Abstract:
:AMID, also called PRG3, is an AIF-homologous and mitochondria-associated protein that has been implicated in caspase-independent apoptosis. In this report, we demonstrated that human AMID gene promoter was activated by p53 in reporter gene assays. Chromatin immunoprecipitation experiments indicated that p53 could bind to human AMID promoter. Deletion mutagenesis indicated that human AMID promoter contains two p53-responsive elements. Furthermore, expression array analysis indicated that human AMID mRNA expression was downregulated in a majority of human tumors. Our findings point to the possibility that AMID is a p53-downstream gene involved in tumorigenesis.
journal_name
Oncogenejournal_title
Oncogeneauthors
Wu M,Xu LG,Su T,Tian Y,Zhai Z,Shu HBdoi
10.1038/sj.onc.1207909subject
Has Abstractpub_date
2004-09-02 00:00:00pages
6815-9issue
40eissn
0950-9232issn
1476-5594pii
1207909journal_volume
23pub_type
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