Long-term pulmonary function in esophageal atresia-A case-control study.


BACKGROUND:Esophageal atresia (EA) is a congenital anomaly associated with substantial pulmonary morbidity throughout childhood. AIM:The aim of this study was to evaluate pulmonary complications among 59 five to 15-year-old children and adolescents with surgically corrected congenital EA. METHODS:Participants underwent a structured interview, spirometry, body plethysmography, mannitol challenge test, skin prick test, as well as measurements of the diffusion capacity, airway resistance, fraction of exhaled NO, and specific immunoglobulin E in serum. A control group consisted of 25 children being evaluated for gastroesophageal reflux disease. RESULTS:Among the EA patients 33 (55.9%) had respiratory symptoms, 31 (53.4%) had a history of at least three pneumonias, and 32 (54.2%) reported more frequent cough episodes than peers. The Forced Vital Capacity (FVC) was 84.9% ± 13.2% of predicted, forced expiratory volume 1 sec (FEV1) was 78.2% ± 12.4% of predicted, and forced expiratory fraction 25-75% (FEF25-75%) was 71.5 ± 17.8% of predicted in EA patients, lower than disease controls (P < 0.0001 for all). In addition, the total lung capacity (TLC) was lower in patients with EA than in the controls (P < 0.0001). Fifteen patients (28.8%) with EA had obstructive ventilatory impairment, compared to nine patients (17.3%) with restrictive ventilatory impairment, while one had a combination. CONCLUSIONS:The present study demonstrated significantly decreased pulmonary characteristics in EA patients. Restrictive ventilatory impairment occurring in EA is probably due to poor lung growth after thoracotomy. No single factor predicted ventilatory impairment in children and adolescents with EA. Pediatr Pulmonol. 2017;52:98-106. © 2016 Wiley Periodicals, Inc.


Pediatr Pulmonol


Pediatric pulmonology


Pedersen RN,Markøw S,Kruse-Andersen S,Qvist N,Gerke O,Husby S,Agertoft L




Has Abstract


2017-01-01 00:00:00












  • Combination anti-inflammatory and antiviral therapy of influenza in a cotton rat model.

    abstract::The cotton rat was evaluated as a model for anti-inflammatory and antiviral influenza therapy. Beginning 3 days after intranasal infection with 10(7) tissue culture infectious doses-50% (TCID)(50) of an H3N2 human influenza, animals were treated topically via intranasal lavage with a range of doses of triamcinolone ac...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Ottolini M,Blanco J,Porter D,Peterson L,Curtis S,Prince G

    更新日期:2003-10-01 00:00:00

  • Generalized lymphangiomatosis and chylothorax in the pediatric age group.

    abstract::Four patients with generalized lymphangiomatosis presenting with chylothoraces are described. All four had bone involvement, two had involvement of the spleen, and one of the pericardium. The diagnosis was confirmed by typical radiology, histology, and in three patients by immunohistochemistry. Treatment was mainly pa...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Shah AR,Dinwiddie R,Woolf D,Ramani R,Higgins JN,Matthew DJ

    更新日期:1992-10-01 00:00:00

  • Exercise-induced stridor due to abnormal movement of the arytenoid area: videoendoscopic diagnosis and characterization of the "at risk" group.

    abstract::We evaluated 4 patients who developed severe, symptomatic stridor during maximal cardiopulmonary exercise testing, all referred due to exercise-related dyspnea. All underwent resting, unsedated transnasal fiberoptic laryngoscopy and had normal findings. Four patients performed repeat maximal exercise testing with fibe...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Fahey JT,Bryant NJ,Karas D,Goldberg B,Destefano R,Gracco LC

    更新日期:2005-01-01 00:00:00

  • Down-regulation of regulatory proteins for differentiation and proliferation in murine fetal hypoplastic lungs: altered mesenchymal-epithelial interactions.

    abstract::We compared proliferation (growth) and differentiation (development) related proteins in normal and hypoplastic fetal murine lungs. The hypoplastic lungs were created in CD-1 fetal mice by nitrofen exposure (25 mg per pregnant mouse given intragastrically on gestational day 8 [Gd8]), as published earlier. The lungs we...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Chinoy MR,Chi X,Cilley RE

    更新日期:2001-08-01 00:00:00

  • Ten-year follow up of hydroxychloroquine treatment for ABCA3 deficiency.

    abstract::We present a child with interstitial lung disease (ILD) who was diagnosed with desquamative interstitial pneumonitis following CT thorax and open lung biopsy aged 2 years. Subsequently, surfactant protein gene analysis revealed mutations in the ABCA3 gene. This case of ABCA3 deficient ILD describes a stable clinical c...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Williamson M,Wallis C

    更新日期:2014-03-01 00:00:00

  • Humoral immune response against 38- and 16-kDa mycobacterial antigens in childhood tuberculosis.

    abstract::Several enzyme-linked immunosorbent assays (ELISAs) based on mycobacterial antigens have been tried for the rapid diagnosis of tuberculosis (TB). In this study, the value of the 16 and 38-kDa mycobacterial antigens in the diagnosis of TB was investigated in pediatric patients in Izmir, Turkey in whom they were found u...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Senol G,Ecevit C,Oztürk A

    更新日期:2009-09-01 00:00:00

  • Identifying pediatric lung disease: A comparison of forced oscillation technique outcomes.

    abstract:RATIONALE:Increasing evidence suggests the forced oscillation technique (FOT) has the capacity to provide non-invasive monitoring and diagnosis of respiratory disease in young children. However, which FOT outcomes provide the most pertinent clinical information is currently unknown. The aim of this study was to determi...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Evans DJ,Schultz A,Verheggen M,Hall GL,Simpson SJ

    更新日期:2019-06-01 00:00:00

  • Glucocorticoid receptor disruption delays structural maturation in the lungs of newborn mice.

    abstract::In order to better understand the regulation of lung maturation by glucocorticoid-glucocorticoid receptor signaling, we studied glucocorticoid receptor (GR) hypomorphic mice with a mixed C57Bl6/129 sv background, in which disruption of exon 2 of the GR gene produces an N-terminal truncated GR protein. Four groups of m...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Nemati B,Atmodjo W,Gagnon S,Humes D,McKerlie C,Kaplan F,Sweezey NB

    更新日期:2008-02-01 00:00:00

  • Waist circumference associated with pulmonary function in children.

    abstract::In adults abdominal obesity is related to lung dysfunction and waist circumference (WC) predicts pulmonary function. It is not known how WC affects pulmonary function in children. A cross-sectional study of 718 children 6-17 years of age was conducted in a rural community to determine the predictability of WC for pulm...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Chen Y,Rennie D,Cormier Y,Dosman JA

    更新日期:2009-03-01 00:00:00

  • Spanish multicentre study on morbidity and pathogenicity of tracheal bronchus in children.

    abstract::Tracheal bronchus (TRB) has been generally considered an anatomical variant of the tracheobronchial tree without a precise pathological effect. Its prevalence is estimated to be between 0.2% to 3% of all children undergoing bronchoscopy and scientific information has been limited to case reports or small case series. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,多中心研究


    authors: Moreno M,Castillo-Corullón S,Pérez-Ruiz E,Luna MC,Antón-Pacheco JL,Mondejar-Lopez P,De-la-Serna O,Villa JR,Osona B,Torres-Borrego J,Santiago-Burruchaga M,Asensio O,Andres-Martin A,Delgado-Pecellin I,González Y,Palmero A,E

    更新日期:2019-10-01 00:00:00

  • Severe systemic adverse reaction to proton pump inhibitors in an infant.

    abstract::Episodes of respiratory distress with chest retraction and wheezing, sometimes associated with facial edema, were noted after administering the proton pump inhibitors omeprazole and esomeprazole in an infant with gastroesophageal reflux. The disturbances relieved dramatically after withdrawing the proton pump inhibito...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Baldassarre E,Sagaon MM,Ferrarini A,Bianchetti MG

    更新日期:2007-06-01 00:00:00

  • Mechanical ventilatory constraints during incremental exercise in healthy and cystic fibrosis children.

    abstract:AIM:To analyze breathing pattern and mechanical ventilatory constraints during incremental exercise in healthy and cystic fibrosis (CF) children. METHODS:Thirteen healthy children and 6 children with cystic fibrosis volunteered to perform an incremental test on a treadmill. Exercise tidal flow/volume loops were plotte...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Borel B,Leclair E,Thevenet D,Beghin L,Gottrand F,Fabre C

    更新日期:2014-03-01 00:00:00

  • Comparison of the occlusion and inflation techniques for measuring total respiratory compliance in sick, intubated infants.

    abstract::Respiratory system compliance (Crs) can be used to assess lung stiffness in sick, intubated infants, avoiding the use of an esophageal balloon. Crs was assessed in a group of 15 sick, intubated infants using the occlusion and inflation techniques. The occlusion technique gave satisfactory results in 13 infants. Apneic...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Heaf DP,Turner H,Stocks J,Helms P

    更新日期:1987-03-01 00:00:00

  • Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis.

    abstract::A thorough understanding of the early natural history of cystic fibrosis (CF) lung disease is critical for the development of effective interventions in the youngest patients. We assessed the evolution of pulmonary infection, inflammation, and clinical course among 40 infants over a 2-year period through annual bronch...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Rosenfeld M,Gibson RL,McNamara S,Emerson J,Burns JL,Castile R,Hiatt P,McCoy K,Wilson CB,Inglis A,Smith A,Martin TR,Ramsey BW

    更新日期:2001-11-01 00:00:00

  • Lung function in hyper IgE syndrome.

    abstract::Pneumatoceles and bronchiectasis are secondary complications of respiratory infections in patients with hyper IgE syndrome (HIgES). We report on a patient with HIgES and recurrent pneumonias since 1 year of age, with progression to pneumatoceles and bronchiectasis and fatal outcome, with disseminated infection and sus...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Roxo P Jr,Torres LA,Menezes UP,Melo JM

    更新日期:2013-01-01 00:00:00

  • Nonbronchoscopic approach to bronchoalveolar lavage in children with artificial airways.

    abstract::Bronchoalveolar lavage (BAL) performed with a fiberoptic bronchoscope (FOB) is a useful method for sampling alveolar contents. Since the smallest FOB with a channel has a diameter of 3.6 mm, BAL is difficult to accomplish through artificial airways (AA) less than 5.0 mm I.D. We used a 4F balloon wedge pressure cathete...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Alpert BE,O'Sullivan BP,Panitch HB

    更新日期:1992-05-01 00:00:00

  • Interpretative consequences of adopting the Global Lungs 2012 reference equations for spirometry for children and adolescents.

    abstract:OBJECTIVE:To determine the interpretative consequences of adopting the Global Lungs 2012 (GLI-2012) spirometric prediction equations in a pediatric hospital population. MATERIAL:Spirometric records from 2,192 white boys and 1,842 white girls, and 412 and 334 African-American boys and girls, respectively, aged 6.0-18.0...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Quanjer PH,Weiner DJ

    更新日期:2014-02-01 00:00:00

  • The effects of an intensive behavior and nutrition intervention compared to standard of care on weight outcomes in CF.

    abstract::Inadequate intake and suboptimal growth are common problems for patients with CF and a critical target for intervention. The purpose of this study was to compare the growth outcomes of children with CF who participated in a randomized clinical trial to improve energy intake and weight to children with CF receiving sta...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,随机对照试验


    authors: Stark LJ,Opipari-Arrigan L,Quittner AL,Bean J,Powers SW

    更新日期:2011-01-01 00:00:00

  • Acid steatocrit determination is not helpful in cystic fibrosis patients without or with mild steatorrhea.

    abstract:BACKGROUND:Most methods used for the assessment of severe steatorrhea in cystic fibrosis (CF) are sensitive. In fact, the tests show their usefulness in a borderline zone of the results. Yet, the existing data related to acid steatocrit (AS) are still contradictory. Therefore, in the present study we have aimed to asse...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Walkowiak J,Lisowska A,Blask-Osipa A,Drzymała-Czyz S,Sobkowiak P,Cichy W,Breborowicz A,Herzig KH,Radzikowski A

    更新日期:2010-03-01 00:00:00

  • Ionic determinants of exhaled breath condensate pH before and after exercise in adolescent athletes.

    abstract:BACKGROUND:The pH of exhaled breath condensate (EBC) of adolescent athletes engaged in vigorous physical activity is low compared to healthy controls; however, the ionic determinants of EBC pH and the acute effects of exercise on those determinants have not been definitively established. OBJECTIVES:This study had two ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Greenwald R,Ferdinands JM,Teague WG

    更新日期:2009-08-01 00:00:00

  • Neurocognitive and behavioral impact of sleep disordered breathing in children.

    abstract::The consequences of poor quality and/or inadequate sleep in children and adolescents have become a major public health concern, and one in which pediatric health care professionals have become increasingly involved. In particular, insufficient and/or fragmented sleep resulting from primary sleep disorders such as obst...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审


    authors: Owens JA

    更新日期:2009-05-01 00:00:00

  • Predicting survival in infants with persistent pulmonary hypertension of the newborn.

    abstract::Since persistent pulmonary hypertension of the newborn (PPHN) often occurs as a life-threatening illness, it would be advantageous to identify the highest-risk infants within the first 24 hours of life so that transfer to centers with extracorporeal membrane oxygenation (ECMO) or high-frequency ventilation can be faci...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Davis JM,Spitzer AR,Cox C,Fox WW

    更新日期:1988-01-01 00:00:00

  • Sleep disordered breathing in bronchopulmonary dysplasia.

    abstract:BACKGROUND:There are limited data on the effect of bronchopulmonary dysplasia (BPD) on sleep disordered breathing (SDB). We hypothesized that both the severity of prematurity and BPD would increase the likelihood of SDB in early childhood. Our secondary aim was to evaluate the association of demographic factors on the ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Ortiz LE,McGrath-Morrow SA,Sterni LM,Collaco JM

    更新日期:2017-12-01 00:00:00

  • Maturity-onset diabetes of the young: Different diabetes in an infant with cystic fibrosis.

    abstract::Cystic fibrosis (CF) is one of the most common autosomal recessive and multisystemic diseases. CF affects many systems. One of these systems is the endocrine and exocrine functions of the pancreas, causing cystic fibrosis-related diabetes, which is extremely complex and has unique pathogenesis. Maturity-onset diabetes...

    journal_title:Pediatric pulmonology



    authors: Hangül M,Erdoğan M,Hatipoğlu N,Köse M

    更新日期:2020-05-01 00:00:00

  • Outcomes of a methicillin-resistant Staphylococcus aureus (MRSA) eradication protocol in pediatric cystic fibrosis (CF) patients.

    abstract:OBJECTIVE:Methicillin-resistant Staphylococcus aureus (MRSA) infections in cystic fibrosis (CF) patients have greatly increased in prevalence in the past two decades and may lead to a more rapid rate of lung function decline. The objective of this study was to determine the impact of a MRSA eradication protocol on long...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Belarski E,Pettit R

    更新日期:2020-03-01 00:00:00

  • Disease severity, mental health, and quality of life of children and adolescents with asthma.

    abstract::Asthma has been found related to a higher risk of psychological problems. Inconsistent results have been reported with respect to the quality of life of children with asthma. So there may be a complex relationship between asthma severity, quality of life, and psychological factors. The aim of this study was to examine...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Goldbeck L,Koffmane K,Lecheler J,Thiessen K,Fegert JM

    更新日期:2007-01-01 00:00:00

  • Pulmonary complications after bone marrow transplantation in children: twenty-four years of experience in a single pediatric center.

    abstract::In children, pulmonary sequelae contribute to early and late morbidity after bone marrow transplantation (BMT). Between 1975-1999, we performed 152 BMTs in 138 pediatric patients with malignant and nonmalignant diseases. Allogenic bone marrow was used from 99 HLA identical siblings and from 23 other related or unrelat...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Griese M,Rampf U,Hofmann D,Führer M,Reinhardt D,Bender-Götze C

    更新日期:2000-11-01 00:00:00

  • Differential effects of chronic intermittent and chronic constant hypoxia on postnatal growth and development.

    abstract::Exposure to chronic constant or intermittent hypoxia (CCH or CIH) may have different effects on growth and development in early life. In this work, we exposed postnatal day 2 (P2) CD1 mice to CCH or CIH (11% O2) for 4 weeks and examined the effect of hypoxia on body and organ growth until P30. Regression analysis show...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Farahani R,Kanaan A,Gavrialov O,Brunnert S,Douglas RM,Morcillo P,Haddad GG

    更新日期:2008-01-01 00:00:00

  • Tracking of lung function in healthy children and adolescents.

    abstract::Two hundred twenty-six healthy school children, with a mean age of 8.8 years; 62 girls mean age 8.8, 48 boys mean age 12.6 and 51 girls mean age 12.6 years at the start, were enrolled in a longitudinal study of lung function and tested annually for 5 years. All were free of respiratory symptoms, and none smoked more t...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Hibbert ME,Hudson IL,Lanigan A,Landau LI,Phelan PD

    更新日期:1990-01-01 00:00:00

  • Asthma and COVID-19 in children: A systematic review and call for data.

    abstract:RATIONALE:Whether asthma constitutes a risk factor for coronavirus disease-2019 (COVID-19) is unclear. Here, we aimed to assess whether asthma, the most common chronic disease in children, is associated with higher COVID-19 risk or severity in pediatric populations. METHODS:We performed a systematic literature search ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,meta分析


    authors: Castro-Rodriguez JA,Forno E

    更新日期:2020-09-01 00:00:00