p300 provides a corepressor function by cooperating with YY1 and HDAC3 to repress c-Myc.

abstract：:Fibronectin extracellular matrix plays a critical role in the microenvironment of cells. Loss of this matrix frequently accompanies oncogenic transformation, allowing changes in cell growth, morphology, and tissue organization. The HT1080 human fibrosarcoma cell line is deficient in formation of fibronectin matrix fib...

journal_title：Oncogene

authors： Brenner KA,Corbett SA,Schwarzbauer JE

更新日期：2000-06-29 00:00:00

abstract：:Pilocytic astrocytomas (PAs, WHO grade I) are the most common brain tumors in the pediatric and adolescent population, accounting for approximately one-fifth of central nervous system tumors. Because few consistent molecular alterations have been identified in PAs compared to higher grade gliomas, we performed array c...

journal_title：Oncogene

authors： Deshmukh H,Yeh TH,Yu J,Sharma MK,Perry A,Leonard JR,Watson MA,Gutmann DH,Nagarajan R

更新日期：2008-08-07 00:00:00

abstract：:Tamoxifen (Tam), besides its action as an anti-estrogen, also inhibits cell proliferation of estrogen receptor (ER)-negative cancer cells by an unknown mechanism. In this study, we used ER-negative lung cancer cells to clarify such ER-independent inhibitory effect of Tam. We found that Tam induced G1 growth arrest in ...

journal_title：Oncogene

authors： Lee TH,Chuang LY,Hung WC

更新日期：1999-07-22 00:00:00

abstract：:Angiogenesis is essential for tumor growth and blocking this process might be a valid tool for the control of cancer growth. We showed previously that tumor angiogenesis in integrin alpha1-null mice is reduced compared to that of wild type animals and that over-expression of matrix metalloproteinase 9 (MMP-9) in the a...

journal_title：Oncogene

authors： Pozzi A,LeVine WF,Gardner HA

更新日期：2002-01-10 00:00:00

abstract：:Genomic instability is a hallmark feature of cancer cells, and can be caused by defective DNA repair, for instance due to inactivation of BRCA2. Paradoxically, loss of Brca2 in mice results in embryonic lethality, whereas cancer cells can tolerate BRCA2 loss. This holds true for multiple DNA repair genes, and suggests...

journal_title：Oncogene

authors： van Gijn SE,Wierenga E,van den Tempel N,Kok YP,Heijink AM,Spierings DCJ,Foijer F,van Vugt MATM,Fehrmann RSN

更新日期：2019-02-01 00:00:00

abstract：:The management of pain and morbidity due to the spreading and growth of cancer within bone remains to be a paramount problem in clinical care. Cancer cells actively transform bone, however, the molecular requirements and mechanisms of this process remain unclear. This study shows that functional modulation of the alph...

journal_title：Oncogene

authors： McCabe NP,De S,Vasanji A,Brainard J,Byzova TV

更新日期：2007-09-13 00:00:00

abstract：:A variety of factors cooperate to regulate neovessel formation and persistence. Proangiogenic growth factors have remained an area of intense interest due to their capacity to promote endothelial cell (EC) proliferation and to initiate the angiogenic program. These growth factors are associated with increased cell sur...

journal_title：Oncogene

authors： Stupack DG,Cheresh DA

更新日期：2003-12-08 00:00:00

abstract：:The initiation, magnitude and duration of an immune response against antigens are a tightly regulated process involving a dynamic, orchestrated balance of pro- and anti-inflammatory pathways in immune cells. Such a delicate balance is critical for allowing efficient immune response against foreign antigens while preve...

journal_title：Oncogene

authors： Villagra A,Sotomayor EM,Seto E

更新日期：2010-01-14 00:00:00

abstract：:Transforming growth factor alpha (TGFalpha) is widely expressed in malignant as well as normal cells and is involved in regulating cell growth and differentiation. Although processing of TGFalpha has been extensively studied in normal cells, there is little information regarding TGFalpha cleavage in malignant cells. T...

journal_title：Oncogene

authors： Yang H,Jiang D,Li W,Liang J,Gentry LE,Brattain MG

更新日期：2000-04-06 00:00:00

abstract：:We previously reported the sequence of a cDNA, TIS11, cloned from TPA-treated Swiss 3T3 cells. Two laboratories have reported sequences for cDNAs that have a region of identity with the TIS11 cDNA, but differ in their 5' and 3' flanking regions. We now report that the original TIS11 cDNA is likely to be a chimeric mol...

journal_title：Oncogene

authors： Ma Q,Herschman HR

更新日期：1991-07-01 00:00:00

abstract：:Helicobacter pylori induces a strong motogenic response in infected gastric epithelial host cells, which is enhanced by translocation of the pathogenic factor cytotoxin-associated gene A (CagA) into host cells via a specialized type IV secretion system. Once injected into the cytosol CagA is rapidly tyrosine phosphory...

journal_title：Oncogene

authors： Poppe M,Feller SM,Römer G,Wessler S

更新日期：2007-05-24 00:00:00

abstract：:Gastrin and its precursors promote proliferation in different gastrointestinal cells. Since mature, amidated gastrin (G-17) can induce cyclin D1, we determined whether G-17-mediated induction of cyclin D1 transcription involved Wnt signaling and CRE-binding protein (CREB) pathways. Our studies indicate that G-17 induc...

journal_title：Oncogene

authors： Pradeep A,Sharma C,Sathyanarayana P,Albanese C,Fleming JV,Wang TC,Wolfe MM,Baker KM,Pestell RG,Rana B

更新日期：2004-04-29 00:00:00

abstract：:Induction of interstrand crosslinks (ICLs) in chromosomal DNA is considered a major reason for the antiproliferative effect of psoralen plus ultraviolet A (PUVA). It is unclear as to whether PUVA-induced cell cycle arrest is caused by ICLs mechanically stalling replication forks or by triggering cell cycle checkpoints...

journal_title：Oncogene

authors： Joerges C,Kuntze I,Herzinger T

更新日期：2003-09-18 00:00:00

abstract：:Prostate tumors develop resistance to androgen deprivation therapy (ADT) by multiple mechanisms, one of which is to express constitutively active androgen receptor (AR) splice variants lacking the ligand-binding domain. AR splice variant 7 (AR-V7, also termed AR3) is the most abundantly expressed variant that drives p...

journal_title：Oncogene

authors： Liu LL,Xie N,Sun S,Plymate S,Mostaghel E,Dong X

更新日期：2014-06-12 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) represents the most frequent and therapy-refractive sub-class of lung cancer. Improving apoptosis induction in NSCLC represents a logical way forward in treating this tumor. Cisplatin, a commonly used therapeutic agent in NSCLC, induces activation of N-terminal-c-Jun kinase (JNK) tha...

journal_title：Oncogene

authors： Chattopadhyay S,Machado-Pinilla R,Manguan-García C,Belda-Iniesta C,Moratilla C,Cejas P,Fresno-Vara JA,de Castro-Carpeño J,Casado E,Nistal M,Gonzalez-Barón M,Perona R

更新日期：2006-06-01 00:00:00

abstract：:Genetically defined mouse models offer an important tool to identify critical secondary genetic alterations with relevance to human cancer pathogenesis. We used newly generated MMTV-Cre105Ayn mice to inactivate p53 and/or Rb strictly in the mammary epithelium, and to determine recurrent genomic changes associated with...

journal_title：Oncogene

authors： Cheng L,Zhou Z,Flesken-Nikitin A,Toshkov IA,Wang W,Camps J,Ried T,Nikitin AY

更新日期：2010-10-21 00:00:00

abstract：:Heat shock protein 110 (HSP110) is induced by different stresses and, through its anti-apoptotic and chaperoning properties, helps cells survive these adverse situations. In colon cancers, HSP110 is abnormally abundant. We have recently shown that colorectal cancer patients with microsatellite instability (MSI) had an...

journal_title：Oncogene

authors： Berthenet K,Bokhari A,Lagrange A,Marcion G,Boudesco C,Causse S,De Thonel A,Svrcek M,Goloudina AR,Dumont S,Hammann A,Biard DS,Demidov ON,Seigneuric R,Duval A,Collura A,Jego G,Garrido C

更新日期：2017-04-20 00:00:00

abstract：:A hallmark of cancer is the deregulation of cell-cycle machinery, ultimately facilitating aberrant proliferation that fuels tumorigenesis and disease progression. Particularly, in breast cancers, cyclin D1 has a crucial role in the development of disease. Recently, a highly specific inhibitor of CDK4/6 activity (PD-03...

journal_title：Oncogene

authors： Dean JL,Thangavel C,McClendon AK,Reed CA,Knudsen ES

更新日期：2010-07-15 00:00:00

abstract：:The transcription factor hypoxia inducible factor 1 (HIF1), an HIF1alpha-aryl hydrocarbon receptor nuclear translocator (ARNT) dimeric factor, is essential to the cellular response to hypoxia. We described a t(1;12)(q21;p13) chromosomal translocation in human acute myeloblastic leukemia that involves the translocated ...

journal_title：Oncogene

authors： Nguyen-Khac F,Della Valle V,Lopez RG,Ravet E,Mauchauffé M,Friedman AD,Huang LE,Fichelson S,Ghysdael J,Bernard OA

更新日期：2006-08-10 00:00:00

abstract：:Recent years have seen a great expansion in our understandings of how silent mutations can drive a disease and that mRNAs are not only mere messengers between the genome and the encoded proteins but also encompass regulatory activities. This review focuses on how silent mutations within open reading frames can affect ...

journal_title：Oncogene

authors： Fåhraeus R,Marin M,Olivares-Illana V

更新日期：2016-07-21 00:00:00

abstract：:Adenoviruses are linear double-stranded DNA viruses that infect human and rodent cell lines, occasionally transform them and cause tumors in animal models. The host cell challenges the virus in multifaceted ways to restrain viral gene expression and DNA replication, and sometimes even eliminates the infected cells by ...

journal_title：Oncogene

authors： Gupta A,Jha S,Engel DA,Ornelles DA,Dutta A

更新日期：2013-10-17 00:00:00

abstract：:A locus in feline DNA, termed flvi-1, has been identified as harboring retroviral integrations commonly found in natural feline lymphomas induced by infection with feline leukemia virus (FeLV). Southern blot analysis of human and murine DNA using restriction fragments representing flvi-1 demonstrates its phylogenetic ...

journal_title：Oncogene

authors： Levesque KS,Mattei MG,Levy LS

更新日期：1991-08-01 00:00:00

abstract：:Birt-Hogg-Dubé syndrome (BHD) is a rare, inherited genodermatosis characterized by hair follicle hamartomas, kidney tumors and spontaneous pneumothorax. The BHD locus was mapped to chromosome 17p11.2 by linkage analysis, and germline mutations in a novel gene (BHD) were identified in a panel of BHD families. Using RNA...

journal_title：Oncogene

authors： Singh SR,Zhen W,Zheng Z,Wang H,Oh SW,Liu W,Zbar B,Schmidt LS,Hou SX

更新日期：2006-09-28 00:00:00

abstract：:Tuftelin1 (TUFT1), an acidic protein constituent of developing and mineralizing tooth tissues, is regulated by hypoxia and the Hedgehog signaling pathway. We investigated the role of TUFT1 in hepatocellular carcinoma (HCC). qRT-PCR, immunohistochemistry and western blot were employed to evaluate TUFT1 level in HCC. MT...

journal_title：Oncogene

authors： Dou C,Zhou Z,Xu Q,Liu Z,Zeng Y,Wang Y,Li Q,Wang L,Yang W,Liu Q,Tu K

更新日期：2019-02-01 00:00:00

abstract：:Constitutive activation of the phosphoinositide 3-kinase (PI3K)-AKT pathway is observed in up to 70% of acute myelogenous leukemia. To investigate the relevance of an intrinsic PI3K-AKT pathway activation in hematopoietic malignancies, we analysed the effect of point mutations in the catalytic (p110alpha) and regulato...

journal_title：Oncogene

authors： Horn S,Bergholz U,Jücker M,McCubrey JA,Trümper L,Stocking C,Bäsecke J

更新日期：2008-07-03 00:00:00

abstract：:The Ewing sarcoma is the second most common bone tumor in children and young adults. Despite the advances in therapy, the 5-year survival rate for patients with metastatic disease is poor, indicating the need for alternative treatments. Here, we report that 2-methoxy-estradiol (2-Me), a natural estrogen metabolite, in...

journal_title：Oncogene

authors： Djavaheri-Mergny M,Wietzerbin J,Besançon F

更新日期：2003-05-01 00:00:00

abstract：:Low molecular weight protein tyrosine phosphatases (LMW-PTPs) are an enzyme family that plays a key role in cell proliferation control by dephosphorylating/inactivating both tyrosine kinase receptors (such as PDGF, insulin, and ephrin receptors) and docking proteins (such, as beta-catenin) endowed with both adhesion a...

journal_title：Oncogene

authors： Chiarugi P,Taddei ML,Schiavone N,Papucci L,Giannoni E,Fiaschi T,Capaccioli S,Raugei G,Ramponi G

更新日期：2004-05-13 00:00:00

abstract：:Loss of genetic material, including loss of loci on chromosome arms 6q, 9p, and 10q, occurs frequently in cutaneous melanoma but infrequently in benign melanocytic nevi or other melanocytic lesions, suggesting that these genetic alterations are important in the development and progression of melanoma. To examine wheth...

journal_title：Oncogene

authors： Healy E,Belgaid C,Takata M,Harrison D,Zhu NW,Burd DA,Rigby HS,Matthews JN,Rees JL

更新日期：1998-04-30 00:00:00

abstract：:Stat3 (signal transducer and activator of transcription-3) activity is required for transformation by a number of oncogenes, while a constitutively active form of Stat3 alone is sufficient to induce neoplastic transformation. Although in most instances Stat3 is growth-promoting, the impact of cell density on Stat3 act...

journal_title：Oncogene

authors： Vultur A,Cao J,Arulanandam R,Turkson J,Jove R,Greer P,Craig A,Elliott B,Raptis L

更新日期：2004-04-08 00:00:00

abstract：:Different diagnostic and prognostic groups of colorectal carcinoma (CRC) have been defined. However, accurate diagnosis and prediction of survival are sometimes difficult. Gene expression profiling might improve these classifications and bring new insights into underlying molecular mechanisms. We profiled 50 cancerous...

journal_title：Oncogene

authors： Bertucci F,Salas S,Eysteries S,Nasser V,Finetti P,Ginestier C,Charafe-Jauffret E,Loriod B,Bachelart L,Montfort J,Victorero G,Viret F,Ollendorff V,Fert V,Giovaninni M,Delpero JR,Nguyen C,Viens P,Monges G,Birnbaum D,

更新日期：2004-02-19 00:00:00