Abstract:
:Insights into the pathogenesis of human leukemia have relied heavily on studies of the identified chromosomal translocations found in this group of malignant diseases. Acquired, balanced translocations in acute myelogenous leukemia (AML) generally involve transcriptional regulatory genes, whereas in the myeloproliferative disorders tyrosine kinases are frequently involved. These rearrangements alter the function of at least one and often both of the involved genes. In this review, we focus on the AML1-ETO (a.k.a. RUNX1-ETO) fusion protein, which is found in t(8;21)+ AML. Expression of AML1-ETO in human hematopoietic stem cells (HSCs) preferentially enhances their maintenance, as opposed to their differentiation. The direct effects of AML1-ETO on human and murine HSCs, and the potentially cooperating events that may contribute to its leukemogenic properties, are discussed.
journal_name
Oncogenejournal_title
Oncogeneauthors
Nimer SD,Moore MAdoi
10.1038/sj.onc.1207673subject
Has Abstractpub_date
2004-05-24 00:00:00pages
4249-54issue
24eissn
0950-9232issn
1476-5594pii
1207673journal_volume
23pub_type
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