Inactivation of the remaining allele of the WT1 gene in a Wilms' tumour from a WAGR patient.

abstract：:Colorectal cancer (CRC) is a heterogeneous disease posing a challenge for accurate classification and treatment of this malignancy. There is no common genetic molecular feature that would allow for the identification of patients at risk for developing recurrences and thus selecting patients who would benefit from more...

journal_title：Oncogene

authors： Fessler E,Jansen M,De Sousa E Melo F,Zhao L,Prasetyanti PR,Rodermond H,Kandimalla R,Linnekamp JF,Franitza M,van Hooff SR,de Jong JH,Oppeneer SC,van Noesel CJ,Dekker E,Stassi G,Wang X,Medema JP,Vermeulen L

更新日期：2016-11-17 00:00:00

abstract：:Brahma (BRM) is a novel anticancer gene, which is frequently inactivated in a variety of tumor types. Unlike many anticancer genes, BRM is not mutated, but rather epigenetically silenced. In addition, histone deacetylase complex (HDAC) inhibitors are known to reverse BRM silencing, but they also inactivate it via acet...

journal_title：Oncogene

authors： Kahali B,Gramling SJ,Marquez SB,Thompson K,Lu L,Reisman D

更新日期：2014-01-30 00:00:00

abstract：:We have characterized a chromosomal translocation in a cell line (SU-DUL5) established from a patient with lymphoblastic lymphoma in which the c-myc gene on chromosome 8 was juxtaposed to a t(14;18). Cytogenetic analysis of this cell line showed 14q+, 18q-, and 8p+q+ marker chromosomes in the absence of t(14;18). Geno...

journal_title：Oncogene

authors： Kiem HP,Nourse J,Saltman DL,Blume KG,Cleary ML

更新日期：1990-12-01 00:00:00

abstract：:A lot of attention has been dedicated to investigate the role of the tyrosine kinase receptor MET in tumors. The acquired notion that cancer cells from different histological origin strictly rely on the engagement of this specific oncogene for their growth and survival has certainly justified the development and the u...

journal_title：Oncogene

authors： Finisguerra V,Prenen H,Mazzone M

更新日期：2016-10-20 00:00:00

abstract：:Cbl proteins are ubiquitin protein ligases, which ubiquitinate activated tyrosine kinases and target them for degradation. Both c-Cbl and Cbl-b have an ubiquitin associated (UBA) domain at their C-terminal end. We observed that high molecular weight ubiquitinated proteins constitutively coimmunoprecipitated with trans...

journal_title：Oncogene

authors： Davies GC,Ettenberg SA,Coats AO,Mussante M,Ravichandran S,Collins J,Nau MM,Lipkowitz S

更新日期：2004-09-16 00:00:00

abstract：:Constitutive activation of the signal transducer and activator of transcription 3 (Stat3) and mutation of the p53 are both commonly detected in human prostate cancer cells. We sought to investigate whether there is functional regulation of Stat3 by wild-type (wt) p53. Our results demonstrate that expression of wt p53 ...

journal_title：Oncogene

authors： Lin J,Tang H,Jin X,Jia G,Hsieh JT

更新日期：2002-05-02 00:00:00

abstract：:The steady-state levels of p53 mRNA and protein were barely detectable by Northern and Western blot analysis in spontaneously immortalized (10)3 and (10)7 murine embryo fibroblast (MEF) cells. But when cells were treated with cycloheximide (CHX) or emetine, expression levels were restored to those observed in primary ...

journal_title：Oncogene

authors： Kim H,You S,Farris J,Foster LK,Foster DN

更新日期：2001-05-31 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western countries and is currently incurable due, in part, to difficulty in eliminating the leukemia cells protected by stromal microenvironment. Based on previous observations that CLL cells exhibit mitochondrial dysfunction and altered lipid...

journal_title：Oncogene

authors： Liu PP,Liu J,Jiang WQ,Carew JS,Ogasawara MA,Pelicano H,Croce CM,Estrov Z,Xu RH,Keating MJ,Huang P

更新日期：2016-10-27 00:00:00

abstract：:Progesterone receptor (PR) is usually co-localized with estrogen receptor (ER) in normal mammary cells. It is not known whether ER/PR-negative human breast cancer arises from an ER/PR-negative cell or from an ER/PR-positive cell that later lost ER/PR. Using intraductal injection of a lentivirus to deliver both an onco...

journal_title：Oncogene

authors： Dong J,Zhao W,Shi A,Toneff M,Lydon J,So D,Li Y

更新日期：2016-08-04 00:00:00

abstract：:We have established conditions for the immortalization of human fibroblasts by the large T antigen of the rodent virus polyoma. This allows the mechanism of immortalization to be studied, without interference by transformation events, in cells with relatively stable chromosomes. Large T antigen could immortalize human...

journal_title：Oncogene

authors： Strauss M,Hering S,Lubbe L,Griffin BE

更新日期：1990-08-01 00:00:00

abstract：:A recent large multi-centre study convincingly confirmed previous observations that the SYT-SSX1 fusion type, compared to SYT-SSX2, of synovial sarcoma is associated with a worse clinical outcome. Apart from the clinical impact, this fact also suggests (1) that the SYT-SSX fusion gene may influence molecular mechanism...

journal_title：Oncogene

authors： Xie Y,Skytting B,Nilsson G,Grimer RJ,Mangham CD,Fisher C,Shipley J,Bjerkehagen B,Myklebost O,Larsson O

更新日期：2002-08-22 00:00:00

abstract：:The transcription factor Snail has been recently proposed as an important mediator of tumour invasion because of its role in downregulation of E-cadherin and induction of epithelial-mesenchymal transitions (EMT). This behaviour has led to the consideration of Snail as a potential therapeutic target to block tumour pro...

journal_title：Oncogene

authors： Olmeda D,Jordá M,Peinado H,Fabra A,Cano A

更新日期：2007-03-22 00:00:00

abstract：:E2F is a complex family of transcription factors which appears to regulate the transcription of genes required for the S phase of the mammalian cell cycle. In the present work, we have examined the mechanisms regulating E2F-3 accumulation in mouse fibroblasts. We have determined that E2F-3 DNA binding activity is rest...

journal_title：Oncogene

authors： Flores AM,Kassatly RF,Cress WD

更新日期：1998-03-12 00:00:00

abstract：:Immunoreceptor tyrosine-based activation motifs (ITAMs) are involved in the transduction of signals necessary for activation, differentiation, and survival in hematopoietic cells. Several viruses have been shown to encode ITAM-containing transmembrane proteins. Although expression of these viral proteins has in some c...

journal_title：Oncogene

authors： Grande SM,Katz E,Crowley JE,Bernardini MS,Ross SR,Monroe JG

更新日期：2006-05-04 00:00:00

abstract：:Transcripts of the c-mos proto-oncogene were recently found to accumulate to high levels in mouse oocytes. We report here that the oocyte c-mos RNA is polyadenylated in concert with oocyte maturation, retained in mature ovulated eggs and zygotes but degraded by the late two cell embryo stage. These results suggest tha...

journal_title：Oncogene

authors： Goldman DS,Kiessling AA,Cooper GM

更新日期：1988-08-01 00:00:00

abstract：:The proangiogenic cytokine Interleukin-3 (IL-3) is released by inflammatory cells in breast and ovarian cancer tissue microenvironments and also acts as an autocrine factor for human breast and kidney tumor-derived endothelial cells (TECs). We have previously shown that IL-3-treated endothelial cells (ECs) release ext...

journal_title：Oncogene

authors： Lombardo G,Gili M,Grange C,Cavallari C,Dentelli P,Togliatto G,Taverna D,Camussi G,Brizzi MF

更新日期：2018-03-01 00:00:00

abstract：:Mice transgenic for the leukemia oncogene E2A-PBX1 invariably develop lethal, high-grade T-cell lymphomas by 5 months of age. In this study, retroviral insertional mutagenesis was employed to identify oncogenes that cooperate with the E2A-PBX1 transgene in lymphomagenesis. Neonatal retroviral infection substantially r...

journal_title：Oncogene

authors： Feldman BJ,Reid TR,Cleary ML

更新日期：1997-11-27 00:00:00

abstract：:Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, and pluripotency. The positioning of chromosomes within the nuclear three-dimensional space involves interaction...

journal_title：Oncogene

authors： Li Z,Jiao X,Di Sante G,Ertel A,Casimiro MC,Wang M,Katiyar S,Ju X,Klopfenstein DV,Tozeren A,Dampier W,Chepelev I,Jeltsch A,Pestell RG

更新日期：2019-05-01 00:00:00

abstract：:SALL4, a zinc-finger transcriptional factor for embryonic stem cell self-renewal and pluripotency, has been suggested to be involved in tumorigenesis. The role of SALL4 in human gastric cancer, however, remains largely unknown. In this study, we demonstrated that SALL4 was aberrantly expressed at both mRNA and protein...

journal_title：Oncogene

authors： Zhang L,Xu Z,Xu X,Zhang B,Wu H,Wang M,Zhang X,Yang T,Cai J,Yan Y,Mao F,Zhu W,Shao Q,Qian H,Xu W

更新日期：2014-11-27 00:00:00

abstract：:The MTG (Myeloid Translocation Gene) proteins are a family of novel transcriptional corepressors. We report that MTG16a, a protein isoform encoded by the MTG16 gene deranged by the t (16; 21) in myeloid malignancies, is targeted to the nucleolus. The amino acid sequence necessary for nucleolar localization was mapped ...

journal_title：Oncogene

authors： Hoogeveen AT,Rossetti S,Stoyanova V,Schonkeren J,Fenaroli A,Schiaffonati L,van Unen L,Sacchi N

更新日期：2002-09-26 00:00:00

abstract：:The most frequent genetic alterations described in neuroblastoma (NB) are amplification of MYCN oncogene and deletion of chromosome 1p, although somatic deletions have been demonstrated at other chromosomal intervals. Since loss of heterozygosity (LOH) at distal 4p has been observed in about 20-29% of neuroblastomas, ...

journal_title：Oncogene

authors： Perri P,Longo L,Cusano R,McConville CM,Rees SA,Devoto M,Conte M,Ferrara GB,Seri M,Romeo G,Tonini GP

更新日期：2002-11-28 00:00:00

abstract：:The Ewing sarcoma is the second most common bone tumor in children and young adults. Despite the advances in therapy, the 5-year survival rate for patients with metastatic disease is poor, indicating the need for alternative treatments. Here, we report that 2-methoxy-estradiol (2-Me), a natural estrogen metabolite, in...

journal_title：Oncogene

authors： Djavaheri-Mergny M,Wietzerbin J,Besançon F

更新日期：2003-05-01 00:00:00

abstract：:Gene expression patterns in normal and v-myc-transformed quail embryo fibroblasts were compared by mRNA differential display. Displaying approximately 2500 mRNA species by reverse transcription/PCR, reamplification of 73 differential cDNA fragments and rescreening by Northern analysis led to the isolation of a clone, ...

journal_title：Oncogene

authors： Oberst C,Weiskirchen R,Hartl M,Bister K

更新日期：1997-03-06 00:00:00

abstract：:The cellular response to ionizing radiation (IR) includes the induction of apoptosis. The p300/CBP proteins possess histone acetyltransferase activity and function as transcriptional coactivators of p53. We have prepared cells deficient in p300 or CBP to define the roles of these proteins in the cellular response to D...

journal_title：Oncogene

authors： Yuan ZM,Huang Y,Ishiko T,Nakada S,Utsugisawa T,Shioya H,Utsugisawa Y,Shi Y,Weichselbaum R,Kufe D

更新日期：1999-10-07 00:00:00

abstract：:We present an approach making use of technology established in the context of the genome project to describe a pancreatic cancer-specific expression profile and to identify new potential disease genes or disease-associated-genes. By use of gridded arrays of pancreatic cancer cDNA libraries and differential hybridizati...

journal_title：Oncogene

authors： Gress TM,Müller-Pillasch F,Geng M,Zimmerhackl F,Zehetner G,Friess H,Büchler M,Adler G,Lehrach H

更新日期：1996-10-17 00:00:00

abstract：:Chromosomal deletions are a common feature of epithelial tumours and when further defined by homozygous deletions, are often the location of tumour suppressor genes. Deletions within the short arm of chromosome 3 occur very frequently in human carcinomas: a minimal region of loss at 3p21.3 (the Luca) region has been d...

journal_title：Oncogene

authors： Smith AJ,Xian J,Richardson M,Johnstone KA,Rabbitts PH

更新日期：2002-07-04 00:00:00

abstract：:Prostate cancer is the most common malignancy of elderly men in the United States. Since there is no curative treatment for advanced prostate cancer, exploration of novel modalities of treatment is essential. Telomerase, a ribonucleoprotein, is detected in the vast majority of prostate cancer, but not in normal or ben...

journal_title：Oncogene

authors： Kondo Y,Koga S,Komata T,Kondo S

更新日期：2000-04-27 00:00:00

abstract：:Cancer cells enhance their glycolysis, producing lactate, even in the presence of oxygen. Glycolysis is a series of ten metabolic reactions catalysed by enzymes whose expression is most often increased in tumour cells. HKII and phosphoglucose isomerase (PGI) have mainly an antiapoptotic effect; PGI and glyceraldehyde-...

journal_title：Oncogene

authors： Lincet H,Icard P

更新日期：2015-07-01 00:00:00

abstract：:The DCC (deleted in colorectal cancer) gene was originally identified as a candidate tumour suppressor gene in colon carcinogenesis on the basis of allelic losses in chromosome 18q.21 in 70% of colon cancers. Reverse transcriptase polymerase chain reaction (RT-PCR) of DCC mRNA suggests that DCC expression may also be ...

journal_title：Oncogene

authors： Gotley DC,Reeder JA,Fawcett J,Walsh MD,Bates P,Simmons DL,Antalis TM

更新日期：1996-08-15 00:00:00

abstract：:Apoptotic cell death is an active process which regulates the maintenance of the hematopoietic homeostasis. It has been reported that wild-type p53 (wt-p53) protein induces apoptosis in leukemia cells. To assess whether p53 is involved in the apoptotic process of normal hematopoietic cells, we introduced the temperatu...

journal_title：Oncogene

authors： Blandino G,Scardigli R,Rizzo MG,Crescenzi M,Soddu S,Sacchi A

更新日期：1995-02-16 00:00:00