Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b.

abstract：:Mesoderm formation in the frog, Xenopus laevis, is dependent on the activity of one or more members of the Src family kinases; the molecular interactions underlying this requirement are not well understood. The C-terminal Src Kinase (Csk) is a potent inhibitor of Src activity, and is required for normal mammalian deve...

journal_title：Oncogene

authors： Song Y,Cohler AN,Weinstein DC

更新日期：2001-08-23 00:00:00

abstract：:Survivin is a member of the inhibitor of apoptosis (IAP) gene family that has attracted attention from several viewpoints of basic and translational research. Its cell cycle-regulated expression at mitosis and association with the mitotic apparatus have been of interest to cell biologists studying faithful segregation...

journal_title：Oncogene

authors： Altieri DC

更新日期：2003-11-24 00:00:00

abstract：:We have cloned and sequenced the nov gene (novH) which is the homolog of the chicken nov proto-oncogene overexpressed in avian nephroblastomas. The novH gene is highly conserved and encodes a putative IGF-binding protein similar to that of chicken. We report that relative to autologous normal kidney expression of novH...

journal_title：Oncogene

authors： Martinerie C,Huff V,Joubert I,Badzioch M,Saunders G,Strong L,Perbal B

更新日期：1994-09-01 00:00:00

abstract：:Inactivation of the transforming growth factor-beta (TGF-beta) pathway occurs often in malignancies of the gastrointestinal (GI) system. However, only a fraction of sporadic GI tumors exhibit inactivating mutations in early stages of cancer formation, suggesting that other mechanisms play a critical role in the inacti...

journal_title：Oncogene

authors： Katuri V,Tang Y,Li C,Jogunoori W,Deng CX,Rashid A,Sidawy AN,Evans S,Reddy EP,Mishra B,Mishra L

更新日期：2006-03-23 00:00:00

abstract：:MCF2/DBL is an X-linked proto-oncogene encoding a protein with a yet undetermined function. It can be activated in vitro by loss of 5' sequences in NIH3T3 bioassays; in vivo, deletion of the gene has been found in some hemophilia B patients. PCR analysis of its expression in mouse tissues shows a restriction to the go...

journal_title：Oncogene

authors： Galland F,Pirisi V,de Lapeyriere O,Birnbaum D

更新日期：1991-05-01 00:00:00

abstract：:The expression of the monocyte-chemoattractant-protein-1 (MCP-1) is closely linked with a non-tumorigenic phenotype in somatic cell hybrids made between the human papillomavirus type 18 (HPV 18) positive cervical carcinoma cell line HeLa and normal human fibroblasts. In contrast, MCP-1 transcription is absent in tumor...

journal_title：Oncogene

authors： Finzer P,Soto U,Delius H,Patzelt A,Coy JF,Poustka A,zur Hausen H,Rösl F

更新日期：2000-07-06 00:00:00

abstract：:DAL-1 (differentially expressed in adenocarcinoma of the lung)/4.1B is a tumor suppressor gene on human chromosome 18p11.3 whose expression is lost in >50% of primary non-small-cell lung carcinomas. Based on sequence similarity, DAL-1/4.1B has been assigned to the Protein 4.1 superfamily whose members interact with pl...

journal_title：Oncogene

authors： Singh V,Miranda TB,Jiang W,Frankel A,Roemer ME,Robb VA,Gutmann DH,Herschman HR,Clarke S,Newsham IF

更新日期：2004-10-14 00:00:00

abstract：:The plasma membrane-associated tyrosine phosphatase PTPRO is frequently transcriptionally repressed in cancers and signifies poor prognosis of breast cancer patients. In this study, deletion of Ptpro in MMTV-Erbb2 transgenic mice dramatically shortened the mammary tumor latency and accelerated tumor growth due to loss...

journal_title：Oncogene

authors： Dong H,Ma L,Gan J,Lin W,Chen C,Yao Z,Du L,Zheng L,Ke C,Huang X,Song H,Kumar R,Yeung SC,Zhang H

更新日期：2017-01-19 00:00:00

abstract：:EndoA is a type II keratin and with EndoB (type I keratin), constitutes intermediate filaments in various simple epithelial tissues. EndoA is developmentally regulated and has an enhancer that is located at the 3'- end of the gene. This enhancer contains two single and five dual Ets binding sites. Thus far, no other p...

journal_title：Oncogene

authors： Seth A,Robinson L,Panayiotakis A,Thompson DM,Hodge DR,Zhang XK,Watson DK,Ozato K,Papas TS

更新日期：1994-02-01 00:00:00

abstract：:A search for protein tyrosine kinases expressed during murine cardiogenesis resulted in the isolation of a novel tyrosine kinase, designated tek, which maps to mouse chromosome 4 between the brown and pmv-23 loci. The deduced amino acid sequence of tek predicts that it encodes a putative receptor tyrosine kinase that ...

journal_title：Oncogene

authors： Dumont DJ,Yamaguchi TP,Conlon RA,Rossant J,Breitman ML

更新日期：1992-08-01 00:00:00

abstract：:ErbB2 amplification and overexpression in breast cancer correlates with aggressive disease and poor prognosis. To find novel ErbB2-interacting proteins, we used stable isotope labeling of amino acids in cell culture followed by peptide affinity pull-downs and identified specific binders using relative quantification b...

journal_title：Oncogene

authors： Heinrich C,Keller C,Boulay A,Vecchi M,Bianchi M,Sack R,Lienhard S,Duss S,Hofsteenge J,Hynes NE

更新日期：2010-03-18 00:00:00

abstract：:The development of hepatocellular carcinomas (HCC) depends on their local microenvironment and the induction of neovascularization is a decisive step in tumor progression, since the growth of solid tumors is limited by nutrient and oxygen supply. Hypoxia is the critical factor that induces transcription of the hypoxia...

journal_title：Oncogene

authors： Wen Y,Zhou X,Lu M,He M,Tian Y,Liu L,Wang M,Tan W,Deng Y,Yang X,Mayer MP,Zou F,Chen X

更新日期：2019-03-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is involved in diverse processes such as inflammation, carcinogenesis and apoptosis. As COX-2 inhibitors interfere with these processes, inhibition of COX-2 has been suggested as a promising anticancer treatment. However, the role of COX-2 in modulation of apoptosis as well as the death pathwa...

journal_title：Oncogene

authors： Totzke G,Schulze-Osthoff K,Jänicke RU

更新日期：2003-09-11 00:00:00

abstract：:Cancer cells acquire several traits that allow for their survival and progression, including the ability to evade the host immune response. However, the mechanisms by which cancer cells evade host immune responses remain largely elusive. Here we study the phenomena of immune evasion in malignant melanoma cells. We fin...

journal_title：Oncogene

authors： Dong Y,Richards JA,Gupta R,Aung PP,Emley A,Kluger Y,Dogra SK,Mahalingam M,Wajapeyee N

更新日期：2014-09-18 00:00:00

abstract：:Despite extensive characterization of the role of the EWS-ETS fusions, little is known about secondary genetic alterations and their clinical contribution to Ewing sarcoma (ES). It has been demonstrated that the molecular structure of EWS-ETS lacks prognostic value. Moreover, CDKN2A deletion and TP53 mutation, despite...

journal_title：Oncogene

authors： Mackintosh C,Ordóñez JL,García-Domínguez DJ,Sevillano V,Llombart-Bosch A,Szuhai K,Scotlandi K,Alberghini M,Sciot R,Sinnaeve F,Hogendoorn PC,Picci P,Knuutila S,Dirksen U,Debiec-Rychter M,Schaefer KL,de Álava E

更新日期：2012-03-08 00:00:00

abstract：:Polo-like kinases play critical roles during multiple stages of cell cycle progression. All Polo-like kinases contain an N-terminal Ser/Thr kinase catalytic domain and a C-terminal region that contains one or two Polo-boxes. For Polo-like kinase 1, 2, and 3, and their homologs, the entire C-terminal region, including ...

journal_title：Oncogene

authors： Lowery DM,Lim D,Yaffe MB

更新日期：2005-01-10 00:00:00

abstract：:A dual role of transforming growth factor β (TGF-β), to both suppress and promote tumor progression and metastasis, has been well established, but its molecular basis has remained elusive. In this review, we focus on Smad proteins, which are central mediators of the signal transduction of TGF-β family members. We desc...

journal_title：Oncogene

authors： Morikawa M,Koinuma D,Miyazono K,Heldin CH

更新日期：2013-03-28 00:00:00

abstract：:The NRG4 gene is a member of a family of four genes that encode a class of epidermal growth factors. This gene has been reported to express a protein designated here as NRG4A1. We describe here a novel splice variant of the NRG4 gene, NRG4A2, which encodes a C-terminal region containing a predicted type I PDZ-binding ...

journal_title：Oncogene

authors： Hayes NV,Newsam RJ,Baines AJ,Gullick WJ

更新日期：2008-01-24 00:00:00

abstract：:The adenomatous polyposis coli (APC) tumor suppressor is a nucleocytoplasmic protein. The nuclear accumulation of APC was recently found to vary depending on cell density, suggesting that putative APC function(s) in the nucleus is controlled by the establishment of cell contacts. We report here that the density-depend...

journal_title：Oncogene

authors： Fagman H,Larsson F,Arvidsson Y,Meuller J,Nordling M,Martinsson T,Helmbrecht K,Brabant G,Nilsson M

更新日期：2003-09-04 00:00:00

abstract：:Colon carcinogenesis is a multiple-step process involving the accumulation of a series of genetic and epigenetic alterations. The most commonly initiating event of intestinal carcinogenesis is mutation of the adenomatous polyposis coli (APC) gene, which leads to activation of the Wnt/β-catenin pathway. Olfactomedin 4 ...

journal_title：Oncogene

authors： Liu W,Li H,Hong SH,Piszczek GP,Chen W,Rodgers GP

更新日期：2016-10-06 00:00:00

abstract：:PSP94, for prostatic secretory protein of 94 amino acids, is secreted by the prostate gland and functions as a suppressor of tumor growth and metastasis. The expression of PSP94 is lost in advanced, hormone-refractory prostate cancer and this correlates with an increased expression of the Polycomb protein EZH2 (enhanc...

journal_title：Oncogene

authors： Beke L,Nuytten M,Van Eynde A,Beullens M,Bollen M

更新日期：2007-07-05 00:00:00

abstract：:The transcription factor NF-kappa-B is normally sequestered in the cytoplasm by its inhibitory subunit IkappaB. Most extracellular signals activate NF-kappa-B through a mechanism involving the phosphorylation and proteasome-dependent degradation of IkappaB. EGF activates NF-kappaB in A-431 carcinoma cells, which overe...

journal_title：Oncogene

authors： Sun L,Carpenter G

更新日期：1998-04-23 00:00:00

abstract：:Hepatitis C virus (HCV) core has a pleiotropic effect on various promoters. In this study, we found that the expression of nucleolar phosphoprotein B23 was enhanced in HCV core-expressing cells and, moreover, HCV core interacts directly with the C-terminal end of B23. Using sucrose gradient centrifugation analysis and...

journal_title：Oncogene

authors： Mai RT,Yeh TS,Kao CF,Sun SK,Huang HH,Wu Lee YH

更新日期：2006-01-19 00:00:00

abstract：:SALL4, a zinc-finger transcriptional factor for embryonic stem cell self-renewal and pluripotency, has been suggested to be involved in tumorigenesis. The role of SALL4 in human gastric cancer, however, remains largely unknown. In this study, we demonstrated that SALL4 was aberrantly expressed at both mRNA and protein...

journal_title：Oncogene

authors： Zhang L,Xu Z,Xu X,Zhang B,Wu H,Wang M,Zhang X,Yang T,Cai J,Yan Y,Mao F,Zhu W,Shao Q,Qian H,Xu W

更新日期：2014-11-27 00:00:00

abstract：:Unique hybrids (HINS and CANS lines) between macrophages and a myeloma cell line, NS1 initially expressed myeloma functions but later expressed active macrophage functions together with constitutive expression of c-fos gene. Enhancement of c-fos transcription was also observed in activated mouse peritoneal macrophages...

journal_title：Oncogene

authors： Higuchi Y,Setoguchi M,Yoshida S,Akizuki S,Yamamoto S

更新日期：1988-05-01 00:00:00

abstract：:The Wilms' tumor suppressor gene, WT1, functions as a transcriptional regulator that represses or activates the expression of a variety of putative target genes. However, it is not clear which genes are the biological targets of WT1, nor which cellular pathway(s) is critically altered in tumors as a result of WT1 muta...

journal_title：Oncogene

authors： Udtha M,Lee SJ,Alam R,Coombes K,Huff V

更新日期：2003-06-12 00:00:00

abstract：:Centromeric instability is characterized by dynamic formation of centromeric breaks, deletions, isochromosomes and translocations, which are commonly observed in cancer. So far, however, the mechanisms of centromeric instability in cancer cells are still poorly understood. In this study, we tested the hypothesis that ...

journal_title：Oncogene

authors： Deng W,Tsao SW,Mak GW,Tsang CM,Ching YP,Guan XY,Huen MS,Cheung AL

更新日期：2011-03-17 00:00:00

abstract：:Galectin-3 is a multifunctional carbohydrate-binding protein found in the nucleus, cytoplasm and the extracellular milieu. Nuclear galectin-3 expression is associated with cell proliferation, and its role in pre-mRNA splicing has been suggested. In this report, we investigated the role of galectin-3 on cyclin D(1) gen...

journal_title：Oncogene

authors： Lin HM,Pestell RG,Raz A,Kim HR

更新日期：2002-11-14 00:00:00

abstract：:The tumor suppressor p53 has been found to be the most commonly mutated gene in human cancers; however, the frequency of p53 mutations varies from 10 to 70% across different cancer types. This variability can partly be explained by inactivating mechanisms aside from direct genomic polymorphisms. The p53 gene encodes 1...

journal_title：Oncogene

authors： Takahashi R,Giannini C,Sarkaria JN,Schroeder M,Rogers J,Mastroeni D,Scrable H

更新日期：2013-06-27 00:00:00

abstract：:Since defects in molecular mechanisms controlling DNA repair, cell cycle checkpoint and apoptosis could modify cellular sensitivity to DNA damaging agents, we have conducted a multiparametric molecular analysis for better understanding the regulation pathways leading to cell survival or cell death after irradiation. U...

journal_title：Oncogene

authors： Bishay K,Ory K,Lebeau J,Levalois C,Olivier MF,Chevillard S

更新日期：2000-02-17 00:00:00