 is a small RING-finger protein and harbors a RING-H2 domain and a PY motif that...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207319

    authors： Li H,Seth A

    更新日期：2004-03-11 00:00:00

  • The biology and clinical significance of acquired genomic copy number aberrations and recurrent gene mutations in chronic lymphocytic leukemia.

    abstract：:Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world and remains incurable with conventional chemotherapy treatment approaches. CLL as a disease entity is defined by a relatively parsimonious set of diagnostic criteria and therefore likely constitutes an umbrella term for multiple relate...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/onc.2012.411

    authors： Malek SN

    更新日期：2013-06-06 00:00:00

  • Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis.

    abstract：:The release of cytochrome c from the intermembrane space of mitochondria into the cytosol is one of the critical events in apoptotic cell death. In the present study, it is shown that release of cytochrome c and apoptosis induced by tumor necrosis factor alpha (TNF) in HeLa cells can be inhibited by (i) overexpression...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1206053

    authors： Shchepina LA,Pletjushkina OY,Avetisyan AV,Bakeeva LE,Fetisova EK,Izyumov DS,Saprunova VB,Vyssokikh MY,Chernyak BV,Skulachev VP

    更新日期：2002-11-21 00:00:00

  • Characterization of a c-met proto-oncogene activated in human xeroderma pigmentosum cells after treatment with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).

    abstract：:Human xeroderma pigmentosum (XP) fibroblasts were transformed with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The transformed cells, called ASKMN, were immortalized, grew in agar and were tumorigenic in nude mice. A trp-met oncogene was identified in ASKMN cells, after transfection of high molecular weight DNA on 3T...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Michelin S,Daya-Grosjean L,Sureau F,Saïd S,Sarasin A,Suárez HG

    更新日期：1993-07-01 00:00:00

  • Parkin and mitophagy in cancer.

    abstract：:Mitophagy, the selective engulfment and clearance of mitochondria, is essential for the homeostasis of a healthy network of functioning mitochondria and prevents excessive production of cytotoxic reactive oxygen species from damaged mitochondria. The mitochondrially targeted PTEN-induced kinase-1 (PINK1) and the E3 ub...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/onc.2016.302

    authors： Bernardini JP,Lazarou M,Dewson G

    更新日期：2017-03-01 00:00:00

  • Mode of action of trabectedin in myxoid liposarcomas.

    abstract：:To elucidate the mechanisms behind the high sensitivity of myxoid/round cell liposarcoma (MRCL) to trabectedin and the suggested selectivity for specific subtypes, we have developed and characterized three MRCL xenografts, namely ML017, ML015 and ML004 differing for the break point of the fusion gene FUS-CHOP, respect...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2013.462

    authors： Di Giandomenico S,Frapolli R,Bello E,Uboldi S,Licandro SA,Marchini S,Beltrame L,Brich S,Mauro V,Tamborini E,Pilotti S,Casali PG,Grosso F,Sanfilippo R,Gronchi A,Mantovani R,Gatta R,Galmarini CM,Sousa-Faro JM,D'Incalc

    更新日期：2014-10-30 00:00:00

  • Modulation of p53 dependent gene expression and cell death through thioredoxin-thioredoxin reductase by the Interferon-Retinoid combination.

    abstract：:We have shown earlier that the IFN-beta and all-trans retinoic acid (RA) combination, but not the single agents, induces death in several tumor cell lines. Employing a genetic technique we have identified several Genes associated with Retinoid-IFN induced Mortality (GRIM). One of the GRIMs was human thioredoxin reduct...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204585

    authors： Hu J,Ma X,Lindner DJ,Karra S,Hofmann ER,Reddy SP,Kalvakolanu DV

    更新日期：2001-07-12 00:00:00

  • The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins.

    abstract：:Infection by HTLV-1 has been correlated with the appearance of various proliferative or degenerative diseases. Some of these disorders have been observed in transgenic mice expressing the Tax protein, which is known to transactivate various viral and cellular promoters through interactions with several transcription f...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201567

    authors： Rousset R,Fabre S,Desbois C,Bantignies F,Jalinot P

    更新日期：1998-02-05 00:00:00

  • Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects.

    abstract：:While 25% of human cancers harbor oncogenic Ras mutations, such mutations are not found in astrocytomas. We have previously demonstrated that the activation of receptor tyrosine kinases expressed by malignant human astrocytoma cells and specimens results in functional upregulation of the Ras signalling pathway and inc...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203105

    authors： Feldkamp MM,Lau N,Guha A

    更新日期：1999-12-09 00:00:00

  • Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells.

    abstract：:MOZ and MLL, encoding a histone acetyltransferase (HAT) and a histone methyltransferase, respectively, are targets for recurrent chromosomal translocations found in acute myeloblastic or lymphoblastic leukemia. In MOZ (MOnocytic leukemia Zinc-finger protein)/CBP- or mixed lineage leukemia (MLL)-rearranged leukemias, a...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.254

    authors： Paggetti J,Largeot A,Aucagne R,Jacquel A,Lagrange B,Yang XJ,Solary E,Bastie JN,Delva L

    更新日期：2010-09-09 00:00:00

  • Expression of the NF-kappaB-responsive gene BTG2 is aberrantly regulated in breast cancer.

    abstract：:BTG2, a p53-inducible antiproliferative gene, is stimulated in breast cancer cells by activation of nuclear factor kappa B (NF-kappaB). In rat mammary glands, BTG2 is expressed in epithelial cells and levels decreased during pregnancy and lactation but recovered during involution. Estrogen and progestin suppress BTG2 ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208008

    authors： Kawakubo H,Carey JL,Brachtel E,Gupta V,Green JE,Walden PD,Maheswaran S

    更新日期：2004-10-28 00:00:00

  • Hypermethylated gene ANKDD1A is a candidate tumor suppressor that interacts with FIH1 and decreases HIF1α stability to inhibit cell autophagy in the glioblastoma multiforme hypoxia microenvironment.

    abstract：:Ectopic epigenetic mechanisms play important roles in facilitating tumorigenesis. Here, we first demonstrated that ANKDD1A is a functional tumor suppressor gene, especially in the hypoxia microenvironment. ANKDD1A directly interacts with FIH1 and inhibits the transcriptional activity of HIF1α by upregulating FIH1. In ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-018-0423-9

    authors： Feng J,Zhang Y,She X,Sun Y,Fan L,Ren X,Fu H,Liu C,Li P,Zhao C,Liu Q,Liu Q,Li G,Wu M

    更新日期：2019-01-01 00:00:00

  • HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs.

    abstract：:Most cases of breast cancer (BrCa) mortality are due to vascular metastasis. BrCa cells must intravasate through endothelial cells (ECs) to enter a blood vessel in the primary tumor and then adhere to ECs and extravasate at the metastatic site. In this study we demonstrate that inhibition of hypoxia-inducible factor (...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.365

    authors： Zhang H,Wong CC,Wei H,Gilkes DM,Korangath P,Chaturvedi P,Schito L,Chen J,Krishnamachary B,Winnard PT Jr,Raman V,Zhen L,Mitzner WA,Sukumar S,Semenza GL

    更新日期：2012-04-05 00:00:00

  • DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo.

    abstract：:DAL-1 (differentially expressed in adenocarcinoma of the lung)/4.1B is a tumor suppressor gene on human chromosome 18p11.3 whose expression is lost in >50% of primary non-small-cell lung carcinomas. Based on sequence similarity, DAL-1/4.1B has been assigned to the Protein 4.1 superfamily whose members interact with pl...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208057

    authors： Singh V,Miranda TB,Jiang W,Frankel A,Roemer ME,Robb VA,Gutmann DH,Herschman HR,Clarke S,Newsham IF

    更新日期：2004-10-14 00:00:00

  • Stat3-coordinated Lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelial-mesenchymal transition.

    abstract：:Inflammation can act as a crucial mediator of epithelial-to-mesenchymal transition (EMT). In this study, we show that oncostatin M (OSM) is expressed in an autocrine/paracrine fashion in invasive breast carcinoma. OSM stimulation promotes spontaneous lung metastasis of MCF-7 xenografts in nude mice. A conspicuous epig...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2012.573

    authors： Guo L,Chen C,Shi M,Wang F,Chen X,Diao D,Hu M,Yu M,Qian L,Guo N

    更新日期：2013-11-07 00:00:00

  • RARRES2 functions as a tumor suppressor by promoting β-catenin phosphorylation/degradation and inhibiting p38 phosphorylation in adrenocortical carcinoma.

    abstract：:Tumor suppressor genes and the immune system are critical players in inhibiting cancer initiation and/or progression. However, little is known about whether a tumor suppressor gene can function through both immune-dependent and -independent mechanisms. Retinoic acid receptor responder 2 (RARRES2) is transcriptionally ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2016.497

    authors： Liu-Chittenden Y,Jain M,Gaskins K,Wang S,Merino MJ,Kotian S,Kumar Gara S,Davis S,Zhang L,Kebebew E

    更新日期：2017-06-22 00:00:00

  • Functional similarity between HPV16E7, SV40 large T and adenovirus E1a proteins.

    abstract：:We have analysed the immortalizing function of Human Papillomavirus type 16 (HPV16) in a rat cell line which has been derived by immortalizing rat embryo fibroblasts with a thermolabile SV40 large T antigen and is temperature sensitive for growth. Introduction of wild type SV40 large T antigen or the adenovirus E1a 12...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Vousden KH,Jat PS

    更新日期：1989-02-01 00:00:00

  • An FGFR inhibitor converts the tumor promoting effect of TGF-β by the induction of fibroblast-associated genes of hepatoma cells.

    abstract：:Tumors consistently mimic wound-generating chronic inflammation; however, why they do not heal like wounds with fibrotic scars remains unknown. The components of the tumor microenvironment, such as transforming growth factor β (TGF-β) and fibroblast growth factors (FGFs), may account for this phenomenon. Tumor formati...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2016.512

    authors： Zhang HR,Wang XD,Yang X,Chen D,Hao J,Cao R,Wu XZ

    更新日期：2017-07-06 00:00:00