Abstract:
:Zebrafish are making big waves in the field of cancer research. The effect has been widespread and continues to gain speed as more and more cancer researchers ride the wave of zebrafish biology. This has been largely due to the development of transgenic and xenograft models of cancer, which recapitulate many aspects of different human cancers including lymphoblastic T-cell leukemia, pancreatic cancer, melanoma and rhabdomyosarcoma. These models are already being utilized by academia and industry to search for genetic and chemical modifiers of cancer with success. The attention has been further stimulated by the amenability of zebrafish to pharmacological testing and the superior imaging properties of fish tissues that allow visualization of cancer progression and angiogenesis in live animals. This review summarizes the current zebrafish models of cancer and discusses their utility in human cancer research and future directions in the field.
journal_name
Oncogenejournal_title
Oncogeneauthors
Stoletov K,Klemke Rdoi
10.1038/onc.2008.95subject
Has Abstractpub_date
2008-07-31 00:00:00pages
4509-20issue
33eissn
0950-9232issn
1476-5594pii
onc200895journal_volume
27pub_type
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