Abstract:
:Frequent allelic losses of chromosome 3p in lung cancer have been reported in a number of studies, and we previously demonstrated that 3p21.3 is one of the common regions of deletion in lung cancers and renal cell carcinomas. To further define a region containing the putative tumor suppressor gene, we performed Southern-blot analysis of 26 small cell lung cancer (SCLC) cell lines and ten non-small cell lung cancer (NSCLC) cell lines with 40 cosmid markers located at 3p21.3-p22. One marker detected homozygous deletions of four SCLC cell lines and one NSCLC cell line. None of the other markers revealed homozygous deletions or chromosomal rearrangements in these cell lines. The region of homozygous deletion described here is estimated to consist of less than 1 megabase of DNA, and it is very likely to contain at least one of the tumor suppressor genes associated with carcinogenesis of lung cancer and, possibly, renal cell carcinoma.
journal_name
Oncogenejournal_title
Oncogeneauthors
Yamakawa K,Takahashi T,Horio Y,Murata Y,Takahashi E,Hibi K,Yokoyama S,Ueda R,Takahashi T,Nakamura Ysubject
Has Abstractpub_date
1993-02-01 00:00:00pages
327-30issue
2eissn
0950-9232issn
1476-5594journal_volume
8pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::The BCL6 gene, mapped at the chromosomal band 3q27, encodes a POZ/Zinc finger transcription repressor protein. It is frequently activated in Non-Hodgkin's lymphomas (NHL) by translocations with breakpoints clustering in the 5' major breakpoint region (MBR) as well as by mutations in the same region. The translocations...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202098
更新日期:1998-10-01 00:00:00
abstract::Activating mutations of K-ras are frequent in colon tumors and aberrant crypt foci, and may play important roles in colon carcinogenesis. Here, we investigated the effects of a K-ras codon 12 mutation on inducible nitric oxide synthase (iNOS) expression. When rat intestinal epithelial cells (IEC-6) were transfected wi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207051
更新日期:2003-10-23 00:00:00
abstract::Although p73alpha induces many of the same cellular events as p53, it is structurally distinct from p53 in that it possesses a unique COOH-terminal domain. To dissect the function of this domain, we performed yeast two-hybrid screening of a HeLa cDNA library using residues 552-636 of p73alpha as bait. Among the clones...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.452
更新日期:2009-02-19 00:00:00
abstract::Loss of actin stress fibers has been associated with cell transformation and metastasis. TGF-beta induction of stress fibers in epithelial cells requires high molecular weight tropomyosins encoded by TPM1 and TPM2 genes. Here, we investigated the mechanism underlying the failure of TGF-beta to induce stress fibers and...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208688
更新日期:2005-07-28 00:00:00
abstract::The heterodimeric nuclear factor (NF) 90/NF45 complex (NF90/NF45) binds nucleic acids and is a multifunctional regulator of gene expression. Here we report that depletion of NF90/NF45 restores the expression of the p53 and p21 proteins in cervical carcinoma cells infected with high-risk human papillomaviruses (HPVs). ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.533
更新日期:2013-10-24 00:00:00
abstract::This issue attempts to give a 'state of the art' overview of the AP-1 transcription factor family, a fundamental class of transcriptional regulators. The AP-1 family consists of several bZIP (basic region leucine zipper) domain proteins, the Jun, the Fos, and the ATF subfamilies, which all have to dimerize before they...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204416
更新日期:2001-04-30 00:00:00
abstract::Mitochondrial membrane permeabilization is a critical event in the process leading to physiological or chemotherapy-induced apoptosis. This permeabilization event is at least in part under the control of the permeability transition pore complex (PTPC), which interacts with oncoproteins from the Bcl-2 family as well as...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203299
更新日期:2000-01-13 00:00:00
abstract::Caspase-8 is a key effector of death-receptor-triggered apoptosis. In a previous study, we demonstrated, however, that caspase-8 can also be activated in a death receptor-independent manner via the mitochondrial apoptosis pathway, downstream of caspase-3. Here, we show that caspases-3 and -8 mediate a mitochondrial am...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206280
更新日期:2003-04-17 00:00:00
abstract::In the course of our study on the amplification of 11q13 sequences in human breast cancer, we have investigated the amplification status of the anonymous DNA fragment D11S97 in a series of 125 mammary tumors. Our results indicate that, as with bladder carcinomas, D11S97 can be amplified separately from BCL1. In additi...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::Treatment with retinoic acid (RA) is effective to restore radioactive iodine uptake in metastases of a small fraction of thyroid cancer patients. In order to find predictive markers of response, we took advantage of two thyroid cancer cell lines, FTC133 and FTC238, with low RA-receptor (RAR)beta expression but differi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210178
更新日期:2007-06-07 00:00:00
abstract::The breast cancer susceptibility gene 1 (Brca1) has a key role in both hereditary and sporadic mammary tumorigenesis. However, the reasons why Brca1-deficiency leads to the development of cancer are not clearly understood. Activation of Akt kinase is one of the most common molecular alterations associated with human m...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.603
更新日期:2011-05-26 00:00:00
abstract::Expression of viral proteins may result in susceptibility of cells to the cytotoxic effect of Tumor Necrosis Factor Alpha (TNF). While murine C127 cells containing the bovine papillomavirus type 1 (BPV-1) genome were reported to exhibit increased TNF sensitivity, the gene(s) responsible was not identified. The BPV-1 E...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202373
更新日期:1999-01-21 00:00:00
abstract::With the development of a specific anti-rab2 antiserum, p23rab2, a ras-like GTPase with a -GGGCC C-terminus, has been localized mainly to the particulate (P100) fraction in NIH3T3 cells, although a small amount of this protein also appears in the soluble fraction. The endogenous p23rab2 is isoprenylated in intact cell...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
abstract::Temozolomide was recognized as the first-line therapy for glioblastoma to prolong the survival of patients noticeably, while recent clinical studies found that some patients were not sensitive to temozolomide treatment. The possible mechanisms seemed to be methylguanine-DNA-methyltransferase (MGMT), mismatch repair, P...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0596-2
更新日期:2019-04-01 00:00:00
abstract::Several cytokines, growth factors and the HIV transactivator Tat were shown to be involved in the pathogenesis of Kaposi's sarcoma. BKV/tat transgenic mice develop Kaposi's sarcoma-like lesions, and spindle-shaped cells (TTB) have been derived from these lesions. Here we show that TTB cells co-express hepatocyte growt...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-09-05 00:00:00
abstract::Cancer therapy drugs, such as diamminedichloroplatinum (cisplatin), mitomycin C, etoposide and a number of other compounds, as well as energy-rich radiation, are known to act on cellular DNA. These agents are shown to induce nuclear accumulation of the so-called tumor-suppressor protein p53 in fibroblastoid cells, as ...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract::We analysed the involvement of proteases during taxol-mediated cell death of human A549 non-small-cell lung carcinoma cells using a proteomics approach that specifically targets protein N termini and further detects newly formed N termini that are the result of protein processing. Our analysis revealed 27 protease-med...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.96
更新日期:2008-07-31 00:00:00
abstract::Forkhead box O class transcription factors are homeostasis regulators that control cell death, longevity and therapy-resistance. In neuroblastoma (NB), nuclear FOXO3 correlates with stage M disease and poor prognosis. To analyze whether FOXO3 contributes to drug-resistance in this childhood cancer, we investigated how...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.288
更新日期:2017-11-02 00:00:00
abstract::The Interleukin-1beta converting enzyme (ICE) family of proteins, homologs of the C elegans cell death gene product CED-3, play important roles in controlling vertebrate programmed cell death. Because inhibition of apoptosis may be an essential step in tumorigenesis, we investigated the interaction of the simian virus...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1200943
更新日期:1997-03-13 00:00:00
abstract::The effect of p53-dependent cell-cycle arrest and senescence on Emu-myc-induced B-cell lymphoma development remains controversial. To address this question, we crossed Emu-myc mice with the p53(515C) mutant mouse, encoding the mutant p53R172P protein that retains the ability to activate the cell-cycle inhibitor and se...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.423
更新日期:2010-03-04 00:00:00
abstract::Lymphoblastoid cell lines derived from cancer prone Bloom's Syndrome patients differ from cell lines representative of several other disorders by exhibiting a constitutive elevation in the level of the c-myc protein. This may be a contributing factor in the strong predisposition to malignancy observed in Bloom's syndr...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract::We have recently isolated the erythroleukemic cell line, HB60-5, that proliferates in the presence of erythropoietin (Epo) and stem cell factor (SCF), but undergoes terminal differentiation in the presence of Epo alone. Ectopic expression of the ets related transcription factor Fli-1 in these cells resulted in the est...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203590
更新日期:2000-05-04 00:00:00
abstract::Differentiation inducible leukemic as well as normal myeloid precursors treated with physiological myeloid differentiation inducer have been used to explore the immediate early genetic response of cells to terminal differentiation and growth arrest stimuli. cDNA clones of 12 distinct genes, referred to as MyD genes, w...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract::Mutations in p53 change the sensitivity to cancer chemotherapeutic drugs. Whereas many drugs, including the vinca alkaloids, often become less effective when p53 is transcriptionally inactivated, several, most notably paclitaxel, may become more effective. In studying the underlying mechanism(s), we found that increas...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201658
更新日期:1998-03-26 00:00:00
abstract::Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that governs cellular responses to reduced O2 availability by mediating crucial homeostatic processes. HIF-1 is composed of an HIF-1alpha subunit and an HIF-1beta subunit. HIF-1alpha is degraded following enzyme-dependent hydroxylation of prolines of HIF-1al...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208986
更新日期:2005-12-08 00:00:00
abstract::The epithelium-specific transcription factor, ERT/ESX/ESE-1/ELF3, binds to the TGF-beta RII promoter in a sequence specific manner and regulates its expression. In this study, we investigated whether ERT could regulate endogenous TGF-beta RII expression in Hs578t breast cancer cells. Analyses of the Hs578t parental ce...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203252
更新日期:2000-01-06 00:00:00
abstract::Senescence is an irreversible growth arrest phenotype adopted by cells that has a key role in protecting organisms from cancer. There is now considerable interest in therapeutic strategies that reactivate this process to control the growth of cancer cells. Protein kinase-Cι (PKCι) is a member of the atypical PKC famil...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.524
更新日期:2012-08-02 00:00:00
abstract::The BRCA1-associated RING domain protein BARD1 acts with BRCA1 in double-strand break repair and ubiquitination. BARD1 plays a role as mediator of apoptosis by binding to and stabilizing p53, and BARD1-repressed cells are resistant to apoptosis. We therefore investigated the mechanism by which BARD1 induces p53 stabil...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208491
更新日期:2005-05-26 00:00:00
abstract::The stress-activated protein kinases (SAPKs), also known as c-Jun amino-terminal kinases (JNKs), are activated in response to diverse stimuli including DNA damage, heat shock, interleukin-1, tumor necrosis factor-alpha and Fas. Although all these inducers cause apoptosis, whether SAPK/JNK activation is required for ap...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201253
更新日期:1997-08-14 00:00:00
abstract::Clear cell renal cell cancer (CC-RCC) is a highly chemoresistant tumor characterized by frequent inactivation of the von Hippel-Lindau (VHL) gene. The prognosis is reportedly worse in patients whose tumors express immunoreactive type I insulin-like growth factor receptor (IGF1R), a key mediator of tumor cell survival....
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210474
更新日期:2007-10-04 00:00:00