Safety and tolerability of inhaled hypertonic saline in young children with cystic fibrosis.

abstract：BACKGROUND:Decreased lung function is common in preterm-born survivors. Increased fractional exhaled nitric oxide (FeNO) appears to be a reliable test for eosinophillic airway inflammation especially in asthma. We, systematically, reviewed the literature to compare FeNO levels in preterm-born children and adults who di...

journal_title：Pediatric pulmonology

authors： Course CW,Kotecha S,Kotecha SJ

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Lung involvement in children with Niemann-Pick disease has rarely been studied systematically. OBJECTIVE:To assess the involvement of the lung and the value of bronchoalveolar lavage in children with Niemann-Pick diseases. DESIGN:Retrospective analysis of patient records. PATIENTS:Thirteen patients, with ...

journal_title：Pediatric pulmonology

authors： Guillemot N,Troadec C,de Villemeur TB,Clément A,Fauroux B

更新日期：2007-12-01 00:00:00

abstract：:Airway inflammation of eosinophilic asthma (EA) attributes to Th2 response, leaving the role of Th17 response unknown. Signal transducer and activator of transcription 3 (STAT3) induce both suppressors of cytokine signaling 3 (SOCS3) and retinoic acid receptor-related orphan nuclear receptor γ (RORγt) to initiate Th17...

journal_title：Pediatric pulmonology

authors： Lin X,Lv J,Ge D,Bai H,Yang Y,Wu J

更新日期：2020-06-01 00:00:00

abstract：RATIONALE:Whether asthma constitutes a risk factor for coronavirus disease-2019 (COVID-19) is unclear. Here, we aimed to assess whether asthma, the most common chronic disease in children, is associated with higher COVID-19 risk or severity in pediatric populations. METHODS:We performed a systematic literature search ...

journal_title：Pediatric pulmonology

authors： Castro-Rodriguez JA,Forno E

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Pentraxin 3 (PTX-3) is an acute-phase protein that increases in the plasma during inflammation. OBJECTIVE:We aimed to evaluate the usefulness of PTX-3 as a clinical marker in children with lower respiratory tract infection (LRTI) and examine the correlation of PTX-3 with other biomarkers such as C-reactive ...

journal_title：Pediatric pulmonology

authors： Kim HS,Won S,Lee EK,Chun YH,Yoon JS,Kim HH,Kim JT

更新日期：2016-01-01 00:00:00

abstract：:A new method that permits the measurement of adult-type maximal expiratory flow-volume curves and fractional lung volumes in sedated infants was recently described. The purpose of this study was to define the normal range for these new measures of pulmonary function in infants and young children. Measurements of force...

journal_title：Pediatric pulmonology

authors： Castile R,Filbrun D,Flucke R,Franklin W,McCoy K

更新日期：2000-09-01 00:00:00

abstract：:The optimal duration of therapy for acute exacerbations of cystic fibrosis (CF) has not been defined, and the utility of serial pulmonary function testing in predicting the duration of therapy has yet to be established. In a review of 90 pulmonary exacerbations of 39 patients with CF requiring hospitalization, we foun...

journal_title：Pediatric pulmonology

authors： Rosenberg SM,Schramm CM

更新日期：1993-10-01 00:00:00

abstract：:The aim of this study was to validate our Dalhousie Dyspnea Scales in children referred for histamine bronchoprovocation challenge. Seventy-four children rated their dyspnea after each FEV(1) measurement following inhalation of doubling histamine concentrations from 0.125 to 8.0 mg/ml by the standard tidal breathing m...

journal_title：Pediatric pulmonology

authors： Pianosi P,Smith CP,Almudevar A,McGrath PJ

更新日期：2006-12-01 00:00:00

abstract：:Since July 1988, a total of 92 transbronchial biopsies (TBB) have been performed in 18 patients (aged 3-16 years). Twelve patients (67%) were heart-lung transplant (HLT) recipients undergoing surveillance for pulmonary graft rejection and infection. The remainder included immunocompromised patients at risk of opportun...

journal_title：Pediatric pulmonology

authors： Whitehead B,Scott JP,Helms P,Malone M,Macrae D,Higenbottam TW,Smyth RL,Wallwork J,Elliott M,de Leval M

更新日期：1992-04-01 00:00:00

abstract：:A potentially useful method to monitor respiratory mechanics in artificially ventilated patients consists of analyzing the relationship between tracheal pressure (P), lung volume (V), and gas flow (V) by multiple linear regression (MLR) using a suitable model. Contrary to other methods, it does not require any particu...

journal_title：Pediatric pulmonology

authors： Rousselot JM,Peslin R,Duvivier C

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Plastic bronchitis (PB) is a rare, variable, and potentially fatal disease. This study aimed to assess the efficacy of fiberoptic bronchoscopy (FOB) and bronchoalveolar lavage (BAL) in treating children with PB. METHODS:In total, 15 children with PB, between 2012 and 2020, were enrolled in our study. Within...

journal_title：Pediatric pulmonology

authors： Wang L,Wang W,Sun JM,Ni SW,Ding JL,Zhu YL,Ding SG

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:Respiratory illnesses compose the most common diagnoses of patients admitted to pediatric intensive care units. In pediatrics, high-flow nasal cannula (HFNC) therapy is an intermediate level of respiratory support with variability in practice. We conducted a pre-post intervention study of patients placed on H...

journal_title：Pediatric pulmonology

authors： Wiser RK,Smith AC,Khallouq BB,Chen JG

更新日期：2020-12-09 00:00:00

abstract：:Maternal retinoid administration has beneficial effects on lung development in the nitrofen rodent toxic model of congenital diaphragmatic hernia (DH). We wanted to investigate the effects in a surgical model, where the retinoid signaling pathway is not primarily disrupted by the toxic agent. We created DH in fetal ra...

journal_title：Pediatric pulmonology

authors： Gallot D,Coste K,Jani J,Roubliova X,Marceau G,Velemir L,Verheyen A,Lemery D,Sapin V,Deprest J

更新日期：2008-06-01 00:00:00

abstract：:Cystic fibrosis (CF) patients with advanced lung disease are at risk for developing pulmonary vascular disease and pulmonary hypertension, characterized by progressive exercise intolerance beyond the exercise-limiting effects of airways disease in CF. We report on a patient with severe CF lung disease who experienced ...

journal_title：Pediatric pulmonology

authors： Montgomery GS,Sagel SD,Taylor AL,Abman SH

更新日期：2006-04-01 00:00:00

abstract：:Impulse oscillometry (IOS) evaluates non-effort-dependent respiratory mechanics, and thus it may be useful to evaluate patients with Duchenne muscular dystrophy (DMD). OBJECTIVES:We aimed (1) to describe the behavior of IOS parameters in patients with DMD, and compare it to those from a control group; (2) to determin...

journal_title：Pediatric pulmonology

authors： Gochicoa-Rangel L,Vargas MH,Alonso-Gómez JL,Rodríguez-Moreno L,Martínez-Briseño D,Baños-Mejía O,Torre-Bouscoulet L

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:There are few published data on the efficacy of systemic corticosteroids in preterm infants with very severe forms of bronchopulmonary dysplasia (BPD), requiring respiratory support after 3 months of age. The aim of this study was to report the use of pulses of methylprednisolone in this population and its...

journal_title：Pediatric pulmonology

authors： Billion E,Hadchouel A,Garcelon N,Delacourt C,Drummond D

更新日期：2021-01-01 00:00:00

abstract：:Allergic bronchopulmonary aspergillosis (ABPA) is a complication commonly encountered in patients with CF that produces significant respiratory morbidity. Chronic airway colonization with Aspergillus induces strong inflammatory responses with high IgE levels. Current guidelines for therapy include prolonged courses of...

journal_title：Pediatric pulmonology

authors： Zirbes JM,Milla CE

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Hypoxia and reactive oxygen species (ROS) including H(2)O(2) play major roles in triggering and progression of pulmonary vascular remodeling in persistent pulmonary hypertension. Catalase (CAT), the major endogenous enzyme scavenging H(2)O(2), is regulated in a tissue- and context-specific manner. OBJECTIVE...

journal_title：Pediatric pulmonology

authors： Awad H,Nolette N,Hinton M,Dakshinamurti S

更新日期：2014-09-01 00:00:00

abstract：:Four patients with generalized lymphangiomatosis presenting with chylothoraces are described. All four had bone involvement, two had involvement of the spleen, and one of the pericardium. The diagnosis was confirmed by typical radiology, histology, and in three patients by immunohistochemistry. Treatment was mainly pa...

journal_title：Pediatric pulmonology

authors： Shah AR,Dinwiddie R,Woolf D,Ramani R,Higgins JN,Matthew DJ

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVES:We assessed the performance of a tracheostomy decannulation protocol privileging safety over quickness, in pediatric patients undergoing rehabilitation from severe acquired brain injury. We analyzed factors associated with decannulation timing and possibility and examined cases of failure. HYPOTHESIS:A safe...

journal_title：Pediatric pulmonology

authors： Pozzi M,Galbiati S,Locatelli F,Clementi E,Strazzer S

更新日期：2017-11-01 00:00:00

abstract：:Corticosteroids continue to be used by many physicians to treat infants with bronchiolitis. The aim of this study was to examine the short-term and long-term efficacy of oral corticosteroid therapy when added to beta2-agonists in infants with mild to moderate bronchiolitis (defined as the first episode of wheezing ass...

journal_title：Pediatric pulmonology

authors： Berger I,Argaman Z,Schwartz SB,Segal E,Kiderman A,Branski D,Kerem E

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Discussions on the diagnostic and management of acquired pediatric lung pathology are usually published by large tertiary children's hospitals. It is likely that much of this pathology is actually seen and managed in nonacademic practices. METHODS:A 10-year retrospective review of patients under 18-years of...

journal_title：Pediatric pulmonology

authors： Kanitra JJ,Thampy CA,Cullen ML

更新日期：2021-01-02 00:00:00

abstract：:Childhood interstitial lung disease (chILD) comprises a wide heterogeneous group of rare parenchymal lung disorders associated with substantial morbidity and mortality. Pulmonary hypertension is a common comorbidity in adults with interstitial lung disease (ILD) and associated with poor survival. We aimed to systemati...

journal_title：Pediatric pulmonology

authors： Bromley S,Vizcaya D

更新日期：2017-05-01 00:00:00

abstract：:To systematically review the clinical outcomes of surfactant administration via a thin endotracheal catheter during spontaneous breathing compared with conventional administration involving tracheal intubation, mechanical ventilation (MV), and tracheal extubation, in preterm infants. PubMed, EMBASE, and the Cochrane L...

journal_title：Pediatric pulmonology

authors： Wu W,Shi Y,Li F,Wen Z,Liu H

更新日期：2017-06-01 00:00:00

abstract：:Little attention has been focused on the progressive pulmonary deterioration which occurs in mechanically ventilated infants with normal or mildly abnormal lungs. We hypothesized that lung function would deteriorate over a 24-hr period in anesthetized neonatal piglets with normal lungs mechanically ventilated at 2 cm ...

journal_title：Pediatric pulmonology

authors： Easa D,Finn KC,Balaraman V,Sood S,Wilkerson S,Takenaka W,Mundie TG

更新日期：1995-03-01 00:00:00

abstract：:The free running test is a useful method for evaluation of exercise-induced bronchospasm in children. In young children this test simulates real-life circumstances and can be done more easily than histamine or methacholine challenges. The interrupter technique is a noninvasive method for measuring airflow resistance d...

journal_title：Pediatric pulmonology

authors： Kannisto S,Vanninen E,Remes K,Korppi M

更新日期：1999-03-01 00:00:00

abstract：:Physicians and physiotherapists who care for CF patients have recommended the use of trampolines as a physiotherapeutic tool for enhancing cardiopulmonary performance, encouraging sputum production, and improving general well-being. Despite some therapeutic and recreational benefits associated with trampoline use, pap...

journal_title：Pediatric pulmonology

authors： Barak A,Wexler ID,Efrati O,Bentur L,Augarten A,Mussaffi H,Avital A,Rivlin J,Aviram M,Yahav Y,Kerem E

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections worldwide, causing disproportionate morbidity and mortality in infants and children. Infants with stronger Th1 responses have less severe disease, yet little is known about the infant T-cell response within the air spa...

journal_title：Pediatric pulmonology

authors： Eichinger KM,Kosanovich JL,Empey KM

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Asthma is a chronic lower airway inflammatory disease. Nitric oxide is an inflammatory mediator produced endogenously in the airway. Previous studies have demonstrated that the fractional concentration of exhaled nitric oxide (FeNO) is increased in asthma. OBJECTIVES:To investigate if FeNO concentrations we...

journal_title：Pediatric pulmonology

authors： Oh MA,Shim JY,Jung YH,Seo JH,Young Kim H,Kwon JW,Kim BJ,Kim HB,Kim WK,Lee SY,Jang GC,Song DJ,Kim HJ,Shin YJ,Park JW,Cho SH,Lee JS,Hong SJ

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Most international asthma guidelines recommend that children ≤5 years with asthma or recurrent wheezing be treated with daily low- moderate dose inhaled corticosteroids (ICS) as the preferred controller and leukotriene receptor antagonists (LTRA) as alternative therapy. There is no systematic review comparin...

journal_title：Pediatric pulmonology

authors： Castro-Rodriguez JA,Rodriguez-Martinez CE,Ducharme FM

更新日期：2018-12-01 00:00:00