Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins.

abstract：:The short isoform of single-minded 2 (SIM2s), a basic helix-loop-helix/PAS (bHLH/PAS) transcription factor, is upregulated in pancreatic and prostate tumours; however, a mechanistic role for SIM2s in these cancers is unknown. Microarray studies in prostate DU145 cells identified the pro-cell death gene, BNIP3 (Bcl-2/a...

journal_title：Oncogene

authors： Farrall AL,Whitelaw ML

更新日期：2009-10-15 00:00:00

abstract：:Stimulation of the endometrium by estrogens without the differentiating effect of progestins is the primary etiological factor associated with the development of endometrial hyperplasia and adenocarcinoma. However, the correlation between sex steroids and gap junctional intercellular communication (GJIC), which is con...

journal_title：Oncogene

authors： Saito T,Tanaka R,Wataba K,Kudo R,Yamasaki H

更新日期：2004-02-05 00:00:00

abstract：:Transcriptional silencing of antitumor genes via CpG island methylation could be a mechanism mediating prostate cancer (PCa) progression from an androgen-sensitive (AS) to an androgen-insensitive (AI) state. We have used the methylation-sensitive restriction fingerprinting (MSRF) technique to identify novel CpG-rich s...

journal_title：Oncogene

authors： Wu M,Ho SM

更新日期：2004-01-08 00:00:00

abstract：:Many of the current antitumor therapeutic strategies are based on the perturbation of the cell cycle, especially during mitosis. Antimitotic drugs trigger mitotic checkpoint activation, mitotic arrest and eventually cell death. However, mitotic slippage represents a major mechanism of resistance to these treatments. I...

journal_title：Oncogene

authors： Sánchez-Pérez T,Medema RH,López-Rivas A

更新日期：2015-01-29 00:00:00

abstract：:In the course of screening for inhibitors of tumorigenic phenotype of K-ras-transformed NIH3T3 cells (DT cells), we found a novel compound, oxamflatin, an aromatic sulfonamide hydroxamate derivative, which induces flat phenotype in these cells and suppresses their anchorage-independent growth. In contrast to DT cells,...

journal_title：Oncogene

authors： Sonoda H,Nishida K,Yoshioka T,Ohtani M,Sugita K

更新日期：1996-07-04 00:00:00

abstract：:An elevated proteasome activity contributes to tumorigenesis, particularly by providing cancer cells with antiapoptotic protection and efficient clearance from irregular proteins. Still, the underlying mechanisms are poorly known. In this study, we report that in colon cancer patients, higher proteasome activity was d...

journal_title：Oncogene

authors： Arlt A,Bauer I,Schafmayer C,Tepel J,Müerköster SS,Brosch M,Röder C,Kalthoff H,Hampe J,Moyer MP,Fölsch UR,Schäfer H

更新日期：2009-11-12 00:00:00

abstract：:Leukemic lymphoblasts within different immunophenotypic populations possess stem cell properties. However, whether or not the self-renewal program is retained from stem cells or conferred on progenitors by leukemogenic molecules remains unknown. We have addressed the issue in the context of TEL-AML1-associated acute l...

journal_title：Oncogene

authors： Fan D,Zhou X,Li Z,Li ZQ,Duan C,Liu T,Zhang F,Huang Y,Zhang Y,Gao F,Guo Y,Gupta R,Chen G,Enver T,Tang J,Hong D

更新日期：2015-04-16 00:00:00

abstract：:Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine with the capability to act as tumour suppressor or tumour promoter depending on the cellular context. TGF-beta receptor type-2 (TGFBR2) is the ligand-binding receptor for all members of the TGF-β family. Data from mouse model experiments demonstrated th...

journal_title：Oncogene

authors： Busch S,Acar A,Magnusson Y,Gregersson P,Rydén L,Landberg G

更新日期：2015-01-02 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is associated with an increased risk for lung cancer and an aberrant microbiota of the lung. Microbial colonization contributes to chronic neutrophilic inflammation in COPD. Nontypeable Haemophilus influenzae (NTHi) is frequently found in lungs of stable COPD patients and i...

journal_title：Oncogene

authors： Jungnickel C,Schmidt LH,Bittigkoffer L,Wolf L,Wolf A,Ritzmann F,Kamyschnikow A,Herr C,Menger MD,Spieker T,Wiewrodt R,Bals R,Beisswenger C

更新日期：2017-07-20 00:00:00

abstract：:A lot of effort has been done to study how cancer cells react to low-oxygen tension, a condition known as hypoxia. Indeed, abnormal and dysfunctional blood vessels in the tumor are incapable to restore oxygenation, therefore perpetuating hypoxia, which, in turn, will fuel tumor progression, metastasis and resistance t...

journal_title：Oncogene

authors： Casazza A,Di Conza G,Wenes M,Finisguerra V,Deschoemaeker S,Mazzone M

更新日期：2014-04-03 00:00:00

abstract：:Tumor metastasis, but not primary overgrowth, is the leading cause of mortality for cancer patients. During the past decade, Drosophila melanogaster has been well-accepted as an excellent model to address the intrinsic mechanism of different aspects of cancer progression, ranging from tumor initiation to metastasis. I...

journal_title：Oncogene

authors： Ma X,Huang J,Tian Y,Chen Y,Yang Y,Zhang X,Zhang F,Xue L

更新日期：2017-06-01 00:00:00

abstract：:RAS is a small GTP binding protein mutated in approximately 30% human cancer. Despite its important role in the initiation and progression of human cancer, the underlying mechanism of RAS-induced human epithelial transformation remains elusive. In this study, we probe the cellular and molecular mechanisms of RAS-media...

journal_title：Oncogene

authors： Young T,Mei F,Liu J,Bast RC Jr,Kurosky A,Cheng X

更新日期：2005-09-08 00:00:00

abstract：:In the presence of ERbeta, trans-hydroxytamoxifen (TOT) protects cells against 17beta-estradiol (E(2))-induced oxidative DNA damage (ODD) and this correlates with increased expression of the antioxidative enzyme quinone reductase (QR). Here, we investigate the molecular mechanism responsible for ERbeta-mediated protec...

journal_title：Oncogene

authors： Sripathy SP,Chaplin LJ,Gaikwad NW,Rogan EG,Montano MM

更新日期：2008-10-23 00:00:00

abstract：:RING-finger proteins play crucial roles in ubiquitination events involved in diverse cellular processes including signal transduction, differentiation and apoptosis. Most of the RING-finger proteins have E3-ubiquitin ligase activity. RNF11 is a small RING-finger protein and harbors a RING-H2 domain and a PY motif that...

journal_title：Oncogene

authors： Li H,Seth A

更新日期：2004-03-11 00:00:00

abstract：:High Mobility Group AT-hook 2 (HMGA2) is a chromatin modifier and its overexpression has been found in patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Level of Hmga2 expression is fine-tuned by Lin28b-Let-7 axis and Polycomb Repressive Complex 2, in which deletion of Ezh2 leads to activa...

journal_title：Oncogene

authors： Bai J,Yokomizo-Nakano T,Kubota S,Sun Y,Kanai A,Iimori M,Harada H,Iwama A,Sashida G

更新日期：2021-01-15 00:00:00

abstract：:Cytokine receptors have different signaling requirements which ultimately lead to various physiological responses. In an effort to precisely characterize the molecular determinants involved in the proliferative response mediated by cytokines, we examine dose-dependent proliferation of the betac (GM-CSF, IL-3, IL-5) an...

journal_title：Oncogene

authors： Piu F,Magnani M,Ader ME

更新日期：2002-05-16 00:00:00

abstract：:Formation of meningiomas has been associated with the loss of genetic material on chromosome 22. To approach the additional chromosomal events that underlie progression of these tumors to malignancy, we have examined several other chromosomal regions for loss of heterozygosity (LOH) in these tumors. Fifty-eight tumors...

journal_title：Oncogene

authors： Menon AG,Rutter JL,von Sattel JP,Synder H,Murdoch C,Blumenfeld A,Martuza RL,von Deimling A,Gusella JF,Houseal TW

更新日期：1997-02-06 00:00:00

abstract：:Emerging evidence has shown that cancer stem cells (CSCs) are the cellular determinants to promote cancer invasion and metastasis. However, the mechanism underlying CSC invasion remains unknown. MicroRNAs are evolutionally conserved small noncoding RNAs that are critical for the regulation of gene expression, and thei...

journal_title：Oncogene

authors： Wang Z,Wang B,Shi Y,Xu C,Xiao HL,Ma LN,Xu SL,Yang L,Wang QL,Dang WQ,Cui W,Yu SC,Ping YF,Cui YH,Kung HF,Qian C,Zhang X,Bian XW

更新日期：2015-03-12 00:00:00

abstract：:Recent studies suggest that the action of platelet-activating factor (PAF), a potent phospholipid modulator of allergic and inflammatory reactions, is diverse and functions as a modulator of a variety of physiological and pathological events in many cell types and tissues. Its role (if any) in modulating the prolifera...

journal_title：Oncogene

authors： Wang H,Chakrabarty S

更新日期：2003-04-10 00:00:00

abstract：:The ataxia-telangiectasia-mutated (ATM) kinase is a key transducer of DNA damage signals within the genome maintenance machinery and a tumour suppressor whose germline mutations predispose to familial breast cancer. ATM signalling is constitutively activated in early stages of diverse types of human malignancies and c...

journal_title：Oncogene

authors： Tommiska J,Bartkova J,Heinonen M,Hautala L,Kilpivaara O,Eerola H,Aittomäki K,Hofstetter B,Lukas J,von Smitten K,Blomqvist C,Ristimäki A,Heikkilä P,Bartek J,Nevanlinna H

更新日期：2008-04-10 00:00:00

abstract：:Deleted in breast cancer-1 (DBC-1) was initially cloned from a homozygously deleted region in breast and other cancers on human chromosome 8p21, although no function is known for the protein product it encodes. We identified the generation of amino-terminally truncated versions of DBC-1 during tumor necrosis factor (T...

journal_title：Oncogene

authors： Sundararajan R,Chen G,Mukherjee C,White E

更新日期：2005-07-21 00:00:00

abstract：:Acute myeloid leukemia (AML) is a heterogeneous disease comprising a large number of subtypes defined by specific chromosome abnormalities. One such subtype carries the t(6;9)(p22;q34) chromosome rearrangement, which leads to expression of the DEK-NUP214 chimeric gene, and has a particularly poor outcome. To provide a...

journal_title：Oncogene

authors： Qin H,Malek S,Cowell JK,Ren M

更新日期：2016-10-27 00:00:00

abstract：:Genetic mutations of oncogenes often underlie deranged cell growth and altered differentiation pathways leading to malignant transformation of B-lymphocytes. However, addiction to oncogenes is not the only drive to lymphoid tumor pathogenesis. Dependence on non-oncogenes, which act by propelling basic mechanisms of ce...

journal_title：Oncogene

authors： Mandato E,Manni S,Zaffino F,Semenzato G,Piazza F

更新日期：2016-11-24 00:00:00

abstract：:Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. Here we report the identification by yeast interaction trap of a CK2 interacting protein, UBC3B, which is highly homologous to the E2 ubiquitin conjugating enzyme UBC3/CDC34. UBC3B complements the yeas...

journal_title：Oncogene

authors： Semplici F,Meggio F,Pinna LA,Oliviero S

更新日期：2002-06-06 00:00:00

abstract：:Millions of somatic mutations have recently been discovered in cancer genomes. These mutations in cancer genomes occur due to internal and external mutagenesis forces. Decoding the mutational processes by examining their unique patterns has successfully revealed many known and novel signatures from whole exome data, b...

journal_title：Oncogene

authors： Pei G,Hu R,Dai Y,Zhao Z,Jia P

更新日期：2020-07-01 00:00:00

abstract：:EBP1 was identified as a protein that interacts with the ErbB-3 receptor and possibly contributes to transducing growth regulatory signals. The existence of EBP1 homologs across species from simple eukaryotes to humans and its wide tissue expression pattern suggest that EBP1 acts as a general signaling molecule. We pr...

journal_title：Oncogene

authors： Squatrito M,Mancino M,Donzelli M,Areces LB,Draetta GF

更新日期：2004-05-27 00:00:00

abstract：:Functional alterations or loss of tumor-suppressor genes are an important feature of neoplastic progression in humans. The employment of suitable animal model systems would greatly facilitate the detection and manipulation of such genes. We describe here an experimental approach to this problem based on the analysis o...

journal_title：Oncogene

authors： Burns PA,Kemp CJ,Gannon JV,Lane DP,Bremner R,Balmain A

更新日期：1991-12-01 00:00:00

abstract：:Birt-Hogg-Dubé syndrome (BHD) is a rare, inherited genodermatosis characterized by hair follicle hamartomas, kidney tumors and spontaneous pneumothorax. The BHD locus was mapped to chromosome 17p11.2 by linkage analysis, and germline mutations in a novel gene (BHD) were identified in a panel of BHD families. Using RNA...

journal_title：Oncogene

authors： Singh SR,Zhen W,Zheng Z,Wang H,Oh SW,Liu W,Zbar B,Schmidt LS,Hou SX

更新日期：2006-09-28 00:00:00

abstract：:The most frequent targets of genetic alterations in human lymphoid leukemias are transcription factor genes with essential functions in blood cell development. TAL1, LYL1, HOX11 and other transcription factors essential for normal hematopoiesis are often misexpressed in the thymus in T-cell acute lymphoblastic leukemi...

journal_title：Oncogene

authors： O'Neil J,Look AT

更新日期：2007-10-15 00:00:00

abstract：:Mel-18 has been implicated in several processes in tumor progression, in which the Akt pathway is involved as an important key molecular event. However, the function of Mel-18 in human cancers has not been fully established yet. Here, we examined the effect of Mel-18 on tumor angiogenesis in human breast cancer, and f...

journal_title：Oncogene

authors： Park JH,Lee JY,Shin DH,Jang KS,Kim HJ,Kong G

更新日期：2011-11-10 00:00:00