Abstract:
:FES is a non-receptor protein tyrosine kinase expressed in hematopoietic progenitors and differentiated myeloid cells. It has recently been implicated in granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and erythropoietin signal transduction. To better understand the role played by FES in normal and neoplastic hematopoiesis, we used cell fractionation techniques to examine the subcellular localization of FES in myeloid cells and cell lines. FES was observed in the nuclear, granular and plasma membrane fractions of primary human neutrophils and the myeloid leukemia cell line, HL-60. The nuclear localization was confirmed by immunocytochemistry of neutrophils.
journal_name
Oncogenejournal_title
Oncogeneauthors
Yates KE,Lynch MR,Wong SG,Slamon DJ,Gasson JCsubject
Has Abstractpub_date
1995-03-16 00:00:00pages
1239-42issue
6eissn
0950-9232issn
1476-5594journal_volume
10pub_type
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