Abstract:
:Chronic exposure to intraperitoneal asbestos triggered a marked response in the mesothelium well before tumor development. Macrophages, mesothelial precursor cells, cytokines, and growth factors accumulated in the peritoneal lavage. Transcriptome profiling revealed YAP/TAZ activation in inflamed mesothelium with further activation in tumors, paralleled by increased levels of cells with nuclear YAP/TAZ. Arg1 was one of the highest upregulated genes in inflamed tissue and tumor. Inflamed tissue showed increased levels of single-nucleotide variations, with an RNA-editing signature, which were even higher in the tumor samples. Subcutaneous injection of asbestos-treated, but tumor-free mice with syngeneic mesothelioma tumor cells resulted in a significantly higher incidence of tumor growth when compared to naïve mice supporting the role of the environment in tumor progression.
journal_name
Oncogenejournal_title
Oncogeneauthors
Rehrauer H,Wu L,Blum W,Pecze L,Henzi T,Serre-Beinier V,Aquino C,Vrugt B,de Perrot M,Schwaller B,Felley-Bosco Edoi
10.1038/s41388-018-0153-zsubject
Has Abstractpub_date
2018-05-01 00:00:00pages
2645-2659issue
20eissn
0950-9232issn
1476-5594pii
10.1038/s41388-018-0153-zjournal_volume
37pub_type
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