Human c-FES is a nuclear tyrosine kinase.

Abstract:

:FES is a non-receptor protein tyrosine kinase expressed in hematopoietic progenitors and differentiated myeloid cells. It has recently been implicated in granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and erythropoietin signal transduction. To better understand the role played by FES in normal and neoplastic hematopoiesis, we used cell fractionation techniques to examine the subcellular localization of FES in myeloid cells and cell lines. FES was observed in the nuclear, granular and plasma membrane fractions of primary human neutrophils and the myeloid leukemia cell line, HL-60. The nuclear localization was confirmed by immunocytochemistry of neutrophils.

journal_name

Oncogene

journal_title

Oncogene

authors

Yates KE,Lynch MR,Wong SG,Slamon DJ,Gasson JC

subject

Has Abstract

pub_date

1995-03-16 00:00:00

pages

1239-42

issue

6

eissn

0950-9232

issn

1476-5594

journal_volume

10

pub_type

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