Hypermethylated gene ANKDD1A is a candidate tumor suppressor that interacts with FIH1 and decreases HIF1α stability to inhibit cell autophagy in the glioblastoma multiforme hypoxia microenvironment.

abstract：:Over the past five decades, a plethora of nonrandom chromosomal abnormalities have been consistently reported in malignant cells facilitating the identification of cancer-associated protein coding oncogenes and tumor suppressors. The genetic dissection of hot spots for chromosomal abnormalities in the age of the seque...

journal_title：Oncogene

authors： Calin GA,Croce CM

更新日期：2006-10-09 00:00:00

abstract：:BRCA1, a familial breast and ovarian cancer susceptibility gene encodes nuclear phosphoproteins that function as tumor suppressors in human breast cancer cells. Previously, we have shown that overexpression of a BRCA1 splice variant BRCA1a accelerates apoptosis in human breast cancer cells. In an attempt to determine ...

journal_title：Oncogene

authors： Wang H,Shao N,Ding QM,Cui J,Reddy ES,Rao VN

更新日期：1997-07-10 00:00:00

abstract：:In this study, we investigated the regulation of FOXM1 expression by estrogen receptor alpha (ERalpha) and its role in hormonal therapy and endocrine resistance. FOXM1 protein and mRNA expression was regulated by ER-ligands, including estrogen, tamoxifen (OHT) and fulvestrant (ICI182780; ICI) in breast carcinoma cell ...

journal_title：Oncogene

authors： Millour J,Constantinidou D,Stavropoulou AV,Wilson MS,Myatt SS,Kwok JM,Sivanandan K,Coombes RC,Medema RH,Hartman J,Lykkesfeldt AE,Lam EW

更新日期：2010-05-20 00:00:00

abstract：:Although TGFalpha mRNA and protein are frequently elevated in neoplastic cells, neither the level at which deregulation occurs nor the mechanism(s) responsible have been well characterized. As a first step, we examined the induction of TGFalpha mRNA in two series of clonally-derived rat liver epithelial cell lines tha...

journal_title：Oncogene

authors： Berkowitz EA,Hissong MA,Lee DC

更新日期：1996-05-02 00:00:00

abstract：:The gfi-1 gene encodes a zinc finger containing protein that is specifically expressed in T-lymphocytes and is a frequent target of proviral insertion in T-cell lymphoma provoked by infection with MoMuLV--a non acute transforming retrovirus. Expression of a gfi-1 transgene targeted to T-cells by the lck proximal promo...

journal_title：Oncogene

authors： Schmidt T,Karsunky H,Gau E,Zevnik B,Elsässer HP,Möröy T

更新日期：1998-11-19 00:00:00

abstract：:Reexpression of hypermethylated tumor suppressor genes using DNA methyltransferase (DNMT) and histone deacetylase inhibitors occurs by a mechanism whereby promoter demethylation is the dominant event. In support of this model, we found in acute myeloid leukemia cells with hypermethylated p15INK4B and E-cadherin promot...

journal_title：Oncogene

authors： Lakshmikuttyamma A,Scott SA,DeCoteau JF,Geyer CR

更新日期：2010-01-28 00:00:00

abstract：:RelA and RelB are two members of the NF-kappaB family that differ structurally and functionally. While RelA is regulated through its cytosolic localization by inhibitor proteins or IkappaB and not through transcriptional mechanisms, the regulation of RelB is poorly understood. In this study we demonstrate that stimuli...

journal_title：Oncogene

authors： Bren GD,Solan NJ,Miyoshi H,Pennington KN,Pobst LJ,Paya CV

更新日期：2001-11-22 00:00:00

abstract：:In the G2 phase cell cycle checkpoint arrest, the cdc25-dependent activation of cyclin B/cdc2, a critical step in regulating entry into mitosis, is blocked. Studies in yeast have demonstrated that the inhibition of cdc25 function involves 14-3-3 binding to cdc25. In humans, two cdc25 isoforms have roles in G2/M progre...

journal_title：Oncogene

authors： Forrest A,Gabrielli B

更新日期：2001-07-19 00:00:00

abstract：:Transcription factors of the Maf proto-oncogene family have been shown to participate in the regulation of several differentiation specific genes. We previously reported that a member(s) of this family is involved in the regulation of the neuroretina specific gene, QR1, through a promoter region, designated the A box,...

journal_title：Oncogene

authors： Benkhelifa S,Provot S,Lecoq O,Pouponnot C,Calothy G,Felder-Schmittbuhl MP

更新日期：1998-07-16 00:00:00

abstract：:Cancer cells are known to adopt aerobic glycolysis in order to fuel tumor growth, but the molecular basis of this metabolic shift remains largely undefined. O-GlcNAcase (OGA) is an enzyme harboring O-linked β-N-acetylglucosamine (O-GlcNAc) hydrolase and cryptic lysine acetyltransferase activities. Here, we report that...

journal_title：Oncogene

authors： Singh JP,Qian K,Lee JS,Zhou J,Han X,Zhang B,Ong Q,Ni W,Jiang M,Ruan HB,Li MD,Zhang K,Ding Z,Lee P,Singh K,Wu J,Herzog RI,Kaech S,Wendel HG,Yates JR 3rd,Han W,Sherwin RS,Nie Y,Yang X

更新日期：2020-01-01 00:00:00

abstract：:The dominant paradigm for HPV carcinogenesis includes integration into the host genome followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic pathway characterized by episomal E2, E4, and E5 (E2/E4/E5) expression. Half of HPV positive cervical and pharyngeal cancers comprised a subtype wi...

journal_title：Oncogene

authors： Ren S,Gaykalova DA,Guo T,Favorov AV,Fertig EJ,Tamayo P,Callejas-Valera JL,Allevato M,Gilardi M,Santos J,Fukusumi T,Sakai A,Ando M,Sadat S,Liu C,Xu G,Fisch KM,Wang Z,Molinolo AA,Gutkind JS,Ideker T,Koch WM,Cali

更新日期：2020-10-01 00:00:00

abstract：:The carboxyl terminus of c-Myb contains a negative regulatory domain that is absent in the v-Myb oncoprotein, but conserved among all the known Myb proteins of animals. This domain inhibits transcriptional activation by c-Myb in animal cells, but not in budding yeast, suggesting that additional protein(s) present in a...

journal_title：Oncogene

authors： Ladendorff NE,Wu S,Lipsick JS

更新日期：2001-01-04 00:00:00

abstract：:Pancreatic cancer is characterized by early metastatic spread, but the process of tumor cell dissemination is largely unknown. In this study we show that the soluble protein pancreatic adenocarcinoma upregulated factor (PAUF) has an important role in the metastasis and progression of the disease. Variations in the lev...

journal_title：Oncogene

authors： Lee Y,Kim SJ,Park HD,Park EH,Huang SM,Jeon SB,Kim JM,Lim DS,Koh SS

更新日期：2010-01-07 00:00:00

abstract：:The C3H/HeJ (C3H), A/J and BALB/cByJ (BALB) mouse strains are respectively resistant, sensitive and intermediate regarding the induction of lung tumors by urethane. The phenotypic difference between C3H and A/J is largely determined by the Pas1 (Pulmonary adenoma susceptibility 1) gene on chromosome 6, the A/J allele ...

journal_title：Oncogene

authors： Karasaki H,Obata M,Ogawa K,Lee GH

更新日期：1997-10-09 00:00:00

abstract：:We have developed a new yeast-based assay for the detection of PTEN nonsense mutation, and applied it to a total of 42 astrocytic tumors. The assay utilizes homologous recombination of PCR-amplified PTEN cDNA samples to a yeast vector which expresses an in-frame PTEN::ADE2 chimera protein. An allele of nonsense mutati...

journal_title：Oncogene

authors： Zhang CL,Tada M,Kobayashi H,Nozaki M,Moriuchi T,Abe H

更新日期：2000-09-07 00:00:00

abstract：:Epigenetic regulation of gene expression is critical in the maintenance of cellular homeostasis. Dysregulation of normal epigenetic transcription occurs in abnormal physiological conditions, such as those seen in cancer cells and cells infected with parasites, making the mechanism underlying abnormal epigenetic transc...

journal_title：Oncogene

authors： Ego T,Tanaka Y,Shimotohno K

更新日期：2005-03-10 00:00:00

abstract：:The p53/p21Cip1/Waf1-dependent checkpoint control of G1/S and G2/M phases of the cell cycle in response to DNA damage is an important mechanism of genome stability maintenance in normal cells. In many tumor cells, due to frequent point mutations and deletions of p53, the stringent control of the cell cycle and apoptos...

journal_title：Oncogene

authors： Bulavin DV,Tararova ND,Aksenov ND,Pospelov VA,Pospelova TV

更新日期：1999-10-07 00:00:00

abstract：:Cell cycle checkpoints and tumor suppressor gene functions appear to be required for the maintenance of a stable genome in proliferating cells. In this study chromosomal destabilization was monitored in relation to telomere structure, lifespan control and G2 checkpoint function. Replicative senescence was inactivated ...

journal_title：Oncogene

authors： Filatov L,Golubovskaya V,Hurt JC,Byrd LL,Phillips JM,Kaufmann WK

更新日期：1998-04-09 00:00:00

abstract：:Protein kinases are known to undergo phosphorylation to regulate their activity. To determine whether the protein kinase activity of p37v-mos was similarly regulated, we investigated the influence of two well known protein kinases, namely protein kinase C and protein kinase A, on the activity of p37v-mos in vivo. NIH3...

journal_title：Oncogene

authors： al-Bagdadi F,Singh B,Arlinghaus RB

更新日期：1990-08-01 00:00:00

abstract：:Tumor metastasis is the leading cause of death among breast cancer patients. PELP1 (proline, glutamic acid and leucine rich protein 1) is a nuclear receptor coregulator that is upregulated during breast cancer progression to metastasis and is an independent prognostic predictor of shorter survival of breast cancer pat...

journal_title：Oncogene

authors： Roy SS,Gonugunta VK,Bandyopadhyay A,Rao MK,Goodall GJ,Sun LZ,Tekmal RR,Vadlamudi RK

更新日期：2014-07-10 00:00:00

abstract：:Hepatitis B virus (HBV) infection is a major risk factor worldwide for the development of hepatocellular carcinoma (HCC). Integrated HBV DNA fragments, often highly rearranged, are frequently detected in HCC. In woodchuck, the viral enhancer plays a central role in hepatocarcinogenesis, but in humans the mechanism of ...

journal_title：Oncogene

authors： Shamay M,Agami R,Shaul Y

更新日期：2001-10-18 00:00:00

abstract：:Dasatinib, a dual Src family kinase and Abl inhibitor, is being tested clinically for the treatment of prostate cancer bone metastasis. Bidirectional interactions between osteoblasts and prostate cancer cells are critical in the progression of prostate cancer in bone, but the effect of dasatinib on osteoblasts is unkn...

journal_title：Oncogene

authors： Lee YC,Huang CF,Murshed M,Chu K,Araujo JC,Ye X,deCrombrugghe B,Yu-Lee LY,Gallick GE,Lin SH

更新日期：2010-06-03 00:00:00

abstract：:Cytokinesis is the final step of cell division. Increasing evidence suggests failure of cytokinesis might contribute to the development of cancer. Here, we demonstrate that the serologically defined colon cancer antigen-3 (SDCCAG3) forms a complex with PTPN13, a protein tyrosine phosphatase known to be involved in the...

journal_title：Oncogene

authors： Hagemann N,Ackermann N,Christmann J,Brier S,Yu F,Erdmann KS

更新日期：2013-09-26 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a process during which normal epithelial cells acquire mesenchymal characteristics. EMT has a critical role in various human diseases especially in cancer. EMT facilitates tumor initiation and progression by mediating cancer cell stemness and motility. Zinc finger transcripti...

journal_title：Oncogene

authors： Liu Y,Zhou H,Zhu R,Ding F,Li Y,Cao X,Liu Z

更新日期：2018-02-08 00:00:00

abstract：:FGFR1 (fibroblast growth factor receptor 1) regulates many key cellular responses including proliferation, migration and differentiation through activation of signaling pathways. Irregularities in FGFR1 signaling have been implicated in several pathological conditions, including human cancer. In order to discover nove...

journal_title：Oncogene

authors： Nadratowska-Wesolowska B,Haugsten EM,Zakrzewska M,Jakimowicz P,Zhen Y,Pajdzik D,Wesche J,Wiedlocha A

更新日期：2014-10-02 00:00:00

abstract：:p53 is involved in several DNA repair pathways. Some of these require the specific transactivation of p53-dependent genes and others involve direct interactions between the p53 protein and DNA repair associated proteins. Previously, we have shown that p53 acts directly in Base Excision Repair (BER) when assayed under ...

journal_title：Oncogene

authors： Offer H,Milyavsky M,Erez N,Matas D,Zurer I,Harris CC,Rotter V

更新日期：2001-02-01 00:00:00

abstract：:Many reports have shown a link between mismatch repair (MMR) deficiency and loss of normal cell cycle control, particularly loss of G2 arrest. However almost all of these studies utilized transformed cell lines, and thus the involvement of other genes in this phenotype cannot be excluded. We have examined the effects ...

journal_title：Oncogene

authors： Strathdee G,Sansom OJ,Sim A,Clarke AR,Brown R

更新日期：2001-04-05 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) production by stromal fibroblasts plays an important role in tumor angiogenesis. However, VEGF is also expressed by normal tissue fibroblasts, raising the question of how the VEGF activity of fibroblasts is regulated. Here we report that the latent VEGF angiogenic activity of ...

journal_title：Oncogene

authors： Ito TK,Ishii G,Chiba H,Ochiai A

更新日期：2007-11-08 00:00:00

abstract：:The antifolates were the first class of antimetabolites to enter the clinics more than 50 years ago. Over the following decades, a full understanding of their mechanisms of action and chemotherapeutic potential evolved along with the mechanisms by which cells develop resistance to these drugs. These principals served ...

journal_title：Oncogene

authors： Zhao R,Goldman ID

更新日期：2003-10-20 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), an important angiogenic factor, regulates cell proliferation, differentiation, and apoptosis through activation of its tyrosine-kinase receptors, such as Flt-1 and Flk-1/Kdr. Human malignant mesothelioma cells (HMC), which have wild-type p53, express VEGF and exhibit cell gro...

journal_title：Oncogene

authors： Catalano A,Romano M,Martinotti S,Procopio A

更新日期：2002-04-25 00:00:00