Measurement of single breath-hold carbon monoxide diffusing capacity in healthy infants and toddlers.

Abstract:

:We describe a method for measuring carbon monoxide diffusing capacity (DL(CO)) and alveolar volume (V(A)) in sleeping infants, using a single 4-sec breath-hold technique. The breath-hold maneuver is obtained by inducing a respiratory pause of the respiratory system. Several inflations of the respiratory system with room air to a lung volume with an airway pressure of 30 cmH2O (V30) inhibit inspiratory effort. The respiratory system is then inflated with a test gas containing helium and a stable isotope of carbon monoxide (C18O), and a respiratory pause is maintained for 4 sec and followed by passive expiration to functional residual capacity. Concentrations of helium and C18O are continuously measured with a mass spectrometer. Twelve healthy infants between 6-22 months of age were evaluated. For 9 of 12 subjects, duplicate measurements of alveolar volume at 30 cmH2O (V(A30)) and DL(CO) were within 10%, which are the recommendations for older children and adults. Among these 9 subjects, values of V(A30) and DL(CO) increased with increasing body length (r2 = 0.82 and 0.79, respectively). The remaining 3 subjects had two values within 10-15%. Measurement of V(A) and DL(CO) with the single breath-hold technique at an elevated lung volume offers the potential to assess growth and development of the lung parenchyma early in life.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Castillo A,Llapur CJ,Martinez T,Kisling J,Williams-Nkomo T,Coates C,Tepper RS

doi

10.1002/ppul.20403

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

544-50

issue

6

eissn

8755-6863

issn

1099-0496

journal_volume

41

pub_type

杂志文章
  • Elevated vascular endothelial growth factor is correlated with elevated erythropoietin in stable, young cystic fibrosis patients.

    abstract::Angiogenesis is an important mechanism of airway remodeling in lung disease. We previously demonstrated that serum vascular endothelial growth factor (VEGF) is elevated in cystic fibrosis (CF) patients and declines with therapy for pulmonary exacerbation. We hypothesized that VEGF is elevated early in the course of CF...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21428

    authors: Watts KD,McColley SA

    更新日期:2011-07-01 00:00:00

  • Pilot study: The effect of reducing treatment on exercise induced bronchoconstriction.

    abstract:UNLABELLED:SUMMARY RATIONALE: Asthma therapy should be stepped up or stepped down in response to changes in asthma control. However, there is little evidence available on the optimal timing, sequence, and degree of medication reductions. In this study we analyzed clinically stable asthmatic children who underwent a med...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21278

    authors: Kersten ET,Driessen JM,van Leeuwen JC,Thio BJ

    更新日期:2010-09-01 00:00:00

  • Parent-reported asthma in Puerto Rican children.

    abstract::We conducted a survey to determine parent-reported asthma prevalence, morbidity, and healthcare utilization among 3527 children attending public schools (n = 2849) and private schools (n = 678) in San Juan, Puerto Rico. Schools were randomly selected from each of 12 geographic regions of the San Juan metropolitan area...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20022

    authors: Nazario S,Casal JR,Torres-Palacios A,Rodriguez W,Delamater AM,Applegate EB,Piedimonte G,Wanner A

    更新日期:2004-05-01 00:00:00

  • Antimicrobial susceptibility profile of molecular typed cystic fibrosis Stenotrophomonas maltophilia isolates and differences with noncystic fibrosis isolates.

    abstract::Multiresistance in Stenotrophomonas maltophilia limits the effectiveness of antimicrobial therapy for infections due to this organism. It can be of special concern in cystic fibrosis (CF) patients due to frequent antimicrobial administration. The in vitro activity of 41 antimicrobial agents against 76 epidemiologicall...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10216

    authors: Cantón R,Valdezate S,Vindel A,Sánchez Del Saz B,Maíz L,Baquero F

    更新日期:2003-02-01 00:00:00

  • Dynamics of nasopharyngeal pneumococcal carriage during the course of viral bronchiolitis.

    abstract::The effect of viral infection on nasopharyngeal carriage of Streptococcus pneumoniae during childhood is not well known. We studied dynamics of pneumococcal colonization by quantitative PCR during the natural course of viral bronchiolitis. At time of admission, 47 (47%) of 100 patients with bronchiolitis carried pneum...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23390

    authors: Faber TE,Schuurs TA,Veeger NJ,Hennus MP,Bont LJ

    更新日期:2016-08-01 00:00:00

  • Harvesting airway surface liquid: a comparison of two techniques.

    abstract::The quantity and composition of airway surface liquid (ASL) are essential to host defense. To date, attempts to harvest ASL and measure its composition have yielded conflicting results. We investigated the physical principles underlying two techniques that were proposed for harvesting ASL: filter paper pledgets and po...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10409

    authors: Landry JS,Landry C,Cowley EA,Govindaraju K,Eidelman DH

    更新日期:2004-02-01 00:00:00

  • Factors that influence adherence to exercise and their effectiveness: application to cystic fibrosis.

    abstract::Appropriate, regular exercise is of benefit to patients with cystic fibrosis (CF). As with other segments of the population, it has been difficult to devise exercise programs to which most patients will adhere for long periods of time. In healthy children, factors that are related to positive exercise compliance inclu...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.10126

    authors: Prasad SA,Cerny FJ

    更新日期:2002-07-01 00:00:00

  • Advance care planning in adolescents with cystic fibrosis: A quality improvement project.

    abstract:INTRODUCTION:Advance care planning (ACP), though recommended, has not been studied in adolescents with cystic fibrosis (CF). This quality improvement project engaged adolescents with advanced CF disease in ACP and assessed patient and CF provider attitudes and preferences regarding ACP discussions and tools. MATERIALS...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23559

    authors: Kazmerski TM,Weiner DJ,Matisko J,Schachner D,Lerch W,May C,Maurer SH

    更新日期:2016-12-01 00:00:00

  • Management of empyema in children.

    abstract::The incidence of empyema complicating community-acquired pneumonia is increasing and causes significant childhood morbidity. Pneumococcal infection remains the most common isolated cause in developed countries, with Staphylococcus aureus the predominant pathogen in the developing world. Newer molecular techniques util...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.20251

    authors: Jaffé A,Balfour-Lynn IM

    更新日期:2005-08-01 00:00:00

  • Pediatrician intervention impacts parental smoking in cystic fibrosis, diabetes and bronchiolitis.

    abstract:BACKGROUND:Child exposure to cigarette smoke is harmful. It should be reduced through parental smoking cessation interventions. The aim of our study was to determine the impact of simple advice provided by the pediatrician on the smoking habits of parents of children with cystic fibrosis (CF), diabetes mellitus (DM) an...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25277

    authors: Lafont M,Morin C,Arrouy A,Rabeau A,Labouret G,Roditis L,Michelet M,Mittaine M

    更新日期:2021-01-22 00:00:00

  • Lung function among infants born preterm, with or without bronchopulmonary dysplasia.

    abstract:OBJECTIVE:Both healthy preterm infants and those with bronchopulmonary dysplasia (BPD) have poor lung function during childhood and adolescence, although there is no evidence whether prematurity alone explains the reduction in lung function found in BPD infants. Our study seeks to know if lung function, measured in inf...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21609

    authors: Sanchez-Solis M,Garcia-Marcos L,Bosch-Gimenez V,Pérez-Fernandez V,Pastor-Vivero MD,Mondéjar-Lopez P

    更新日期:2012-07-01 00:00:00

  • Successful treatment of pulmonary hemangioma with propranolol.

    abstract::Pulmonary hemangioma is a rare benign tumor of the lungs. Airway hemangiomas in particular may lead to feeding difficulties, barking cough, stridor, respiratory distress, and even acute airway obstruction. Hence, such hemangiomas usually require early and aggressive treatment; however, the treatment modalities employe...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23008

    authors: Emiralioğlu N,Oğuz B,Akyüz C,Yalçın B,Kiper N,Ersöz DD,Yalçın E,Özçelik U

    更新日期:2014-08-01 00:00:00

  • Pseudomonas aeruginosa colonization in cystic fibrosis: Impact on neutrophil functions and cytokine secretion capacity.

    abstract:BACKGROUND:Chronic colonization with Pseudomonas (P.) aeruginosa worsens the prognosis of cystic fibrosis (CF) patients. This study aims to analyze the functional properties of neutrophils in CF patients with P. aeruginosa colonization. METHODS:Patients with CF (n = 16) were grouped by positivity of P. aeruginosa in s...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25294

    authors: Aslanhan U,Cakir E,Ozyigit LP,Kucuksezer UC,Gelmez YM,Yuksel M,Deniz G,Aktas EC

    更新日期:2021-01-29 00:00:00

  • Intrinsic catch-up growth of hypoplastic fetal lungs is mediated by interleukin-6.

    abstract::Fetal lung hypoplasia is a common finding in several fetal conditions such as congenital diaphragmatic hernia (CDH). Interestingly, previous studies have demonstrated that hypoplastic lungs have the ability to recover to normal size, when relieved from mechanical factors. However, the underlying mechanisms remain larg...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20840

    authors: Nogueira-Silva C,Moura RS,Esteves N,Gonzaga S,Correia-Pinto J

    更新日期:2008-07-01 00:00:00

  • Long-term pulmonary function in esophageal atresia-A case-control study.

    abstract:BACKGROUND:Esophageal atresia (EA) is a congenital anomaly associated with substantial pulmonary morbidity throughout childhood. AIM:The aim of this study was to evaluate pulmonary complications among 59 five to 15-year-old children and adolescents with surgically corrected congenital EA. METHODS:Participants underwe...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23477

    authors: Pedersen RN,Markøw S,Kruse-Andersen S,Qvist N,Gerke O,Husby S,Agertoft L

    更新日期:2017-01-01 00:00:00

  • Nonlinear pressure/volume relationship and measurements of lung mechanics in infants.

    abstract::We examined the effects of within-breath changes in compliance (C) upon the accuracy of measurements of compliance and resistance (R) by linear regression analysis and by Mead and Wittenberger's method. These effects were illustrated by a computer model and by lung models with linear and nonlinear pressure/volume rela...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950120304

    authors: Silva Neto G,Gerhardt T,Silberberg A,Gerhardt T,Claure N,Duara S,Bancalari E

    更新日期:1992-03-01 00:00:00

  • The correlation of adenosine challenge test results with subsequent clinical course among young children with suspected asthma: a retrospective cohort study.

    abstract:AIM:Our aim was to evaluate the correlation of Adenosine monophosphate challenge test (AMP-PCW) results with the patients' subsequent clinical course. METHODS:We performed a 6-year retrospective cohort study of young children with suspected asthma who underwent AMP-PCW test. RESULTS:Fifty four children were included ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24337

    authors: Levin G,Rottensctreich A,Picard E,Avital A,Springer C,Cohen S

    更新日期:2019-07-01 00:00:00

  • Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury.

    abstract:OBJECTIVES:To determine B-type natriuretic peptide (BNP) levels in infants and children with acute lung injury (ALI), and to investigate associations between BNP levels and clinical outcome. DESIGN:Prospective observational study. SUBJECTS:After informed consent, plasma was collected from 48 pediatric patients on day...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21111

    authors: Reel B,Oishi PE,Hsu JH,Gildengorin G,Matthay MA,Fineman JR,Flori H

    更新日期:2009-11-01 00:00:00

  • Terbutaline alleviates the lung injury in the neonatal rats exposed to endotoxin: Potential roles of epithelial sodium channels.

    abstract::Intrauterine inflammation generates inflammatory mediators that damage the developing bronchoalveolar epithelium, resulting in neonatal lung injury. Lung fluid transport disorders are the main reasons for the development of pulmonary edema, an important pathology of lung injury. Previous studies suggested that epithel...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24242

    authors: Lu K,Chen X,Zhu W,Mao X,Yang Y,Qiu J,Zhang M,Cheng R

    更新日期:2019-03-01 00:00:00

  • Early-term deliveries as an independent risk factor for long-term respiratory morbidity of the offspring.

    abstract:OBJECTIVE:Newborns exhibit the lowest immediate respiratory morbidity rates when born following 39 completed weeks of gestation. We sought to determine whether early-term delivery (37-38 + 6 weeks' gestation) impacts on long-term pediatric respiratory morbidity. STUDY DESIGN:In this population-based prospective cohort...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23529

    authors: Walfisch A,Beharier O,Wainstock T,Sergienko R,Landau D,Sheiner E

    更新日期:2017-02-01 00:00:00

  • Fulminant pertussis: a multi-center study with new insights into the clinico-pathological mechanisms.

    abstract::Pertussis carries a high risk of mortality in very young infants. The mechanism of refractory cardio-respiratory failure is complex and not clearly delineated. We aimed to examine the clinico-pathological features and suggest how they may be related to outcome, by multi-center review of clinical records and post-morte...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ppul.21082

    authors: Sawal M,Cohen M,Irazuzta JE,Kumar R,Kirton C,Brundler MA,Evans CA,Wilson JA,Raffeeq P,Azaz A,Rotta AT,Vora A,Vohra A,Abboud P,Mirkin LD,Cooper M,Dishop MK,Graf JM,Petros A,Klonin H

    更新日期:2009-10-01 00:00:00

  • Compliance in cystic fibrosis: an examination of infection control guidelines.

    abstract::The goal of this research was to begin the process of evaluating acceptability of infection control (IC) recommendations to CF patients and their families, determine whether compliance with IC guidelines differs from compliance with traditional CF medical treatment with respect to the variables predictive of complianc...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20781

    authors: Masterson T,Wildman BG,Newberry B,Omlor G,Bryson E,Kukay A

    更新日期:2008-05-01 00:00:00

  • Irreversible airway obstruction in childhood asthma? A clinician's viewpoint.

    abstract::Even though childhood asthma is assumed to comprise reversible airway obstruction, some children develop irreversible airway obstruction (not reversed by a bronchodilator or corticosteroids); this may be due to inflammation that has caused remodeling. Lately, it has been claimed that in the absence of treatment with i...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10090

    authors: König P

    更新日期:2002-04-01 00:00:00

  • Congenital lung abnormality quantification by computed tomography: The CLAQ method.

    abstract:INTRODUCTION:To date, no consensus has been reached on the optimal management of congenital lung abnormalities, and factors predicting postnatal outcome have not been identified. We developed an objective quantitative computed tomography (CT) scoring method, and assessed its value for clinical decision-making. METHODS...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25032

    authors: Hermelijn SM,Dragt OV,Bosch JJ,Hijkoop A,Riera L,Ciet P,Wijnen RMH,Schnater JM,Tiddens HAWM

    更新日期:2020-11-01 00:00:00

  • Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR.

    abstract::The gasdermin A (GSDMA) and gasdermin B (GSDMB) genes are located at 17q21.2. The GSDM family genes have been studied in the gastrointestinal tract but recent reports suggest that GSDMB is associated with childhood asthma in several populations. We investigated the association of the GSDMA and GSDMB variants with asth...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21424

    authors: Yu J,Kang MJ,Kim BJ,Kwon JW,Song YH,Choi WA,Shin YJ,Hong SJ

    更新日期:2011-07-01 00:00:00

  • Fractional exhaled nitric oxide in healthy non-asthmatic 7-year olds and prenatal exposure to polycyclic aromatic hydrocarbons: nested regression analysis.

    abstract:UNLABELLED:The main goal of the study was to assess possible association between transplacental exposure to genotoxic PAH compounds assessed by the cord blood PAH-DNA adducts and fractional exhaled nitric oxide (FeNO) measured in healthy non-asthmatic children at the age of 7 years. The subjects included the subsample ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22570

    authors: Jedrychowski W,Maugeri U,Mroz E,Flak E,Rembiasz M,Jacek R,Sowa A

    更新日期:2012-11-01 00:00:00

  • Respiratory morbidity in children with profound intellectual and multiple disability.

    abstract:BACKGROUND:'Profound intellectual and multiple disability' (PIMD) is defined as a profound cognitive disability with severe sensory and motor impairments. The aim of this study was to evaluate the respiratory morbidity in children with PIMD and investigate possible risk factors. METHODS:In 10 specialized facilities fo...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23114

    authors: Proesmans M,Vreys M,Huenaerts E,Haest E,Coremans S,Vermeulen F,Feys H

    更新日期:2015-10-01 00:00:00

  • Interrupter technique for evaluation of exercise-induced bronchospasm in children.

    abstract::The free running test is a useful method for evaluation of exercise-induced bronchospasm in children. In young children this test simulates real-life circumstances and can be done more easily than histamine or methacholine challenges. The interrupter technique is a noninvasive method for measuring airflow resistance d...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1099-0496(199903)27:3<203::aid-ppul9

    authors: Kannisto S,Vanninen E,Remes K,Korppi M

    更新日期:1999-03-01 00:00:00

  • Mucus obstruction and inflammation in early cystic fibrosis lung disease: Emerging role of the IL-1 signaling pathway.

    abstract::Mucus plugging constitutes a nutrient-rich nidus for a bacterial infection that has long been recognized as a potent stimulus for neutrophilic airway inflammation driving progressive lung damage in people with cystic fibrosis (CF). However, mucus plugging and neutrophilic inflammation are already present in many infan...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.24462

    authors: Balázs A,Mall MA

    更新日期:2019-11-01 00:00:00

  • Acute pulmonary toxicity following intralesional administration of bleomycin for a lymphovenous malformation.

    abstract:OBJECTIVE:To describe the clinical course and treatment of an infant with acute pulmonary toxicity following intralesional administration of bleomycin for a lymphovenous malformation. DESIGN:Case report. SETTING:A tertiary care University-affiliated hospital. PATIENT, INTERVENTION, AND RESULTS:An 8-month-old girl de...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21139

    authors: Atwa K,Abuhasna S,Shihab Z,Hashaykeh N,Hasan R

    更新日期:2010-02-01 00:00:00