A peptide that inhibits function of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis.

abstract：:The role of specificity protein 1 (Sp1) in controlling gene expression in lung tumor development and metastasis is not well understood. In this study, we showed that the Sp1 level was highly increased and required for lung tumor growth in transgenic mice bearing Kras-induced lung tumors under the control of doxycyclin...

journal_title：Oncogene

authors： Hsu TI,Wang MC,Chen SY,Yeh YM,Su WC,Chang WC,Hung JJ

更新日期：2012-08-30 00:00:00

abstract：:In chronic myelogenous leukemia (CML), the oncogene bcr-abl encodes a dysregulated tyrosine kinase that inhibits apoptosis. We showed previously that human erythroleukemia K562 cells are resistant to antineoplastic drug (taxol)-induced apoptosis through the atypical protein kinase C iota isozyme (PKC iota), a kinase d...

journal_title：Oncogene

authors： Lu Y,Jamieson L,Brasier AR,Fields AP

更新日期：2001-08-09 00:00:00

abstract：:Mdm2, a regulator of the p53 tumor suppressor, is frequently overexpressed in lymphomas, including lymphomas that have inactivated p53. However, the biological consequences of Mdm2 overexpression in lymphocytes are not fully resolved. Here, we report that increased expression of Mdm2 in B cells augmented proliferation...

journal_title：Oncogene

authors： Wang P,Lushnikova T,Odvody J,Greiner TC,Jones SN,Eischen CM

更新日期：2008-03-06 00:00:00

abstract：:Met tyrosine kinase has been implicated in tumorigenesis and metastasis; its overexpression and deregulation is often observed in cancer. Although Met's functions in cell motility has been studied extensively, its involvement in bleb-based, amoeboid motility is yet to be determined. The aim of this work is to study th...

journal_title：Oncogene

authors： Laser-Azogui A,Diamant-Levi T,Israeli S,Roytman Y,Tsarfaty I

更新日期：2014-04-03 00:00:00

abstract：:Treatment of mouse (12)1/CA cells with adriamycin or irradiation with U.V.C. induces p53-dependent transcription of a beta-galactosidase reporter and the endogenous p21/Waf1/Cip1 gene. Despite the induction of Waf1, the cells arrest only transiently in G1 or G2, then resume growth and eventually undergo apoptosis. In ...

journal_title：Oncogene

authors： Chernov MV,Stark GR

更新日期：1997-05-29 00:00:00

abstract：:The ability of Src-family kinases (SFKs) to mediate signaling from cell surface receptors in hematopoietic cells is a function of their catalytic activity, location and binding partners. Kinase activity is regulated in the cell by kinases and phosphatases that alter the state of phosphorylation of key tyrosine residue...

journal_title：Oncogene

authors： Geahlen RL,Handley MD,Harrison ML

更新日期：2004-10-18 00:00:00

abstract：:The leukemia-associated fusion proteins share several structural or functional similarities, suggesting that they may impart a leukemic phenotype through common modes of transcriptional dysregulation. The fusion proteins generated by these translocations usually contain a DNA-binding domain, domains responsible for ho...

journal_title：Oncogene

authors： Scandura JM,Boccuni P,Cammenga J,Nimer SD

更新日期：2002-05-13 00:00:00

abstract：:The tumor suppressor gene phosphatase and tensin homologue (PTEN) regulates the phosphatidylinositol-3'-kinase (PI3K) signaling pathway and has been shown to correlate with poor prognosis in high-grade astrocytomas when mutational inactivation or loss of the PTEN gene occurs. PTEN mutation leads to constitutive activa...

journal_title：Oncogene

authors： Edwards LA,Thiessen B,Dragowska WH,Daynard T,Bally MB,Dedhar S

更新日期：2005-05-19 00:00:00

abstract：:Antimicrobial peptides, such as the cathelicidin LL-37/hCAP-18 and its mouse homolog cathelicidin-related antimicrobial peptide (CRAMP), are important effectors of the innate immune system with direct anti-bacterial activity. Cathelicidin is possibly involved in the regulation of tumor cell growth. The aim of this stu...

journal_title：Oncogene

authors： Li D,Beisswenger C,Herr C,Schmid RM,Gallo RL,Han G,Zakharkina T,Bals R

更新日期：2014-05-22 00:00:00

abstract：:SCC-S2/GG2-1/NDED is a recently discovered antiapoptotic molecule induced by the activation of the transcription factor NF-kappaB. Here we have examined a role of SCC-S2 in cell growth regulation in vitro and in vivo. Western blotting using an antipeptide antibody revealed endogenous SCC-S2 as a approximately 21 kDa c...

journal_title：Oncogene

authors： Kumar D,Gokhale P,Broustas C,Chakravarty D,Ahmad I,Kasid U

更新日期：2004-01-15 00:00:00

abstract：:The genes for the M2 subunit of ribonucleotide reductase (RRM2), ornithine decarboxylase (ODC1), and 55,000-Daltons protein (P5), are amplified in hydroxyurea-resistant hamster and human cell lines. These genomic sequences have been mapped to hamster chromosome 7 and to human chromosome 2p24-25 near the cytogenetic lo...

journal_title：Oncogene

authors： Tonin PN,Yeger H,Stallings RL,Srinivasan PR,Lewis WH

更新日期：1989-09-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is involved in diverse processes such as inflammation, carcinogenesis and apoptosis. As COX-2 inhibitors interfere with these processes, inhibition of COX-2 has been suggested as a promising anticancer treatment. However, the role of COX-2 in modulation of apoptosis as well as the death pathwa...

journal_title：Oncogene

authors： Totzke G,Schulze-Osthoff K,Jänicke RU

更新日期：2003-09-11 00:00:00

abstract：:Although Kruppel-like factor 5 (KLF5) is a transcription factor that has been implicated in pathways critical to carcinogenesis, controversy persists as to whether it functions as a tumor suppressor or as an oncogene. Here, we describe a novel role for KLF5 in a p53-independent apoptotic pathway. Using RNA-interferenc...

journal_title：Oncogene

authors： Zhao Y,Hamza MS,Leong HS,Lim CB,Pan YF,Cheung E,Soo KC,Iyer NG

更新日期：2008-01-03 00:00:00

abstract：:The 5' untranslated region of the proto-oncogene c-myc contains an internal ribosome entry segment (IRES) (Nanbru et al., 1997; Stoneley et al., 1998) and thus c-myc protein synthesis can be initiated by a cap-independent as well as a cap-dependent mechanism (Stoneley et al., 2000). In cell lines derived from patients...

journal_title：Oncogene

authors： Chappell SA,LeQuesne JP,Paulin FE,deSchoolmeester ML,Stoneley M,Soutar RL,Ralston SH,Helfrich MH,Willis AE

更新日期：2000-09-07 00:00:00

abstract：:There is currently a great interest in delayed chromosomal and other damaging effects of low-dose exposure to a variety of pollutants which appear collectively to act through induction of stress-response pathways related to oxidative stress and ageing. These have been studied mostly in the radiation field but evidence...

journal_title：Oncogene

authors： Glaviano A,Nayak V,Cabuy E,Baird DM,Yin Z,Newson R,Ladon D,Rubio MA,Slijepcevic P,Lyng F,Mothersill C,Case CP

更新日期：2006-06-08 00:00:00

abstract：:The chicken c-ets-1 locus encodes two transcription factors, p54c-ets-1 and p68c-ets-1 that differ in their N-termini, encoded respectively by the I54 and alpha beta exons. p68c-ets-1 equivalents are only found in birds and reptiles while p54c-ets-1 is widely conserved in vertebrates, from amphibians to mammals. Thus,...

journal_title：Oncogene

authors： Albagli O,Soudant N,Ferreira E,Dhordain P,Dewitte F,Begue A,Flourens A,Stehelin D,Leprince D

更新日期：1994-11-01 00:00:00

abstract：:The t(12;21) translocation, generating the TEL/AML1 fusion protein, is the most common genetic lesion in childhood cancer. Using a bone marrow transplantation model, we demonstrate that TEL/AML1 expression impinges on normal hematopoietic differentiation, leading to the in vivo accumulation and persistence of an early...

journal_title：Oncogene

authors： Fischer M,Schwieger M,Horn S,Niebuhr B,Ford A,Roscher S,Bergholz U,Greaves M,Löhler J,Stocking C

更新日期：2005-11-17 00:00:00

abstract：:Wild-type (wt) p53 acts as a tumor suppressor, while certain mutant type (mt) p53 may exhibit 'oncogenic' function. We have recently demonstrated that human papillomavirus type 18 (HPV-18) E6 can partially overcome the growth-suppressive effects of wt p53, but it remains unclear what role p53 plays in cervical carcino...

journal_title：Oncogene

authors： Chen TM,Chen CA,Hsieh CY,Chang DY,Chen YH,Defendi V

更新日期：1993-06-01 00:00:00

abstract：:In chronic myelogenous leukemia, the constitutive activation of the BCR-ABL kinase transforms cells to an addicted state that requires glucose metabolism for survival. We investigated S6K1, a protein kinase that drives glycolysis in leukemia cells, as a target for counteracting glucose-dependent survival induced by BC...

journal_title：Oncogene

authors： Barger JF,Gallo CA,Tandon P,Liu H,Sullivan A,Grimes HL,Plas DR

更新日期：2013-01-24 00:00:00

abstract：:Dysregulation of pleiotropic growth factors, receptors and their downstream signaling pathway components represent a central protumorigenic principle in human hepatocarcinogenesis. Especially the Insulin-like Growth Factor/IGF-1 receptor (IGF/IGF-1R), Hepatocyte Growth Factor (HGF/MET), Wingless (Wnt/beta-catenin/FZD)...

journal_title：Oncogene

authors： Breuhahn K,Longerich T,Schirmacher P

更新日期：2006-06-26 00:00:00

abstract：:Dysregulated microRNA (miRNA) mediate malignant phenotypes, including metabolic reprogramming. By performing an integrative analysis of miRNA and metabolome data for the NCI-60 cell line panel, we identified an miRNA cluster strongly associated with both c-Myc expression and global metabolic variation. Within this clu...

journal_title：Oncogene

authors： Koufaris C,Valbuena GN,Pomyen Y,Tredwell GD,Nevedomskaya E,Lau CH,Yang T,Benito A,Ellis JK,Keun HC

更新日期：2016-05-01 00:00:00

abstract：:Approximately a third of all drugs act by binding directly to cell surface receptors coupled to G proteins. Other drugs act indirectly on these same pathways, for example, by inhibiting neurotransmitter reuptake or by blocking the inactivation of intracellular second messengers. These drugs have revolutionized the tre...

journal_title：Oncogene

authors： Hao N,Behar M,Elston TC,Dohlman HG

更新日期：2007-05-14 00:00:00

abstract：:Inhibitor of growth (ING)4, member of a gene family encoding potential tumor suppressors, is implicated as a repressor of angiogenesis and tumor growth and suppresses loss of contact inhibition in vitro. Here, we report that ING4 undergoes alternative splicing. Expression analysis identified novel ING4 spliced variant...

journal_title：Oncogene

authors： Raho G,Miranda C,Tamborini E,Pierotti MA,Greco A

更新日期：2007-08-09 00:00:00

abstract：:Cyclin D1, encoded by the gene CCND1, is a major regulator of the cell cycle transition from G1 phase to S phase. A CCND1 polymorphism (G to A) at codon 242, the boundary of exon 4 and intron 4, affects splicing such that exon 5 is not expressed in the A allele. Since exon 5 is involved in rapid turnover, the variant ...

journal_title：Oncogene

authors： Pakakasama S,Chen TT,Frawley W,Muller CY,Douglass EC,Lee R,Pollock BH,Tomlinson GE

更新日期：2004-06-10 00:00:00

abstract：:The recent years have seen a significant shift in the expectations for the therapeutic management of disseminated melanoma. The clinical success of BRAF targeted therapy suggests that long-term disease control may one day be a reality for genetically defined subgroups of melanoma patients. Despite this progress, few a...

journal_title：Oncogene

authors： Fedorenko IV,Gibney GT,Smalley KS

更新日期：2013-06-20 00:00:00

abstract：:Expression of Brca1 in mouse mammary cancer has yet to be analysed. We use a progressive model of neoplasia based on several mouse epithelial cell lines that represent distinct steps toward the fully tumorigenic state. Using RNase protection analysis because acceptable anti-Brca1 antibodies are not available we invest...

journal_title：Oncogene

authors： Mixon M,Kittrell F,Medina D

更新日期：2000-11-02 00:00:00

abstract：:Molecular, functional, and clinical analyses strongly suggest that chromosome segment 11p15.5 contains a gene involved in lung cancer pathogenesis. The critical region of allele loss is 310 kb in size. We used our contig of P1-phage artificial chromosome (PAC) clones together with newly identified bacterial artificial...

journal_title：Oncogene

authors： Zhao B,Bepler G

更新日期：2001-12-06 00:00:00

abstract：:Expression of polyomavirus middle-T antigen (middle-T) is involved in the formation of various tumors in vivo, e.g. hemangiomas and mammary gland tumors. Several genes have been shown to be activated in middle-T-expressing cells, but the underlying mechanisms have only been partially elucidated. Among the genes regula...

journal_title：Oncogene

authors： Besser D,Urich M,Sakaue M,Messerschmitt A,Ballmer-Hofer K,Nagamine Y

更新日期：1995-12-07 00:00:00

abstract：:The chromatin organizer SATB1 has been implicated in the development and progression of multiple cancers including breast and colorectal cancers. However, the regulation and role of SATB1 in colorectal cancers is poorly understood. Here, we demonstrate that expression of SATB1 is induced upon hyperactivation of Wnt/β-...

journal_title：Oncogene

authors： Mir R,Pradhan SJ,Patil P,Mulherkar R,Galande S

更新日期：2016-03-31 00:00:00

abstract：:Polyoma virus (Py) causes neoplastic transformation in vitro and multiple tumors in vivo. The role played by large and middle T antigens (LT, MT) and their mechanisms of action are focused here. Py-transformed Balb-3T3 cells become independent of platelet-derived growth factor (PDGF) for growth. JE, c-fos, c-jun and c...

journal_title：Oncogene

authors： Rameh LE,Armelin MC

更新日期：1991-06-01 00:00:00