The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.

abstract：:In previous studies examining the role of pp60c-src in cellular proliferation, we demonstrated that overexpression of wild type (wt) but not mutated c-src in C3H10T1/2 murine embryo fibroblasts resulted in a 2 to 5 fold enhancement of DNA synthesis in response to epidermal growth factor (EGF). Using phosphotyrosine an...

journal_title：Oncogene

authors： Wilson LK,Parsons SJ

更新日期：1990-10-01 00:00:00

abstract：:A candidate gene (WT1) has recently been described for the 11p13 tumour-suppressor gene involved in the development of Wilms' tumour. This gene encodes a zinc finger protein which can bind to a specific DNA sequence. We have found a 226 base deletion in the mRNA from a unilateral Wilms' tumour, which would cause a fra...

journal_title：Oncogene

authors： Brown KW,Watson JE,Poirier V,Mott MG,Berry PJ,Maitland NJ

更新日期：1992-04-01 00:00:00

abstract：:N-cadherin is a cell-cell adhesion molecule that plays a role in breast cancer metastasis. Here, we show that in vivo expression of N-cadherin in the PyMT mouse model, which enhances mammary tumor metastasis, results in selective inhibition of Akt3 expression and phosphorylation. Similarly, exogenous expression of N-c...

journal_title：Oncogene

authors： Chung S,Yao J,Suyama K,Bajaj S,Qian X,Loudig OD,Eugenin EA,Phillips GR,Hazan RB

更新日期：2013-01-24 00:00:00

abstract：:p8 is a stress-induced DNA-binding protein, biochemically related to the architectural chromatin binding HMG protein family and whose function is presently unknown. We obtained fibroblast from mice lacking p8 and found that p8 is involved in cell growth regulation and in apoptosis. p8(-/-) mouse embryonic fibroblasts ...

journal_title：Oncogene

authors： Vasseur S,Hoffmeister A,Garcia-Montero A,Mallo GV,Feil R,Kühbandner S,Dagorn JC,Iovanna JL

更新日期：2002-03-07 00:00:00

abstract：:We have previously reported that there is a high incidence of microsatellite instability (MSI) and germline mismatch repair gene mutation in colorectal cancer arising from young Hong Kong Chinese. Most of the germline mutations involve hMSH2, which is different from the mutation spectrum in the Western population. It ...

journal_title：Oncogene

authors： Chan TL,Yuen ST,Ho JW,Chan AS,Kwan K,Chung LP,Lam PW,Tse CW,Leung SY

更新日期：2001-05-24 00:00:00

abstract：:We showed earlier that p300/CBP plays an important role in G1 progression by negatively regulating c-Myc and thereby preventing premature G1 exit. Here, we have studied the mechanism by which p300 represses c-Myc and show that in quiescent cells p300 cooperates with histone deacetylase 3 (HDAC3) to repress transcripti...

journal_title：Oncogene

authors： Sankar N,Baluchamy S,Kadeppagari RK,Singhal G,Weitzman S,Thimmapaya B

更新日期：2008-09-25 00:00:00

abstract：:Protein kinase A (PKA) hyperactivation causes hereditary endocrine neoplasias; however, its role in sporadic epithelial cancers is unknown. Here, we show that heightened PKA activity in the mammary epithelium generates tumors. Mammary-restricted biallelic ablation of Prkar1a, which encodes for the critical type-I PKA ...

journal_title：Oncogene

authors： Beristain AG,Molyneux SD,Joshi PA,Pomroy NC,Di Grappa MA,Chang MC,Kirschner LS,Privé GG,Pujana MA,Khokha R

更新日期：2015-02-26 00:00:00

abstract：:Tumor necrosis factor (TNF) induces both cell death and survival signals. NF-kappaB, a transcription factor activated by TNF, is critical for controlling survival signals through trans-activation of downstream target genes. However, few NF-kappaB target survival genes have been identified with direct roles in oncogene...

journal_title：Oncogene

authors： Au PY,Martin N,Chau H,Moemeni B,Chia M,Liu FF,Minden M,Yeh WC

更新日期：2005-04-28 00:00:00

abstract：:The p14ARF tumor suppressor is a key regulator of cellular proliferation, frequently inactivated in human cancer. The mechanisms that regulate alternative reading frame (ARF) turnover have been obscure for long time, being ARF a relatively stable protein. Recently, it has been described that its degradation depends, a...

journal_title：Oncogene

authors： Pollice A,Sepe M,Villella VR,Tolino F,Vivo M,Calabrò V,La Mantia G

更新日期：2007-08-02 00:00:00

abstract：:Myogenic transcription is repressed in myoblasts by serum-activated cyclin-dependent kinases, such as cdk2 and cdk4. Serum withdrawal promotes muscle-specific gene expression at least in part by down-regulating the activity of these cdks. Unlike the other cdks, cdk9 is not serum- or cell cycle-regulated and is instead...

journal_title：Oncogene

authors： Simone C,Stiegler P,Bagella L,Pucci B,Bellan C,De Falco G,De Luca A,Guanti G,Puri PL,Giordano A

更新日期：2002-06-13 00:00:00

abstract：:Much evidence has been gathered in support of a critical role for p53 in the cellular response to DNA damage. p53 dysfunction is associated with progression and poor prognosis of many human cancers and with a high incidence of tumours in p53 knockout mice. The absence of a p53-dependent G1 arrest that facilitates DNA ...

journal_title：Oncogene

authors： Griffiths SD,Clarke AR,Healy LE,Ross G,Ford AM,Hooper ML,Wyllie AH,Greaves M

更新日期：1997-02-06 00:00:00

abstract：:Tumor cells are characterized by deregulated proliferation and resistance to proapoptotic stimuli. The Bcl-2 family of antiapoptotic proteins is overexpressed in a large number of chemoresistant tumors. Downregulation or inhibition of antiapoptotic proteins might result in the sensitization of cancer cells to chemothe...

journal_title：Oncogene

authors： Nouvion AL,Thibaut J,Lohez OD,Venet S,Colas P,Gillet G,Lalle P

更新日期：2007-02-01 00:00:00

abstract：:Krüppel-like factor 8 (KLF8) is a transcriptional factor critical for metastatic progression of breast cancer. Epithelial stromal interaction 1 (EPSTI1), a recently identified stromal fibroblast-induced gene in non-invasive breast cancer cells is highly overexpressed in invasive breast carcinomas. The function and reg...

journal_title：Oncogene

authors： Li T,Lu H,Shen C,Lahiri SK,Wason MS,Mukherjee D,Yu L,Zhao J

更新日期：2014-09-25 00:00:00

abstract：:Prostate cancer (PCa) cell proliferation is dependent on activation of the androgen receptor (AR), a ligand-dependent transcription factor. AR activation controls G1-S phase progression through fostering enhanced translation of the D-type cyclins, which promote cell cycle progression through activation of CDK4/6. Howe...

journal_title：Oncogene

authors： Olshavsky NA,Groh EM,Comstock CE,Morey LM,Wang Y,Revelo MP,Burd C,Meller J,Knudsen KE

更新日期：2008-05-15 00:00:00

abstract：:The cochaperone CDC37 promotes the association of HSP90 with the protein kinase subset of client proteins to maintain their stability and signalling functions. HSP90 inhibitors induce depletion of clients, which include several oncogenic kinases. We hypothesized that the targeting of CDC37 using siRNAs would compromis...

journal_title：Oncogene

authors： Smith JR,Clarke PA,de Billy E,Workman P

更新日期：2009-01-15 00:00:00

abstract：:A distinctive property of Hepatocyte Growth Factor (HGF) is its ability to induce differentiation of tubular structures from epithelial and endothelial cells (branching tubulogenesis). The HGF receptor directly activates PI3 kinase, Ras and STAT signalling pathways and phosphorylates the adaptator GRB2 Associated Bind...

journal_title：Oncogene

authors： Gual P,Giordano S,Williams TA,Rocchi S,Van Obberghen E,Comoglio PM

更新日期：2000-03-16 00:00:00

abstract：:wnt genes encode secretory glycoproteins that have been implicated in growth control and development in mice, frogs and insects. In this report we examine properties of two wnt genes recently identified in the nematode Caenorhabditis elegans. The first gene, Ce-wnt-1, was previously identified by a polymerase chain re...

journal_title：Oncogene

authors： Shackleford GM,Shivakumar S,Shiue L,Mason J,Kenyon C,Varmus HE

更新日期：1993-07-01 00:00:00

abstract：:The recent identification of the mouse White spotting and Steel loci as genes encoding the c-kit receptor and its ligand, respectively, has shed light on the importance of this ligand and receptor in embryogenesis, melanogenesis and hematopoiesis. In order to determine if the c-kit proto-oncogene is involved in human ...

journal_title：Oncogene

authors： Vandenbark GR,deCastro CM,Taylor H,Dew-Knight S,Kaufman RE

更新日期：1992-07-01 00:00:00

abstract：:p53 is a tumour suppressor gene which functions as a transcription factor to upregulate genes for growth arrest and apoptosis following DNA damage. p53 mutations are associated with Li-Fraumeni and Li-Fraumeni like syndromes. Recently mutations of the oligomerization domain have been isolated from an LFS and an LFL fa...

journal_title：Oncogene

authors： Lomax ME,Barnes DM,Hupp TR,Picksley SM,Camplejohn RS

更新日期：1998-08-06 00:00:00

abstract：:To investigate the effect of p33(ING1) on wild-type p53 gene therapy, T.Tn human esophageal carcinoma cells were stably transfected with p33(ING1) cDNA. Infection with Ad-p53 (recombinant adenovirus containing wild-type p53) into p33-transfected cells reduced cell viability, while infection with empty vector had littl...

journal_title：Oncogene

authors： Shimada H,Liu TL,Ochiai T,Shimizu T,Haupt Y,Hamada H,Abe T,Oka M,Takiguchi M,Hiwasa T

更新日期：2002-02-14 00:00:00

abstract：:A hallmark of plasma cells is the expression of syndecan-1, which has major functions in epithelial cells, in particular as the coreceptor of heparin-binding growth factors. We previously found that heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a growth factor for malignant plasma cells. As am...

journal_title：Oncogene

authors： Mahtouk K,Hose D,Rème T,De Vos J,Jourdan M,Moreaux J,Fiol G,Raab M,Jourdan E,Grau V,Moos M,Goldschmidt H,Baudard M,Rossi JF,Cremer FW,Klein B

更新日期：2005-05-12 00:00:00

abstract：:Type I interferon (IFN) enhances the transcription of the tumor suppressor gene p53. To elucidate the molecular mechanism mediating IFN-induced apoptosis, we analysed programmed cell death in response to type I (IFNalpha) or type II (IFNgamma) treatment in relation to p53 status. In two cell lines (MCF-7, SKNSH), IFNa...

journal_title：Oncogene

authors： Porta C,Hadj-Slimane R,Nejmeddine M,Pampin M,Tovey MG,Espert L,Alvarez S,Chelbi-Alix MK

更新日期：2005-01-20 00:00:00

abstract：:Snail1 is a master regulator of the epithelial-mesenchymal transition (EMT) and has been implicated in key tumor biological processes such as invasion and metastasis. It has been previously shown that poly(ADP-ribose) polymerase-1 (PARP-1) knockdown, but not PARP inhibition, downregulates the expression of Snail1. In ...

journal_title：Oncogene

authors： Rodríguez MI,González-Flores A,Dantzer F,Collard J,de Herreros AG,Oliver FJ

更新日期：2011-10-20 00:00:00

abstract：:Chromosome 17 is one of the most frequently altered chromosomes in malignant breast cancer. At least four genes implicated in breast cancer reside on chromosome 17 (p53, 17p13; Her-2/neu/ERBB2, 17q12; BRCA1, 17q21; and nm23, 17q22). In addition, allelic imbalance has been described for at least five regions of chromos...

journal_title：Oncogene

authors： Plummer SJ,Adams L,Simmons JA,Casey G

更新日期：1997-05-15 00:00:00

abstract：:Mammalian nuclear Dbf2-related (NDR) kinases (LATS1 and 2, NDR1 and 2) play a role in cell proliferation, apoptosis and morphological changes. These kinases are regulated by mammalian sterile 20-like kinases (MSTs) and Mps one binder (MOB) 1. Okadaic acid (OA), which activates MST2, facilitates the complex formation o...

journal_title：Oncogene

authors： Hirabayashi S,Nakagawa K,Sumita K,Hidaka S,Kawai T,Ikeda M,Kawata A,Ohno K,Hata Y

更新日期：2008-07-17 00:00:00

abstract：:Interaction of tumour cells with their microenvironment impacts on all aspects of cancer, ranging from development through to treatment response. In this issue, Dvorak and colleagues(1) reveal a novel tumour/microenvironment relationship that may drive leukemia pathogenesis. Specifically, they find that leukemic cells...

journal_title：Oncogene

authors： Tait S

更新日期：2013-10-31 00:00:00

abstract：:The tumour suppressor p53 is a transcription factor with high affinity for specific DNA target sequences. Wild type p53 has a very short half life in normal cells but the protein shows transient accumulation in response to DNA damage, accompanied by up-regulation of target genes such as p21 and induction of growth arr...

journal_title：Oncogene

authors： Molinari M,Milner J

更新日期：1995-05-04 00:00:00

abstract：:Topors was identified recently as a human protein that binds to topoisomerase I and p53. Topors contains a highly conserved RING domain and localizes in promyelocytic leukemia nuclear bodies. Relatively little is known regarding topors expression patterns or function. We now demonstrate that topors mRNA and protein ar...

journal_title：Oncogene

authors： Saleem A,Dutta J,Malegaonkar D,Rasheed F,Rasheed Z,Rajendra R,Marshall H,Luo M,Li H,Rubin EH

更新日期：2004-07-08 00:00:00

abstract：:A new class of nontransformed revertant cells has been isolated from the ras-transformed cell line DT using cis-4-hydroxy-L-proline (CHP) as a selective agent. The new revertants, CHP 9CJ and CHP CB4, each contain two copies of the v-Ki-ras gene, elevated levels of phosphorylated p21ras protein, and rescuable transfor...

journal_title：Oncogene

authors： Yanagihara K,Ciardiello F,Talbot N,McGeady ML,Cooper H,Benade L,Salomon DS,Bassin RH

更新日期：1990-08-01 00:00:00

abstract：:An essential mode of acquired resistance to radiotherapy (RT) appears to be promotion of tumor cell motility and invasiveness in various cancer types, including glioblastoma, a process resembling 'evasive resistance'. Hence, a logical advancement of RT would be to identify suitable complementary treatment strategies, ...

journal_title：Oncogene

authors： Weiler M,Pfenning PN,Thiepold AL,Blaes J,Jestaedt L,Gronych J,Dittmann LM,Berger B,Jugold M,Kosch M,Combs SE,von Deimling A,Weller M,Bendszus M,Platten M,Wick W

更新日期：2013-02-28 00:00:00