Abstract：
:The c-Myc transcription factor activates a cascade of downstream targets to form a complex transcriptional program that ultimately leads to cellular transformation. Although a large number of protein-encoding genes as well as non-coding RNAs were identified as Myc targets, only a few have been validated to be functionally important for c-Myc-driven transformation. Here, we identify a microRNA (miRNA), miR-378, as a novel target of the c-Myc oncoprotein that is able to cooperate with activated Ras or HER2 to promote cellular transformation. Mechanistically, miR-378 achieves this oncogenic effect, at least in part, by targeting and inhibiting the anti-proliferative BTG family member, TOB2, which is further elucidated as a candidate tumor suppressor to transcriptionally repress proto-oncogene cyclin D1. Therefore, our study identifies miR-378-TOB2-cyclin D1 as a functional module to mediate the cross talk between Myc and Ras signaling in cellular transformation.
journal_name
Oncogenejournal_title
Oncogeneauthors
Feng M,Li Z,Aau M,Wong CH,Yang X,Yu Qdoi
10.1038/onc.2010.602subject
Has Abstractpub_date
2011-05-12 00:00:00pages
2242-51issue
19eissn
0950-9232issn
1476-5594pii
onc2010602journal_volume
30pub_type
杂志文章相关文献
ONCOGENE文献大全abstract：:Genetic analysis of beta-catenin-induced oncogenic transformation in chicken embryo fibroblasts (CEF) revealed the following prerequisites for oncogenicity: (1) removal of the N terminal phosphorylation sites targeted by glycogen synthase kinase 3beta (GSK3beta), (2) retention of the N terminal transactivation domain,...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1205796
更新日期：2002-10-10 00:00:00
abstract：:Although it has been demonstrated that transformed progenitor cell population can contribute to tumor initiation, factors contributing to this malignant transformation are poorly known. Using in vitro and xenograft-based models, previous studies demonstrated that miR-489 acts as a tumor suppressor miRNA by targeting v...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-018-0439-1
更新日期：2019-01-01 00:00:00
abstract：:Internal tandem duplication (ITD) of the juxtamembrane (JM) domain of FLT3 is the most frequent mutation in human acute myeloid leukemia, and is significantly associated with leukocytosis and a poor prognosis. Previously we reported that FLT3 with ITD (FLT3/ITD) formed a homodimer and was autophosphorylated on tyrosin...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1205332
更新日期：2002-04-11 00:00:00
abstract：:Basal type breast cancer is the most aggressive and has mesenchymal features with a high metastatic ability. However, the signaling node that determines the basal type features in breast cancer remains obscure. Here, we report that FYN among SRC family kinases is required for the maintenance of basal type breast cance...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-017-0114-y
更新日期：2018-04-01 00:00:00
abstract：:The introduction of highly active antiretroviral therapy (HAART) has changed dramatically the landscape of HIV disease. Deaths from AIDS-related diseases have been reduced by 75% since protease inhibitor therapy and combination antiretroviral therapy came into use in late 1995. While KS is declining, the situation for...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1206771
更新日期：2003-09-29 00:00:00
abstract：:Dietary effects are presumed to underlie many of the large international differences in incidence seen for most cancers. Apart from alcohol and a few micronutrients, however, the role of specific nutritional factors remains ill-defined. The evidence for a role of energy balance, physical inactivity, and obesity has st...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1207716
更新日期：2004-08-23 00:00:00
abstract：:The antifolates were the first class of antimetabolites to enter the clinics more than 50 years ago. Over the following decades, a full understanding of their mechanisms of action and chemotherapeutic potential evolved along with the mechanisms by which cells develop resistance to these drugs. These principals served ...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1206946
更新日期：2003-10-20 00:00:00
abstract：:Angiogenesis is essential for tumor growth and blocking this process might be a valid tool for the control of cancer growth. We showed previously that tumor angiogenesis in integrin alpha1-null mice is reduced compared to that of wild type animals and that over-expression of matrix metalloproteinase 9 (MMP-9) in the a...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1205045
更新日期：2002-01-10 00:00:00
abstract：:PIKE-A (phosphoinositide 3-kinases (PI 3)-kinase enhancer) is a ubiquitously expressed GTPase, which binds to and enhances protein kinase B (Akt) kinase activity in a guanine nucleotide-dependent manner. PIKE-A is one of the components of the CDK4 amplicon that is amplified in numerous human cancers. However, whether ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1210290
更新日期：2007-07-26 00:00:00
abstract：:MCF2/DBL is an X-linked proto-oncogene encoding a protein with a yet undetermined function. It can be activated in vitro by loss of 5' sequences in NIH3T3 bioassays; in vivo, deletion of the gene has been found in some hemophilia B patients. PCR analysis of its expression in mouse tissues shows a restriction to the go...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：:EndoA is a type II keratin and with EndoB (type I keratin), constitutes intermediate filaments in various simple epithelial tissues. EndoA is developmentally regulated and has an enhancer that is located at the 3'- end of the gene. This enhancer contains two single and five dual Ets binding sites. Thus far, no other p...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1994-02-01 00:00:00
abstract：:Epstein-Barr virus (EBV) is associated with tumours of both lymphoid and epithelial origin. Whilst a role for EBV latent genes in the development of these malignancies is accepted, it is also possible that viral proteins involved in EBV replication may influence the oncogenic process. BHRF1 is an immediate early prote...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-01-05 00:00:00
abstract：:To identify tyrosine kinases that may regulate regeneration of the mammalian intestinal epithelium, we amplified portions of the catalytic domains of protein kinases expressed in intestinal crypt cells, using the polymerase chain reaction technique with primers directed against two invariant amino acid sequence motifs...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:Arg and c-Abl represent the mammalian member of the Abelson family of nonreceptor protein tyrosine kinases. The two proteins are composed of SH2, SH3, kinase and C-terminal domains. To examine Arg structure-function relationships we analysed a Gag-Arg fusion protein, analogous to the oncogenic Gag-Abl fusion protein o...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：:As apoptosis defects limit efficacy of anticancer agents, autophagy has been proposed as a novel strategy for radiotherapy enhancement. We previously showed that caspase-3/7 inhibition induces autophagy and promotes radiosensitivity in vitro and in vivo. Therefore, we further investigated the mechanism by which radiat...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2010.74
更新日期：2010-06-03 00:00:00
abstract：:Amplification and overexpression of the E2F3 gene at 6p22 in human bladder cancer is associated with increased tumour stage, grade and proliferation index, and in prostate cancer E2F3 overexpression is linked to tumour aggressiveness. We first used small interfering RNA technology to confirm the potential importance o...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209854
更新日期：2007-02-15 00:00:00
abstract：:Amplification of the N-myc gene is a significant adverse prognostic factor in neuroblastoma, a common childhood tumor. In non-transformed cells, myc expression is controlled through an autoregulatory circuit, through which elevated Myc protein levels lead to down-regulation of myc transcription. The precise mechanism ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1201363
更新日期：1997-10-16 00:00:00
abstract：:Human polyomaviruses (JC virus, BK virus and simian virus 40) are causative agents of some human diseases and, interestingly, are involved in processes of cell transformation and oncogenesis. These viruses need the cell cycle machinery of the host cell to complete their replication; so they evolved mechanisms that can...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1209681
更新日期：2006-08-28 00:00:00
abstract：:Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER-) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however,...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-018-0624-2
更新日期：2019-04-01 00:00:00
abstract：:We have previously reported that carboxyl terminal truncations of the normal human fyn gene, a member of the src subfamily, can transform immortal mouse fibroblasts to full malignancy. In search of evidence which suggests the possible activation of the human fyn gene, we have screened DNAs and RNAs from a number of hu...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：:Retinoic acid receptor alpha (RARα) has a critical role in the differentiation process of osteosarcoma cells induced by all-trans retinoic acid (ATRA). However, degradation of RARα through ubiquitin proteasome pathway weakens the differentiation efficiency of osteosarcoma cells. In this study, we discover that murine ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2015.503
更新日期：2016-08-18 00:00:00
abstract：:Antioxidant response element (ARE)-mediated expression and coordinated induction of genes encoding detoxifying enzymes is one mechanism of critical importance to cellular protection against oxidative stress. In the present report, we demonstrate that nuclear transcription factors Nrf2 and Nrf1 associate with Jun (c-Ju...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1202237
更新日期：1998-12-17 00:00:00
abstract：:Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different human DNA glycosylases may remove uracil and thus generate an abasic site, which is itself cytotoxic and potentially mutagenic. These e...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1205996
更新日期：2002-12-16 00:00:00
abstract：:Exposure of CV-1P cells to hypoxic conditions results in reversible cell cycle arrest concomitant with accumulation of pRB in the hypophosphorylated, growth suppressive form. Similar to cell cycle arrest induced by serum starvation, we show here that hypoxia-induced arrest is accompanied by a decrease in pRB-directed ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1202159
更新日期：1998-11-05 00:00:00
abstract：:Chromosome 17 is one of the most frequently altered chromosomes in malignant breast cancer. At least four genes implicated in breast cancer reside on chromosome 17 (p53, 17p13; Her-2/neu/ERBB2, 17q12; BRCA1, 17q21; and nm23, 17q22). In addition, allelic imbalance has been described for at least five regions of chromos...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1201073
更新日期：1997-05-15 00:00:00
abstract：:The epithelium-specific transcription factor, ERT/ESX/ESE-1/ELF3, binds to the TGF-beta RII promoter in a sequence specific manner and regulates its expression. In this study, we investigated whether ERT could regulate endogenous TGF-beta RII expression in Hs578t breast cancer cells. Analyses of the Hs578t parental ce...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203252
更新日期：2000-01-06 00:00:00
abstract：:The angiogenic peptide adrenomedullin (ADM) has been implicated as a mediator of the increased risk of endometrial hyperplasia and cancer resulting from the use of tamoxifen for the treatment and prevention of breast cancer. ADM has been shown to be induced by tamoxifen in the endometrium and to be a growth factor for...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1205374
更新日期：2002-04-25 00:00:00
abstract：:The NF-kappaB signaling pathway has particular relevance to several liver diseases including hepatitis (liver infection by Helicobacter, viral hepatitis induced by HBV and HCV), liver fibrosis and cirrhosis and hepatocellular carcinoma. Furthermore, the NF-kappaB signaling pathway is a potential target for development...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/onc.2008.300
更新日期：2008-10-20 00:00:00
abstract：:Deletion or loss-of-function mutation of LKB1, frequently occurring in non-small cell lung cancers (NSCLCs), is a predominant caution of NSCLC initiation and progression. However, the upstream signaling pathways governing LKB1 activation are largely unknown. Here, we report that LKB1 undergoes Aurora kinase A (AURKA)-...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2017.354
更新日期：2018-01-25 00:00:00
abstract：:High-grade gliomas (HGG) afflict both children and adults and respond poorly to current therapies. Epigenetic regulators have a role in gliomagenesis, but a broad, functional investigation of the impact and role of specific epigenetic targets has not been undertaken. Using a two-step, in vitro/in vivo epigenomic shRNA...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-019-1125-7
更新日期：2020-03-01 00:00:00
