Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer.

abstract：:To investigate the mechanisms of colorectal carcinogenesis, we searched for genes regulated by adenomatous polyposis coli gene product (APC) and identified a novel gene, termed HELAD1 (helicase, APC down-regulated 1). A recombinant polypeptide representing the ATPases associated with cellular activities (AAA) domain o...

journal_title：Oncogene

authors： Ishiguro H,Shimokawa T,Tsunoda T,Tanaka T,Fujii Y,Nakamura Y,Furukawa Y

更新日期：2002-09-12 00:00:00

abstract：:Cytokines can influence the interactions between members of the integrin cell adhesion receptor family and the extracellular matrix thereby potentially affecting cell function and promoting cell adhesion, growth and migration of malignant astrocytoma tumor cells. As malignant astrocytoma cells synthesize TGF-beta1 in ...

journal_title：Oncogene

authors： Han X,Stewart JE Jr,Bellis SL,Benveniste EN,Ding Q,Tachibana K,Grammer JR,Gladson CL

更新日期：2001-11-29 00:00:00

abstract：:The KLF6 gene encodes the Krüppel-like factor 6, a transcription factor that has been individualized as a tumor-suppressor gene involved in the regulation of cell proliferation and differentiation. Recently, high frequency (42%) of KLF6 mutations have been reported in colorectal cancers (CRC) as in prostate cancers, a...

journal_title：Oncogene

authors： Lièvre A,Landi B,Côté JF,Veyrie N,Zucman-Rossi J,Berger A,Laurent-Puig P

更新日期：2005-11-03 00:00:00

abstract：:G2A is a heptahelical cell surface protein that has recently been described as a potential tumor suppressor, based on its ability to counteract transformation of pre-B cells and fibroblasts by Bcr-Abl, an oncogenic tyrosine kinase. We have isolated cDNAs encoding G2A in the course of screening libraries for clones tha...

journal_title：Oncogene

authors： Zohn IE,Klinger M,Karp X,Kirk H,Symons M,Chrzanowska-Wodnicka M,Der CJ,Kay RJ

更新日期：2000-08-10 00:00:00

abstract：:The RASSF8 gene, which maps close to the KRAS2 gene, contains a RAS-associated domain and encodes a protein that is evolutionarily conserved from fish to humans. Analysis of the RASSF8 transcript revealed a complex expression pattern of 5'-UTR mRNA isoforms in normal lung and in lung adenocarcinomas (ADCAs), with no a...

journal_title：Oncogene

authors： Falvella FS,Manenti G,Spinola M,Pignatiello C,Conti B,Pastorino U,Dragani TA

更新日期：2006-06-29 00:00:00

abstract：:The c-erbB-2 proto-oncogene encodes a receptor tyrosine kinase (RTK) closely related to the epidermal growth factor receptor (EGFR). Overexpression of erbB-2 occurs in approximately 20% of human breast tumours, where increased expression correlates with poor patient prognosis. The EGFR is coupled to the Ras signalling...

journal_title：Oncogene

authors： Janes PW,Daly RJ,deFazio A,Sutherland RL

更新日期：1994-12-01 00:00:00

abstract：:As a result of the synovial sarcoma-associated t(X;18) translocation, the SS18 gene on chromosome 18 is fused to either one of the three closely related SSX genes on the X chromosome. The SS18 protein is thought to act as a transcriptional co-activator, whereas the SSX proteins are thought to act as transcriptional co...

journal_title：Oncogene

authors： de Bruijn DR,van Dijk AH,Willemse MP,van Kessel AG

更新日期：2008-01-24 00:00:00

abstract：:Cytokinesis is the final step of cell division. Increasing evidence suggests failure of cytokinesis might contribute to the development of cancer. Here, we demonstrate that the serologically defined colon cancer antigen-3 (SDCCAG3) forms a complex with PTPN13, a protein tyrosine phosphatase known to be involved in the...

journal_title：Oncogene

authors： Hagemann N,Ackermann N,Christmann J,Brier S,Yu F,Erdmann KS

更新日期：2013-09-26 00:00:00

abstract：:Hexokinase-II (HK2) is a key enzyme involved in glycolysis, which is required for breast cancer progression. However, the underlying post-translational mechanisms of HK2 activity are poorly understood. Here, we showed that Proviral Insertion in Murine Lymphomas 2 (PIM2) directly bound to HK2 and phosphorylated HK2 on ...

journal_title：Oncogene

authors： Yang T,Ren C,Qiao P,Han X,Wang L,Lv S,Sun Y,Liu Z,Du Y,Yu Z

更新日期：2018-11-01 00:00:00

abstract：:RRR-alpha-tocopheryl succinate (alpha-vitamin E succinate, VES), one of the vitamin E derivatives, can effectively inhibit the proliferation of human prostate cancer cells. However, little is known about its effect on prostate cancer cell invasive ability. Tumor metastasis is a complex process and the extracellular ma...

journal_title：Oncogene

authors： Zhang M,Altuwaijri S,Yeh S

更新日期：2004-04-15 00:00:00

abstract：:Replacement of leucine 301 in the human colony stimulating factor 1 receptor (CSF-1R) by serine, threonine, glutamic acid, or proline induced ligand-independent transforming activity in mouse NIH3T3 cells, whereas substitution by phenylalanine, methionine, cysteine, or lysine did not. Serine, glutamic acid, and prolin...

journal_title：Oncogene

authors： Roussel MF,Downing JR,Sherr CJ

更新日期：1990-01-01 00:00:00

abstract：:REF cells transformed by oncogenes E1A and cHa-ras reveal high and constitutive DNA-binding activity of AP-1 factor lacking in c-Fos protein. Consistently, the transcription of c-fos gene has been found to be downregulated. To elucidate the mechanisms of c-fos downregulation in E1A+cHa-ras transformants, we studied th...

journal_title：Oncogene

authors： Kukushkin AN,Abramova MV,Svetlikova SB,Darieva ZA,Pospelova TV,Pospelov VA

更新日期：2002-01-24 00:00:00

abstract：:SHP-2 protein tyrosine phosphatase plays an important role in activation of the RAS-dependent signaling. Gain-of-function mutations in the PTPN11 gene, which encodes SHP-2, have been found in the leukemia-prone developmental disorder Noonan syndrome as well as sporadic childhood leukemias, indicating that SHP-2 is a b...

journal_title：Oncogene

authors： Miyamoto D,Miyamoto M,Takahashi A,Yomogita Y,Higashi H,Kondo S,Hatakeyama M

更新日期：2008-06-05 00:00:00

abstract：:We reconstituted a three-dimensional gastric carcinoma model similar to invasive gastric carcinoma tissue. This model consists of a human gastric carcinoma cell line, GCTM-1, a human fibroblast cell line, TIG-1-20, and transforming growth factor-beta (TGF-beta)-containing type I collagen gel. Using this model, we were...

journal_title：Oncogene

authors： Kuga H,Morisaki T,Nakamura K,Onishi H,Noshiro H,Uchiyama A,Tanaka M,Katano M

更新日期：2003-10-30 00:00:00

abstract：:The microtubule-targeting antineoplastic agent, paclitaxel, is highly efficacious against a wide spectrum of human cancers. However, dose-limiting toxicity and development of drug resistance limit its clinical application. Development of novel strategies that overcome chemoresistance and sensitize cancer cells to pacl...

journal_title：Oncogene

authors： Sreekanth CN,Bava SV,Sreekumar E,Anto RJ

更新日期：2011-07-14 00:00:00

abstract：:Oxygen is the ultimate source of oxidizing power for disulfide bond formation, suggesting that under limiting oxygen proper protein folding might be compromised. We show that secretion of vascular endothelial growth factor (VEGF), a protein with multiple disulfide bonds, was indeed impeded under hypoxia and was partia...

journal_title：Oncogene

authors： May D,Itin A,Gal O,Kalinski H,Feinstein E,Keshet E

更新日期：2005-02-03 00:00:00

abstract：:Activating mutations of K-ras are frequent in colon tumors and aberrant crypt foci, and may play important roles in colon carcinogenesis. Here, we investigated the effects of a K-ras codon 12 mutation on inducible nitric oxide synthase (iNOS) expression. When rat intestinal epithelial cells (IEC-6) were transfected wi...

journal_title：Oncogene

authors： Takahashi M,Mutoh M,Shoji Y,Kamanaka Y,Naka M,Maruyama T,Sugimura T,Wakabayashi K

更新日期：2003-10-23 00:00:00

abstract：:Complementary DNA (cDNA) encoding a novel member of the receptor tyrosine kinase (RTK) family has been isolated from colon carcinoma tissue. Colon carcinoma kinase 4 (CCK-4) mRNA is highly expressed in human lung tissue and at lower levels in the thyroid gland and ovary. While no mRNA was found in human adult colon ti...

journal_title：Oncogene

authors： Mossie K,Jallal B,Alves F,Sures I,Plowman GD,Ullrich A

更新日期：1995-11-16 00:00:00

abstract：:Two thirds of breast cancers express estrogen receptors (ER). ER alpha (ERα) mediates breast cancer cell proliferation, and expression of ERα is the standard choice to indicate adjuvant endocrine therapy. ERbeta (ERβ) inhibits growth in vitro; its effects in vivo have been incompletely investigated and its role in bre...

journal_title：Oncogene

authors： Cotrim CZ,Fabris V,Doria ML,Lindberg K,Gustafsson JÅ,Amado F,Lanari C,Helguero LA

更新日期：2013-05-09 00:00:00

abstract：:Dual specificity kinases that phosphorylate the Thr- and Tyr-residues within the TXY motif of MAP-kinases of play a central role in the regulation of various processes of cell growth. These dual specificity kinases also known as MAP kinase kinases are constituents of the sequential kinase signaling modules. Seven dist...

journal_title：Oncogene

authors： Dhanasekaran N,Premkumar Reddy E

更新日期：1998-09-17 00:00:00

abstract：:Alterations affecting the epidermal growth factor (EGF)/transforming growth factor alpha (TGF alpha)-responsive mitogenic pathway are frequently detected in malignancies. In particular, the EGF-receptor (EGFR) molecule has been found overexpressed in a number of human tumors, and TGF alpha is produced by a large array...

journal_title：Oncogene

authors： Di Marco E,Pierce JH,Fleming TP,Kraus MH,Molloy CJ,Aaronson SA,Di Fiore PP

更新日期：1989-07-01 00:00:00

abstract：:The role of cbl-b in signaling by the epidermal growth factor receptor (EGFR) was studied and compared with c-cbl. We demonstrate in vivo, that cbl-b, like c-cbl, is phosphorylated and recruited to the EGFR upon EGF stimulation and both cbl proteins can bind to the Grb2 adaptor protein. To investigate the functional r...

journal_title：Oncogene

authors： Ettenberg SA,Keane MM,Nau MM,Frankel M,Wang LM,Pierce JH,Lipkowitz S

更新日期：1999-03-11 00:00:00

abstract：:An essential mode of acquired resistance to radiotherapy (RT) appears to be promotion of tumor cell motility and invasiveness in various cancer types, including glioblastoma, a process resembling 'evasive resistance'. Hence, a logical advancement of RT would be to identify suitable complementary treatment strategies, ...

journal_title：Oncogene

authors： Weiler M,Pfenning PN,Thiepold AL,Blaes J,Jestaedt L,Gronych J,Dittmann LM,Berger B,Jugold M,Kosch M,Combs SE,von Deimling A,Weller M,Bendszus M,Platten M,Wick W

更新日期：2013-02-28 00:00:00

abstract：:Fallopian tube carcinoma (FTC) is a rare, poorly studied and aggressive cancer, associated with poor survival. Since tumorigenesis is related to the acquisition of genetic changes, we used genome-wide array comparative genomic hybridization to analyse copy number aberrations occurring in FTC in order to obtain a bette...

journal_title：Oncogene

authors： Snijders AM,Nowee ME,Fridlyand J,Piek JM,Dorsman JC,Jain AN,Pinkel D,van Diest PJ,Verheijen RH,Albertson DG

更新日期：2003-07-03 00:00:00

abstract：:The DNA-binding, transcriptional activation and transforming activities of the Myc protein require dimerization with Max. Max can form also homodimers which are able to bind the same DNA sequence as Myc/Max heterodimers and suppress Myc-induced transcription and transformation. We have recently identified a naturally ...

journal_title：Oncogene

authors： Västrik I,Mäkelä TP,Koskinen PJ,Alitalo K

更新日期：1995-08-03 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are strongly immunosuppressive via producing nitric oxide (NO) and known to migrate into tumor sites to promote tumor growth, but the underlying mechanisms remain largely elusive. Here, we found that interferon alpha (IFNα)-secreting MSCs showed more dramatic inhibition effect on tumor...

journal_title：Oncogene

authors： Shou P,Chen Q,Jiang J,Xu C,Zhang J,Zheng C,Jiang M,Velletri T,Cao W,Huang Y,Yang Q,Han X,Zhang L,Wei L,Rabson AB,Chin YE,Wang Y,Shi Y

更新日期：2016-11-17 00:00:00

abstract：:Terminal differentiation of skeletal myoblasts is accompanied by down-regulation of vimentin and beta-, gamma-actins and up-regulation of desmin and sarcomeric alpha-actin(s). To investigate whether the normal decline in expression of vimentin and beta-, gamma-actins was coupled to withdrawal of proliferating myoblast...

journal_title：Oncogene

authors： Olson EN,Capetanaki YG

更新日期：1989-07-01 00:00:00

abstract：:Local intravitreal or intra-arterial chemotherapy has improved therapeutic success for the pediatric cancer retinoblastoma (RB), but toxicity remains a major caveat. RB initiates primarily with RB1 loss or, rarely, MYCN amplification, but the critical downstream networks are incompletely understood. We set out to unco...

journal_title：Oncogene

authors： Aubry A,Pearson JD,Huang K,Livne-Bar I,Ahmad M,Jagadeesan M,Khetan V,Ketela T,Brown KR,Yu T,Lu S,Wrana JL,Moffat J,Bremner R

更新日期：2020-07-01 00:00:00

abstract：:Nuclear-enriched RNA-binding proteins (RBPs) are mainly involved in transcriptional regulation, which is a critical checkpoint to tune gene diversity and expression levels. We analyzed nuclear RBPs in human HCC tissues and matched normal control tissues. Based on the gene expression levels, PTBP3 was identified as top...

journal_title：Oncogene

authors： Yang X,Qu S,Wang L,Zhang H,Yang Z,Wang J,Dai B,Tao K,Shang R,Liu Z,Li X,Zhang Z,Xia C,Ma B,Liu W,Li H,Dou K

更新日期：2018-12-01 00:00:00

abstract：:Proteolytic cleavage of the extracellular domain of CD44 from the surface of cells has been observed recently in different cell types. In cell culture supernatants of human melanoma cell lines a 70 kDa soluble CD44 protein (solCD44) was detected at concentrations of 250-300 ng/ml. Protease inhibitor studies revealed t...

journal_title：Oncogene

authors： Ahrens T,Sleeman JP,Schempp CM,Howells N,Hofmann M,Ponta H,Herrlich P,Simon JC

更新日期：2001-06-07 00:00:00