The stem cell transcription factor ZFP57 induces IGF2 expression to promote anchorage-independent growth in cancer cells.

abstract：:Since defects in molecular mechanisms controlling DNA repair, cell cycle checkpoint and apoptosis could modify cellular sensitivity to DNA damaging agents, we have conducted a multiparametric molecular analysis for better understanding the regulation pathways leading to cell survival or cell death after irradiation. U...

journal_title：Oncogene

authors： Bishay K,Ory K,Lebeau J,Levalois C,Olivier MF,Chevillard S

更新日期：2000-02-17 00:00:00

abstract：:The discovery of constitutive nuclear factor-κB (NF-κB) activation in Hodgkin's lymphoma tumor cells almost two decades ago was one of the first reports that directly connected deregulated NF-κB signaling to human cancer. Subsequent studies demonstrated that enhanced NF-κB signaling is a common hallmark of many lympho...

journal_title：Oncogene

authors： Nagel D,Vincendeau M,Eitelhuber AC,Krappmann D

更新日期：2014-12-11 00:00:00

abstract：:RRR-alpha-tocopheryl succinate (alpha-vitamin E succinate, VES), one of the vitamin E derivatives, can effectively inhibit the proliferation of human prostate cancer cells. However, little is known about its effect on prostate cancer cell invasive ability. Tumor metastasis is a complex process and the extracellular ma...

journal_title：Oncogene

authors： Zhang M,Altuwaijri S,Yeh S

更新日期：2004-04-15 00:00:00

abstract：:Invadopodia are cell protrusions that mediate cancer cell extravasation but the microenvironmental cues and signaling factors that induce invadopodia formation during extravasation remain unclear. Using intravital imaging and loss of function experiments, we determined invadopodia contain receptors involved in chemota...

journal_title：Oncogene

authors： Williams KC,Cepeda MA,Javed S,Searle K,Parkins KM,Makela AV,Hamilton AM,Soukhtehzari S,Kim Y,Tuck AB,Ronald JA,Foster PJ,Chambers AF,Leong HS

更新日期：2019-05-01 00:00:00

abstract：:Treatment of fibroblasts with the phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA), specifically inhibits fibroblast growth factor-2 (FGF-2) induced proliferation. TPA treatment has little or no effect on FGF receptor activation but specifically inhibits the activation of p38 MAPK but not other downstream si...

journal_title：Oncogene

authors： Maher P

更新日期：2002-03-27 00:00:00

abstract：:Cortactin, a p80/85 protein first identified as a src kinase substrate, is thought to be involved in the signaling pathway of mitogenic receptors and adhesion molecules mediating cytoskeletal reorganization. The cortactin gene, EMS1, maps to chromosome 11q13, a region amplified in head and neck squamous cell carcinoma...

journal_title：Oncogene

authors： Patel AS,Schechter GL,Wasilenko WJ,Somers KD

更新日期：1998-06-25 00:00:00

abstract：:Human polyomaviruses (JC virus, BK virus and simian virus 40) are causative agents of some human diseases and, interestingly, are involved in processes of cell transformation and oncogenesis. These viruses need the cell cycle machinery of the host cell to complete their replication; so they evolved mechanisms that can...

journal_title：Oncogene

authors： Caracciolo V,Reiss K,Khalili K,De Falco G,Giordano A

更新日期：2006-08-28 00:00:00

abstract：:Anemia in cancer patients is associated with reduced quality of life and local failure after radiation treatment. However, the use of erythropoietin to correct cancer anemia and to improve radiation efficacy was disappointing. Erythropoietin-receptor signaling mainly acts via activation of STAT 5, but also crossactiva...

journal_title：Oncogene

authors： Pajonk F,Weil A,Sommer A,Suwinski R,Henke M

更新日期：2004-11-25 00:00:00

abstract：:Melanoma is the deadliest form of skin cancer with rising incidence, creating a significant health problem. We discovered increased expression of bone morphogenetic protein 6 (BMP6) in melanoma cells and tissues, and observed that BMP6 deficiency caused significantly delayed tumor onset and decelerated tumor progressi...

journal_title：Oncogene

authors： Stieglitz D,Lamm S,Braig S,Feuerer L,Kuphal S,Dietrich P,Arndt S,Echtenacher B,Hellerbrand C,Karrer S,Bosserhoff AK

更新日期：2019-01-01 00:00:00

abstract：:Alterations affecting the epidermal growth factor (EGF)/transforming growth factor alpha (TGF alpha)-responsive mitogenic pathway are frequently detected in malignancies. In particular, the EGF-receptor (EGFR) molecule has been found overexpressed in a number of human tumors, and TGF alpha is produced by a large array...

journal_title：Oncogene

authors： Di Marco E,Pierce JH,Fleming TP,Kraus MH,Molloy CJ,Aaronson SA,Di Fiore PP

更新日期：1989-07-01 00:00:00

abstract：:Recently Gadd45, a p53-regulated stress protein, has been implicated in the activation of a G2/M checkpoint after damage by UV radiation and alkylating agents. While inhibitory phosphorylation of Cdc2 and suppression of cyclin B1 levels are known to be involved in G2 delays after genotoxic stress, Gadd45 has now been ...

journal_title：Oncogene

authors： Zhan Q,Antinore MJ,Wang XW,Carrier F,Smith ML,Harris CC,Fornace AJ Jr

更新日期：1999-05-06 00:00:00

abstract：:PTEN, encoding a lipid phosphatase, is a tumor suppressor gene and is mutated in various types of cancers. It is reported to regulate G1 to S phase transition of the cell cycle by influencing the expression, protein stability and subcellular location of cyclin D1. Here, we provide evidence that PTEN modulates the tran...

journal_title：Oncogene

authors： Huang W,Chang HY,Fei T,Wu H,Chen YG

更新日期：2007-04-12 00:00:00

abstract：:Mutations in the p53 tumour suppressor gene have been recently described in hepatocellular carcinomas (HCC) from high risk areas such as China and South Africa. Our study was designed to assess the importance of p53 aberrations in HCCs from Europe, where the major risk factors in hepatocarcinogenesis, aflatoxin exposu...

journal_title：Oncogene

authors： Volkmann M,Hofmann WJ,Müller M,Räth U,Otto G,Zentgraf H,Galle PR

更新日期：1994-01-01 00:00:00

abstract：:Exposure of CV-1P cells to hypoxic conditions results in reversible cell cycle arrest concomitant with accumulation of pRB in the hypophosphorylated, growth suppressive form. Similar to cell cycle arrest induced by serum starvation, we show here that hypoxia-induced arrest is accompanied by a decrease in pRB-directed ...

journal_title：Oncogene

authors： Krtolica A,Krucher NA,Ludlow JW

更新日期：1998-11-05 00:00:00

abstract：:Adenoviruses are linear double-stranded DNA viruses that infect human and rodent cell lines, occasionally transform them and cause tumors in animal models. The host cell challenges the virus in multifaceted ways to restrain viral gene expression and DNA replication, and sometimes even eliminates the infected cells by ...

journal_title：Oncogene

authors： Gupta A,Jha S,Engel DA,Ornelles DA,Dutta A

更新日期：2013-10-17 00:00:00

abstract：:A lot of attention has been dedicated to investigate the role of the tyrosine kinase receptor MET in tumors. The acquired notion that cancer cells from different histological origin strictly rely on the engagement of this specific oncogene for their growth and survival has certainly justified the development and the u...

journal_title：Oncogene

authors： Finisguerra V,Prenen H,Mazzone M

更新日期：2016-10-20 00:00:00

abstract：:Procollagen lysyl hydroxylase 1 (PLOD1) is highly expressed in malignant tumors such as esophageal squamous cell carcinoma, gastric cancer, and colorectal cancer. Bioinformatics analysis revealed that PLOD1 is associated with the progression of GBM, particularly the most malignant mesenchymal subtype (MES). Moreover, ...

journal_title：Oncogene

authors： Wang Z,Shi Y,Ying C,Jiang Y,Hu J

更新日期：2021-01-08 00:00:00

abstract：:Castration-resistant prostate cancer (CRPC) continues to be a major clinical problem and the mechanisms behind it remain unclear. Thioredoxin domain-containing protein 5 (TXNDC5) is involved in protein folding and chaperone activity, and its overexpression has been reported in multiple malignancies. In the current stu...

journal_title：Oncogene

authors： Wang L,Song G,Chang X,Tan W,Pan J,Zhu X,Liu Z,Qi M,Yu J,Han B

更新日期：2015-09-03 00:00:00

abstract：:All-trans retinoic acid (RA), the principle biologically active form of vitamin A, is essential for many developmental process as well as homeostasis in the adult. Many lines of evidence also suggest that RA, acting through the RA receptors (RARs), can also suppress growth of tumors of diverse origin. To assess direct...

journal_title：Oncogene

authors： Chen CF,Goyette P,Lohnes D

更新日期：2004-07-08 00:00:00

abstract：:Acute myeloid leukemia (AML) is a heterogeneous disease comprising a large number of subtypes defined by specific chromosome abnormalities. One such subtype carries the t(6;9)(p22;q34) chromosome rearrangement, which leads to expression of the DEK-NUP214 chimeric gene, and has a particularly poor outcome. To provide a...

journal_title：Oncogene

authors： Qin H,Malek S,Cowell JK,Ren M

更新日期：2016-10-27 00:00:00

abstract：:Previous observations suggest expression of cyclooxygenase-2 to convey macrophage protection towards apoptotic cell death. We reasoned prostaglandin formation and in turn a cAMP increase as the underlying protective principle. Here we report that exposure of macrophages to lipopolysaccharide/interferon-gamma or lipoph...

journal_title：Oncogene

authors： von Knethen A,Lotero A,Brüne B

更新日期：1998-07-23 00:00:00

abstract：:Graft versus host disease (GvHD), which is the primary complication of allogeneic bone marrow transplantation, can alter the intestinal barrier targeted by activated donor T-cells. Chemical inhibition of the stress protein HSP90 was demonstrated in vitro to inhibit T-cell activation and to modulate endoplasmic reticul...

journal_title：Oncogene

authors： Joly AL,Deepti A,Seignez A,Goloudina A,Hebrard S,Schmitt E,Richaud S,Fourmaux E,Hammann A,Collura A,Svrcek M,Jego G,Robinet E,Solary E,Demidov O,Kohli E,Garrido C

更新日期：2016-06-02 00:00:00

abstract：:Human Papillomavirus (HPV) type 16 is the most frequently detected HPV in cervical cancer. Although epidemiologic and experimental evidence indicates a prominent role for HPV infection in the development of this disease, other factors are also involved. Altered expression of the ets family transcription factors erg an...

journal_title：Oncogene

authors： Simpson S,Woodworth CD,DiPaolo JA

更新日期：1997-05-08 00:00:00

abstract：:TNFα is a pleiotropic cytokine which fuels tumor cell growth, invasion, and metastasis in some malignancies, while in others it induces cytotoxic cell death. However, the molecular mechanism by which TNFα exerts its diverse effects on breast cancer subtypes remains elusive. Using in vitro assays and mouse xenografts, ...

journal_title：Oncogene

authors： Lee E,Ouzounova M,Piranlioglu R,Ma MT,Guzel M,Marasco D,Chadli A,Gestwicki JE,Cowell JK,Wicha MS,Hassan KA,Korkaya H

更新日期：2019-01-01 00:00:00

abstract：:A correction to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Oncogene

authors： Wagner S,Vlachogiannis G,De Haven Brandon A,Valenti M,Box G,Jenkins L,Mancusi C,Self A,Manodoro F,Assiotis I,Robinson P,Chauhan R,Rust AG,Matthews N,Eason K,Khan K,Starling N,Cunningham D,Sadanandam A,Isacke CM,Ki

更新日期：2019-07-01 00:00:00

abstract：:bcl-XS, a member of the bcl-2 family, has been shown to induce and/or sensitize some cells to undergo programmed cell death, and to negate the anti-apoptotic activity of bcl-XL and bcl-2 by mechanisms which are still uncertain. To help understand these mechanisms we have established stable derivatives of the K12 rat c...

journal_title：Oncogene

authors： Fridman JS,Rehemtulla A,Hofmann A,Blau HM,Maybaum J

更新日期：1998-12-10 00:00:00

abstract：:The most common mutations in the familial breast and ovarian cancer susceptibility gene BRCA1 are frameshift and nonsense mutations, which lead to the synthesis of truncated proteins. On this ground, we have analysed BRCA1 exon 11, which includes about 61% of coding region, in germline DNA from 70 Italian breast and/o...

journal_title：Oncogene

authors： De Benedetti VM,Radice P,Mondini P,Spatti G,Conti A,Illeni MT,Caligo MA,Cipollini G,Bevilaqua G,Pilotti S,Pierotti MA

更新日期：1996-09-19 00:00:00

abstract：:The E2F1 transcription factor plays a pivotal role in driving cells out of a quiescent state and into the S phase of the cell cycle, in part by transactivating genes needed for DNA replication including DHFR, thymidine kinase, and DNA Polymerase alpha. E2F1 has also been implicated in regulating an S phase checkpoint,...

journal_title：Oncogene

authors： Stubbs MC,Hall DJ

更新日期：2002-05-23 00:00:00

abstract：:Bloom's syndrome (BS) is an autosomal recessive disorder associated with an elevated incidence of cancers. The gene mutated in BS, BLM, encodes a RecQ helicase family member. BS cells exhibit genomic instability, including excessive homologous recombination and chromosomal aberrations. We reported previously that BS c...

journal_title：Oncogene

authors： Rassool FV,North PS,Mufti GJ,Hickson ID

更新日期：2003-11-27 00:00:00

abstract：:Colony-stimulating factors and other cytokines signal via their cognate receptors to regulate hematopoiesis. In many developmental systems, inductive signalling determines cell fate and, by analogy with this, it has been postulated that cytokines, signalling via their cognate receptors, may play an instructive role in...

journal_title：Oncogene

authors： Robb L

更新日期：2007-10-15 00:00:00