Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma.

abstract：:Protein kinase C (PKC)ɛ, a member of the novel PKC family, has key roles in mitogenesis and survival in normal and cancer cells. PKCɛ is frequently overexpressed in epithelial cancers, particularly in lung cancer. Using a short-hairpin RNA approach, here we established that PKCɛ is required for non-small cell lung car...

journal_title：Oncogene

authors： Caino MC,Lopez-Haber C,Kim J,Mochly-Rosen D,Kazanietz MG

更新日期：2012-05-17 00:00:00

abstract：:Matrix metalloproteinase-2 (MMP-2) has pivotal role in the degradation of extracellular matrix, and thereby enhances the invasive, proliferative and metastatic potential in cancer. Knockdown of MMP-2 using MMP-2 small interfering RNA (pM) in human glioma xenograft cell lines 4910 and 5310 decreased cell proliferation ...

journal_title：Oncogene

authors： Kesanakurti D,Chetty C,Dinh DH,Gujrati M,Rao JS

更新日期：2013-01-17 00:00:00

abstract：:In breast cancer (BC) patients, local recurrences often arise in proximity of the surgical scar, suggesting that response to surgery may have a causative role. Radiotherapy (RT) after lumpectomy significantly reduces the risk of recurrence. We investigated the direct effects of surgery and of RT delivered intraoperati...

journal_title：Oncogene

authors： Fabris L,Berton S,Citron F,D'Andrea S,Segatto I,Nicoloso MS,Massarut S,Armenia J,Zafarana G,Rossi S,Ivan C,Perin T,Vaidya JS,Avanzo M,Roncadin M,Schiappacassi M,Bristow RG,Calin G,Baldassarre G,Belletti B

更新日期：2016-09-15 00:00:00

abstract：:In spite of relentless efforts to devise new treatment strategies, primary glioblastomas invariably recur as aggressive, therapy-resistant relapses and patients rapidly succumb to these tumors. Many therapeutic agents are first tested in clinical trials involving recurrent glioblastomas. Remarkably, however, fundament...

journal_title：Oncogene

authors： Campos B,Olsen LR,Urup T,Poulsen HS

更新日期：2016-11-10 00:00:00

abstract：:Following discovery of c-Cbl, a cellular form of the transforming retroviral protein v-Cbl, multiple Cbl-related proteins have been identified in vertebrate and invertebrate organisms. c-Cbl and its homologues are capable of interacting with numerous proteins involved in cell signaling, including various molecular ada...

journal_title：Oncogene

authors： Tsygankov AY,Teckchandani AM,Feshchenko EA,Swaminathan G

更新日期：2001-10-01 00:00:00

abstract：:The few imprinted genes characterized so far include the insulin-like growth factor-2 gene (IGF2) coding for a foetal growth factor and the H19 gene whose normal function is unknown but which is likely to act as an RNA with an antitumour effect. IGF2 is expressed by the paternal allele and H19 by the maternal allele. ...

journal_title：Oncogene

authors： Douc-Rasy S,Barrois M,Fogel S,Ahomadegbe JC,Stéhelin D,Coll J,Riou G

更新日期：1996-01-18 00:00:00

abstract：:The cdk2 gene has been identified as a human cdc2/CDC28-related gene that encodes a protein kinase essential for the G1/S transition in mammalian cells, but not for the G2/M transition, which requires Cdk1, another p34cdc2/CDC28 homolog. Novel potential functions of Cdk2 have been uncovered by using two potent and spe...

journal_title：Oncogene

authors： David-Pfeuty T

更新日期：1999-12-09 00:00:00

abstract：:We present an approach making use of technology established in the context of the genome project to describe a pancreatic cancer-specific expression profile and to identify new potential disease genes or disease-associated-genes. By use of gridded arrays of pancreatic cancer cDNA libraries and differential hybridizati...

journal_title：Oncogene

authors： Gress TM,Müller-Pillasch F,Geng M,Zimmerhackl F,Zehetner G,Friess H,Büchler M,Adler G,Lehrach H

更新日期：1996-10-17 00:00:00

abstract：:Mcl-1 is a critical antiapoptotic survival factor for human multiple myeloma (MM). We examined the importance of IL-6 for Mcl-1 expression in five MM cell lines and in primary MM cells from 14 patients. While culture of MM.1S cells in IL-6 did induce Mcl-1 expression, four other MM cell lines exhibited high levels of ...

journal_title：Oncogene

authors： Zhang B,Potyagaylo V,Fenton RG

更新日期：2003-03-27 00:00:00

abstract：:p53 is involved in several DNA repair pathways. Some of these require the specific transactivation of p53-dependent genes and others involve direct interactions between the p53 protein and DNA repair associated proteins. Previously, we have shown that p53 acts directly in Base Excision Repair (BER) when assayed under ...

journal_title：Oncogene

authors： Offer H,Milyavsky M,Erez N,Matas D,Zurer I,Harris CC,Rotter V

更新日期：2001-02-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (TRAIL-R1) and tumor necrosis factor-related apoptosis-inducing ligand-receptor 2 (TRAIL-R2) are cell-surface receptors involved in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell-death signaling. TRAIL-R1 and TRAIL-R2 gene...

journal_title：Oncogene

authors： Lee SH,Shin MS,Kim HS,Lee HK,Park WS,Kim SY,Lee JH,Han SY,Park JY,Oh RR,Kang CS,Kim KM,Jang JJ,Nam SW,Lee JY,Yoo NJ

更新日期：2001-01-18 00:00:00

abstract：:The introduction of new therapies against particular genetic mutations in non-small-cell lung cancer is a promising avenue for improving patient survival, but the target population is small. There is a need to discover new potential actionable genetic lesions, to which end, non-conventional cancer pathways, such as RN...

journal_title：Oncogene

authors： Anadón C,Guil S,Simó-Riudalbas L,Moutinho C,Setien F,Martínez-Cardús A,Moran S,Villanueva A,Calaf M,Vidal A,Lazo PA,Zondervan I,Savola S,Kohno T,Yokota J,Ribas de Pouplana L,Esteller M

更新日期：2016-08-18 00:00:00

abstract：:Accumulating evidences indicate that p120 catenin, a member of the E-cadherin (E-CD)/catenin adhesion complex, plays a role in tumor invasion. To establish the expression pattern of p120 in breast cancer, we analysed 326 breast tissue biopsies by tissue microarray. Most of the lobular tumors (88%) showed exclusive cyt...

journal_title：Oncogene

authors： Sarrió D,Pérez-Mies B,Hardisson D,Moreno-Bueno G,Suárez A,Cano A,Martín-Pérez J,Gamallo C,Palacios J

更新日期：2004-04-22 00:00:00

abstract：:Breast cancer is a heterogeneous genetic disease driven by the accumulation of individual mutations per tumor. Whole-genome sequencing approaches have identified numerous genes with recurrent mutations in primary tumors. Although mutations in well characterized tumor suppressors and oncogenes are overrepresented in th...

journal_title：Oncogene

authors： Block I,Müller C,Sdogati D,Pedersen H,List M,Jaskot AM,Syse SD,Lund Hansen P,Schmidt S,Christiansen H,Casella C,Bering Olsen S,Blomstrøm MM,Riedel A,Thomassen M,Kruse TA,Karlskov Hansen SW,Kioschis P,Mollenhauer J

更新日期：2019-06-01 00:00:00

abstract：:Oncofetal genes are expressed in embryos or fetuses, are downregulated or undetectable in adult tissues, and then re-expressed in tumors. Known oncofetal genes, such as AFP, GCB, FGF18, IMP-1 and SOX1, often have important clinical applications or pivotal biological functions. To find new oncofetal-like genes, we used...

journal_title：Oncogene

authors： Hsu CC,Chiang CW,Cheng HC,Chang WT,Chou CY,Tsai HW,Lee CT,Wu ZH,Lee TY,Chao A,Chow NH,Ho CL

更新日期：2011-02-10 00:00:00

abstract：:The programmed cell death 4 (PDCD4) gene was originally identified as a tumor-related gene in humans and acts as a tumor-suppressor in mouse epidermal carcinoma cells. However, its function and regulatory mechanisms of expression in human cancer remain to be elucidated. We therefore investigated the expression of PDCD...

journal_title：Oncogene

authors： Zhang H,Ozaki I,Mizuta T,Hamajima H,Yasutake T,Eguchi Y,Ideguchi H,Yamamoto K,Matsuhashi S

更新日期：2006-10-05 00:00:00

abstract：:Although ErbB2 is known to enhance breast cancer metastasis, the signaling events responsible for this remain elusive. Alpha-isozyme of protein kinase C (PKCalpha), which is involved in cancer development and progression, has been suggested to be activated by ErbB2 without direct evidence. In addition, the roles of PK...

journal_title：Oncogene

authors： Tan M,Li P,Sun M,Yin G,Yu D

更新日期：2006-06-01 00:00:00

abstract：:Proteins containing a caveolin-binding domain (CBD), such as the Rho-GTPases, can interact with caveolin-1 (Cav1) through its caveolin scaffold domain. Rho-GTPases are important regulators of p130(Cas), which is crucial for both normal cell migration and Src kinase-mediated metastasis of cancer cells. However, althoug...

journal_title：Oncogene

authors： Arpaia E,Blaser H,Quintela-Fandino M,Duncan G,Leong HS,Ablack A,Nambiar SC,Lind EF,Silvester J,Fleming CK,Rufini A,Tusche MW,Brüstle A,Ohashi PS,Lewis JD,Mak TW

更新日期：2012-02-16 00:00:00

abstract：:Replication origins are 'licensed' for a single initiation event by loading Mcm2-7 complexes during late mitosis and G1. Licensing is blocked at other cell cycle stages by the activity of cyclin-dependent kinases and a small protein called geminin. Here, we describe the effects of over-expressing a non-degradable form...

journal_title：Oncogene

authors： Shreeram S,Sparks A,Lane DP,Blow JJ

更新日期：2002-09-26 00:00:00

abstract：:To ensure that their mRNAs are translated and that the viral proteins necessary for assembling the next generation of infectious progeny are produced, viruses must effectively seize control of the translational machinery within their host cells. In many cases, the ability to productively engage host translational comp...

journal_title：Oncogene

authors： Mohr I

更新日期：2005-11-21 00:00:00

abstract：:Oligonucleotide microarray analysis was applied to assess the expression profile of 332 probe sets representing 308 genes or expressed sequence tags (ESTs) that map to chromosome 17 in order to address epigenetic events that result in alterations in gene expression in epithelial ovarian cancer (EOC). Expression profil...

journal_title：Oncogene

authors： Presneau N,Mes-Masson AM,Ge B,Provencher D,Hudson TJ,Tonin PN

更新日期：2003-03-13 00:00:00

abstract：:The naked mole rat (nmr) is cancer resistant due to the abundant production of extremely high-molecular-weight hyaluronan (EHMW-HA). However, whether EHMW-HA has similar anti-cancer effects in mice and humans remains to be determined. The present study used breast cancer cells to clarify the effect of EHMW-HA on breas...

journal_title：Oncogene

authors： Zhao Y,Qiao S,Hou X,Tian H,Deng S,Ye K,Nie Y,Chen X,Yan H,Tian W

更新日期：2019-05-01 00:00:00

abstract：:H1 histamine receptor (H1HR) belongs to the family of rhodopsin-like G-protein-coupled receptors. Recent studies have shown that H1HR expression is increased in several types of cancer. However, its functional roles in tumor progression remain largely unknown, especially in hepatocellular carcinoma (HCC). We found tha...

journal_title：Oncogene

authors： Zhao J,Hou Y,Yin C,Hu J,Gao T,Huang X,Zhang X,Xing J,An J,Wan S,Li J

更新日期：2020-02-01 00:00:00

abstract：:Since defects in molecular mechanisms controlling DNA repair, cell cycle checkpoint and apoptosis could modify cellular sensitivity to DNA damaging agents, we have conducted a multiparametric molecular analysis for better understanding the regulation pathways leading to cell survival or cell death after irradiation. U...

journal_title：Oncogene

authors： Bishay K,Ory K,Lebeau J,Levalois C,Olivier MF,Chevillard S

更新日期：2000-02-17 00:00:00

abstract：:Interaction of tumour cells with their microenvironment impacts on all aspects of cancer, ranging from development through to treatment response. In this issue, Dvorak and colleagues(1) reveal a novel tumour/microenvironment relationship that may drive leukemia pathogenesis. Specifically, they find that leukemic cells...

journal_title：Oncogene

authors： Tait S

更新日期：2013-10-31 00:00:00

abstract：:The myb family of genes encodes highly homologous nuclear transcription factors that play distinct roles in the development of breast, germ cells and hematoid organs. While the mechanisms associated with the regulation of these genes remain unknown, the transactivation of c-Myb was previously shown to be upregulated b...

journal_title：Oncogene

authors： Kang AD,Park G,Kim YH,Oh IH

更新日期：2004-05-20 00:00:00

abstract：:Loss of PTEN tumor suppressor enhances metastatic risk in breast cancer, although the underlying mechanisms are poorly defined. We report that homozygous deletion of PTEN in mammary epithelial cells induces tubulin-based microtentacles (McTNs) that facilitate cell reattachment and homotypic aggregation. Treatment with...

journal_title：Oncogene

authors： Vitolo MI,Boggs AE,Whipple RA,Yoon JR,Thompson K,Matrone MA,Cho EH,Balzer EM,Martin SS

更新日期：2013-04-25 00:00:00

abstract：:EndoA is a type II keratin and with EndoB (type I keratin), constitutes intermediate filaments in various simple epithelial tissues. EndoA is developmentally regulated and has an enhancer that is located at the 3'- end of the gene. This enhancer contains two single and five dual Ets binding sites. Thus far, no other p...

journal_title：Oncogene

authors： Seth A,Robinson L,Panayiotakis A,Thompson DM,Hodge DR,Zhang XK,Watson DK,Ozato K,Papas TS

更新日期：1994-02-01 00:00:00

abstract：:Melanoma-associated antigen A1 (MAGEA1) is member of the MAGE gene family that is expressed in male germ line cells and placenta under normal physiological conditions. Although MAGEA1's expression levels have been evaluated as one of the cancer testis (CT) antigens for immunotherapy in melanoma and several other cance...

journal_title：Oncogene

authors： Zhao J,Wang Y,Mu C,Xu Y,Sang J

更新日期：2017-08-31 00:00:00

abstract：:Many chromosomal regions undergo loss of heterozygosity (LOH) in ovarian adenocarcinomas but few of the target regions have been finely mapped. One of the chromosome arms likely to harbour one or more tumour suppressor genes inactivated in ovarian cancer is the short arm of chromosome 8 which is frequently deleted in ...

journal_title：Oncogene

authors： Wright K,Wilson PJ,Kerr J,Do K,Hurst T,Khoo SK,Ward B,Chenevix-Trench G

更新日期：1998-09-03 00:00:00