Abstract:
:The eph gene encodes a putative receptor tyrosine kinase for an as yet unknown ligand. Some human cancer cells have been found to overexpress eph mRNAs without gene amplification. We show here that NIH3T3 cells acquire tumorigenic ability in nude mice and make colonies in soft agar with a viral LTR (Long Terminal Repeat)-driven artificial expression of the eph gene to a high level. This result supports the alleged contribution of overexpressed receptor tyrosine kinases to cell transformation.
journal_name
Oncogenejournal_title
Oncogeneauthors
Maru Y,Hirai H,Takaku Fsubject
Has Abstractpub_date
1990-03-01 00:00:00pages
445-7issue
3eissn
0950-9232issn
1476-5594journal_volume
5pub_type
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