Structure of the human LC-PTP (HePTP) gene: similarity in genomic organization within protein-tyrosine phosphatase genes.

abstract：:For many years the precise genetic etiology of the majority of Wilms' tumors has remained unexplained. Recently, the WTX gene, mapped to chromosome Xq11.1, has been reported to be lost or mutated in approximately one-third of Wilms' tumors. Moreover, in female cases, the somatically inactivated alleles were found to i...

journal_title：Oncogene

authors： Perotti D,Gamba B,Sardella M,Spreafico F,Terenziani M,Collini P,Pession A,Nantron M,Fossati-Bellani F,Radice P

更新日期：2008-07-31 00:00:00

abstract：:Chromosome 8 loss of heterozygosity (LOH) in cancer of the urinary bladder is associated with high tumour grade and stage. We have screened 193 cases of transitional cell carcinoma (TCC) of the bladder using 30 microsatellite polymorphisms on chromosome 8. Forty three cases (22%) showed LOH on 8p, the majority of whic...

journal_title：Oncogene

authors： Takle LA,Knowles MA

更新日期：1996-03-07 00:00:00

abstract：:Adenoviruses are linear double-stranded DNA viruses that infect human and rodent cell lines, occasionally transform them and cause tumors in animal models. The host cell challenges the virus in multifaceted ways to restrain viral gene expression and DNA replication, and sometimes even eliminates the infected cells by ...

journal_title：Oncogene

authors： Gupta A,Jha S,Engel DA,Ornelles DA,Dutta A

更新日期：2013-10-17 00:00:00

abstract：:Homology PCR has been used to identify receptor tyrosine kinases (RTKs) expressed during activation of rat hepatic stellate cells, the key fibrogenic mesenchymal element in the liver. Partial cDNAs encoding several RTKs were cloned from stellate cells activated in vivo, including those of Flt-1, Flk-1, c-met, PDGFR, a...

journal_title：Oncogene

authors： Ankoma-Sey V,Matli M,Chang KB,Lalazar A,Donner DB,Wong L,Warren RS,Friedman SL

更新日期：1998-07-09 00:00:00

abstract：:A proportion of familial breast cancer has recently been shown by genetic linkage analysis to map to chromosome l3q12 (Wooster et al, 1994). This locus contains a tumor suppressor gene BRCA2, mutations in which lead to tumorigenesis. Genetic alterations at this locus have also been shown in pancreatic adenocarcinoma a...

journal_title：Oncogene

authors： Jacob AN,Kandpal G,Kandpal RP

更新日期：1996-07-04 00:00:00

abstract：:Large cancer projects measure somatic mutations in thousands of samples, gradually assembling a catalog of recurring mutations in cancer. Many methods analyze these data jointly with auxiliary information with the aim of identifying subtype-specific results. Here, we show that somatic gene mutations alone can reliably...

journal_title：Oncogene

authors： Amar D,Izraeli S,Shamir R

更新日期：2017-06-15 00:00:00

abstract：:The signal transduction pathways, orchestrating the differentiation of hematopoietic stem and progenitor cells in response to cytokine stimulation, are strictly controlled by networks of feedback loops, highly selective protein interactions and finely tuned on/off switches. In hematological malignancies, the aberrant ...

journal_title：Oncogene

authors： Gery S,Koeffler HP

更新日期：2013-06-27 00:00:00

abstract：:To clarify the incidence, timing and pathogenetic significance of p53 gene alterations in the progression of small-cell lung carcinoma (SCLC), 17 primary tumors, 13 metastases and nine cell lines from 27 patients were analysed by a polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis. ...

journal_title：Oncogene

authors： Sameshima Y,Matsuno Y,Hirohashi S,Shimosato Y,Mizoguchi H,Sugimura T,Terada M,Yokota J

更新日期：1992-03-01 00:00:00

abstract：:The efficacy of anticancer therapy is limited by the development of drug resistance. While the role of p53 in the intrinsic sensitivity of human cancer cells to paclitaxel (PTX) remains controversial, its role in acquired paclitaxel resistance has never been addressed. In this study we examined the p53 status of three...

journal_title：Oncogene

authors： Giannakakou P,Poy G,Zhan Z,Knutsen T,Blagosklonny MV,Fojo T

更新日期：2000-06-22 00:00:00

abstract：:TP53 mutation in acute myeloid leukemia (AML) is associated with poor prognosis. Since no targeted therapy is available to restore p53 function, it is of great interest to test whether other pathways activated by TP53 mutations can be therapeutically targeted. Here, we showed HIF-1α target genes are enriched in TP53-m...

journal_title：Oncogene

authors： Wang Y,Liu Y,Bailey C,Zhang H,He M,Sun D,Zhang P,Parkin B,Baer MR,Zheng P,Malek SN,Liu Y

更新日期：2020-04-01 00:00:00

abstract：:LIM-kinase 2 (LIMK2) belongs to the LIMK family of proteins, which comprises LIMK1 and LIMK2. Both proteins regulate actin polymerization through phosphorylation and inactivation of the actin depolymerizing factor cofilin. In this study, we show that the level of LIMK2 protein is increased in neuroblastoma, BE(2)-C ce...

journal_title：Oncogene

authors： Po'uha ST,Shum MS,Goebel A,Bernard O,Kavallaris M

更新日期：2010-01-28 00:00:00

abstract：:Caspases are a family of cysteine proteases expressed as inactive zymogens in virtually all animal cells. These enzymes play a central role in most cell death pathways leading to apoptosis but growing evidences implicate caspases also in nonapoptotic functions. Several of these enzymes, activated in molecular platform...

journal_title：Oncogene

authors： Launay S,Hermine O,Fontenay M,Kroemer G,Solary E,Garrido C

更新日期：2005-08-04 00:00:00

abstract：:Functional alterations or loss of tumor-suppressor genes are an important feature of neoplastic progression in humans. The employment of suitable animal model systems would greatly facilitate the detection and manipulation of such genes. We describe here an experimental approach to this problem based on the analysis o...

journal_title：Oncogene

authors： Burns PA,Kemp CJ,Gannon JV,Lane DP,Bremner R,Balmain A

更新日期：1991-12-01 00:00:00

abstract：:The integrin linked kinase (ILK) is a cytoplasmic effector of integrin receptors, involved in the regulation of integrin binding properties as well as the activation of cell survival and proliferative pathways, including those involving MAP kinase, PKB/Akt and GSK-3beta. Overexpression of ILK in cultured intestinal an...

journal_title：Oncogene

authors： White DE,Cardiff RD,Dedhar S,Muller WJ

更新日期：2001-10-25 00:00:00

abstract：:Matrilysin (MMP-7) is thought to contribute to invasive growth and metastasis of colon carcinoma and many other human cancers. The present study demonstrates that treatment of human colon carcinoma cells with active matrilysin induces cell aggregation in vitro and promotes liver metastasis in nude mice. When two kinds...

journal_title：Oncogene

authors： Kioi M,Yamamoto K,Higashi S,Koshikawa N,Fujita K,Miyazaki K

更新日期：2003-11-27 00:00:00

abstract：:Vascular endothelial (VE)-cadherin is exclusively expressed at interendothelial junctions of normal and tumour vessels. In this report, we characterized the transcriptional activity of the human VE-cadherin promoter. Transient transfection assays revealed that sequences at positions --1135/-744 and -166/-5 base pairs ...

journal_title：Oncogene

authors： Prandini MH,Dreher I,Bouillot S,Benkerri S,Moll T,Huber P

更新日期：2005-04-21 00:00:00

abstract：:In a large proportion of familial and sporadic cases of Hirschsprung disease (HSCR) mutations in the RET (rearranged during transfection) protooncogene have been described. We have investigated the structure of the RET gene promoter and have analysed a region of approximately 1000 nucleotides in its promoter and 5'-up...

journal_title：Oncogene

authors： Munnes M,Patrone G,Schmitz B,Romeo G,Doerfler W

更新日期：1998-11-19 00:00:00

abstract：:REF cells transformed by oncogenes E1A and cHa-ras reveal high and constitutive DNA-binding activity of AP-1 factor lacking in c-Fos protein. Consistently, the transcription of c-fos gene has been found to be downregulated. To elucidate the mechanisms of c-fos downregulation in E1A+cHa-ras transformants, we studied th...

journal_title：Oncogene

authors： Kukushkin AN,Abramova MV,Svetlikova SB,Darieva ZA,Pospelova TV,Pospelov VA

更新日期：2002-01-24 00:00:00

abstract：:The naevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by multiple developmental defects and cancer susceptibility, in particular to basal cell carcinomas (BCCs). Medulloblastomas, primitive neuroectodermal tumours (PNETs) arising in childhood, occur in about 3-5% of NBCCS pa...

journal_title：Oncogene

authors： Vorechovský I,Tingby O,Hartman M,Strömberg B,Nister M,Collins VP,Toftgård R

更新日期：1997-07-17 00:00:00

abstract：:Inherited mutations in the BRCA1 gene confer increased susceptibility to breast and ovarian cancer. Its role in sporadic carcinogenesis is not well defined. Somatic mutations in breast cancers have not been reported and to date there are only three reports of somatic mutations in sporadic ovarian cancers. To investiga...

journal_title：Oncogene

authors： Khoo US,Ozcelik H,Cheung AN,Chow LW,Ngan HY,Done SJ,Liang AC,Chan VW,Au GK,Ng WF,Poon CS,Leung YF,Loong F,Ip P,Chan GS,Andrulis IL,Lu J,Ho FC

更新日期：1999-08-12 00:00:00

abstract：:Activation of the p53 tumor suppressor protein can lead to either cell cycle arrest or apoptosis. Several functional domains necessary for mediating cell cycle arrest and apoptosis in p53 have been mapped, e.g., the proline-rich domain. The proline-rich domain is located within residues 60-90, which comprise five PXXP...

journal_title：Oncogene

authors： Zhu J,Jiang J,Zhou W,Zhu K,Chen X

更新日期：1999-03-25 00:00:00

abstract：:Persistent activation of the Abl tyrosine kinase in the BCR-ABL fusion protein is the major cause of chronic myeloid leukemia (CML). Among many other substrates BCR-ABL phosphorylates STAT5 and Src family kinases (SFK). Activated pSTAT5 is essential for initial transformation and maintenance of the disease. Cytokine-i...

journal_title：Oncogene

authors： Chatain N,Ziegler P,Fahrenkamp D,Jost E,Moriggl R,Schmitz-Van de Leur H,Müller-Newen G

更新日期：2013-08-01 00:00:00

abstract：:The introduction of highly active antiretroviral therapy (HAART) has changed dramatically the landscape of HIV disease. Deaths from AIDS-related diseases have been reduced by 75% since protease inhibitor therapy and combination antiretroviral therapy came into use in late 1995. While KS is declining, the situation for...

journal_title：Oncogene

authors： Berretta M,Cinelli R,Martellotta F,Spina M,Vaccher E,Tirelli U

更新日期：2003-09-29 00:00:00

abstract：:We screened cdc2 kinase inhibitors from cultured mediums of micro organisms using purified mouse cyclin B-cdc2 kinase and a specific substrate peptide for cdc2 kinase. A selective inhibitor of cdc2 kinase was isolated from the cultured medium of Aspergillus species F-25799, and identified as butyrolactone I. Butyrolac...

journal_title：Oncogene

authors： Kitagawa M,Okabe T,Ogino H,Matsumoto H,Suzuki-Takahashi I,Kokubo T,Higashi H,Saitoh S,Taya Y,Yasuda H

更新日期：1993-09-01 00:00:00

abstract：:CCAAT/enhancer-binding protein-δ (C/EBP-δ), a transcription factor, is elevated in carcinoma compared with that in normal tissue. This study reports a novel function of C/EBP-δ in lymphangiogenesis and tumor metastasis. Genetic deletion of C/EBP-δ in mice resulted in a significant reduction of lymphangiogenesis and pu...

journal_title：Oncogene

authors： Min Y,Ghose S,Boelte K,Li J,Yang L,Lin PC

更新日期：2011-12-08 00:00:00

abstract：:Lymphoblastoid cell lines derived from cancer prone Bloom's Syndrome patients differ from cell lines representative of several other disorders by exhibiting a constitutive elevation in the level of the c-myc protein. This may be a contributing factor in the strong predisposition to malignancy observed in Bloom's syndr...

journal_title：Oncogene

authors： Sullivan NF,Willis AE,Moore JP,Lindahl T

更新日期：1989-12-01 00:00:00

abstract：:Ras genes, frequently mutated in human tumors, promote malignant transformation. Ras transformation requires membrane anchorage, which is promoted by Ras farnesylcysteine carboxymethylester and by a second signal. Previously we showed that the farnesylcysteine mimetic, farnesylthiosalicylic acid (FTS) disrupts Ras mem...

journal_title：Oncogene

authors： Paz A,Haklai R,Elad-Sfadia G,Ballan E,Kloog Y

更新日期：2001-11-08 00:00:00

abstract：:Basal cell carcinoma (BCC) is one of the most common skin neoplasms in humans and is usually characterized by local aggressiveness with little metastatic potential, although deep invasion, recurrence, and regional and distant metastases may occur. Here, we studied the mechanism of BCC invasion. We found that human BCC...

journal_title：Oncogene

authors： Chu CY,Cha ST,Chang CC,Hsiao CH,Tan CT,Lu YC,Jee SH,Kuo ML

更新日期：2007-04-12 00:00:00

abstract：:We have cloned and sequenced the nov gene (novH) which is the homolog of the chicken nov proto-oncogene overexpressed in avian nephroblastomas. The novH gene is highly conserved and encodes a putative IGF-binding protein similar to that of chicken. We report that relative to autologous normal kidney expression of novH...

journal_title：Oncogene

authors： Martinerie C,Huff V,Joubert I,Badzioch M,Saunders G,Strong L,Perbal B

更新日期：1994-09-01 00:00:00

abstract：:ID4 gene is a member of the inhibitor of DNA-binding (ID) family, which inhibits DNA binding of basic helix-loop-helix transcription factors. Certain human primary breast cancers reportedly have low or no expression of ID4 protein, but its role in carcinogenesis and cancer progression is unknown. To determine its poss...

journal_title：Oncogene

authors： Umetani N,Mori T,Koyanagi K,Shinozaki M,Kim J,Giuliano AE,Hoon DS

更新日期：2005-07-07 00:00:00