Discovery of a novel dual-target inhibitor against RSK1 and MSK2 to suppress growth of human colon cancer.

abstract：:In spite of relentless efforts to devise new treatment strategies, primary glioblastomas invariably recur as aggressive, therapy-resistant relapses and patients rapidly succumb to these tumors. Many therapeutic agents are first tested in clinical trials involving recurrent glioblastomas. Remarkably, however, fundament...

journal_title：Oncogene

authors： Campos B,Olsen LR,Urup T,Poulsen HS

更新日期：2016-11-10 00:00:00

abstract：:Fos protein heterodimerizes through one surface of an alpha-helical domain called the leucine zipper. We have investigated the effect of destabilizing this domain by multiply substituting small residues of its non-interacting surface with glycine. Ternary complex formation between mutated Fos, Jun and DNA was determin...

journal_title：Oncogene

authors： Nicklin MJ,Zechner D,Kislyakova T

更新日期：1993-07-01 00:00:00

abstract：:Expression of PTEN tumor suppressor gene has been known to dephosphorylate the phosphatidylinositol 3' kinase (PI3K) products on the 3 prime inositol ring, resulting in reduced Akt activation. Loss of PTEN expression in OPM2 and delta47 human myeloma lines led to high Akt activity toward insulin-like growth factor I (...

journal_title：Oncogene

authors： Choi Y,Zhang J,Murga C,Yu H,Koller E,Monia BP,Gutkind JS,Li W

更新日期：2002-08-08 00:00:00

abstract：:Colony-stimulating factors and other cytokines signal via their cognate receptors to regulate hematopoiesis. In many developmental systems, inductive signalling determines cell fate and, by analogy with this, it has been postulated that cytokines, signalling via their cognate receptors, may play an instructive role in...

journal_title：Oncogene

authors： Robb L

更新日期：2007-10-15 00:00:00

abstract：:Protein-protein interaction can play an important role in the control of several biological events including gene transcription, replication and cell proliferation. E2F-1 is a DNA-binding transcription factor which, upon interaction with its target DNA sequence, induces expression of several S phase specific genes all...

journal_title：Oncogene

authors： Darbinian N,Gallia GL,Kundu M,Shcherbik N,Tretiakova A,Giordano A,Khalili K

更新日期：1999-11-04 00:00:00

abstract：:All mature blood cells originate from a small population of self-renewing pluripotent hematopoietic stem cells (HSCs). The capacity to self-renew characterizes all stem cells, whether normal or neoplastic. Interestingly, recent studies suggest that self-renewal is essential for tumor cell maintenance, implicating that...

journal_title：Oncogene

authors： Lessard J,Faubert A,Sauvageau G

更新日期：2004-09-20 00:00:00

abstract：:We have recently described the N-terminal RAS association domain family of genes, RASSF7-10. Previously, we cloned the N-terminal RASSF10 gene and demonstrated frequent methylation of the associated 5'-CpG island in acute lymphoblastic leukemia. To characterize RASSF10 gene expression, we demonstrate that in developin...

journal_title：Oncogene

authors： Hill VK,Underhill-Day N,Krex D,Robel K,Sangan CB,Summersgill HR,Morris M,Gentle D,Chalmers AD,Maher ER,Latif F

更新日期：2011-02-24 00:00:00

abstract：:The protein kinase encoded by the ataxia telangiectasia and Rad3-related (ATR) gene is activated by DNA-damaging agents that are frequently used as anticancer therapeutics. Inhibition of ATR expression in cultured cancer cells has been demonstrated to increase sensitivity to chemotherapeutic drugs, including the DNA-c...

journal_title：Oncogene

authors： Sangster-Guity N,Conrad BH,Papadopoulos N,Bunz F

更新日期：2011-06-02 00:00:00

abstract：:The adenomatous polyposis coli (APC) tumor suppressor is a nucleocytoplasmic protein. The nuclear accumulation of APC was recently found to vary depending on cell density, suggesting that putative APC function(s) in the nucleus is controlled by the establishment of cell contacts. We report here that the density-depend...

journal_title：Oncogene

authors： Fagman H,Larsson F,Arvidsson Y,Meuller J,Nordling M,Martinsson T,Helmbrecht K,Brabant G,Nilsson M

更新日期：2003-09-04 00:00:00

abstract：:Histone acetyltransferases (HATs) have a central role in the modification of chromatin as well as in the pathogenesis of a broad set of diseases including cancers. Gcn5 is the first identified transcription-related HAT that has been implicated in the regulation of diverse cellular functions. However, how Gcn5 proteins...

journal_title：Oncogene

authors： Li Y,Jaramillo-Lambert AN,Yang Y,Williams R,Lee NH,Zhu W

更新日期：2012-02-02 00:00:00

abstract：:Urothelial carcinoma (UC) carcinogenesis has been hypothesized to occur through epigenetic repression of tumor-suppressor genes (TSGs). By quantitative real-time polymerase chain reaction array, we found that one potential TSG, angiopoietin-like 4 (ANGPTL4), was expressed at very low levels in all bladder cancer cell ...

journal_title：Oncogene

authors： Hsieh HY,Jou YC,Tung CL,Tsai YS,Wang YH,Chi CL,Lin RI,Hung SK,Chuang YM,Wu SF,Li C,Shen CH,Chan MWY,Hsu CD

更新日期：2018-02-01 00:00:00

abstract：:Binding partners of the Src homology domains of Vav-1 were characterized by a two-hybrid screening of a Jurkat cell cDNA library. One of the isolated clones encoded a new protein named VIK that belongs to the Kruppel-like zinc-finger gene family. Genome mapping showed that a single gene positioned at chromosome 7q22.1...

journal_title：Oncogene

authors： Houlard M,Romero-Portillo F,Germani A,Depaux A,Regnier-Ricard F,Gisselbrecht S,Varin-Blank N

更新日期：2005-01-06 00:00:00

abstract：:The crizotinib-resistant ALK(F1174L) mutation arises de novo in neuroblastoma (NB) and is acquired in ALK translocation-driven cancers, lending impetus to the development of novel anaplastic lymphoma kinase (ALK) inhibitors with different modes of action. The diaminopyrimidine TAE684 and its derivative ceritinib (LDK3...

journal_title：Oncogene

authors： Debruyne DN,Bhatnagar N,Sharma B,Luther W,Moore NF,Cheung NK,Gray NS,George RE

更新日期：2016-07-14 00:00:00

abstract：:Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human m...

journal_title：Oncogene

authors： Filippou PS,Karagiannis GS,Constantinidou A

更新日期：2020-03-01 00:00:00

abstract：:Nucleophosmin (NPM) is a nucleus-cytoplasmic shuttling protein that is implicated in centrosome duplication, cell cycle progression and stress response. At the steady state, NPM localizes mainly in the nucleolus, where it forms a complex with different cellular proteins. One-third of acute myeloid leukemias (AML) are ...

journal_title：Oncogene

authors： Mariano AR,Colombo E,Luzi L,Martinelli P,Volorio S,Bernard L,Meani N,Bergomas R,Alcalay M,Pelicci PG

更新日期：2006-07-20 00:00:00

abstract：:Deregulation of Wnt signalling has recently been implicated in human renal cancer. Here, we directly test this association by using a Cre-LoxP strategy to inactivate the Adenomatous Polyposis Coli (Apc) gene in the murine renal epithelium. Mice homozygous for a conditional Apc allele were intercrossed with mice transg...

journal_title：Oncogene

authors： Sansom OJ,Griffiths DF,Reed KR,Winton DJ,Clarke AR

更新日期：2005-12-08 00:00:00

abstract：:The growth and dissemination of tumors rely on an altered vascular network, which supports their survival and expansion and provides accessibility to the vasculature and a route of transport for metastasizing tumor cells. The remodeling of vascular structures through generation of new vessels (for example, via tumor a...

journal_title：Oncogene

authors： Farnsworth RH,Lackmann M,Achen MG,Stacker SA

更新日期：2014-07-03 00:00:00

abstract：:Hec1 (highly expressed in cancer 1) or Nek2 (NIMA-related kinase 2) is often overexpressed in cancers with poor prognosis. Both are critical mitotic regulators, and phosphorylation of Hec1 S165 by Nek2 is required for proper chromosome segregation. Therefore, inactivation of Hec1 and Nek2 by targeting their interactio...

journal_title：Oncogene

authors： Hu CM,Zhu J,Guo XE,Chen W,Qiu XL,Ngo B,Chien R,Wang YV,Tsai CY,Wu G,Kim Y,Lopez R,Chamberlin AR,Lee EY,Lee WH

更新日期：2015-03-05 00:00:00

abstract：:Proteolytic cleavage of the extracellular domain of CD44 from the surface of cells has been observed recently in different cell types. In cell culture supernatants of human melanoma cell lines a 70 kDa soluble CD44 protein (solCD44) was detected at concentrations of 250-300 ng/ml. Protease inhibitor studies revealed t...

journal_title：Oncogene

authors： Ahrens T,Sleeman JP,Schempp CM,Howells N,Hofmann M,Ponta H,Herrlich P,Simon JC

更新日期：2001-06-07 00:00:00

abstract：:Knowledge of the type of biological reaction to chemotherapy is a prerequisite for its rational enhancement. We previously showed that irinotecan-induced DNA damage triggers in the HCT116p53(wt) colon carcinoma cell line a long-term cell cycle arrest and in HCT116p53(-/-) cells apoptosis (Magrini et al., 2002). To com...

journal_title：Oncogene

authors： Bhonde MR,Hanski ML,Notter M,Gillissen BF,Daniel PT,Zeitz M,Hanski C

更新日期：2006-01-12 00:00:00

abstract：:Collagenase1 (MMP1) and stromelysin1 (MMP3) are extracellular proteolytic enzymes that degrade connective tissue macromolecules and basement membranes. Both genes are regulated by the Ets and Fos/Jun families of transcription factors/oncoproteins. Here, we show that two members of the Ets-family, Ets2 and Erg and thei...

journal_title：Oncogene

authors： Butticè G,Duterque-Coquillaud M,Basuyaux JP,Carrère S,Kurkinen M,Stéhelin D

更新日期：1996-12-05 00:00:00

abstract：:Treatment of mice with the carcinogen azoxymethane (AOM) induces a number of lesions in the colon, including hyperplastic lesions, as well adenomas and carcinomas in situ. Inbred strains of mice show different responses to AOM-induced carcinogenesis. A/J mice are highly susceptible and develop a greater number of hype...

journal_title：Oncogene

authors： Meunier C,Cai J,Fortin A,Kwan T,Marquis JF,Turbide C,Van Der Kraak L,Jothy S,Beauchemin N,Gros P

更新日期：2010-02-04 00:00:00

abstract：:Epigenetic regulation of gene expression is critical in the maintenance of cellular homeostasis. Dysregulation of normal epigenetic transcription occurs in abnormal physiological conditions, such as those seen in cancer cells and cells infected with parasites, making the mechanism underlying abnormal epigenetic transc...

journal_title：Oncogene

authors： Ego T,Tanaka Y,Shimotohno K

更新日期：2005-03-10 00:00:00

abstract：:The mitochondrial apoptosis pathway mediates cell death through the release of various pro-apoptotic factors including cytochrome c and Smac, the second mitochondrial activator of caspases, into the cytosol. Smac was shown previously to inhibit IAP proteins and to facilitate initiation of the caspase cascade upon cyto...

journal_title：Oncogene

authors： Hasenjäger A,Gillissen B,Müller A,Normand G,Hemmati PG,Schuler M,Dörken B,Daniel PT

更新日期：2004-06-03 00:00:00

abstract：:Tumor recurrence following treatment remains a major clinical challenge in oral cavity cancer. Cancer stem cells (CSCs) have been isolated from human oral cancers and been considered as the driving force of tumor recurrence and metastasis. However, it still remains unclear whether targeting CSCs in oral cancer is a cl...

journal_title：Oncogene

authors： Hu J,Mirshahidi S,Simental A,Lee SC,De Andrade Filho PA,Peterson NR,Duerksen-Hughes P,Yuan X

更新日期：2019-07-01 00:00:00

abstract：:Ewing sarcoma is characterized by the expression of the chimeric EWSR1-FLI1 transcription factor. Proteomic analyses indicate that the decrease of EWSR1-FLI1 expression leads to major changes in effectors of the dynamics of the actin cytoskeleton and the adhesion processes with a shift from cell-to-cell to cell-matrix...

journal_title：Oncogene

authors： Franzetti GA,Laud-Duval K,van der Ent W,Brisac A,Irondelle M,Aubert S,Dirksen U,Bouvier C,de Pinieux G,Snaar-Jagalska E,Chavrier P,Delattre O

更新日期：2017-06-22 00:00:00

abstract：:We have utilized c-abl antibodies and an in vitro kinase assay to identify the protein products of the c-abl gene in mouse testis. Although the testis contains high levels of a unique c-abl mRNA, along with lower amounts of two c-abl mRNAs common to somatic cells, we detected only a single polypeptide of approximately...

journal_title：Oncogene

authors： Ponzetto C,Wadewitz AG,Pendergast AM,Witte ON,Wolgemuth DJ

更新日期：1989-06-01 00:00:00

abstract：:To gain better understanding of the molecular alterations responsible for the aggressive growth potential of epidermal growth factor receptor (EGFR)-positive breast cancers, we utilized an expression cloning strategy to seek gene products that mediate the EGF-independent growth of human breast cancer cells. A retrovir...

journal_title：Oncogene

authors： Berquin IM,Dziubinski ML,Nolan GP,Ethier SP

更新日期：2001-07-05 00:00:00

abstract：:Caveolin-1 (Cav1) is an integral membrane, scaffolding protein found in plasma membrane invaginations (caveolae). Cav1 regulates multiple cancer-associated processes. In breast cancer, a tumor suppressive role for Cav1 has been suggested; however, Cav1 is frequently overexpressed in aggressive breast cancer subtypes, ...

journal_title：Oncogene

authors： Rao X,Evans J,Chae H,Pilrose J,Kim S,Yan P,Huang RL,Lai HC,Lin H,Liu Y,Miller D,Rhee JK,Huang YW,Gu F,Gray JW,Huang TM,Nephew KP

更新日期：2013-09-19 00:00:00

abstract：:Mitochondria have been classically characterized as organelles with responsibility for cellular energy production in the form of ATP, but they are also the organelles through which apoptotic signaling occurs. Cell stress stimuli can result in outer membrane permeabilization, after which mitochondria release numerous p...

journal_title：Oncogene

authors： Kilbride SM,Prehn JH

更新日期：2013-05-30 00:00:00