Abstract:
BACKGROUND:Pulmonary function testing is commonly performed for diagnosis and clinical management of respiratory diseases. It is important to use appropriate reference equations from healthy subjects for interpretation of data from infants with lung disease. This study aimed to determine if published reference equations were similar to forced flow measures and plethysmographic infant pulmonary function testing data collected in the Canadian Healthy Infant Longitudinal Development (CHILD) Study. METHODS:Reference equations for five pulmonary function variables (FEV0.5 , FVC, FEF25-75 , FEV0.5 /FVC ratio and plethysmography (FRCpleth )) were developed using data from the nSpire system. New reference equations developed using healthy data from the CHILD Study were compared to previously published reference equations for forced flow and plethysmographic measures. RESULTS:The current analysis included 131 infants (on 181 test occasions) with forced flow measures and 161 infants (on 246 test occasions) with plethysmography measures, aged 3-24 months. Age and length were major determinants of both forced flow and plethysmography measures. In addition, ethnicity (Caucasian vs non-Caucasian) was significantly associated with FEV0.5 /FVC and FEF25-75 measures. We found that the published reference equations based on custom-built equipment or commercially available systems provided poor fit to our current pulmonary function testing data, resulting in placing a large proportion of our healthy population outside the normal ranges. CONCLUSIONS:Our current data support the need for population and device specific reference data for infant pulmonary function studies. By deriving new equipment-specific reference equations for our healthy population, we provide normative data to other centers utilizing this equipment.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Lu Z,Foong RE,Kowalik K,Moraes TJ,Dubeau A,Lefebvre D,Davis SD,Balkovec S,Becker A,Mandhane P,Turvey SE,Lou W,Sears MR,Ratjen F,Subbarao Pdoi
10.1002/ppul.24063subject
Has Abstractpub_date
2018-07-01 00:00:00pages
907-916issue
7eissn
8755-6863issn
1099-0496journal_volume
53pub_type
杂志文章abstract::The main physiological impact of high flow nasal cannula (HFNC) therapy is presumed to be a decrease in work of breathing (WOB). To assess this, diaphragmatic electrical activity and esophageal pressure changes were measured off then on HFNC delivered at 2 L/kg/min, in 14 infants with bronchiolitis and 14 cardiac infa...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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doi:10.1002/ppul.24739
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20886
更新日期:2008-12-01 00:00:00
abstract::Eight patients with cystic fibrosis [CF] colonized with Pseudomonas aeruginosa (P. aeruginosa) had serial lung function, peripheral blood inflammatory markers, and serum IgG antibodies to Burkholderia cepacia (B. cepacia) lipopolysaccharide measured in the months preceding and following colonisation with B. cepacia. O...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-10-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20751
更新日期:2008-02-01 00:00:00
abstract::This report describes a patient with biliary atresia (BA) associated with polysplenia syndrome who showed a rapid progression of intrapulmonary arteriovenous shunting (IPS), resulting in a fatal outcome. Intrauterine ultrasonography at 36 weeks of gestation revealed fetal abnormalities, including situs inversus, absen...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.10285
更新日期:2003-06-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24889
更新日期:2020-08-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20882
更新日期:2008-09-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20910
更新日期:2008-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ppul.20961
更新日期:2009-05-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,meta分析
doi:10.1002/ppul.24909
更新日期:2020-09-01 00:00:00
abstract::Most pneumatoceles disappear spontaneously and do not cause severe symptoms. Treatment alternatives include various conventional or surgical methods. However, an enlarging, complicated pneumatocele with cardiorespiratory instability requires imaging-guided catheter drainage or surgery. Here, we report the case of a ne...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23311
更新日期:2016-02-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/(sici)1099-0496(199907)28:1<47::aid-ppul8>
更新日期:1999-07-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24591
更新日期:2020-02-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(sici)1099-0496(199905)27:5<318::aid-ppul4
更新日期:1999-05-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24768
更新日期:2020-07-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
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更新日期:2011-06-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2004-07-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950050407
更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1989-01-01 00:00:00