Abstract:
:Animal models of BCR-ABL+ leukemias have provided important new knowledge about the molecular pathophysiology of these diseases, and answered questions that are difficult or impossible to address using BCR-ABL-expressing cell lines or primary Ph+ leukemia samples from patients. The power of mouse models lies in their ability to recapitulate precisely the phenotypes of BCR-ABL+ leukemias in vivo, but this comes at the price of significant complexity. Here I review recent studies of leukemias induced in mice by BCR-ABL with an emphasis on the intricate nature of these diseases and the need for careful pathological and molecular analysis.
journal_name
Oncogenejournal_title
Oncogeneauthors
Van Etten RAdoi
10.1038/sj.onc.1206091subject
Has Abstractpub_date
2002-12-09 00:00:00pages
8643-51issue
56eissn
0950-9232issn
1476-5594pii
1206091journal_volume
21pub_type
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