Abstract:
:The product of the proto-oncogene fos is a nuclear phosphoprotein. We have investigated if nuclear location of Fos protein is mediated by a nuclear targeting sequence. We show that the cytoplasmic chicken pyruvate kinase protein translocates to the nucleus if fused to the 22 amino acid Fos basic region (amino acids 139-161). However, the nuclear localization of the Fos protein is not affected if the basic region is deleted. We propose that Fos protein contains multiple nuclear targeting sequences which may act independently or in concert with one another.
journal_name
Oncogenejournal_title
Oncogeneauthors
Tratner I,Verma IMsubject
Has Abstractpub_date
1991-11-01 00:00:00pages
2049-53issue
11eissn
0950-9232issn
1476-5594journal_volume
6pub_type
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