Loss of heterozygosity of chromosome 17 in human borderline and invasive epithelial ovarian tumors.

abstract：:Pancreatic cancer is characterized by early metastatic spread, but the process of tumor cell dissemination is largely unknown. In this study we show that the soluble protein pancreatic adenocarcinoma upregulated factor (PAUF) has an important role in the metastasis and progression of the disease. Variations in the lev...

journal_title：Oncogene

authors： Lee Y,Kim SJ,Park HD,Park EH,Huang SM,Jeon SB,Kim JM,Lim DS,Koh SS

更新日期：2010-01-07 00:00:00

abstract：:The human cellular homolog of v-rel, the transforming gene of reticuloendotheliosis virus, strain T, was previously localized to 2 cent-2p13 by a combination of somatic cell hybrid and in situ hybridization analyses. In this study, we use translocation chromosome analysis to refine c-rel's genetic assignment to 2p12-2...

journal_title：Oncogene

authors： Brownell E,Fell HP,Tucker PW,Geurts van Kessel AH,Hagemeijer A,Rice NR

更新日期：1988-05-01 00:00:00

abstract：:Fli-1 is a proto-oncogene which is rearranged in tumors induced by three different retroviruses, Cas-Br-E, F-MuLV, and 10A1. This gene is a member of the Ets gene family, a class of transcription factors that recognize and bind to a DNA motif known as the Ets binding site (EBS). Our laboratory has previously cloned an...

journal_title：Oncogene

authors： Barbeau B,Barat C,Bergeron D,Rassart E

更新日期：1999-09-30 00:00:00

abstract：:An oncogenic mutation (G49A:E17K) in the AKT1 gene has been described recently in human breast, colon, and ovarian cancers. The low frequency of this mutation and perhaps other selective pressures have prevented the isolation of human cancer cell lines that harbor this mutation thereby limiting functional analysis. He...

journal_title：Oncogene

authors： Lauring J,Cosgrove DP,Fontana S,Gustin JP,Konishi H,Abukhdeir AM,Garay JP,Mohseni M,Wang GM,Higgins MJ,Gorkin D,Reis M,Vogelstein B,Polyak K,Cowherd M,Buckhaults PJ,Park BH

更新日期：2010-04-22 00:00:00

abstract：:Twenty five human glial tumours of different grades of malignancy were examined by Southern blotting and polymerase chain reaction (PCR) for alterations (rearrangements, amplification and deletions) in the c-myc gene. Number of c-myc positive cells per thousand cells were also counted in all the tumours after immunohi...

journal_title：Oncogene

authors： Chattopadhyay P,Banerjee M,Sarkar C,Mathur M,Mohapatra AK,Sinha S

更新日期：1995-12-21 00:00:00

abstract：:Viruses have been engineered to replicate selectively in cancer cells, based on a number of innovative principles. Several of these viruses have entered clinical trials and have proven relatively safe, and have shown evidence of efficacy. However, further research is required to enable these agents to function systemi...

journal_title：Oncogene

authors： McCormick F

更新日期：2005-11-21 00:00:00

abstract：:The human papovaviruses BK virus (BKV) and JC virus (JCV) both encode a large-tumor (T) antigen which are highly homologous to each other as well as to simian virus 40 (SV40) large-T antigen. This high conservation of amino acid sequence has resulted in overlapping antigenicity such that immunological differentiation ...

journal_title：Oncogene

authors： Marshall J,Smith AE,Cheng SH

更新日期：1991-09-01 00:00:00

abstract：:Inheritance of genomic information independent of the DNA sequence, the epigenetics, as well as gene transcription are profoundly shaped by serine/threonine and tyrosine signaling kinases and components of the chromatin remodeling complexes. To precisely respond to a changing external milieu, human cells efficiently t...

journal_title：Oncogene

authors： Kumar R,Deivendran S,Santhoshkumar TR,Pillai MR

更新日期：2017-10-26 00:00:00

abstract：:Melanoma-associated antigen A1 (MAGEA1) is member of the MAGE gene family that is expressed in male germ line cells and placenta under normal physiological conditions. Although MAGEA1's expression levels have been evaluated as one of the cancer testis (CT) antigens for immunotherapy in melanoma and several other cance...

journal_title：Oncogene

authors： Zhao J,Wang Y,Mu C,Xu Y,Sang J

更新日期：2017-08-31 00:00:00

abstract：:During the evolution into castration or therapy resistance, prostate cancer cells reprogram the androgen responses to cope with the diminishing level of androgens, and undergo metabolic adaption to the nutritionally deprived and hypoxia conditions. AR (androgen receptor) and PKM2 (pyruvate kinase M2) have key roles in...

journal_title：Oncogene

authors： Wang HJ,Pochampalli M,Wang LY,Zou JX,Li PS,Hsu SC,Wang BJ,Huang SH,Yang P,Yang JC,Chu CY,Hsieh CL,Sung SY,Li CF,Tepper CG,Ann DK,Gao AC,Evans CP,Izumiya Y,Chuu CP,Wang WC,Chen HW,Kung HJ

更新日期：2019-01-01 00:00:00

abstract：:We have isolated a human cDNA clone encoding a novel protein of 22 kDa that is a human counterpart of the rat oncoprotein PTTG. We show that the corresponding gene (hpttg) is overexpressed in Jurkat cells (a human T lymphoma cell line) and in samples from patients with different kinds of hematopoietic malignancies. An...

journal_title：Oncogene

authors： Domínguez A,Ramos-Morales F,Romero F,Rios RM,Dreyfus F,Tortolero M,Pintor-Toro JA

更新日期：1998-10-29 00:00:00

abstract：:The S-phase kinase-associated protein-2 (SKP2) plays a key role in ubiquitin-mediated proteolysis, which results in the progression of cells from a quiescence to proliferative state. SKP2 is overexpressed in a variety of tumors. In this study, we used small interfering RNAs (siRNAs) to inhibit the SKP2 expression in l...

journal_title：Oncogene

authors： Jiang F,Caraway NP,Li R,Katz RL

更新日期：2005-05-12 00:00:00

abstract：:Interleukin-6 (IL-6) is a cytokine that regulates the proliferation of some tumor cells including multiple myeloma (MM). Ectopic expression of fibroblast growth factor receptor 3 (FGFR 3) associated with the chromosomal translocation, t(4;14)(p16.3;q32), is frequently found in MM, and therefore, has been implicated in...

journal_title：Oncogene

authors： Ishikawa H,Tsuyama N,Liu S,Abroun S,Li FJ,Otsuyama K,Zheng X,Ma Z,Maki Y,Iqbal MS,Obata M,Kawano MM

更新日期：2005-09-15 00:00:00

abstract：:Endothelial cells expressing fibroblast growth factor receptor-1 (FGFR-1) migrate and proliferate in response to treatment with FGF. We analysed ligand-induced migration and proliferation of porcine aortic endothelial cells expressing wild-type FGFR-1, point-mutated Y766F FGFR-1, unable to activate phospholipase C-gam...

journal_title：Oncogene

authors： Landgren E,Klint P,Yokote K,Claesson-Welsh L

更新日期：1998-07-23 00:00:00

abstract：:To investigate Mad1 function in vivo, transgenic mice were generated that express a Mad1 transgene in T lineage cells under the control of the proximal lck promoter. Thymus size in lck-Mad1 transgenic mice is drastically reduced although representation of the various thymocyte sub populations appears normal. To invest...

journal_title：Oncogene

authors： Rudolph B,Hueber AO,Evan GI

更新日期：2001-03-08 00:00:00

abstract：:The PI3K/AKT signaling pathway is aberrant in a wide variety of cancers. Downstream effectors of AKT are involved in survival, growth and metabolic-related pathways. In contrast, contradictory data relating to AKT effects on cell motility and invasion, crucial prometastatic processes, have been reported pointing to a ...

journal_title：Oncogene

authors： Zhu QS,Rosenblatt K,Huang KL,Lahat G,Brobey R,Bolshakov S,Nguyen T,Ding Z,Belousov R,Bill K,Luo X,Lazar A,Dicker A,Mills GB,Hung MC,Lev D

更新日期：2011-01-27 00:00:00

abstract：:Based on observations suggesting a role for the tumor suppressor protein p53 in regulating expression of the 67-kDa laminin receptor precursor, 37LRP, we analysed the 37LRP promoter activity in a wild-type p53 (wt p53) ovarian carcinoma cell line and in a cisplatin-resistant subline with mutated p53. We observed an in...

journal_title：Oncogene

authors： Modugno M,Tagliabue E,Ardini E,Berno V,Galmozzi E,De Bortoli M,Castronovo V,Ménard S

更新日期：2002-10-24 00:00:00

abstract：:The p53 tumor suppressor protein and the Akt/PKB kinase play important roles in the transduction of pro-apoptotic and anti-apoptotic signals, respectively. We provide evidence that conflicting signals transduced by Akt and p53 are integrated via negative feedback between the two pathways. On the one hand, the combinat...

journal_title：Oncogene

authors： Gottlieb TM,Leal JF,Seger R,Taya Y,Oren M

更新日期：2002-02-14 00:00:00

abstract：:p53 is known to play a role in iron homeostasis and is required for FDXR-mediated iron metabolism via iron regulatory protein 2 (IRP2). Interestingly, p53 is frequently mutated in tumors wherein iron is often accumulated, suggesting that mutant p53 may exert its gain of function by altering iron metabolism. In this st...

journal_title：Oncogene

authors： Zhang Y,Feng X,Zhang J,Chen M,Huang E,Chen X

更新日期：2019-08-01 00:00:00

abstract：:The role of the hepatitis B virus protein HBx in liver cell proliferation and apoptosis remains controversial. Using a transgenic mouse model, we have recently shown that HBx stimulates the apoptotic turnover of hepatocytes, independently of p53. In this paper, we tested whether the proapoptotic function of HBx can in...

journal_title：Oncogene

authors： Terradillos O,de La Coste A,Pollicino T,Neuveut C,Sitterlin D,Lecoeur H,Gougeon ML,Kahn A,Buendia MA

更新日期：2002-01-17 00:00:00

abstract：:Our recent study showed critical roles of Dmp1 as a sensor of oncogenic Ras, HER2/neu signaling and activation of the Arf-p53 pathway. To elucidate the role of human DMP1 (hDMP1) in breast cancer, one hundred and ten pairs of human breast cancer specimen were studied for the alterations of the hDMP1-ARF-Hdm2-p53 pathw...

journal_title：Oncogene

authors： Maglic D,Zhu S,Fry EA,Taneja P,Kai F,Kendig RD,Sugiyama T,Miller LD,Willingham MC,Inoue K

更新日期：2013-08-29 00:00:00

abstract：:The Ets family of transcription factors is one of a growing number of master regulators of development. This family was originally defined by the presence of a conserved DNA binding domain, the Ets domain. To date, nearly 30 members of this family have been identified and implicated in a wide range of physiological an...

journal_title：Oncogene

authors： Bartel FO,Higuchi T,Spyropoulos DD

更新日期：2000-12-18 00:00:00

abstract：:Small cell lung cancer (SCLC) is an aggressive cancer characterized by several autocrine growth mechanisms including stem cell factor and its receptor c-Kit. In order to arrive at potentially new and novel therapy for SCLC, we have investigated the effects of the tyrosine kinase inhibitor, STI 571, on SCLC cell lines....

journal_title：Oncogene

authors： Wang WL,Healy ME,Sattler M,Verma S,Lin J,Maulik G,Stiles CD,Griffin JD,Johnson BE,Salgia R

更新日期：2000-07-20 00:00:00

abstract：:Glioblastoma (GBM) is a highly malignant glioma, which has the propensity to infiltrate throughout the brain in contrast to pilocytic astrocytoma (PA) of the posterior fossa, which does not spread and can be cured by surgery. We have used Suppression Subtractive Hybridization to define markers that better delineate th...

journal_title：Oncogene

authors： Colin C,Baeza N,Bartoli C,Fina F,Eudes N,Nanni I,Martin PM,Ouafik L,Figarella-Branger D

更新日期：2006-05-04 00:00:00

abstract：:The Interleukin-1beta converting enzyme (ICE) family of proteins, homologs of the C elegans cell death gene product CED-3, play important roles in controlling vertebrate programmed cell death. Because inhibition of apoptosis may be an essential step in tumorigenesis, we investigated the interaction of the simian virus...

journal_title：Oncogene

authors： Jung YK,Yuan J

更新日期：1997-03-13 00:00:00

abstract：:Low dose treatment with the DNA methylation inhibitor decitabine has been shown to be applicable for the management of certain types of cancer. However, its antitumor effect and mechanisms are context dependent and its activity has never been systematically studied in bladder cancer treatment. We used mouse models, cu...

journal_title：Oncogene

authors： Wu M,Sheng L,Cheng M,Zhang H,Jiang Y,Lin S,Liang Y,Zhu F,Liu Z,Zhang Y,Zhang X,Gao Q,Chen D,Li J,Li Y

更新日期：2019-07-01 00:00:00

abstract：:Experimental studies performed prior to 1990 led to the widely held belief that matrix metalloproteinases (MMPs) produced by cancer cells are of critical importance in tumor invasion and metastasis. Based on this evidence, the pharmaceutical industry produced several well tolerated, orally active MMP inhibitors (MMPIs...

journal_title：Oncogene

authors： Zucker S,Cao J,Chen WT

更新日期：2000-12-27 00:00:00

abstract：:dMax, a naturally occurring splice variant of the Myc binding protein Max, lacks the DNA binding basic region and helix 1 of the Helix-Loop-Helix domain; dMax interacts with c-Myc in vitro and in vivo, and inhibits E-box Myc site driven transcription in transient transfection assays. Here we have investigated the expr...

journal_title：Oncogene

authors： FitzGerald MJ,Arsura M,Bellas RE,Yang W,Wu M,Chin L,Mann KK,DePinho RA,Sonenshein GE

更新日期：1999-04-15 00:00:00

abstract：:Aurora kinases are known to play a key role in maintaining mitotic fidelity, and overexpression of aurora kinases has been noted in various tumors. Overexpression of aurora kinase activity is thought to promote cancer development through a loss of centrosome or chromosome number integrity. Here we observed augmentatio...

journal_title：Oncogene

authors： Tatsuka M,Sato S,Kitajima S,Suto S,Kawai H,Miyauchi M,Ogawa I,Maeda M,Ota T,Takata T

更新日期：2005-02-03 00:00:00

abstract：:Cell cycle checkpoints and tumor suppressor gene functions appear to be required for the maintenance of a stable genome in proliferating cells. In this study chromosomal destabilization was monitored in relation to telomere structure, lifespan control and G2 checkpoint function. Replicative senescence was inactivated ...

journal_title：Oncogene

authors： Filatov L,Golubovskaya V,Hurt JC,Byrd LL,Phillips JM,Kaufmann WK

更新日期：1998-04-09 00:00:00