Atm heterozygosity does not increase tumor susceptibility to ionizing radiation alone or in a p53 heterozygous background.

abstract：:Familial adenomatous polyposis (FAP) is caused by germline mutations in the adenomatous polyposis coli (APC) gene. Two promoters, 1A and 1B, have been recognized in APC, and 1B is thought to have a minor role in the regulation of the gene. We have identified a novel deletion encompassing half of this promoter in the l...

journal_title：Oncogene

authors： Rohlin A,Engwall Y,Fritzell K,Göransson K,Bergsten A,Einbeigi Z,Nilbert M,Karlsson P,Björk J,Nordling M

更新日期：2011-12-15 00:00:00

abstract：:Observations that genome-wide DNA hypomethylation induces genome instability and tumors in animals caution against the indiscriminate use of demethylating agents, such as 5-aza-2'-deoxycytidine (5-Aza-dC). Using primary mouse embryonic fibroblasts harboring a lacZ mutational reporter construct that allows the quantifi...

journal_title：Oncogene

authors： Maslov AY,Lee M,Gundry M,Gravina S,Strogonova N,Tazearslan C,Bendebury A,Suh Y,Vijg J

更新日期：2012-12-13 00:00:00

abstract：:Recently, the MLL gene at 11q23 was found to be involved in a subset of leukemias with an 11q23 abnormality. In the present study, we isolated chimeric cDNAs between the MLL and a gene designated MLLT3 at 9p22 from a cDNA library of an IMS-M1 cell line with a t(9;11)(p22;q23) translocation, a representative karyotypic...

journal_title：Oncogene

authors： Iida S,Seto M,Yamamoto K,Komatsu H,Tojo A,Asano S,Kamada N,Ariyoshi Y,Takahashi T,Ueda R

更新日期：1993-11-01 00:00:00

abstract：:We have previously shown that tumor necrosis factor (TNF)α produced from primary tumor-induced expression of two endogenous Toll-like receptor 4 (TLR4) ligands, S100A8 and serum amyloid A3 (SAA3), in pre-metastatic lungs. However, mechanistic details of the signaling network and relevance to pulmonary physiology are p...

journal_title：Oncogene

authors： Tomita T,Sakurai Y,Ishibashi S,Maru Y

更新日期：2011-08-04 00:00:00

abstract：:Polymerase chain reaction (PCR) analysis of microsatellite polymorphisms corresponding to four loci which map to chromosome 17p and 11 loci which map to chromosome 17q was performed to screen for loss of heterozygosity (LOH) in paired normal and tumor tissues from 27 cases of borderline epithelial ovarian tumors (BEOT...

journal_title：Oncogene

authors： Wertheim I,Tangir J,Muto MG,Welch WR,Berkowitz RS,Chen WY,Mok SC

更新日期：1996-05-16 00:00:00

abstract：:We reported previously that the v-rel protein (p59v-rel) exists in a high molecular weight complex with at least four other proteins in the cytoplasm of v-rel-transformed chicken pre-B lymphoid cells (Simek, S. & Rice, N.R., J. Virol., 62, 4730-4736, 1989). One of these proteins is the chicken c-rel protein, but the i...

journal_title：Oncogene

authors： Kochel T,Mushinski JF,Rice NR

更新日期：1991-04-01 00:00:00

abstract：:In the present study we investigated the frequency of p16 gene exon 2 mutations in 35 malignant gliomas, using either direct sequencing of the PCR products or cloning into the pCRII vector and sequencing of the cloned PCR products. No mutations were detected during direct sequencing of the PCR products. However, after...

journal_title：Oncogene

authors： Kyritsis AP,Zhang B,Zhang W,Xiao M,Takeshima H,Bondy ML,Cunningham JE,Levin VA,Bruner J

更新日期：1996-01-04 00:00:00

abstract：:Several lines of evidence suggest that gastrin and the CCK-2 receptor (CCK2R) could contribute to pancreatic carcinogenesis by modulating processes such as proliferation, cell adhesion or migration. In the current study, we used a 'cancer gene array' and identified beta1-integrin subunit as a new gastrin-regulated gen...

journal_title：Oncogene

authors： Cayrol C,Clerc P,Bertrand C,Gigoux V,Portolan G,Fourmy D,Dufresne M,Seva C

更新日期：2006-07-27 00:00:00

abstract：:Promyelocytic leukemia (PML) nuclear bodies (PML NBs) are discrete subnuclear domains organized by the promyelocytic leukemia protein PML, a tumor suppressor essential for multiple apoptotic pathways. We have recently described a novel family of cellular factors, the THAP proteins, characterized by the presence at the...

journal_title：Oncogene

authors： Roussigne M,Cayrol C,Clouaire T,Amalric F,Girard JP

更新日期：2003-04-24 00:00:00

abstract：:The myb family of genes encodes highly homologous nuclear transcription factors that play distinct roles in the development of breast, germ cells and hematoid organs. While the mechanisms associated with the regulation of these genes remain unknown, the transactivation of c-Myb was previously shown to be upregulated b...

journal_title：Oncogene

authors： Kang AD,Park G,Kim YH,Oh IH

更新日期：2004-05-20 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is generally accompanied by high mortality and low cure rate. CCAAT enhancer-binding proteins (CEBPs) are transcriptional regulators that play a key role in maintaining liver function. Altered expression of C/EBPα and C/EBPβ occurs in many tumours including HCC. saRNAs are small double-s...

journal_title：Oncogene

authors： Zhao X,Reebye V,Hitchen P,Fan J,Jiang H,Sætrom P,Rossi J,Habib NA,Huang KW

更新日期：2019-05-01 00:00:00

abstract：:The c-Myc oncoprotein is a basic-helix-loop-helix-leucine zipper (b-HLH-LZ) transcription factor involved in regulating cell proliferation and differentiation. We have used retrovirus-mediated gene transfer to investigate the effect of ectopic c-Myc expression on the spontaneous differentiation of primary quail myobla...

journal_title：Oncogene

authors： La Rocca SA,Crouch DH,Gillespie DA

更新日期：1994-12-01 00:00:00

abstract：:Expression of Brca1 in mouse mammary cancer has yet to be analysed. We use a progressive model of neoplasia based on several mouse epithelial cell lines that represent distinct steps toward the fully tumorigenic state. Using RNase protection analysis because acceptable anti-Brca1 antibodies are not available we invest...

journal_title：Oncogene

authors： Mixon M,Kittrell F,Medina D

更新日期：2000-11-02 00:00:00

abstract：:The mechanism by which the p53 family of proteins coordinately regulates select target genes after various types of cell stress is not well understood. To further define factors that dictate regulation of target genes, we examined the binding of p53, DeltaNp63alpha and RNA polymerase II (pol II) to the regulatory regi...

journal_title：Oncogene

authors： Schavolt KL,Pietenpol JA

更新日期：2007-09-13 00:00:00

abstract：:Survivin is a member of the inhibitor of apoptosis protein family and has an essential role in mitosis. Survivin is overexpressed in a large variety of human cancers and represents an attractive target for cancer therapy. Epidermal growth factor receptor and Her/neu-transformed human tumors in particular exhibit high ...

journal_title：Oncogene

authors： Berezov A,Cai Z,Freudenberg JA,Zhang H,Cheng X,Thompson T,Murali R,Greene MI,Wang Q

更新日期：2012-04-12 00:00:00

abstract：:The C-terminal src kinase (Csk) is responsible for the phosphorylation of the carboxy-terminal tyrosine of several tyrosine kinases of the Src family. This phosphorylation site has a negative regulatory function. Csk is unique among the members of the protein tyrosine kinase family because it lacks the conserved tyros...

journal_title：Oncogene

authors： Bougeret C,Rothhut B,Jullien P,Fischer S,Benarous R

更新日期：1993-05-01 00:00:00

abstract：:The transcription factor DRTF1/E2F is implicated in the control of cellular proliferation due to its interaction with key regulators of cell cycle progression, such as the retinoblastoma tumour suppressor gene product and related pocket proteins, cyclins and cyclin-dependent kinases. DRTF1/E2F DNA binding activity ari...

journal_title：Oncogene

authors： Buck V,Allen KE,Sørensen T,Bybee A,Hijmans EM,Voorhoeve PM,Bernards R,La Thangue NB

更新日期：1995-07-06 00:00:00

abstract：:The v-erbA oncogene transforms chicken erythrocytic progenitors (T2EC) by blocking their differentiation and freezing them in a state of self-renewal. Transcriptomes of T2EC, expressing either v-erbA or a non-transforming form of v-erbA (S61G), were compared using serial analysis of gene expression and some, but not a...

journal_title：Oncogene

authors： Nguyen-Lefebvre AT,Leprun G,Morin V,Viñuelas J,Couté Y,Madjar JJ,Gandrillon O,Gonin-Giraud S

更新日期：2014-03-20 00:00:00

abstract：:Interferon (IFN)-beta induces S-phase slowing and apoptosis in human papilloma virus (HPV)-positive cervical carcinoma cell line ME-180. Here, we show that apoptosis is a consequence of the S-phase lengthening imposed by IFN-beta, demonstrating the functional correlation between S-phase alteration and apoptosis induct...

journal_title：Oncogene

authors： Vannucchi S,Chiantore MV,Fiorucci G,Percario ZA,Leone S,Affabris E,Romeo G

更新日期：2005-04-07 00:00:00

abstract：:Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER-) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however,...

journal_title：Oncogene

authors： Lan Q,Peyvandi S,Duffey N,Huang YT,Barras D,Held W,Richard F,Delorenzi M,Sotiriou C,Desmedt C,Lorusso G,Rüegg C

更新日期：2019-04-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) production by stromal fibroblasts plays an important role in tumor angiogenesis. However, VEGF is also expressed by normal tissue fibroblasts, raising the question of how the VEGF activity of fibroblasts is regulated. Here we report that the latent VEGF angiogenic activity of ...

journal_title：Oncogene

authors： Ito TK,Ishii G,Chiba H,Ochiai A

更新日期：2007-11-08 00:00:00

abstract：:Stat3 (signal transducer and activator of transcription-3) activity is required for transformation by a number of oncogenes, while a constitutively active form of Stat3 alone is sufficient to induce neoplastic transformation. Although in most instances Stat3 is growth-promoting, the impact of cell density on Stat3 act...

journal_title：Oncogene

authors： Vultur A,Cao J,Arulanandam R,Turkson J,Jove R,Greer P,Craig A,Elliott B,Raptis L

更新日期：2004-04-08 00:00:00

abstract：:TGF-β is a multifunctional cytokine affecting many cell types and implicated in tissue remodeling processes. Due to its many functions and cell-specific effects, the consequences of TGF-β signaling are process-and stage-dependent, and it is not uncommon that TGF-β exerts distinct and sometimes opposing effects on a di...

journal_title：Oncogene

authors： Muppala S,Xiao R,Krukovets I,Verbovetsky D,Yendamuri R,Habib N,Raman P,Plow E,Stenina-Adognravi O

更新日期：2017-09-07 00:00:00

abstract：:We recently reported an interaction between the p14(ARF) protein and human topoisomerase I (Topo I) resulting in the stimulation of the relaxation activity of Topo I. Our data showed that the complex between the two proteins was located within the nucleolus. In the present work, we have investigated the regions of p14...

journal_title：Oncogene

authors： Ayrault O,Karayan L,Riou JF,Larsen CJ,Séité P

更新日期：2003-04-03 00:00:00

abstract：:Low dose treatment with the DNA methylation inhibitor decitabine has been shown to be applicable for the management of certain types of cancer. However, its antitumor effect and mechanisms are context dependent and its activity has never been systematically studied in bladder cancer treatment. We used mouse models, cu...

journal_title：Oncogene

authors： Wu M,Sheng L,Cheng M,Zhang H,Jiang Y,Lin S,Liang Y,Zhu F,Liu Z,Zhang Y,Zhang X,Gao Q,Chen D,Li J,Li Y

更新日期：2019-07-01 00:00:00

abstract：:The Epstein-Barr virus latency-associated membrane protein LMP2A has been shown to activate the survival kinase Akt in epithelial and B cells in a phosphoinositide 3-kinase-dependent fashion. In this study, we demonstrate that the signalling scaffold Shb associates through SH2 and PTB domain interactions with phosphor...

journal_title：Oncogene

authors： Matskova LV,Helmstetter C,Ingham RJ,Gish G,Lindholm CK,Ernberg I,Pawson T,Winberg G

更新日期：2007-07-26 00:00:00

abstract：:Polyomavirus large T-antigen (PyLT-Ag), a nucleophosphoprotein essential for regulating viral gene expression, modulates the cell cycle by binding to the Rb tumor suppressor gene product. PyLT-Ag/Rb binding is essential for in vitro immortalization. However, the effect of PyLT-Ag on apoptosis has not been extensively ...

journal_title：Oncogene

authors： Rodier F,Bertrand R,Bossolasco M,Mes-Masson AM

更新日期：2000-12-14 00:00:00

abstract：:As apoptosis defects limit efficacy of anticancer agents, autophagy has been proposed as a novel strategy for radiotherapy enhancement. We previously showed that caspase-3/7 inhibition induces autophagy and promotes radiosensitivity in vitro and in vivo. Therefore, we further investigated the mechanism by which radiat...

journal_title：Oncogene

authors： Kim KW,Moretti L,Mitchell LR,Jung DK,Lu B

更新日期：2010-06-03 00:00:00

abstract：:The mechanism by which Bcl-2 inhibits apoptosis is unknown. The Bcl-2 protein is localized to intracellular membranes, including the endoplasmic reticulum (ER). The ER is the major intracellular reservoir of Ca2+ in non-muscle cells, sequestering Ca2+ for use in intracellular signaling, and is a prime target of oxidat...

journal_title：Oncogene

authors： Distelhorst CW,Lam M,McCormick TS

更新日期：1996-05-16 00:00:00

abstract：:There is a large body of evidence suggesting the connexin gap junction proteins appear to act as tumor suppressors, and their tumor inhibitory effect is usually attributed to their main function of cell coupling through gap junctions. However, some cancer cells (e.g. the rat bladder carcinoma BC31 cell line) are cell-...

journal_title：Oncogene

authors： Krutovskikh VA,Troyanovsky SM,Piccoli C,Tsuda H,Asamoto M,Yamasaki H

更新日期：2000-01-27 00:00:00