The PR status of the originating cell of ER/PR-negative mouse mammary tumors.

abstract：:The majority (75%) of human breast cancers express estrogen receptor (ER). Although ER-positive tumors usually respond to antiestrogen therapies, 30% of them do not. It is not known what controls the ER status of breast cancers or their responsiveness to antihormone interventions. In this report, we document that tran...

journal_title：Oncogene

authors： Zhang X,Podsypanina K,Huang S,Mohsin SK,Chamness GC,Hatsell S,Cowin P,Schiff R,Li Y

更新日期：2005-06-16 00:00:00

abstract：:The role of cyclooxygenase-2 (COX-2) in cancer remains controversial. Using cervical carcinoma cells (HeLa), the present study investigates the involvement of COX-2 in apoptosis elicited by the chemotherapeutics paclitaxel, cisplatin and 5-fluorouracil. Each compound led to a profound induction of COX-2 expression and...

journal_title：Oncogene

authors： Eichele K,Ramer R,Hinz B

更新日期：2008-05-08 00:00:00

abstract：:As part of a cloning strategy to identify genes involved in early mouse liver development we have isolated Praja1, a gene with similar sequences to the Drosophila melanogaster gene goliath (gl) which is involved in the fate of mesodermal cells ultimately forming gut musculatures, fat body, and the heart. Praja1 is a 2...

journal_title：Oncogene

authors： Mishra L,Tully RE,Monga SP,Yu P,Cai T,Makalowski W,Mezey E,Pavan WJ,Mishra B

更新日期：1997-11-06 00:00:00

abstract：:Formation of meningiomas has been associated with the loss of genetic material on chromosome 22. To approach the additional chromosomal events that underlie progression of these tumors to malignancy, we have examined several other chromosomal regions for loss of heterozygosity (LOH) in these tumors. Fifty-eight tumors...

journal_title：Oncogene

authors： Menon AG,Rutter JL,von Sattel JP,Synder H,Murdoch C,Blumenfeld A,Martuza RL,von Deimling A,Gusella JF,Houseal TW

更新日期：1997-02-06 00:00:00

abstract：:During tumor initiation, oncogene-induced senescence (OIS) is proposed to limit the progression of preneoplasms to invasive carcinoma unless circumvented by the acquisition of certain tumor suppressor mutations. Using a variety of biomarkers, OIS has been previously reported in a wide range of human and murine precurs...

journal_title：Oncogene

authors： Caldwell ME,DeNicola GM,Martins CP,Jacobetz MA,Maitra A,Hruban RH,Tuveson DA

更新日期：2012-03-22 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy characterized by an accumulation of immature T cells. Although patient outcomes have improved, novel targeted therapies are needed to reduce the intensity of chemotherapy and improve the prognosis of high-risk patients. Interleukin-7...

journal_title：Oncogene

authors： Buffière A,Uzan B,Aucagne R,Hermetet F,Mas M,Nassurdine S,Aznague A,Carmignac V,Tournier B,Bouchot O,Ballerini P,Barata JT,Bastie JN,Delva L,Pflumio F,Quéré R

更新日期：2019-11-01 00:00:00

abstract：:Drosophila tumor suppressor WARTS (Wts) is an evolutionally conserved serine / threonine kinase and participates in a signaling complex that regulates both proliferation and apoptosis to ensure the proper size and shape of the fly. Human counterparts of this complex have been found to be frequently downregulated or mu...

journal_title：Oncogene

authors： Kuninaka S,Nomura M,Hirota T,Iida S,Hara T,Honda S,Kunitoku N,Sasayama T,Arima Y,Marumoto T,Koja K,Yonehara S,Saya H

更新日期：2005-08-11 00:00:00

abstract：:The myc proto-oncogenes are transcription factors that directly regulate the expression of other genes, by binding to the specific DNA sequence, CACGTG. Among the target genes for c-Myc regulation are ECA39, p53, ornithine decarboxylase (ODC), alpha-prothymosin and Cdc25A. In this study we examined the involvement of ...

journal_title：Oncogene

authors： Ben-Yosef T,Yanuka O,Halle D,Benvenisty N

更新日期：1998-07-16 00:00:00

abstract：:The tumour suppressor p53 is a transcription factor with high affinity for specific DNA target sequences. Wild type p53 has a very short half life in normal cells but the protein shows transient accumulation in response to DNA damage, accompanied by up-regulation of target genes such as p21 and induction of growth arr...

journal_title：Oncogene

authors： Molinari M,Milner J

更新日期：1995-05-04 00:00:00

abstract：:Poly(ADP-ribose) polymerase 1 (PARP1) interacts genetically with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to suppress early-onset T-lineage lymphomas in the mouse, but the underlying mechanisms have remained unknown. To address this question, we analyzed a series of lymphomas arising in PARP1(-/-)...

journal_title：Oncogene

authors： Rybanska I,Ishaq O,Chou J,Prakash M,Bakhsheshian J,Huso DL,Franco S

更新日期：2013-04-04 00:00:00

abstract：:Signals received at the cell surface must be properly transmitted to critical targets within the cell to achieve the appropriate biological response. This process of signal transduction is often initiated by receptor tyrosine kinases (RTKs), which function as entry points for many extracellular cues and play a critica...

journal_title：Oncogene

authors： McKay MM,Morrison DK

更新日期：2007-05-14 00:00:00

abstract：:Expression of PTEN tumor suppressor gene has been known to dephosphorylate the phosphatidylinositol 3' kinase (PI3K) products on the 3 prime inositol ring, resulting in reduced Akt activation. Loss of PTEN expression in OPM2 and delta47 human myeloma lines led to high Akt activity toward insulin-like growth factor I (...

journal_title：Oncogene

authors： Choi Y,Zhang J,Murga C,Yu H,Koller E,Monia BP,Gutkind JS,Li W

更新日期：2002-08-08 00:00:00

abstract：:Loss of PTEN tumor suppressor enhances metastatic risk in breast cancer, although the underlying mechanisms are poorly defined. We report that homozygous deletion of PTEN in mammary epithelial cells induces tubulin-based microtentacles (McTNs) that facilitate cell reattachment and homotypic aggregation. Treatment with...

journal_title：Oncogene

authors： Vitolo MI,Boggs AE,Whipple RA,Yoon JR,Thompson K,Matrone MA,Cho EH,Balzer EM,Martin SS

更新日期：2013-04-25 00:00:00

abstract：:SH3 and SAM domains are protein interaction motifs that are predominantly seen in signaling molecules, adaptors, and scaffold proteins. We have identified a novel family of putative adaptor genes that includes HACS1. HACS1 encodes a 441 amino acid protein that is differentially expressed in hematopoietic cells and has...

journal_title：Oncogene

authors： Claudio JO,Zhu YX,Benn SJ,Shukla AH,McGlade CJ,Falcioni N,Stewart AK

更新日期：2001-08-30 00:00:00

abstract：:Skeletrophin (mindbomb homolog 2 (MIB2)) is a RING (Really Interesting New Gene) finger-dependent ubiquitin ligase, which targets the intracellular region of Notch ligands. A previous immunohistochemical study demonstrated that skeletrophin was downregulated in many melanomas. In the present study, we have identified ...

journal_title：Oncogene

authors： Takeuchi T,Adachi Y,Sonobe H,Furihata M,Ohtsuki Y

更新日期：2006-11-09 00:00:00

abstract：:Transgenic mice expressing the c-Myc oncogene driven by woodchuck hepatitis virus (WHV) regulatory sequences develop hepatocellular carcinoma with a high frequency. To investigate genetic lesions that cooperate with Myc in liver carcinogenesis, we conducted a genome-wide scan for loss of heterozygosity (LOH) and mutat...

journal_title：Oncogene

authors： Wu Y,Renard CA,Apiou F,Huerre M,Tiollais P,Dutrillaux B,Buendia MA

更新日期：2002-02-28 00:00:00

abstract：:Spindle cell sarcomas consist of tumors with different biological features, of which distant metastasis is the most ominous sign for a poor prognosis. However, metastasis is difficult to predict on the basis of current histopathological analyses. We have identified actin filament-associated protein 1-like 1 (AFAP1L1) ...

journal_title：Oncogene

authors： Furu M,Kajita Y,Nagayama S,Ishibe T,Shima Y,Nishijo K,Uejima D,Takahashi R,Aoyama T,Nakayama T,Nakamura T,Nakashima Y,Ikegawa M,Imoto S,Katagiri T,Nakamura Y,Toguchida J

更新日期：2011-09-22 00:00:00

abstract：:Heat shock protein 110 (HSP110) is induced by different stresses and, through its anti-apoptotic and chaperoning properties, helps cells survive these adverse situations. In colon cancers, HSP110 is abnormally abundant. We have recently shown that colorectal cancer patients with microsatellite instability (MSI) had an...

journal_title：Oncogene

authors： Berthenet K,Bokhari A,Lagrange A,Marcion G,Boudesco C,Causse S,De Thonel A,Svrcek M,Goloudina AR,Dumont S,Hammann A,Biard DS,Demidov ON,Seigneuric R,Duval A,Collura A,Jego G,Garrido C

更新日期：2017-04-20 00:00:00

abstract：:Over the past five decades, a plethora of nonrandom chromosomal abnormalities have been consistently reported in malignant cells facilitating the identification of cancer-associated protein coding oncogenes and tumor suppressors. The genetic dissection of hot spots for chromosomal abnormalities in the age of the seque...

journal_title：Oncogene

authors： Calin GA,Croce CM

更新日期：2006-10-09 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) accounts for ∼80% of all lung cancers. Although some advances in lung cancer therapy have been made, patient survival is still quite poor. Two microRNAs, miR-221 and miR-222, upregulated by the MET proto-oncogene, have been already described to enhance cell survival and to induce TNF...

journal_title：Oncogene

authors： Acunzo M,Visone R,Romano G,Veronese A,Lovat F,Palmieri D,Bottoni A,Garofalo M,Gasparini P,Condorelli G,Chiariello M,Croce CM

更新日期：2012-02-02 00:00:00

abstract：:The RNA-binding motif (RRM) gene on Y chromosome (RBMY), encoding a male germ cell-specific RNA-binding protein associated with spermatogenesis, was found inserted by hepatitis B virus (HBV) DNA in one childhood hepatocellular carcinoma (HCC). This study is aimed to explore the oncogenic potential of the RBMY protein....

journal_title：Oncogene

authors： Tsuei DJ,Hsu HC,Lee PH,Jeng YM,Pu YS,Chen CN,Lee YC,Chou WC,Chang CJ,Ni YH,Chang MH

更新日期：2004-07-29 00:00:00

abstract：:The recepteur d'origine nantais (RON) is a receptor tyrosine kinase (RTK) in the scatter factor family, which includes the c-Met receptor. RON exhibits increased expression in a significant number of human breast cancer tissues as well as in many established breast cancer cell lines. Recent studies have indicated that...

journal_title：Oncogene

authors： Feres KJ,Ischenko I,Hayman MJ

更新日期：2009-01-15 00:00:00

abstract：:Human Papillomavirus (HPV) type 16 is the most frequently detected HPV in cervical cancer. Although epidemiologic and experimental evidence indicates a prominent role for HPV infection in the development of this disease, other factors are also involved. Altered expression of the ets family transcription factors erg an...

journal_title：Oncogene

authors： Simpson S,Woodworth CD,DiPaolo JA

更新日期：1997-05-08 00:00:00

abstract：:One-carbon metabolism plays a central role in a broad array of metabolic processes required for the survival and growth of tumor cells. However, the molecular basis of how one-carbon metabolism may influence RNA methylation and tumorigenesis remains largely unknown. Here we show MTHFD2, a mitochondrial enzyme involved...

journal_title：Oncogene

authors： Green NH,Galvan DL,Badal SS,Chang BH,LeBleu VS,Long J,Jonasch E,Danesh FR

更新日期：2019-08-01 00:00:00

abstract：:The 120 kD product of the c-cbl oncogene is rapidly tyrosine phosphorylated and recruited to the EGF receptor following ligand binding. Cbl's oncogenic potential is activated by a large carboxy-terminal truncation that generated v-cbl and removes the Ring finger and proline-rich SH3-binding domains. Here we show that ...

journal_title：Oncogene

authors： Thien CB,Langdon WY

更新日期：1997-05-08 00:00:00

abstract：:The release of cytochrome c from the intermembrane space of mitochondria into the cytosol is one of the critical events in apoptotic cell death. In the present study, it is shown that release of cytochrome c and apoptosis induced by tumor necrosis factor alpha (TNF) in HeLa cells can be inhibited by (i) overexpression...

journal_title：Oncogene

authors： Shchepina LA,Pletjushkina OY,Avetisyan AV,Bakeeva LE,Fetisova EK,Izyumov DS,Saprunova VB,Vyssokikh MY,Chernyak BV,Skulachev VP

更新日期：2002-11-21 00:00:00

abstract：:The p53 tumor suppressor is regulated by the MDM2 oncoprotein. Overexpression of MDM2 maintains p53 at low levels and contributes to the functional inactivation of p53 in a subset of tumors. We found that treatment with roscovitine and olomoucin, which were originally developed as cyclin-dependent kinase (CDK) inhibit...

journal_title：Oncogene

authors： Lu W,Chen L,Peng Y,Chen J

更新日期：2001-05-31 00:00:00

abstract：:We report the detailed molecular characterization of a human parathyroid adenoma with a clonal parathyroid hormone gene rearrangement. This rearrangement is similar to one we characterized recently in an independent adenoma. In these two, plus a third partially characterized adenoma, one allele of the PTH gene, on 11p...

journal_title：Oncogene

authors： Rosenberg CL,Kim HG,Shows TB,Kronenberg HM,Arnold A

更新日期：1991-03-01 00:00:00

abstract：:ErbB-2 is an orphan receptor that belongs to a family of tyrosine kinase receptors for either epidermal growth factor (EGF) or Neu differentiation factor (NDF/neuregulin). Because overexpression of the erbB-2 proto-oncogene is frequently associated with an aggressive clinical course of certain human adenocarcinomas, t...

journal_title：Oncogene

authors： Klapper LN,Vaisman N,Hurwitz E,Pinkas-Kramarski R,Yarden Y,Sela M

更新日期：1997-05-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) encoded Latent Membrane Protein-1 (LMP1) mimics a constitutively active receptor molecule, and has been shown to activate NF-kappaB and the MAPK and JNK pathways. Two regions within the cytosolic domain of LMP1 have been found to effect cell signalling. One of these, the carboxy-terminal a...

journal_title：Oncogene

authors： Floettmann JE,Eliopoulos AG,Jones M,Young LS,Rowe M

更新日期：1998-11-05 00:00:00