Oxamflatin: a novel compound which reverses malignant phenotype to normal one via induction of JunD.

abstract：:Recent studies suggest that the action of platelet-activating factor (PAF), a potent phospholipid modulator of allergic and inflammatory reactions, is diverse and functions as a modulator of a variety of physiological and pathological events in many cell types and tissues. Its role (if any) in modulating the prolifera...

journal_title：Oncogene

authors： Wang H,Chakrabarty S

更新日期：2003-04-10 00:00:00

abstract：:Breast cancer is genetically and clinically heterogeneous. Triple negative breast cancer (TNBC) is a subtype of breast cancer that is usually associated with poor outcome and lack of benefit from targeted therapy. We used microarray analysis to perform a pathway analysis of TNBC compared with non-triple negative breas...

journal_title：Oncogene

authors： Yang L,Wu X,Wang Y,Zhang K,Wu J,Yuan YC,Deng X,Chen L,Kim CC,Lau S,Somlo G,Yen Y

更新日期：2011-10-27 00:00:00

abstract：:The Kelch-like ECH-associated protein 1 (KEAP1)-nuclear factor E2-related factor 2 (NRF2)pathway has a central role in cellular antioxidant defense. NRF2 activation due to KEAP1 or NRF2 mutations occurs frequently in many cancers, suggesting that NRF2 inhibition could be a promising therapeutic strategy. However, no p...

journal_title：Oncogene

authors： Choi EJ,Jung BJ,Lee SH,Yoo HS,Shin EA,Ko HJ,Chang S,Kim SY,Jeon SM

更新日期：2017-09-14 00:00:00

abstract：:The activities of E2F transcription factors are inhibited by interactions with members of the retinoblastoma (RB) tumor suppressor family, p105RB, p107 and p130. In cycling cells p107 and p130 also interact with heterodimers comprised of Cdk2 and either A or E cyclins. We characterized E2F complexes present in C2C12 a...

journal_title：Oncogene

authors： Corbeil HB,Whyte P,Branton PE

更新日期：1995-09-07 00:00:00

abstract：:Evidence accumulated over the past two decades has indicated that exposure of cell populations to ionizing radiation results in significant biological effects occurring in both the irradiated and nonirradiated cells in the population. This phenomenon, termed the 'bystander response', has been shown to occur both in vi...

journal_title：Oncogene

authors： Azzam EI,de Toledo SM,Little JB

更新日期：2003-10-13 00:00:00

abstract：:Rad23 proteins function in both DNA repair and protein stability regulation. As ubiquitinated forms of p53 are stabilized after DNA damage in concert with p53 functional activation, and human Rad23 proteins (hHR23A and B) regulate p53 stability in unstressed cells, the role of hHR23B in post-genotoxin regulation of p5...

journal_title：Oncogene

authors： Kaur M,Pop M,Shi D,Brignone C,Grossman SR

更新日期：2007-02-22 00:00:00

abstract：:We have cloned a cDNA from the Drosophila elg gene, a new member of the ets family of genes. The D-elg gene is located at 97D on chromosome 3R and is expressed as a 2.0kb RNA in the embryos, pupae and adults, with no detectable expression in third instar larvae. D-elg expression is observed in all cells of early stage...

journal_title：Oncogene

authors： Pribyl LJ,Watson DK,Schulz RA,Papas TS

更新日期：1991-07-01 00:00:00

abstract：:Tripartite motif 24 protein (TRIM24) is a plant homeodomain/bromodomain histone reader, recently associated with poor overall survival of breast-cancer patients. At a molecular level, TRIM24 is a negative regulator of p53 levels and a co-activator of estrogen receptor. However, the role of TRIM24 in breast tumorigenes...

journal_title：Oncogene

authors： Pathiraja TN,Thakkar KN,Jiang S,Stratton S,Liu Z,Gagea M,Shi X,Shah PK,Phan L,Lee MH,Andersen J,Stampfer M,Barton MC

更新日期：2015-05-28 00:00:00

abstract：:Tuftelin1 (TUFT1), an acidic protein constituent of developing and mineralizing tooth tissues, is regulated by hypoxia and the Hedgehog signaling pathway. We investigated the role of TUFT1 in hepatocellular carcinoma (HCC). qRT-PCR, immunohistochemistry and western blot were employed to evaluate TUFT1 level in HCC. MT...

journal_title：Oncogene

authors： Dou C,Zhou Z,Xu Q,Liu Z,Zeng Y,Wang Y,Li Q,Wang L,Yang W,Liu Q,Tu K

更新日期：2019-02-01 00:00:00

abstract：:Inhibition of the chaperone heat-shock protein 90 (HSP90) induces apoptosis, and it is a promising anti-cancer strategy. The mechanisms underpinning apoptosis activation following HSP90 inhibition and how they are modified during acquired drug resistance are unknown. We show for the first time that, to induce apoptosi...

journal_title：Oncogene

authors： Busacca S,Law EW,Powley IR,Proia DA,Sequeira M,Le Quesne J,Klabatsa A,Edwards JM,Matchett KB,Luo JL,Pringle JH,El-Tanani M,MacFarlane M,Fennell DA

更新日期：2016-03-24 00:00:00

abstract：:During the evolution into castration or therapy resistance, prostate cancer cells reprogram the androgen responses to cope with the diminishing level of androgens, and undergo metabolic adaption to the nutritionally deprived and hypoxia conditions. AR (androgen receptor) and PKM2 (pyruvate kinase M2) have key roles in...

journal_title：Oncogene

authors： Wang HJ,Pochampalli M,Wang LY,Zou JX,Li PS,Hsu SC,Wang BJ,Huang SH,Yang P,Yang JC,Chu CY,Hsieh CL,Sung SY,Li CF,Tepper CG,Ann DK,Gao AC,Evans CP,Izumiya Y,Chuu CP,Wang WC,Chen HW,Kung HJ

更新日期：2019-01-01 00:00:00

abstract：:Targeted therapeutics, such as those abrogating hypoxia inducible factor (HIF)/vascular endothelial growth factor signaling, are initially effective against kidney cancer (or renal cell carcinoma, RCC); however, drug resistance frequently occurs via subsequent activation of alternative pathways. Through genome-scale i...

journal_title：Oncogene

authors： Chen CH,Fong LWR,Yu E,Wu R,Trott JF,Weiss RH

更新日期：2017-06-22 00:00:00

abstract：:NUP98 has been involved in multiple recurrent chromosome rearrangements in leukemia. We identified a novel fusion between NUP98 and IQ motif containing G (IQCG) gene from a de novo acute T-lymphoid/myeloid leukemia harboring t(3;11)(q29q13;p15)del(3)(q29). IQCG has two putative coiled-coil domains and one IQ domain. T...

journal_title：Oncogene

authors： Pan Q,Zhu YJ,Gu BW,Cai X,Bai XT,Yun HY,Zhu J,Chen B,Weng L,Chen Z,Xue YQ,Chen SJ

更新日期：2008-05-29 00:00:00

abstract：:Centromeric instability is characterized by dynamic formation of centromeric breaks, deletions, isochromosomes and translocations, which are commonly observed in cancer. So far, however, the mechanisms of centromeric instability in cancer cells are still poorly understood. In this study, we tested the hypothesis that ...

journal_title：Oncogene

authors： Deng W,Tsao SW,Mak GW,Tsang CM,Ching YP,Guan XY,Huen MS,Cheung AL

更新日期：2011-03-17 00:00:00

abstract：:Mutations in p53 change the sensitivity to cancer chemotherapeutic drugs. Whereas many drugs, including the vinca alkaloids, often become less effective when p53 is transcriptionally inactivated, several, most notably paclitaxel, may become more effective. In studying the underlying mechanism(s), we found that increas...

journal_title：Oncogene

authors： Zhang CC,Yang JM,White E,Murphy M,Levine A,Hait WN

更新日期：1998-03-26 00:00:00

abstract：:The phosphatidylinositol 3' kinase (PI3K) pathway is involved in many cellular processes including cell proliferation, survival and glucose transport, and is implicated in various disease states, such as cancer and diabetes. Although there have been numerous studies dissecting the role of PI3K signaling in different c...

journal_title：Oncogene

authors： Ling LS,Voskas D,Woodgett JR

更新日期：2013-11-21 00:00:00

abstract：:Growth arrest after u.v. damage was investigated in C3H mouse primary cultured hepatocytes, spontaneously immortalized liver epithelial cells and their H-ras-transformed derivatives. All cells except for one of the transformed lines had the wild type p53 gene considered necessary for the G1-S checkpoint. Growth arrest...

journal_title：Oncogene

authors： Kadohama T,Tsuji K,Ogawa K

更新日期：1994-10-01 00:00:00

abstract：:Transcription factors of the Maf proto-oncogene family have been shown to participate in the regulation of several differentiation specific genes. We previously reported that a member(s) of this family is involved in the regulation of the neuroretina specific gene, QR1, through a promoter region, designated the A box,...

journal_title：Oncogene

authors： Benkhelifa S,Provot S,Lecoq O,Pouponnot C,Calothy G,Felder-Schmittbuhl MP

更新日期：1998-07-16 00:00:00

abstract：:Keratinocytes undergo a dramatic phenotypic conversion during reepithelialization of skin wounds to become hyperproliferative, migratory, and invasive. This transient healing response phenotypically resembles malignant transformation of keratinocytes during squamous cell carcinoma progression. Here we present the firs...

journal_title：Oncogene

authors： Pedersen TX,Leethanakul C,Patel V,Mitola D,Lund LR,Danø K,Johnsen M,Gutkind JS,Bugge TH

更新日期：2003-06-19 00:00:00

abstract：:An elevated proteasome activity contributes to tumorigenesis, particularly by providing cancer cells with antiapoptotic protection and efficient clearance from irregular proteins. Still, the underlying mechanisms are poorly known. In this study, we report that in colon cancer patients, higher proteasome activity was d...

journal_title：Oncogene

authors： Arlt A,Bauer I,Schafmayer C,Tepel J,Müerköster SS,Brosch M,Röder C,Kalthoff H,Hampe J,Moyer MP,Fölsch UR,Schäfer H

更新日期：2009-11-12 00:00:00

abstract：:The product of the RB susceptibility gene has been shown to be differentially phosphorylated during the cell cycle, suggesting a role in the regulation of cell cycle progression. We examined the expression and phosphorylation status of the RB protein in senescent Syrian hamster embryo cells. Both phosphorylated and un...

journal_title：Oncogene

authors： Futreal PA,Barrett JC

更新日期：1991-07-01 00:00:00

abstract：:Targeting Bruton tyrosine kinase (BTK) by ibrutinib is an effective treatment for patients with relapsed/refractory mantle cell lymphoma (MCL). However, both primary and acquired resistance to ibrutinib have developed in a significant number of these patients. A combinatory strategy targeting multiple oncogenic pathwa...

journal_title：Oncogene

authors： Li Y,Bouchlaka MN,Wolff J,Grindle KM,Lu L,Qian S,Zhong X,Pflum N,Jobin P,Kahl BS,Eickhoff JC,Wuerzberger-Davis SM,Miyamoto S,Thomas CJ,Yang DT,Capitini CM,Rui L

更新日期：2016-12-01 00:00:00

abstract：:Histone modifications such as acetylation, methylation and phosphorylation have been implicated in fundamental cellular processes such as epigenetic regulation of gene expression, organization of chromatin structure, chromosome segregation, DNA replication and DNA repair. Males absent on the first (MOF) is responsible...

journal_title：Oncogene

authors： Rea S,Xouri G,Akhtar A

更新日期：2007-08-13 00:00:00

abstract：:Apoptosis resistance is crucially involved in cancer development and progression, represents the leading cause for failure of anticancer therapy and is caused, for example, by downregulation of proapoptotic intracellular signaling molecules such as caspase-8. We found that the cytotoxic drugs methotrexate (MTX) and 5-...

journal_title：Oncogene

authors： Ehrhardt H,Häcker S,Wittmann S,Maurer M,Borkhardt A,Toloczko A,Debatin KM,Fulda S,Jeremias I

更新日期：2008-01-31 00:00:00

abstract：:MOZ and MLL, encoding a histone acetyltransferase (HAT) and a histone methyltransferase, respectively, are targets for recurrent chromosomal translocations found in acute myeloblastic or lymphoblastic leukemia. In MOZ (MOnocytic leukemia Zinc-finger protein)/CBP- or mixed lineage leukemia (MLL)-rearranged leukemias, a...

journal_title：Oncogene

authors： Paggetti J,Largeot A,Aucagne R,Jacquel A,Lagrange B,Yang XJ,Solary E,Bastie JN,Delva L

更新日期：2010-09-09 00:00:00

abstract：:The occurrence of peritoneal carcinomatosis is a major cause of treatment failure in colorectal cancer and is considered incurable. However, new therapeutic approaches have been proposed, including cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC). Although HIPEC has been effective ...

journal_title：Oncogene

authors： Zunino B,Rubio-Patiño C,Villa E,Meynet O,Proics E,Cornille A,Pommier S,Mondragón L,Chiche J,Bereder JM,Carles M,Ricci JE

更新日期：2016-01-14 00:00:00

abstract：:Polyomavirus infection of adolescent athymic female mice causes a high incidence of mammary adenocarcinomas. We have examined the role of ovarian hormones, age and mammary gland developmental stage at infection on subsequent tumor induction, viral replication and gene expression. Ovariectomy (OVX) of adolescent mice 1...

journal_title：Oncogene

authors： Rondinelli RH,Haslam SZ,Fluck MM

更新日期：1995-11-02 00:00:00

abstract：:EDD (E3 isolated by differential display), located at chromosome 8q22.3, is the human orthologue of the Drosophila melanogaster tumour suppressor gene 'hyperplastic discs' and encodes a HECT domain E3 ubiquitin protein-ligase. To investigate the possible involvement of EDD in human cancer, several cancers from diverse...

journal_title：Oncogene

authors： Clancy JL,Henderson MJ,Russell AJ,Anderson DW,Bova RJ,Campbell IG,Choong DY,Macdonald GA,Mann GJ,Nolan T,Brady G,Olopade OI,Woollatt E,Davies MJ,Segara D,Hacker NF,Henshall SM,Sutherland RL,Watts CK

更新日期：2003-08-07 00:00:00

abstract：:The LoVo colon carcinoma cell line that presents two wild type p53 alleles was used as the recipient for a series of transfections with p53 expression vectors coding for wild-type or three different mutants (143ala, 175his or 273his). The parental cell line as well as all clones that had rearranged the plasmid with co...

journal_title：Oncogene

authors： Pocard M,Chevillard S,Villaudy J,Poupon MF,Dutrillaux B,Remvikos Y

更新日期：1996-02-15 00:00:00

abstract：:Interstitial fluid flow in and around the tumor tissue is a physiologically relevant mechanical signal that regulates intracellular signaling pathways throughout the tumor. Yet, the effects of interstitial flow and associated fluid shear stress on the tumor cell function have been largely overlooked. Using in vitro bi...

journal_title：Oncogene

authors： Wang P,Chen SH,Hung WC,Paul C,Zhu F,Guan PP,Huso DL,Kontrogianni-Konstantopoulos A,Konstantopoulos K

更新日期：2015-08-27 00:00:00