Nuclear import of LASP-1 is regulated by phosphorylation and dynamic protein-protein interactions.

abstract：:Mutations of SMAD4/DPC4 are found in about 60% of human invasive pancreatic ductal adenocarcinomas (PDACs); yet, the manner in which SMAD4 deficiency enhances tumorigenesis remains elusive. Using a Cre-LoxP approach, we generated a mutant mouse carrying a targeted deletion of Smad4 in the pancreas. We showed that the ...

journal_title：Oncogene

authors： Xu X,Ehdaie B,Ohara N,Yoshino T,Deng CX

更新日期：2010-02-04 00:00:00

abstract：:Members of the Myc proto-oncogene family encode transcription factors that function in multiple aspects of cell behavior, including proliferation, differentiation, transformation and apoptosis. Recent studies have shown that MYC activities are modulated by a network of nuclear bHLH-Zip proteins. The MAX protein is at ...

journal_title：Oncogene

authors： Quéva C,Hurlin PJ,Foley KP,Eisenman RN

更新日期：1998-02-26 00:00:00

abstract：:Our group recently identified Ras homolog member I (ARHI), a novel maternally imprinted tumor suppressor gene that encodes a 26 kDa GTP-binding protein with high homology to Ras and Rap. Unlike other Ras family members, ARHI exhibits several unusual structural and functional properties. ARHI contains a unique 34 amino...

journal_title：Oncogene

authors： Luo RZ,Fang X,Marquez R,Liu SY,Mills GB,Liao WS,Yu Y,Bast RC

更新日期：2003-05-15 00:00:00

abstract：:We have optimized the conditions for efficient NIH3T3 focus formation by calcium phosphate transfection of proviral Abelson-murine leukemia virus (A-MuLV) plasmid DNA. Linearized pA-MuLV, P120 or P160 strains, when transfected with calf thymus carrier DNA, will produce 40-50 foci/100 ng pA-MuLV without co-transfecting...

journal_title：Oncogene

authors： Shore SK,Reddy EP

更新日期：1989-11-01 00:00:00

abstract：:The growth and progression of prostate cancer are dependent on androgens and androgen receptor (AR), which act by modulating gene expression. Utilizing a gene microarray approach, we have identified the alpha1-subunit gene of soluble guanylyl cyclase (sGC) as a novel androgen-regulated gene. A heterodimeric cytoplasmi...

journal_title：Oncogene

authors： Cai C,Chen SY,Zheng Z,Omwancha J,Lin MF,Balk SP,Shemshedini L

更新日期：2007-03-08 00:00:00

abstract：:The balance between acetylation and deacetylation of histone and nonhistone proteins controls gene expression in a variety of cellular processes, with transcription being activated by acetyltransferases and silenced by deacetylases. We report here the formation and enzymatic characterization of a complex between the a...

journal_title：Oncogene

authors： Simone C,Stiegler P,Forcales SV,Bagella L,De Luca A,Sartorelli V,Giordano A,Puri PL

更新日期：2004-03-18 00:00:00

abstract：:The oncogene, v-rel is a member of the rel/NF-kappaB family of transcription factors. It causes a rapidly fatal lymphoma in young chicks and is capable of transforming both fibroblasts and primitive hematopoietic cells in culture. To understand the role of v-rel in transformation we constructed an inducible form of v-...

journal_title：Oncogene

authors： Walker AK,Enrietto PJ

更新日期：1996-06-20 00:00:00

abstract：:Two alternatively spliced mouse lymphocyte and brain ltk cDNAs predict small transmembrane tyrosine kinases that use CUG translational start codons and that differ upstream of their transmembrane segment. A recently isolated human neuroblastoma ltk cDNA, in contrast, includes a regular AUG start codon and predicts a m...

journal_title：Oncogene

authors： Snijders AJ,Haase VH,Bernards A

更新日期：1993-01-01 00:00:00

abstract：:Glioma stem cells (GSCs) decrease T cells cognition and evade systemic immunosurveillance via downregulations or defects of major histocompatibility complex class I (MHC-I) molecule and antigen-processing machinery (APM) components. Improvement of tumor surface antigens of GSCs may be effective strategy to trigger an ...

journal_title：Oncogene

authors： Yang W,Li Y,Gao R,Xiu Z,Sun T

更新日期：2020-01-01 00:00:00

abstract：:We analysed 30 primary invasive oral and laryngeal squamous carcinomas (SC), with concurrent dysplastic lesions, for genetic alterations at 15 microsatellite loci on the short arm of chromosome 8. Overall, loss of heterozygosity (LOH) was observed, in at least one informative locus, in 27% of the dysplastic lesions an...

journal_title：Oncogene

authors： El-Naggar AK,Coombes MM,Batsakis JG,Hong WK,Goepfert H,Kagan J

更新日期：1998-06-11 00:00:00

abstract：:We determined whether proteins encoded by the nm23/nucleoside diphosphate (NDP) kinase gene, a potential metastasis-suppressor gene, are expressed on the cell surface. Monoclonal antibodies (mAb) specific for nm23-H1 or H2 proteins were prepared using the corresponding fusion proteins with glutathione S-transferase (G...

journal_title：Oncogene

authors： Urano T,Furukawa K,Shiku H

更新日期：1993-05-01 00:00:00

abstract：:Osteochondroma, the most common benign bone tumor, may occur as a sporadic lesion or as multiple neoplasms in the context of multiple osteochondromas syndrome. The most severe complication is malignant transformation into peripheral secondary chondrosarcoma. Although both benign conditions have been linked to defects ...

journal_title：Oncogene

authors： Zuntini M,Pedrini E,Parra A,Sgariglia F,Gentile FV,Pandolfi M,Alberghini M,Sangiorgi L

更新日期：2010-07-01 00:00:00

abstract：:A hallmark of human cancer is heterogeneity, reflecting the complex series of changes resulting in the activation of oncogenes coupled with inactivation of tumor suppressor genes. Breast cancer is no exception and indeed, many studies have revealed considerable complexity and heterogeneity in the population of primary...

journal_title：Oncogene

authors： Leung JY,Andrechek ER,Cardiff RD,Nevins JR

更新日期：2012-05-17 00:00:00

abstract：:The Myc-deregulating chromosomal T(12;15)(Igh-Myc) translocation, the hallmark mutation of inflammation- and interleukin 6-dependent mouse plasmacytoma (PCT), is the premier model of cancer-associated chromosomal translocations because it is the only translocation in mice that occurs spontaneously (B lymphocyte lineag...

journal_title：Oncogene

authors： Takizawa M,Kim JS,Tessarollo L,McNeil N,Waldschmidt TJ,Casellas R,Ried T,Janz S

更新日期：2010-07-15 00:00:00

abstract：:Downregulation of E-cadherin by the transcriptional repressor Snail is associated with acquisition of metastatic potential. Although hepatitis C virus (HCV) core protein has been implicated in hepatocarcinogenesis, it is unclear whether Snail is involved in HCV core-induced dysregulation of E-cadherin. Herein, we inve...

journal_title：Oncogene

authors： Nie D,Shan X,Nie L,Duan Y,Chen Z,Yang Y,Li Z,Tian L,Gao Q,Shan Y,Tang N

更新日期：2016-07-14 00:00:00

abstract：:Rad23 proteins function in both DNA repair and protein stability regulation. As ubiquitinated forms of p53 are stabilized after DNA damage in concert with p53 functional activation, and human Rad23 proteins (hHR23A and B) regulate p53 stability in unstressed cells, the role of hHR23B in post-genotoxin regulation of p5...

journal_title：Oncogene

authors： Kaur M,Pop M,Shi D,Brignone C,Grossman SR

更新日期：2007-02-22 00:00:00

abstract：:The role of cyclooxygenase-2 (COX-2) in cancer remains controversial. Using cervical carcinoma cells (HeLa), the present study investigates the involvement of COX-2 in apoptosis elicited by the chemotherapeutics paclitaxel, cisplatin and 5-fluorouracil. Each compound led to a profound induction of COX-2 expression and...

journal_title：Oncogene

authors： Eichele K,Ramer R,Hinz B

更新日期：2008-05-08 00:00:00

abstract：:Hexokinase-II (HK2) is a key enzyme involved in glycolysis, which is required for breast cancer progression. However, the underlying post-translational mechanisms of HK2 activity are poorly understood. Here, we showed that Proviral Insertion in Murine Lymphomas 2 (PIM2) directly bound to HK2 and phosphorylated HK2 on ...

journal_title：Oncogene

authors： Yang T,Ren C,Qiao P,Han X,Wang L,Lv S,Sun Y,Liu Z,Du Y,Yu Z

更新日期：2018-11-01 00:00:00

abstract：:BCL11 genes play crucial roles in lymphopoiesis and have been associated with hematopoietic malignancies. Specifically, disruption of the BCL11B (B-cell chronic lymphocytic leukemia/lymphoma 11B) locus is linked to T-cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T-cell lymphoma. ...

journal_title：Oncogene

authors： Cismasiu VB,Adamo K,Gecewicz J,Duque J,Lin Q,Avram D

更新日期：2005-10-13 00:00:00

abstract：:Genetic amplification at chromosome 8p23.1 has been reported in some solid tumors. Translocation of 8p23.1 has also been reported in hematological malignancies and head and neck squamous cell cancer. In an attempt to clarify whether this translocation is implicated in lymphomagenesis, we performed FISH analysis of the...

journal_title：Oncogene

authors： Tagawa H,Karnan S,Kasugai Y,Tuzuki S,Suzuki R,Hosokawa Y,Seto M

更新日期：2004-04-01 00:00:00

abstract：:We tested the cytotoxic action of 8-hydroxyguanine (8ohG) by observing the viability of several leukemic cell lines (KG-1, U937, Jurkat and K 562) in the presence of 8-hydroxydeoxyguanosine (8ohdG), a nucleoside of 8ohG. It was found that 8ohdG showed cytotoxic action only to KG-1 and that only KG-1 showed a homozygou...

journal_title：Oncogene

authors： Hyun JW,Choi JY,Zeng HH,Lee YS,Kim HS,Yoon SH,Chung MH

更新日期：2000-09-14 00:00:00

abstract：:p27Kip1 is a regulator of the mammalian cell cycle and a putative tumor suppressor. Distinct altered patterns of p27Kip1 protein expression are found in a variety of human carcinomas, and p27Kip1 expression levels usually correlate directly with disease-free survival. The mechanism(s) by which p27Kip1 expression is re...

journal_title：Oncogene

authors： Worm J,Bartkova J,Kirkin AF,Straten P,Zeuthen J,Bartek J,Guldberg P

更新日期：2000-10-19 00:00:00

abstract：:A dual role of transforming growth factor β (TGF-β), to both suppress and promote tumor progression and metastasis, has been well established, but its molecular basis has remained elusive. In this review, we focus on Smad proteins, which are central mediators of the signal transduction of TGF-β family members. We desc...

journal_title：Oncogene

authors： Morikawa M,Koinuma D,Miyazono K,Heldin CH

更新日期：2013-03-28 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors induce growth arrest and apoptosis in a variety of human cancer cells. Sodium butyrate (NaB), a short chain fatty acid, is a HDAC inhibitor and is produced in the colonic lumen as a consequence of microbial degradation of dietary fibers. In order to dissect out the mechanism of Na...

journal_title：Oncogene

authors： Joseph J,Mudduluru G,Antony S,Vashistha S,Ajitkumar P,Somasundaram K

更新日期：2004-08-19 00:00:00

abstract：:A lot of attention has been dedicated to investigate the role of the tyrosine kinase receptor MET in tumors. The acquired notion that cancer cells from different histological origin strictly rely on the engagement of this specific oncogene for their growth and survival has certainly justified the development and the u...

journal_title：Oncogene

authors： Finisguerra V,Prenen H,Mazzone M

更新日期：2016-10-20 00:00:00

abstract：:The p14ARF tumor suppressor is a key regulator of cellular proliferation, frequently inactivated in human cancer. The mechanisms that regulate alternative reading frame (ARF) turnover have been obscure for long time, being ARF a relatively stable protein. Recently, it has been described that its degradation depends, a...

journal_title：Oncogene

authors： Pollice A,Sepe M,Villella VR,Tolino F,Vivo M,Calabrò V,La Mantia G

更新日期：2007-08-02 00:00:00

abstract：:Adenovirus E4orf4 protein is a multifunctional viral regulator, which is involved in down regulation of virally-modulated signal transduction, in control of alternative splicing of viral mRNAs, and in induction of apoptosis in transformed cells. It has been previously shown that E4orf4 interacts with protein phosphata...

journal_title：Oncogene

authors： Shtrichman R,Sharf R,Kleinberger T

更新日期：2000-08-03 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasm. While ATL cells in peripheral blood (PB-ATL) are sensitive to anti-CC chemokine receptor 4 treatment, non-PB-ATLs, including lymph node ATLs (LN-ATLs), are more aggressive and resistant. We examined characteristic cytokines and growth factors that ...

journal_title：Oncogene

authors： Totani H,Shinjo K,Suzuki M,Katsushima K,Mase S,Masaki A,Ito A,Ri M,Kusumoto S,Komatsu H,Ishida T,Inagaki H,Iida S,Kondo Y

更新日期：2020-08-01 00:00:00

abstract：:Upstream stimulating factor (USF2) is a basic helix-loop-helix leucine zipper transcription factor, which is found in most tissues. A critical role for USF2 in cellular proliferation has been proposed based on its importance in the regulation of various cyclins and P53 and its capability to antagonize c-myc. In this p...

journal_title：Oncogene

authors： Zhang ZC,Nechushtan H,Jacob-Hirsch J,Avni D,Meyuhas O,Razin E

更新日期：1998-02-12 00:00:00

abstract：:Malignant tumors are exemplified by excessive proliferation and aggressive migration/invasion contributing to increased mortality of cancer patients. Matrix metalloproteinase 9 (MMP9) expression is positively correlated with lung cancer malignancy. The mechanism underlying an elevated MMP9 expression is not clearly de...

journal_title：Oncogene

authors： Cheng X,Yang Y,Fan Z,Yu L,Bai H,Zhou B,Wu X,Xu H,Fang M,Shen A,Chen Q,Xu Y

更新日期：2015-10-29 00:00:00