p53- and p21-dependent premature APC/C-Cdh1 activation in G2 is part of the long-term response to genotoxic stress.

abstract：:Defects in a developmental signaling pathway involving the mammalian homologue of the Drosophila segment polarity gene, patched are associated with human tumors such as basal cell carcinoma, medulloblastoma and squamous cell carcinoma. Loss of heterozygosity (LOH) in some of these tumor cells suggests that patched fun...

journal_title：Oncogene

authors： Koike C,Mizutani T,Ito T,Shimizu Y,Yamamichi N,Kameda T,Michimukai E,Kitamura N,Okamoto T,Iba H

更新日期：2002-04-18 00:00:00

abstract：:Persistent infection with hepatitis B virus (HBV) is one of the primary risk factors for human hepatocellular carcinoma (HCC). In a human ecological study, we have shown that, in addition to HBV, animal food consumption also significantly contributes to the variance of HCC. To test the interacting effect of HBV and an...

journal_title：Oncogene

authors： Hu JF,Cheng Z,Chisari FV,Vu TH,Hoffman AR,Campbell TC

更新日期：1997-12-04 00:00:00

abstract：:p53 is a multifunctional protein that has been shown to inhibit the growth of transformed cells, arrest the cell cycle of normal cells, regulate gene transcription and influence cellular differentiation, apoptosis and senescence. This study was undertaken to determine if the expression of p53 in keratinocytes varied d...

journal_title：Oncogene

authors： Spandau DF

更新日期：1994-07-01 00:00:00

abstract：:Excessive adiposity has long been associated with increased incidence of breast cancer in post-menopausal women, and with increased mortality from breast cancer, regardless of the menopausal status. Although adipose tissue-derived estrogen contributes to obesity-associated risk for estrogen receptor (ER)-positive brea...

journal_title：Oncogene

authors： Walter M,Liang S,Ghosh S,Hornsby PJ,Li R

更新日期：2009-07-30 00:00:00

abstract：:Chronic infection by hepatitis C virus (HCV) is a major risk factor for the onset and development of hepatocellular carcinoma (HCC), although the underlying mechanisms are unclear. The c-Myc oncogene contributes to the genesis of many types of cancers, including HCC, partly via the induction of genetic damage and the ...

journal_title：Oncogene

authors： Higgs MR,Lerat H,Pawlotsky JM

更新日期：2013-09-26 00:00:00

abstract：:Grb2 is an adaptor protein that links receptor and cytoplasmic tyrosine kinases to the Ras signalling pathway by binding the Ras-specific guanine nucleotide exchange factor, Sos1, through its SH3 domains. The Grb2-SH3 domain binding has been localized to the carboxy-terminal two hundred amino acids of Sos1 (Sos1-c). B...

journal_title：Oncogene

authors： Sastry L,Lin W,Wong WT,Di Fiore PP,Scoppa CA,King CR

更新日期：1995-09-21 00:00:00

abstract：:Nuclear Foxc2 is a transcriptional regulator of mesenchymal transformation during developmental epithelial-mesenchymal transition (EMT) and has been associated with EMT in malignant epithelia. Our laboratory has shown that in normal epithelial cells Foxc2 is maintained in the cytoplasm where it promotes an epithelial ...

journal_title：Oncogene

authors： Golden D,Cantley LG

更新日期：2015-09-03 00:00:00

abstract：:Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are extracellular lipid mediators that signal through distinct members of the Edg/LP subfamily of G protein-coupled receptors (GPCRs). LPA and S1P receptors are expressed in almost every cell type and can couple to multiple G proteins (G(i), G(q) and G(12/1...

journal_title：Oncogene

authors： Kranenburg O,Moolenaar WH

更新日期：2001-03-26 00:00:00

abstract：:Chemoprevention has been widely explored as a promising strategy for controlling the incidence of lung cancer, the leading cause of cancer-related death. To maximize the benefit of lung cancer chemoprevention, it is important to identify individuals at high risk for the disease. The genetic background has been shown t...

journal_title：Oncogene

authors： Wang L,Soria JC,Chang YS,Lee HY,Wei Q,Mao L

更新日期：2003-10-16 00:00:00

abstract：:cDNA clones of human fos-related genes fra-1 and fra-2 were isolated by screening human c-DNA libraries with human fos DNA as a probe. We obtained human fra-1 cDNA clones that can code for a protein of 271 amino acid residues with a calculated molecular weight of 29,413 and showed 90% similarity with rat fra-1 protein...

journal_title：Oncogene

authors： Matsui M,Tokuhara M,Konuma Y,Nomura N,Ishizaki R

更新日期：1990-03-01 00:00:00

abstract：:Small cell lung cancer (SCLC) invades locally and metastasizes distantly extremely early when compared with nonsmall cell lung cancer (NSCLC). The underlying molecular mechanisms, however, have not been elucidated. Accumulating evidence suggests that downregulation of several members of tetraspanins is associated with...

journal_title：Oncogene

authors： Funakoshi T,Tachibana I,Hoshida Y,Kimura H,Takeda Y,Kijima T,Nishino K,Goto H,Yoneda T,Kumagai T,Osaki T,Hayashi S,Aozasa K,Kawase I

更新日期：2003-02-06 00:00:00

abstract：:Retinoic acid receptor alpha (RARα) has a critical role in the differentiation process of osteosarcoma cells induced by all-trans retinoic acid (ATRA). However, degradation of RARα through ubiquitin proteasome pathway weakens the differentiation efficiency of osteosarcoma cells. In this study, we discover that murine ...

journal_title：Oncogene

authors： Ying M,Zhang L,Zhou Q,Shao X,Cao J,Zhang N,Li W,Zhu H,Yang B,He Q

更新日期：2016-08-18 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) accounts for ∼80% of all lung cancers. Although some advances in lung cancer therapy have been made, patient survival is still quite poor. Two microRNAs, miR-221 and miR-222, upregulated by the MET proto-oncogene, have been already described to enhance cell survival and to induce TNF...

journal_title：Oncogene

authors： Acunzo M,Visone R,Romano G,Veronese A,Lovat F,Palmieri D,Bottoni A,Garofalo M,Gasparini P,Condorelli G,Chiariello M,Croce CM

更新日期：2012-02-02 00:00:00

abstract：:Aberrant activation of anaplastic lymphoma kinase (ALK) can cause sporadic and familial neuroblastoma. Using a proteomics approach, we identified Bruton's tyrosine kinase (BTK) as a novel ALK interaction partner, and the physical interaction was confirmed by co-immunoprecipitation. BTK is expressed in neuroblastoma ce...

journal_title：Oncogene

authors： Li T,Deng Y,Shi Y,Tian R,Chen Y,Zou L,Kazi JU,Rönnstrand L,Feng B,Chan SO,Chan WY,Sun J,Zhao H

更新日期：2018-11-01 00:00:00

abstract：:The tumour suppressor p53 is a transcription factor with high affinity for specific DNA target sequences. Wild type p53 has a very short half life in normal cells but the protein shows transient accumulation in response to DNA damage, accompanied by up-regulation of target genes such as p21 and induction of growth arr...

journal_title：Oncogene

authors： Molinari M,Milner J

更新日期：1995-05-04 00:00:00

abstract：:Oncogenesis results from changes in kinetics or in abundance of proteins in signal transduction networks. Recently, it was shown that control of signalling cannot reside in a single gene product, and might well be dispersed over many components. Which of the reactions in these complex networks are most important, and ...

journal_title：Oncogene

authors： Hornberg JJ,Binder B,Bruggeman FJ,Schoeberl B,Heinrich R,Westerhoff HV

更新日期：2005-08-25 00:00:00

abstract：:In spite of relentless efforts to devise new treatment strategies, primary glioblastomas invariably recur as aggressive, therapy-resistant relapses and patients rapidly succumb to these tumors. Many therapeutic agents are first tested in clinical trials involving recurrent glioblastomas. Remarkably, however, fundament...

journal_title：Oncogene

authors： Campos B,Olsen LR,Urup T,Poulsen HS

更新日期：2016-11-10 00:00:00

abstract：:Dietary effects are presumed to underlie many of the large international differences in incidence seen for most cancers. Apart from alcohol and a few micronutrients, however, the role of specific nutritional factors remains ill-defined. The evidence for a role of energy balance, physical inactivity, and obesity has st...

journal_title：Oncogene

authors： McCullough ML,Giovannucci EL

更新日期：2004-08-23 00:00:00

abstract：:The MT-2 cell-line, which had been established through in vitro cell to cell transmission of human T-cell leukemia virus type I (HTLV-I) among human primary lymphocytes, was shown to possess multiple copies of integrated proviruses, including defective proviral genomes. By analysing a genomic clone, we identified the ...

journal_title：Oncogene

authors： Kubota S,Siomi H,Hatanaka M,Pomerantz RJ

更新日期：1996-04-04 00:00:00

abstract：:We showed earlier that p300/CBP plays an important role in G1 progression by negatively regulating c-Myc and thereby preventing premature G1 exit. Here, we have studied the mechanism by which p300 represses c-Myc and show that in quiescent cells p300 cooperates with histone deacetylase 3 (HDAC3) to repress transcripti...

journal_title：Oncogene

authors： Sankar N,Baluchamy S,Kadeppagari RK,Singhal G,Weitzman S,Thimmapaya B

更新日期：2008-09-25 00:00:00

abstract：:Maf b-Zip transcription factors are involved in both terminal differentiation and oncogenesis. To investigate this apparent contradiction, we used two different primary cell types and performed an extensive analysis of transformation parameters induced by Maf proteins. We show that MafA and c-Maf are potent oncogenes ...

journal_title：Oncogene

authors： Pouponnot C,Sii-Felice K,Hmitou I,Rocques N,Lecoin L,Druillennec S,Felder-Schmittbuhl MP,Eychène A

更新日期：2006-03-02 00:00:00

abstract：:ErbB2 amplification and overexpression in breast cancer correlates with aggressive disease and poor prognosis. To find novel ErbB2-interacting proteins, we used stable isotope labeling of amino acids in cell culture followed by peptide affinity pull-downs and identified specific binders using relative quantification b...

journal_title：Oncogene

authors： Heinrich C,Keller C,Boulay A,Vecchi M,Bianchi M,Sack R,Lienhard S,Duss S,Hofsteenge J,Hynes NE

更新日期：2010-03-18 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease and a major health problem in the United States. While the cytokine TGF-β has been implicated in PDAC development, it can exert both pro-tumorigenic and anti-tumorigenic effects that are highly context dependent and incompletely understood. Using three-dimens...

journal_title：Oncogene

authors： Handler J,Cullis J,Avanzi A,Vucic EA,Bar-Sagi D

更新日期：2018-08-01 00:00:00

abstract：:Elevated expression of osteopontin (OPN), a secreted adhesive phosphoglycoprotein, is frequently associated with many transformed cell lines of epithelial and stromal origin. Moreover, several clonal lines of preneoplastic JB6 cells derived from Balb/c mouse epidermal cultures (Colburn et al., 1978, 1979), upon treatm...

journal_title：Oncogene

authors： Su L,Mukherjee AB,Mukherjee BB

更新日期：1995-06-01 00:00:00

abstract：:The E2F1 transcription factor plays a pivotal role in driving cells out of a quiescent state and into the S phase of the cell cycle, in part by transactivating genes needed for DNA replication including DHFR, thymidine kinase, and DNA Polymerase alpha. E2F1 has also been implicated in regulating an S phase checkpoint,...

journal_title：Oncogene

authors： Stubbs MC,Hall DJ

更新日期：2002-05-23 00:00:00

abstract：:Our previous studies suggested that chromosome 8p deletion is associated with metastasis of hepatocellular carcinoma (HCC), in which some novel metastasis suppressor genes might be harbored. The present study aimed to identify the metastatic suppressor gene(s). A cDNA chip was constructed with the expressed sequence t...

journal_title：Oncogene

authors： Wu X,Jia HL,Wang YF,Ren N,Ye QH,Sun HC,Wang L,Liu YK,Tang ZY,Qin LX

更新日期：2006-03-16 00:00:00

abstract：:Aneuploidy is frequently detected in solid tumors but the mechanisms regulating the generation of aneuploidy and their relevance in cancer initiation remain under debate and are incompletely characterized. Spatial and temporal regulation of integrin traffic is critical for cell migration and cytokinesis. Impaired inte...

journal_title：Oncogene

authors： Högnäs G,Tuomi S,Veltel S,Mattila E,Murumägi A,Edgren H,Kallioniemi O,Ivaska J

更新日期：2012-08-02 00:00:00

abstract：:We previously reported the presence of mitotic check-point impairment in about 40% of lung cancer cell lines. To gain an insight into the molecular basis of this impairment, we examined 49 lung cancer specimens for alterations in the hMAD1 mitotic checkpoint gene and identified a somatic, non-conservative missense mut...

journal_title：Oncogene

authors： Nomoto S,Haruki N,Takahashi T,Masuda A,Koshikawa T,Takahashi T,Fujii Y,Osada H,Takahashi T

更新日期：1999-11-25 00:00:00

abstract：:L-ascorbate (L-ascorbic acid, vitamin C) clearly has an inhibitory effect on cancer cells. However, the mechanism underlying differential sensitivity of cancer cells from same tissue to L-ascorbate is yet to be clarified. Here, we demonstrate that L-ascorbate has a selective killing effect, which is influenced by sodi...

journal_title：Oncogene

authors： Hong SW,Lee SH,Moon JH,Hwang JJ,Kim DE,Ko E,Kim HS,Cho IJ,Kang JS,Kim DJ,Kim JE,Shin JS,Jung DJ,Jeong YJ,Cho BJ,Kim TW,Lee JS,Kang JS,Hwang YI,Noh DY,Jin DH,Lee WJ

更新日期：2013-03-21 00:00:00

abstract：:A better understanding of the link between cellular metabolism and tumorigenesis is needed. Here, we report characterization of a novel protein named coiled-coil helix tumor and metabolism 1 (CHTM1). We have found that CHTM1 is associated with cancer and cellular metabolism. CHTM1 localizes to mitochondria and cytosol...

journal_title：Oncogene

authors： Babbar M,Huang Y,An J,Landas SK,Sheikh MS

更新日期：2018-04-01 00:00:00