Abstract：
:To gain a more complete understanding of c-myc regulation in chickens, we have completed the structural characterization of the chicken c-myc gene and have begun to investigate c-myc transcription and protein expression. A comparison of c-myc structure and expression between mammals and birds presents an enigma: there are striking similarities in the pattern of gene expression in the absence of obvious sequence similarities in the controlling elements. We have begun to investigate c-myc and v-myc function using retroviral vectors that differ solely in the Myc proteins that they express. We show that while the overexpression of the smaller c-Myc protein is sufficient to induce morphological transformation in chicken embryo fibroblasts, overexpression of v-Myc provides a stronger signal for cells to enter the cell cycle and is a more potent inducer of apoptosis than c-Myc.
journal_name
Oncogenejournal_title
Oncogeneauthors
Petropoulos CJ,Givol I,Hughes SHsubject
Has Abstractpub_date
1996-06-20 00:00:00pages
2611-21issue
12eissn
0950-9232issn
1476-5594journal_volume
12pub_type
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