Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers.

abstract：:Although increasing evidence indicated that the deregulation of microRNAs (miRNAs) contributes to tumorigenesis and invasion, little is known about the role of miR-637 in human gliomas. In the present study, we found that the expression level of miR-637 was significantly reduced in clinical glioma tissues compared wit...

journal_title：Oncogene

authors： Que T,Song Y,Liu Z,Zheng S,Long H,Li Z,Liu Y,Wang G,Liu Y,Zhou J,Zhang X,Fang W,Qi S

更新日期：2015-09-17 00:00:00

abstract：:Binding partners of the Src homology domains of Vav-1 were characterized by a two-hybrid screening of a Jurkat cell cDNA library. One of the isolated clones encoded a new protein named VIK that belongs to the Kruppel-like zinc-finger gene family. Genome mapping showed that a single gene positioned at chromosome 7q22.1...

journal_title：Oncogene

authors： Houlard M,Romero-Portillo F,Germani A,Depaux A,Regnier-Ricard F,Gisselbrecht S,Varin-Blank N

更新日期：2005-01-06 00:00:00

abstract：:A potential role for 1-oleoyl-sn-glycero-3-phosphate or lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) in the regulation of malignant diseases has been widely considered. In this study, we found that in transformed astroglial cells, the expression profile of lysophospholipid receptor mRNA and the action...

journal_title：Oncogene

authors： Malchinkhuu E,Sato K,Horiuchi Y,Mogi C,Ohwada S,Ishiuchi S,Saito N,Kurose H,Tomura H,Okajima F

更新日期：2005-10-06 00:00:00

abstract：:There is increasing evidence that mast cells (MCs) and their mediators are involved in the remodeling of the tumor microenvironment and promote tumor growth, angiogenesis and metastasis. We have found that an increased density of MCs in thyroid cancer (TC) correlates with enhanced invasiveness. However, the MC-derived...

journal_title：Oncogene

authors： Visciano C,Liotti F,Prevete N,Cali' G,Franco R,Collina F,de Paulis A,Marone G,Santoro M,Melillo RM

更新日期：2015-10-01 00:00:00

abstract：:Clinical and experimental evidence is consistent with a key role for transforming human papilloma viruses (HPVs) in the aetiology of anogenital carcinoma. Cervical carcinoma does, however, occasionally occur in the absence of HPV sequences (Riou et al., 1990). We have used a direct cDNA/PCR sequencing protocol to anal...

journal_title：Oncogene

authors： Crook T,Wrede D,Vousden KH

更新日期：1991-05-01 00:00:00

abstract：:A recent large multi-centre study convincingly confirmed previous observations that the SYT-SSX1 fusion type, compared to SYT-SSX2, of synovial sarcoma is associated with a worse clinical outcome. Apart from the clinical impact, this fact also suggests (1) that the SYT-SSX fusion gene may influence molecular mechanism...

journal_title：Oncogene

authors： Xie Y,Skytting B,Nilsson G,Grimer RJ,Mangham CD,Fisher C,Shipley J,Bjerkehagen B,Myklebost O,Larsson O

更新日期：2002-08-22 00:00:00

abstract：:O6-methylguanine-DNA methyltransferase (MGMT) repairs the cytotoxic and mutagenic O6-alkylguanine produced by alkylating agents such as chemotherapeutic agents and mutagens. Recent studies have shown that in a subset of tumors, MGMT expression is inversely linked to hypermethylation of the CpG island in the promoter r...

journal_title：Oncogene

authors： Nakagawachi T,Soejima H,Urano T,Zhao W,Higashimoto K,Satoh Y,Matsukura S,Kudo S,Kitajima Y,Harada H,Furukawa K,Matsuzaki H,Emi M,Nakabeppu Y,Miyazaki K,Sekiguchi M,Mukai T

更新日期：2003-12-04 00:00:00

abstract：:Mantle cell lymphoma (MCL) is characterized by 11q13 chromosomal translocation and CCND1 overexpression, but additional genomic changes are also important for lymphomagenesis. To identify the genomic aberrations of MCL at higher resolutions, we analysed 29 patient samples and seven cell lines using array-based compara...

journal_title：Oncogene

authors： Tagawa H,Karnan S,Suzuki R,Matsuo K,Zhang X,Ota A,Morishima Y,Nakamura S,Seto M

更新日期：2005-02-17 00:00:00

abstract：:Tumors of low malignant potential (LMP) represent 20% of epithelial ovarian cancers (EOCs) and are associated with a better prognosis than the invasive tumors (TOV). Defining the relationship between LMPs and TOVs remains an important goal towards understanding the molecular pathways that contribute to prognosis, as w...

journal_title：Oncogene

authors： Ouellet V,Provencher DM,Maugard CM,Le Page C,Ren F,Lussier C,Novak J,Ge B,Hudson TJ,Tonin PN,Mes-Masson AM

更新日期：2005-07-07 00:00:00

abstract：:Murine double minute (MDM2) binding protein (MTBP) has been implicated in cancer progression. Here, we demonstrate one mechanism by which MTBP inhibits cancer metastasis. Overexpression of MTBP in human osteosarcoma cell lines lacking wild-type p53 did not alter primary tumor growth in mice, but significantly inhibite...

journal_title：Oncogene

authors： Agarwal N,Adhikari AS,Iyer SV,Hekmatdoost K,Welch DR,Iwakuma T

更新日期：2013-01-24 00:00:00

abstract：:Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. Here we report the identification by yeast interaction trap of a CK2 interacting protein, UBC3B, which is highly homologous to the E2 ubiquitin conjugating enzyme UBC3/CDC34. UBC3B complements the yeas...

journal_title：Oncogene

authors： Semplici F,Meggio F,Pinna LA,Oliviero S

更新日期：2002-06-06 00:00:00

abstract：:Rearrangements of the NFKB2 gene are associated with lymphoid malignancies, but the functional significance of these alterations is not known. Here we characterize structurally and functionally a rearranged NFKB2 gene identified at the T cell lymphoma line, HUT78. The rearrangement has truncated NFKB2 sequences within...

journal_title：Oncogene

authors： Zhang J,Chang CC,Lombardi L,Dalla-Favera R

更新日期：1994-07-01 00:00:00

abstract：:We describe the cytogenetic and molecular characterization of a t(1;13)(q22;q12) constitutional rearrangement occurring in a patient with a relatively benign form of neuroblastoma, called ganglioneuroblastoma. Somatic cell hybrids were generated between mouse 3T3 cells and a lymphoblastoid cell line from this patient,...

journal_title：Oncogene

authors： Michalski AJ,Cotter FE,Cowell JK

更新日期：1992-08-01 00:00:00

abstract：:Histone acetylation has a central role in establishing an active chromatin environment. The functional contribution of histone acetylation to chromatin transcription is accomplished by a dominant action of histone acetyltransferases over repressive histone-modifying activities at gene promoters; misregulation of these...

journal_title：Oncogene

authors： Heo K,Kim JS,Kim K,Kim H,Choi J,Yang K,An W

更新日期：2013-05-16 00:00:00

abstract：:Cytokinesis is the final step of cell division. Increasing evidence suggests failure of cytokinesis might contribute to the development of cancer. Here, we demonstrate that the serologically defined colon cancer antigen-3 (SDCCAG3) forms a complex with PTPN13, a protein tyrosine phosphatase known to be involved in the...

journal_title：Oncogene

authors： Hagemann N,Ackermann N,Christmann J,Brier S,Yu F,Erdmann KS

更新日期：2013-09-26 00:00:00

abstract：:Cell migration is an integral component of metastatic disease. The ability of cells to transit between mesenchymal and amoeboid modes of migration has complicated the development of successful therapies designed to target cell migration as a means of inhibiting metastasis. Therefore, investigations of the mechanisms t...

journal_title：Oncogene

authors： Lees JG,Bach CT,Bradbury P,Paul A,Gunning PW,O'Neill GM

更新日期：2011-03-10 00:00:00

abstract：:Signature abnormalities in the cell cycle and apoptotic pathway have been identified in mantle cell lymphoma (MCL), affording the opportunity to develop targeted therapies. In this study, we tested a novel class of kinase inhibitors, styryl sulfones, which differ from prior cell cycle inhibitors in that they are not r...

journal_title：Oncogene

authors： Park IW,Reddy MV,Reddy EP,Groopman JE

更新日期：2007-08-16 00:00:00

abstract：:Oncolytic adenoviruses, such as Delta-24-RGD (Δ24RGD), are replication-competent viruses that are genetically engineered to induce selective cancer cell lysis. In cancer cells, Δ24RGD induces massive autophagy, which is required for efficient cell lysis and adenoviral spread. Understanding the cellular mechanisms unde...

journal_title：Oncogene

authors： Klein SR,Piya S,Lu Z,Xia Y,Alonso MM,White EJ,Wei J,Gomez-Manzano C,Jiang H,Fueyo J

更新日期：2015-10-08 00:00:00

abstract：:Mice transgenic for the leukemia oncogene E2A-PBX1 invariably develop lethal, high-grade T-cell lymphomas by 5 months of age. In this study, retroviral insertional mutagenesis was employed to identify oncogenes that cooperate with the E2A-PBX1 transgene in lymphomagenesis. Neonatal retroviral infection substantially r...

journal_title：Oncogene

authors： Feldman BJ,Reid TR,Cleary ML

更新日期：1997-11-27 00:00:00

abstract：:In most eukaryotic cells, a link between S and M phases of the cell cycle must be assured in order to maintain the ploidy of newly divided cells. However, in some cell l/pes, e.g. the precursors of platelets megakaryocytes, extra S-phases can occur in the absence of concomitant mitoses, resulting in polyploidy. We hav...

journal_title：Oncogene

authors： García P,Calés C

更新日期：1996-08-15 00:00:00

abstract：:While studying Bim, a BH3-only proapoptotic protein, we identified an approximately 36 kDa protein, which was abundantly expressed in all five strains of primary normal human prostate (NHP) epithelial cells but significantly reduced or lost in seven prostate cancer cell lines. The approximately 36 kDa protein was subs...

journal_title：Oncogene

authors： Liu JW,Shen JJ,Tanzillo-Swarts A,Bhatia B,Maldonado CM,Person MD,Lau SS,Tang DG

更新日期：2003-03-13 00:00:00

abstract：:Early studies demonstrated that male melanoma patients have worse survival than female patients, yet the detailed mechanisms for this gender difference remain unclear. We analyzed around 100 cases of human melanoma and found that androgen receptor (AR) positive melanoma patients have worse survival outcomes compared w...

journal_title：Oncogene

authors： Wang Y,Ou Z,Sun Y,Yeh S,Wang X,Long J,Chang C

更新日期：2017-03-23 00:00:00

abstract：:BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets including heat-shock proteins and some nuclear hormone receptors. BAG-1 exists as three major isoforms, BAG-1L, BAG-1M and BAG-1S. BAG-1L contains a nuclear localization signal, which is not present in the other isoforms, and is pr...

journal_title：Oncogene

authors： Cutress RI,Townsend PA,Sharp A,Maison A,Wood L,Lee R,Brimmell M,Mullee MA,Johnson PW,Royle GT,Bateman AC,Packham G

更新日期：2003-08-07 00:00:00

abstract：:The anti-p185(her2/neu) peptidomimetic (AHNP) is a small exo-cyclic peptide derived from the anti-p185(her2/neu) rhumAb 4D5 (h4D5). AHNP mimics many but not all of the antitumor characteristics exhibited by h4D5. However, the pharmacokinetic profiles of AHNP are less than optimal for therapeutic or diagnostic purposes...

journal_title：Oncogene

authors： Masuda K,Richter M,Song X,Berezov A,Masuda K,Murali R,Greene MI,Zhang H

更新日期：2006-12-14 00:00:00

abstract：:Mutant p53 proteins were shown to exert complex DNA-interactions in vitro, like binding to MAR-DNA, but so far it is unknown whether such interactions also occur in vivo. Therefore we analysed the binding of mutant (mut) p53 (Gly245-->Ser) in Onda 11 glioma cells to cellular DNA in vivo, using p53-specific chromatin i...

journal_title：Oncogene

authors： Koga H,Deppert W

更新日期：2000-08-24 00:00:00

abstract：:The most common genetic alteration identified in transitional cell carcinoma (TCC) of the bladder is loss of heterozygosity (LOH) on chromosome 9. However, localization of tumor suppressor genes on 9q has been hampered by the low frequency of subchromosomal deletions. We have analysed 139 primary, initial low stage TC...

journal_title：Oncogene

authors： Simoneau M,Aboulkassim TO,LaRue H,Rousseau F,Fradet Y

更新日期：1999-01-07 00:00:00

abstract：:Polyamines are critical elements in mammals, but it remains unknown whether adenosyl methionine decarboxylase (AMD1), a rate-limiting enzyme in polyamine synthesis, is required for myeloid leukemia. Here, we found that leukemic stem cells (LSCs) were highly differentiated, and leukemia progression was severely impaire...

journal_title：Oncogene

authors： Sari IN,Yang YG,Wijaya YT,Jun N,Lee S,Kim KS,Bajaj J,Oehler VG,Kim SH,Choi SY,Park SH,Kim DW,Reya T,Han J,Kwon HY

更新日期：2021-01-01 00:00:00

abstract：:Prostate stem cell antigen (PSCA) is a recently defined homologue of the Thy-1/Ly-6 family of glycosylphosphatidylinositol (GPI)-anchored cell surface antigens. PSCA mRNA is expressed in the basal cells of normal prostate and in more than 80% of prostate cancers. The purpose of the present study was to examine PSCA pr...

journal_title：Oncogene

authors： Gu Z,Thomas G,Yamashiro J,Shintaku IP,Dorey F,Raitano A,Witte ON,Said JW,Loda M,Reiter RE

更新日期：2000-03-02 00:00:00

abstract：:The p160 nuclear receptor co-activators represent a family of molecules, which are recruited by steroid nuclear receptors as well as other transcription factors that are overexpressed in several tumors. We investigated the role of one member of this family on the sensitivity of cells to apoptosis. We observed that ove...

journal_title：Oncogene

authors： Colo GP,Rubio MF,Nojek IM,Werbajh SE,Echeverría PC,Alvarado CV,Nahmod VE,Galigniana MD,Costas MA

更新日期：2008-04-10 00:00:00

abstract：:Triple negative breast cancer (TNBC) refers to tumors that do not express clinically significant levels of estrogen and progesterone receptors, and lack membrane overexpression or gene amplification of ErbB-2/HER2, a receptor tyrosine kinase. Transcriptome and proteome heterogeneity of TNBC poses a major challenge to ...

journal_title：Oncogene

authors： Chervo MF,Cordo Russo RI,Petrillo E,Izzo F,De Martino M,Bellora N,Cenciarini ME,Chiauzzi VA,Santa María de la Parra L,Pereyra MG,Güttlein LN,Podhajcer OL,Daniotti JL,Dupont A,Barchuk S,Figurelli S,Lopez Della Vecchia D,

更新日期：2020-09-01 00:00:00