5-aza-2'-deoxycytidine upregulates caspase-9 expression cooperating with p53-induced apoptosis in human lung cancer cells.

abstract：:SOX5 is a member of the high-mobility group superfamily of architectural non-histone proteins involved in gene regulation and maintenance of chromatin structure in a wide variety of developmental processes. Sox5 was identified as a brain tumor locus in a retroviral insertional mutagenesis screen of platelet-derived gr...

journal_title：Oncogene

authors： Tchougounova E,Jiang Y,Bråsäter D,Lindberg N,Kastemar M,Asplund A,Westermark B,Uhrbom L

更新日期：2009-03-26 00:00:00

abstract：:ID4 gene is a member of the inhibitor of DNA-binding (ID) family, which inhibits DNA binding of basic helix-loop-helix transcription factors. Certain human primary breast cancers reportedly have low or no expression of ID4 protein, but its role in carcinogenesis and cancer progression is unknown. To determine its poss...

journal_title：Oncogene

authors： Umetani N,Mori T,Koyanagi K,Shinozaki M,Kim J,Giuliano AE,Hoon DS

更新日期：2005-07-07 00:00:00

abstract：:SCC-S2/GG2-1/NDED is a recently discovered antiapoptotic molecule induced by the activation of the transcription factor NF-kappaB. Here we have examined a role of SCC-S2 in cell growth regulation in vitro and in vivo. Western blotting using an antipeptide antibody revealed endogenous SCC-S2 as a approximately 21 kDa c...

journal_title：Oncogene

authors： Kumar D,Gokhale P,Broustas C,Chakravarty D,Ahmad I,Kasid U

更新日期：2004-01-15 00:00:00

abstract：:The tumor suppressor transcription factor IRF-1 inhibits cell growth. In this report we show that IRF-1 also induces apoptosis of highly transformed and tumorigenic cell lines. This activity of IRF-1 is demonstrated with cell lines expressing HER oncogenes and an activatable IRF-1 fusion protein. Growth of cell lines ...

journal_title：Oncogene

authors： Kirchhoff S,Hauser H

更新日期：1999-06-24 00:00:00

abstract：:High-grade gliomas (HGG) afflict both children and adults and respond poorly to current therapies. Epigenetic regulators have a role in gliomagenesis, but a broad, functional investigation of the impact and role of specific epigenetic targets has not been undertaken. Using a two-step, in vitro/in vivo epigenomic shRNA...

journal_title：Oncogene

authors： Green AL,DeSisto J,Flannery P,Lemma R,Knox A,Lemieux M,Sanford B,O'Rourke R,Ramkissoon S,Jones K,Perry J,Hui X,Moroze E,Balakrishnan I,O'Neill AF,Dunn K,DeRyckere D,Danis E,Safadi A,Gilani A,Hubbell-Engler B,Nus

更新日期：2020-03-01 00:00:00

abstract：:Overexpression of members of the myc family of oncogenes contributes to the development of many vertebrate malignancies. Although several functions for myc gene products have been proposed, the targets for Myc activity during oncogenesis or normal development remain to be identified. Oocytes of Xenopus laevis, which a...

journal_title：Oncogene

authors： Gibson AW,Ye R,Johnston RN,Browder LW

更新日期：1992-11-01 00:00:00

abstract：:Many cells die with apoptotic morphology and with documented activation of an effector caspase, but there are also many exceptions. Cells frequently display activation of other proteases, including granzymes, lysosomal cathepsins, matrix metalloproteinases, and proteasomal proteases, and others display morphologies th...

journal_title：Oncogene

authors： Lockshin RA,Zakeri Z

更新日期：2004-04-12 00:00:00

abstract：:Loss of von Hippel Lindau (VHL) protein function is a key driver of VHL diseases, including sporadic and inherited clear cell renal cell carcinoma. Modulation of the proteostasis of VHL, especially missense point-mutated VHL, is a promising approach to augmenting VHL levels and function. VHL proteostasis is regulated ...

journal_title：Oncogene

authors： German P,Bai S,Liu XD,Sun M,Zhou L,Kalra S,Zhang X,Minelli R,Scott KL,Mills GB,Jonasch E,Ding Z

更新日期：2016-09-22 00:00:00

abstract：:Fos protein heterodimerizes through one surface of an alpha-helical domain called the leucine zipper. We have investigated the effect of destabilizing this domain by multiply substituting small residues of its non-interacting surface with glycine. Ternary complex formation between mutated Fos, Jun and DNA was determin...

journal_title：Oncogene

authors： Nicklin MJ,Zechner D,Kislyakova T

更新日期：1993-07-01 00:00:00

abstract：:As apoptosis defects limit efficacy of anticancer agents, autophagy has been proposed as a novel strategy for radiotherapy enhancement. We previously showed that caspase-3/7 inhibition induces autophagy and promotes radiosensitivity in vitro and in vivo. Therefore, we further investigated the mechanism by which radiat...

journal_title：Oncogene

authors： Kim KW,Moretti L,Mitchell LR,Jung DK,Lu B

更新日期：2010-06-03 00:00:00

abstract：:The tumor suppressor protein, p53, plays a critical role as a transcriptional activator of downstream target genes involved in the cellular response to DNA damaging agents. We examined the cell cycle checkpoint response of human mammary epithelial cells (HMEC) and their isogenic fibroblast counterparts to ionizing (IR...

journal_title：Oncogene

authors： Meyer KM,Hess SM,Tlsty TD,Leadon SA

更新日期：1999-10-14 00:00:00

abstract：:Our previous studies suggested that chromosome 8p deletion is associated with metastasis of hepatocellular carcinoma (HCC), in which some novel metastasis suppressor genes might be harbored. The present study aimed to identify the metastatic suppressor gene(s). A cDNA chip was constructed with the expressed sequence t...

journal_title：Oncogene

authors： Wu X,Jia HL,Wang YF,Ren N,Ye QH,Sun HC,Wang L,Liu YK,Tang ZY,Qin LX

更新日期：2006-03-16 00:00:00

abstract：:The exact functions of BRCA1 have not been fully described but it now seems apparent that it has roles in DNA damage repair, transcriptional regulation, cell cycle control and most recently in ubiquitylation. These functions of BRCA1 are most likely interdependent but this review will focus on the role of BRCA1 in rel...

journal_title：Oncogene

authors： Mullan PB,Quinn JE,Harkin DP

更新日期：2006-09-25 00:00:00

abstract：:B7-H4, a member of B7 family, is a transmembrane protein and inhibits T-cells immunity. However, in a variety of tumor cells, B7-H4 was detected predominantly in intracellular compartments with unknown mechanism and functions. In this study, we analyzed B7-H4 expression and subcellular distribution by immunohistochemi...

journal_title：Oncogene

authors： Zhang L,Wu H,Lu D,Li G,Sun C,Song H,Li J,Zhai T,Huang L,Hou C,Wang W,Zhou B,Chen S,Lu B,Zhang X

更新日期：2013-11-14 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), an important angiogenic factor, regulates cell proliferation, differentiation, and apoptosis through activation of its tyrosine-kinase receptors, such as Flt-1 and Flk-1/Kdr. Human malignant mesothelioma cells (HMC), which have wild-type p53, express VEGF and exhibit cell gro...

journal_title：Oncogene

authors： Catalano A,Romano M,Martinotti S,Procopio A

更新日期：2002-04-25 00:00:00

abstract：:Retinoic acid receptor alpha (RARα) has a critical role in the differentiation process of osteosarcoma cells induced by all-trans retinoic acid (ATRA). However, degradation of RARα through ubiquitin proteasome pathway weakens the differentiation efficiency of osteosarcoma cells. In this study, we discover that murine ...

journal_title：Oncogene

authors： Ying M,Zhang L,Zhou Q,Shao X,Cao J,Zhang N,Li W,Zhu H,Yang B,He Q

更新日期：2016-08-18 00:00:00

abstract：:Loss of growth control and a marked resistance to apoptosis are considered major mechanisms driving tumour progression. Protein kinases C (PKC) have been shown to be important in the regulation of proliferation and apoptosis. In this report, we investigated the role of the PKC-like kinase PKCmu in the control of these...

journal_title：Oncogene

authors： Trauzold A,Schmiedel S,Sipos B,Wermann H,Westphal S,Röder C,Klapper W,Arlt A,Lehnert L,Ungefroren H,Johannes FJ,Kalthoff H

更新日期：2003-12-04 00:00:00

abstract：:Chromosome 17 is one of the most frequently altered chromosomes in malignant breast cancer. At least four genes implicated in breast cancer reside on chromosome 17 (p53, 17p13; Her-2/neu/ERBB2, 17q12; BRCA1, 17q21; and nm23, 17q22). In addition, allelic imbalance has been described for at least five regions of chromos...

journal_title：Oncogene

authors： Plummer SJ,Adams L,Simmons JA,Casey G

更新日期：1997-05-15 00:00:00

abstract：:beta-catenin activation, and subsequent upregulation of Wnt-signaling, is an important event in the development of certain human and rodent cancers. Recently, mutations in the beta-catenin gene in the region of the serine-threonine glycogen kinase (GSK)-3beta phosphorylation target sites have been identified in hepato...

journal_title：Oncogene

authors： Devereux TR,Anna CH,Foley JF,White CM,Sills RC,Barrett JC

更新日期：1999-08-19 00:00:00

abstract：:Deregulated expression of c-Myc has been shown to induce or enhance apoptosis in various different cell types. c-Myc requires p53 for apoptosis in some but not all the cell types, indicating heterogeneous mechanisms for c-Myc-induced apoptosis. In B lymphoma line WEHI-231, stable expression of c-Myc has been demonstra...

journal_title：Oncogene

authors： Hagiyama H,Adachi T,Yoshida T,Nomura T,Miyasaka N,Honjo T,Tsubata T

更新日期：1999-07-15 00:00:00

abstract：:The recepteur d'origine nantais (RON) is a receptor tyrosine kinase (RTK) in the scatter factor family, which includes the c-Met receptor. RON exhibits increased expression in a significant number of human breast cancer tissues as well as in many established breast cancer cell lines. Recent studies have indicated that...

journal_title：Oncogene

authors： Feres KJ,Ischenko I,Hayman MJ

更新日期：2009-01-15 00:00:00

abstract：:The differentiation of primary myogenic cultures requires the attachment of the cells to an extracellular matrix substrate using an integrin family receptor. These integrin receptors can be phosphorylated on both their alpha and beta chains, and it has been postulated that phosphorylation regulates the receptor functi...

journal_title：Oncogene

authors： Aneskievich BJ,Haimovich B,Boettiger D

更新日期：1991-08-01 00:00:00

abstract：:Hepatitis B virus (HBV) is a major risk factor for the development of hepatocellular carcinoma (HCC). HBV encodes the potentially oncogenic HBx protein, which mainly functions as a transcriptional co-activator involving in multiple gene deregulations. However, mechanisms underlying HBx-mediated oncogenicity remain unc...

journal_title：Oncogene

authors： Wu CG,Salvay DM,Forgues M,Valerie K,Farnsworth J,Markin RS,Wang XW

更新日期：2001-06-21 00:00:00

abstract：:Snail is a zinc finger transcription factor that triggers the epithelial-mesenchymal transition (EMT) by directly repressing E-cadherin expression. Snail is required for mesoderm and neural crest formation during embryonic development and has recently been implicated in the EMT associated with tumour progression. In a...

journal_title：Oncogene

authors： Blanco MJ,Moreno-Bueno G,Sarrio D,Locascio A,Cano A,Palacios J,Nieto MA

更新日期：2002-05-09 00:00:00

abstract：:Over 70% of human breast cancers are estrogen receptor-positive (ER+), most of which express MYB. In these and other cell types, the MYB transcription factor regulates the expression of many genes involved in cell proliferation, differentiation, tumorigenesis, and apoptosis. So far, no clear link has been established ...

journal_title：Oncogene

authors： Yang RM,Nanayakkara D,Kalimutho M,Mitra P,Khanna KK,Dray E,Gonda TJ

更新日期：2019-06-01 00:00:00

abstract：:The MTG (Myeloid Translocation Gene) proteins are a family of novel transcriptional corepressors. We report that MTG16a, a protein isoform encoded by the MTG16 gene deranged by the t (16; 21) in myeloid malignancies, is targeted to the nucleolus. The amino acid sequence necessary for nucleolar localization was mapped ...

journal_title：Oncogene

authors： Hoogeveen AT,Rossetti S,Stoyanova V,Schonkeren J,Fenaroli A,Schiaffonati L,van Unen L,Sacchi N

更新日期：2002-09-26 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in malignant tumors and plays important roles in multiple aspects of cancer aggressiveness. Thus, targeting STAT3 promises to be an attractive strategy for the treatment of advanced metastatic tumors. Bisindolylmaleimide alkaloid (B...

journal_title：Oncogene

authors： Li X,Ma H,Li L,Chen Y,Sun X,Dong Z,Liu JY,Zhu W,Zhang JT

更新日期：2018-05-01 00:00:00

abstract：:Prostate cancer is the most common malignancy of elderly men in the United States. Since there is no curative treatment for advanced prostate cancer, exploration of novel modalities of treatment is essential. Telomerase, a ribonucleoprotein, is detected in the vast majority of prostate cancer, but not in normal or ben...

journal_title：Oncogene

authors： Kondo Y,Koga S,Komata T,Kondo S

更新日期：2000-04-27 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by a block in myeloid cell differentiation. As a result of a chromosomal translocation in these patients, the promyelocytic leukemia protein PML is disrupted as are the nuclear bodies it forms. Disruption of PML and PML nuclear bodies in APL is linked to a loss of gr...

journal_title：Oncogene

authors： Topcu Z,Mack DL,Hromas RA,Borden KL

更新日期：1999-11-25 00:00:00

abstract：:TSG101 has been identified as a candidate tumor suppressor gene and abnormal transcripts have been identified in a substantial fraction of breast cancers. To determine whether TSG101 expression is commonly altered in other tumors, a series of 15 primary and metastatic prostate cancers were analysed by reverse transcri...

journal_title：Oncogene

authors： Sun Z,Pan J,Bubley G,Balk SP

更新日期：1997-12-18 00:00:00