当前位置： SCI文献检索 > ONCOGENE期刊下所有文献 > Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation.

Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation.

Abstract：

:The adenomatous polyposis coli (APC) tumor suppressor is a nucleocytoplasmic protein. The nuclear accumulation of APC was recently found to vary depending on cell density, suggesting that putative APC function(s) in the nucleus is controlled by the establishment of cell contacts. We report here that the density-dependent redistribution of APC between nucleus and cytoplasm prevails in 6/6 thyroid and colorectal carcinoma cell lines. Moreover, mutated APC lacking known nuclear localization sequences had the similar distribution pattern as the full-length protein. APC invariably accumulated in the nuclei of Ki-67 expressing cells, but was largely cytoplasmic when cell cycle exit was induced by serum starvation or at high cell density. APC colocalized with beta-catenin in the nucleus only in one cell line (SW480). Also, APC maintained a predominantly nuclear position in early confluent states when cytoplasmic beta-catenin was recruited to newly formed adherens-like junctions. The results indicate that nuclear targeting of APC is driven by cell cycle entry rather than altered cell-cell contact. The ability of C-terminally truncated APC to accumulate in the nucleus suggests that nuclear import signals other than NLS1(APC) and NLS2(APC) are functionally important. Residual function(s) of N-terminal APC fragments in tumor cells carrying APC mutations might be beneficial to tumor growth and survival.

journal_name

Oncogene

journal_title

Oncogene

authors

Fagman H,Larsson F,Arvidsson Y,Meuller J,Nordling M,Martinsson T,Helmbrecht K,Brabant G,Nilsson M

doi

10.1038/sj.onc.1206731

subject

Has Abstract

pub_date

2003-09-04 00:00:00

pages

6013-22

issue

38

eissn

0950-9232

issn

1476-5594

pii

1206731

journal_volume

22

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • Decisive role of cyclooxygenase-2 and lipocalin-type prostaglandin D synthase in chemotherapeutics-induced apoptosis of human cervical carcinoma cells.

    abstract：:The role of cyclooxygenase-2 (COX-2) in cancer remains controversial. Using cervical carcinoma cells (HeLa), the present study investigates the involvement of COX-2 in apoptosis elicited by the chemotherapeutics paclitaxel, cisplatin and 5-fluorouracil. Each compound led to a profound induction of COX-2 expression and...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210962

    authors： Eichele K,Ramer R,Hinz B

    更新日期：2008-05-08 00:00:00

  • Aurora-A-mediated phosphorylation of LKB1 compromises LKB1/AMPK signaling axis to facilitate NSCLC growth and migration.

    abstract：:Deletion or loss-of-function mutation of LKB1, frequently occurring in non-small cell lung cancers (NSCLCs), is a predominant caution of NSCLC initiation and progression. However, the upstream signaling pathways governing LKB1 activation are largely unknown. Here, we report that LKB1 undergoes Aurora kinase A (AURKA)-...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2017.354

    authors： Zheng X,Chi J,Zhi J,Zhang H,Yue D,Zhao J,Li D,Li Y,Gao M,Guo J

    更新日期：2018-01-25 00:00:00

  • Transcriptional regulation of A33 antigen expression by gut-enriched Krüppel-like factor.

    abstract：:A33 antigen is a membrane-bound protein that is expressed only in intestinal epithelium and in most human colon cancers. Thus, A33 antigen has been explored as a potential therapeutic target for the treatment of colon cancers. However, little is known about the mechanism responsible for the tissue-specific pattern of ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1206508

    authors： Mao Z,Song S,Zhu Y,Yi X,Zhang H,Shang Y,Tong T

    更新日期：2003-07-10 00:00:00

  • TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells.

    abstract：:Metastatic growth in breast cancer (BC) has been proposed as an exclusive property of cancer stem cells (CSCs). However, formal proof of their identity as cells of origin of recurrences at distant sites and the molecular events that may contribute to tumor cell dissemination and metastasis development are yet to be el...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2014.5

    authors： Bartucci M,Dattilo R,Moriconi C,Pagliuca A,Mottolese M,Federici G,Benedetto AD,Todaro M,Stassi G,Sperati F,Amabile MI,Pilozzi E,Patrizii M,Biffoni M,Maugeri-Saccà M,Piccolo S,De Maria R

    更新日期：2015-02-05 00:00:00

  • Aberrant sensing of extracellular Ca2+ by cultured ataxia telangiectasia fibroblasts.

    abstract：:Ataxia telangiectasia (AT) is a human hereditary syndrome whose underlying gene product, ataxia telangiectasia mutated (ATM) protein kinase, is involved in multiple intracellular signaling pathways. We demonstrated previously that AT fibroblasts are defective in intracellular Ca(2+) mobilization in response to both st...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1206167

    authors： Famulski KS,Al-Hijailan RS,Dobler K,Pienkowska M,Al-Mohanna F,Paterson MC

    更新日期：2003-01-23 00:00:00

  • Expression profiling identifies new function of collapsin response mediator protein 4 as a metastasis-suppressor in prostate cancer.

    abstract：:Metastasis is the chief cause of mortality from cancer, but the mechanisms leading to metastasis are poorly understood. We used a proteomics approach to screen for metastasis-associated proteins and found that collapsin response mediator protein-4 (CRMP4) expression was inversely associated with the lymph node metasta...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.213

    authors： Gao X,Pang J,Li LY,Liu WP,Di JM,Sun QP,Fang YQ,Liu XP,Pu XY,He D,Li MT,Su ZL,Li BY

    更新日期：2010-08-12 00:00:00

  • Twist1 promotes breast cancer invasion and metastasis by silencing Foxa1 expression.

    abstract：:The heterogeneous breast cancers can be classified into different subtypes according to their histopathological characteristics and molecular signatures. Foxa1 expression is linked with luminal breast cancer (LBC) with good prognosis, whereas Twist1 expression is associated with basal-like breast cancer (BLBC) with po...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2016.286

    authors： Xu Y,Qin L,Sun T,Wu H,He T,Yang Z,Mo Q,Liao L,Xu J

    更新日期：2017-02-23 00:00:00

  • Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.

    abstract：:The tumor suppressor gene phosphatase and tensin homologue (PTEN) regulates the phosphatidylinositol-3'-kinase (PI3K) signaling pathway and has been shown to correlate with poor prognosis in high-grade astrocytomas when mutational inactivation or loss of the PTEN gene occurs. PTEN mutation leads to constitutive activa...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208427

    authors： Edwards LA,Thiessen B,Dragowska WH,Daynard T,Bally MB,Dedhar S

    更新日期：2005-05-19 00:00:00

  • Complexity of the immediate early response of myeloid cells to terminal differentiation and growth arrest includes ICAM-1, Jun-B and histone variants.

    abstract：:Differentiation inducible leukemic as well as normal myeloid precursors treated with physiological myeloid differentiation inducer have been used to explore the immediate early genetic response of cells to terminal differentiation and growth arrest stimuli. cDNA clones of 12 distinct genes, referred to as MyD genes, w...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Lord KA,Hoffman-Liebermann B,Liebermann DA

    更新日期：1990-03-01 00:00:00

  • Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors.

    abstract：:Aggrus (also known as T1alpha/podoplanin) is a membrane sialoglycoprotein whose function in tumors is unknown. We recently determined that Aggrus possessed the ability of inducing platelet aggregation and that its expression was frequently upregulated in colorectal tumors. Thus, Aggrus expression might be associated w...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207869

    authors： Kato Y,Sasagawa I,Kaneko M,Osawa M,Fujita N,Tsuruo T

    更新日期：2004-11-04 00:00:00

  • Acquired SETD2 mutation and impaired CREB1 activation confer cisplatin resistance in metastatic non-small cell lung cancer.

    abstract：:Resistance to chemotherapy remains a critical barrier to effective cancer treatment. Although cisplatin is one of the most commonly used chemotherapeutic agents in the treatment of non-small cell lung cancer (NSCLC), mechanisms of resistance to this drug are not fully understood. Here, we report a novel cisplatin-resi...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-018-0429-3

    authors： Kim IK,McCutcheon JN,Rao G,Liu SV,Pommier Y,Skrzypski M,Zhang YW,Giaccone G

    更新日期：2019-01-01 00:00:00

  • A mutation in the c-myc-IRES leads to enhanced internal ribosome entry in multiple myeloma: a novel mechanism of oncogene de-regulation.

    abstract：:The 5' untranslated region of the proto-oncogene c-myc contains an internal ribosome entry segment (IRES) (Nanbru et al., 1997; Stoneley et al., 1998) and thus c-myc protein synthesis can be initiated by a cap-independent as well as a cap-dependent mechanism (Stoneley et al., 2000). In cell lines derived from patients...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203791

    authors： Chappell SA,LeQuesne JP,Paulin FE,deSchoolmeester ML,Stoneley M,Soutar RL,Ralston SH,Helfrich MH,Willis AE

    更新日期：2000-09-07 00:00:00

  • Coordinated regulation of the immunoproteasome subunits by PML/RARα and PU.1 in acute promyelocytic leukemia.

    abstract：:Recognition and elimination of malignant cells by cytotoxic T lymphocytes depends on antigenic peptides generated by proteasomes. It has been established that impairment of the immunoproteasome subunits, that is, PSMB8, PSMB9 and PSMB10 (PSMBs), is critical for malignant cells to escape immune recognition. We report h...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2013.224

    authors： Yang XW,Wang P,Liu JQ,Zhang H,Xi WD,Jia XH,Wang KK

    更新日期：2014-05-22 00:00:00

  • Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation.

    abstract：:Leukemogenesis requires two classes of mutations, one that promotes proliferation and one that blocks differentiation. The erythroleukemia induced by Friend virus is a multistage disease characterized by an early proliferative stage driven by the interaction of the viral glycoprotein, gp55, with Sf-Stk and the EpoR, a...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2009.202

    authors： Hegde S,Ni S,He S,Yoon D,Feng GS,Watowich SS,Paulson RF,Hankey PA

    更新日期：2009-09-24 00:00:00

  • Isolation of expressed sequences that include a gene for familial breast cancer (BRCA2) and other novel transcripts from a five megabase region on chromosome 13q12.

    abstract：:A proportion of familial breast cancer has recently been shown by genetic linkage analysis to map to chromosome l3q12 (Wooster et al, 1994). This locus contains a tumor suppressor gene BRCA2, mutations in which lead to tumorigenesis. Genetic alterations at this locus have also been shown in pancreatic adenocarcinoma a...

    journal_title：Oncogene

    pub_type：

    doi：

    authors： Jacob AN,Kandpal G,Kandpal RP

    更新日期：1996-07-04 00:00:00

  • The BPV-4 co-carcinogen quercetin induces cell cycle arrest and up-regulates transcription from the LCR of BPV-4.

    abstract：:Bracken fern is the environmental co-carcinogen of BPV-4 in the induction of neoplasias of the upper alimentary canal of cattle. The flavonoid quercetin is one of the most potent and best characterised mutagens present in the fern. We have shown that transfection with BPV-4 DNA and exposure to a single dose of quercet...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201796

    authors： Connolly JA,Morgan IM,Jackson ME,Campo MS

    更新日期：1998-05-28 00:00:00

  • WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer.

    abstract：:ErbB4, a member of the epidermal growth factor receptor family, plays a role in normal breast and breast cancer development by regulating mammary epithelial cell proliferation, survival and differentiation. In this study, we show that WWP1, a C2-WW-HECT type E3 ubiquitin ligase, binds, ubiquitinates and destructs ErbB...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2009.162

    authors： Li Y,Zhou Z,Alimandi M,Chen C

    更新日期：2009-08-20 00:00:00

  • Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2alpha.

    abstract：:A previous report demonstrated that AP-2alpha favors the survival of ovarian cancer patients by clinical findings. However, the functional roles of AP-2alpha in human ovarian cancers have not been determined. To clarify the roles, we overexpressed AP-2alpha in SKOV3 human ovarian cancer cells, which originally possess...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207723

    authors： Sumigama S,Ito T,Kajiyama H,Shibata K,Tamakoshi K,Kikkawa F,Williams T,Tainsky MA,Nomura S,Mizutani S

    更新日期：2004-07-15 00:00:00

  • Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex.

    abstract：:Colorectal cancer is a major cause of cancer deaths in Western countries, but epidemiological data suggest that dietary modification might reduce these by as much as 90%. Cyclo-oxygenase 2 (COX2), an inducible isoform of prostaglandin H synthase, which mediates prostaglandin synthesis during inflammation, and which is...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202980

    authors： Plummer SM,Holloway KA,Manson MM,Munks RJ,Kaptein A,Farrow S,Howells L

    更新日期：1999-10-28 00:00:00

  • Polyoma virus disrupts ARF signaling to p53.

    abstract：:Polyoma virus (Py) differs from other small DNA tumor viruses in not encoding a protein that inactivates p53. The complete Py early region encoding the large T-antigen (PyLT), middle T-antigen (PyMT) and small T-antigen (PyST) will transform primary rodent cells and REF52 cells, but PyMT, the main Py oncogene, by itse...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204717

    authors： Lomax M,Fried M

    更新日期：2001-08-16 00:00:00

  • MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation.

    abstract：:MicroRNAs (miRNAs) make up a novel class of gene regulators; they function as oncogenes or tumor suppressors by targeting tumor-suppressor genes or oncogenes. A recent study that analysed a large number of human cancer cell lines showed that miR-330 is a potential tumor-suppressor gene. However, the function and molec...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2009.192

    authors： Lee KH,Chen YL,Yeh SD,Hsiao M,Lin JT,Goan YG,Lu PJ

    更新日期：2009-09-24 00:00:00

  • Retinoids in cancer therapy and chemoprevention: promise meets resistance.

    abstract：:Retinoids (natural and synthetic derivatives of vitamin A) signal potent differentiation and growth-suppressive effects in diverse normal, premalignant, and malignant cells. A strong rationale exists for the use of retinoids in cancer treatment and chemoprevention based on preclinical, epidemiological, and early clini...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1206936

    authors： Freemantle SJ,Spinella MJ,Dmitrovsky E

    更新日期：2003-10-20 00:00:00

  • A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer.

    abstract：:The Kelch-like ECH-associated protein 1 (KEAP1)-nuclear factor E2-related factor 2 (NRF2)pathway has a central role in cellular antioxidant defense. NRF2 activation due to KEAP1 or NRF2 mutations occurs frequently in many cancers, suggesting that NRF2 inhibition could be a promising therapeutic strategy. However, no p...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2017.153

    authors： Choi EJ,Jung BJ,Lee SH,Yoo HS,Shin EA,Ko HJ,Chang S,Kim SY,Jeon SM

    更新日期：2017-09-14 00:00:00

  • Proteinase-activated receptor 2 expression in breast cancer and its role in breast cancer cell migration.

    abstract：:Proteinase-activated receptor 2 (PAR2) is a G protein-coupled receptor that is activated by trypsin-like proteinases. PAR2 is detected in breast tumor specimens; however, it is not clear how PAR2 level in breast cancer cell/tissues compares with normal cell/tissues. Here, we show the elevation of PAR2 protein level in...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2009.163

    authors： Su S,Li Y,Luo Y,Sheng Y,Su Y,Padia RN,Pan ZK,Dong Z,Huang S

    更新日期：2009-08-27 00:00:00

  • Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB.

    abstract：:Histone deacetylase (HDAC) inhibitors induce growth arrest and apoptosis in a variety of human cancer cells. Sodium butyrate (NaB), a short chain fatty acid, is a HDAC inhibitor and is produced in the colonic lumen as a consequence of microbial degradation of dietary fibers. In order to dissect out the mechanism of Na...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207852

    authors： Joseph J,Mudduluru G,Antony S,Vashistha S,Ajitkumar P,Somasundaram K

    更新日期：2004-08-19 00:00:00

  • Activation of p53 by roscovitine-mediated suppression of MDM2 expression.

    abstract：:The p53 tumor suppressor is regulated by the MDM2 oncoprotein. Overexpression of MDM2 maintains p53 at low levels and contributes to the functional inactivation of p53 in a subset of tumors. We found that treatment with roscovitine and olomoucin, which were originally developed as cyclin-dependent kinase (CDK) inhibit...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204412

    authors： Lu W,Chen L,Peng Y,Chen J

    更新日期：2001-05-31 00:00:00

  • Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells.

    abstract：:Squamous cell carcinoma (SCC) cells of the head and neck specifically express collagenase-3 (matrix metalloproteinase-13 (MMP-13)), the expression of which correlates with their invasion capacity. Transforming growth factor-beta (TGF-beta) enhances MMP-13 and collagenase-1 (MMP-1) expression and invasion of SCC cells ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209291

    authors： Leivonen SK,Ala-Aho R,Koli K,Grénman R,Peltonen J,Kähäri VM

    更新日期：2006-04-27 00:00:00

  • Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells.

    abstract：:Human papillomaviruses (HPVs) are involved in the pathogenesis of cancer of the cervix (CaCx). MicroRNA (miRNA) expression analysis using Ambion (Austin, TX, USA) arrays showed that three miRNAs were overexpressed and 24 underexpressed in cervical cell lines containing integrated HPV-16 DNA compared to the normal cerv...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210919

    authors： Martinez I,Gardiner AS,Board KF,Monzon FA,Edwards RP,Khan SA

    更新日期：2008-04-17 00:00:00

  • The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility.

    abstract：:The Ste20-like kinase, SLK, is involved in the control of cell motility through its effects on actin reorganization and focal adhesion turnover. Here we investigated the role of SLK in chemotaxis downstream of the tyrosine kinase receptor, HER2/ErbB2/Neu, which is frequently overexpressed in human breast cancers. Our ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2009.146

    authors： Roovers K,Wagner S,Storbeck CJ,O'Reilly P,Lo V,Northey JJ,Chmielecki J,Muller WJ,Siegel PM,Sabourin LA

    更新日期：2009-08-06 00:00:00

  • siRNA-mediated AML1/MTG8 depletion affects differentiation and proliferation-associated gene expression in t(8;21)-positive cell lines and primary AML blasts.

    abstract：:The chromosomal translocation t(8;21) is associated with 10-15% of all cases of acute myeloid leukaemia (AML). The resultant fusion protein AML1/MTG8 interferes with haematopoietic gene expression and is an important regulator of leukaemogenesis. We studied the effects of small interfering RNA (siRNA)-mediated AML1/MT...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209638

    authors： Dunne J,Cullmann C,Ritter M,Soria NM,Drescher B,Debernardi S,Skoulakis S,Hartmann O,Krause M,Krauter J,Neubauer A,Young BD,Heidenreich O

    更新日期：2006-10-05 00:00:00