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Time to publication as full reports of abstracts of randomized controlled trials in cystic fibrosis.

Abstract：

OBJECTIVES:To determine 1) what proportion of abstracts of randomized controlled trials (RCTs) presented at international conferences on cystic fibrosis (CF) are published as full reports, 2) time to publication, and 3) factors that might delay or prevent publication. METHODS:At the end of 1995, the Cochrane CF Group's register of RCTs contained 199 abstracts describing 180 RCTs. Abstracts were identified by handsearching 44 abstract books of three international CF conferences over a 30-year period. We searched the register for subsequent full reports of these RCTs and used survival analysis to investigate time to publication. Using the log-rank test, we examined 1) whether there is a difference in time to publication between reports where the investigators concluded that the test treatment was as effective as or better than the control treatment, and reports where it was not, and 2) whether there is a difference in time to publication according to sample size. RESULTS:Thirty-two percent of the 178 abstracts analyzed were subsequently published in full. Survival analysis indicated that the proportions published before 12 months, 2 years, and 5 years were 8.1%, 29%, and 40% respectively. No difference in time to publication was identified when the abstracts were stratified according to conclusions or sample size; no significant association (P > 0.05) existed between time to publication and both sample size and conclusions together. CONCLUSION:Only a small proportion of abstracts of RCTs presented at international conferences on CF are followed by full publication, and usually only after several years. Therefore, many potentially valuable studies do not reach a wide audience. However, we found no consistent factors which might delay or prevent publication.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Cheng K,Preston C,Ashby D,O'Hea U,Smyth RL

doi

10.1002/(sici)1099-0496(199808)26:2<101::aid-ppul5

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

101-5

issue

eissn

8755-6863

issn

1099-0496

pii

10.1002/(SICI)1099-0496(199808)26:2<101::AID-PPUL5

journal_volume

pub_type

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Time to publication as full reports of abstracts of randomized controlled trials in cystic fibrosis.