Reference equations for the interpretation of forced expiratory and plethysmographic measurements in infants.

Abstract:

BACKGROUND:Pulmonary function testing is commonly performed for diagnosis and clinical management of respiratory diseases. It is important to use appropriate reference equations from healthy subjects for interpretation of data from infants with lung disease. This study aimed to determine if published reference equations were similar to forced flow measures and plethysmographic infant pulmonary function testing data collected in the Canadian Healthy Infant Longitudinal Development (CHILD) Study. METHODS:Reference equations for five pulmonary function variables (FEV0.5 , FVC, FEF25-75 , FEV0.5 /FVC ratio and plethysmography (FRCpleth )) were developed using data from the nSpire system. New reference equations developed using healthy data from the CHILD Study were compared to previously published reference equations for forced flow and plethysmographic measures. RESULTS:The current analysis included 131 infants (on 181 test occasions) with forced flow measures and 161 infants (on 246 test occasions) with plethysmography measures, aged 3-24 months. Age and length were major determinants of both forced flow and plethysmography measures. In addition, ethnicity (Caucasian vs non-Caucasian) was significantly associated with FEV0.5 /FVC and FEF25-75 measures. We found that the published reference equations based on custom-built equipment or commercially available systems provided poor fit to our current pulmonary function testing data, resulting in placing a large proportion of our healthy population outside the normal ranges. CONCLUSIONS:Our current data support the need for population and device specific reference data for infant pulmonary function studies. By deriving new equipment-specific reference equations for our healthy population, we provide normative data to other centers utilizing this equipment.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Lu Z,Foong RE,Kowalik K,Moraes TJ,Dubeau A,Lefebvre D,Davis SD,Balkovec S,Becker A,Mandhane P,Turvey SE,Lou W,Sears MR,Ratjen F,Subbarao P

doi

10.1002/ppul.24063

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

907-916

issue

7

eissn

8755-6863

issn

1099-0496

journal_volume

53

pub_type

杂志文章
  • The effect of high flow nasal cannula therapy on the work of breathing in infants with bronchiolitis.

    abstract::The main physiological impact of high flow nasal cannula (HFNC) therapy is presumed to be a decrease in work of breathing (WOB). To assess this, diaphragmatic electrical activity and esophageal pressure changes were measured off then on HFNC delivered at 2 L/kg/min, in 14 infants with bronchiolitis and 14 cardiac infa...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23060

    authors: Pham TM,O'Malley L,Mayfield S,Martin S,Schibler A

    更新日期:2015-07-01 00:00:00

  • The correlation of adenosine challenge test results with subsequent clinical course among young children with suspected asthma: a retrospective cohort study.

    abstract:AIM:Our aim was to evaluate the correlation of Adenosine monophosphate challenge test (AMP-PCW) results with the patients' subsequent clinical course. METHODS:We performed a 6-year retrospective cohort study of young children with suspected asthma who underwent AMP-PCW test. RESULTS:Fifty four children were included ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24337

    authors: Levin G,Rottensctreich A,Picard E,Avital A,Springer C,Cohen S

    更新日期:2019-07-01 00:00:00

  • Overexpression of miR-455-5p affects retinol (vitamin A) absorption by downregulating STRA6 in a nitrofen-induced CDH with lung hypoplasia rat model.

    abstract::Lung hypoplasia is the main cause of congenital diaphragmatic hernia (CDH)-associated death but pathogenesis remains unclear. MiR-455-5p is involved in lung hypoplasia. We hypothesized that nitrofen causes abnormal miR-455-5p expression during lung development and designed this study to determine the relationship betw...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24739

    authors: Zheng J,He Q,Tang H,Li J,Xu H,Mao X,Liu G

    更新日期:2020-06-01 00:00:00

  • Assessing bronchodilator responsiveness in infants using partial expiratory flow-volume curves.

    abstract::Our objective was to compare the effectiveness of maximum forced expiratory flow measured at functional residual capacity (V'maxFRC) and the ratio of flow at 75% of the forced expiratory volume to peak forced expiratory flow (FEF(75)/FEF(peak)) for detecting bronchodilator-related changes in wheezy infants. In 55 infa...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章

    doi:10.1002/ppul.10325

    authors: Sheikh S,Castile R,Hayes J,McCoy K,Eid N

    更新日期:2003-09-01 00:00:00

  • Plasma ADMA concentrations at birth and mechanical ventilation in preterm infants: a prospective pilot study.

    abstract:RATIONALE:Nitric oxide (NO) produced in the lung is an important mediator of normal lung development, vascular smooth muscle relaxation, and ventilation perfusion matching. NO is synthesized from arginine by the action of NO-synthase (NOS). Asymmetric dimethylarginine (ADMA), an endogenous derivate of arginine, inhibit...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20886

    authors: Richir MC,van Leeuwen PA,van den Berg A,Wessels R,Twisk JW,Rauwerda JA,Teerlink T,de Vries TP,van Elburg RM

    更新日期:2008-12-01 00:00:00

  • Pulmonary function, serum markers of inflammation, and IgG antibodies to core lipopolysaccharide of Burkholderia cepacia in adults with cystic fibrosis, following colonization with Burkholderia cepacia.

    abstract::Eight patients with cystic fibrosis [CF] colonized with Pseudomonas aeruginosa (P. aeruginosa) had serial lung function, peripheral blood inflammatory markers, and serum IgG antibodies to Burkholderia cepacia (B. cepacia) lipopolysaccharide measured in the months preceding and following colonisation with B. cepacia. O...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-0496(200001)29:1<8::aid-ppul2>3

    authors: Hendry J,Nixon L,Dodd M,Elborn JS,Govan J,Shale DJ,Webb AK

    更新日期:2000-01-01 00:00:00

  • The delivery of therapeutic aerosols through endotracheal tubes.

    abstract::We used an in vitro model system to examine the sites of deposition of aqueous therapeutic aerosols administered through 3-mm, 6-mm, and 9-mm endotracheal tubes (commonly used in infants, children, and adults) at clinically relevant inspiratory flow rates. Aerosol was delivered to the endotracheal tube via a "T" piece...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950020108

    authors: Ahrens RC,Ries RA,Popendorf W,Wiese JA

    更新日期:1986-01-01 00:00:00

  • Acquired somatic mutations in the microsatellite DNA, in children with bronchial asthma.

    abstract:OBJECTIVES:High incidence of genetic alterations at the microsatellite (MS) DNA level has been reported in asthmatic adults. WORKING HYPOTHESIS:The aim of this study was to investigate whether microsatellite instability (MSI) and loss of heterozygosity (LOH) were detectable phenomena in children with asthma. METHODOL...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21097

    authors: Thomou C,Paraskakis E,Neofytou E,Kalmanti M,Siafakas NM,Tzortzaki EG

    更新日期:2009-10-01 00:00:00

  • Associations of obesity and asthma with functional exercise capacity in urban minority adolescents.

    abstract:PURPOSE:To examine the independent association of asthma and obesity and of their co-existence with functional exercise capacity among urban adolescents. METHODS:One hundred eighteen Hispanic- and African-American adolescents including 33 obese asthmatics, 18 normal-weight asthmatics, 38 obese non-asthmatics, and 29 n...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22547

    authors: Rastogi D,Khan UI,Isasi CR,Coupey SM

    更新日期:2012-11-01 00:00:00

  • Prophylaxis against respiratory syncytial virus in young children with cystic fibrosis.

    abstract:INTRODUCTION:In cystic fibrosis (CF) patients, respiratory syncytial virus (RSV) infection is associated with significant morbidity. Although passive prophylaxis with palivizumab lowers hospitalization rate for RSV infection in populations at risk of severe infection, its use is not recommended in infants with CF disea...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20751

    authors: Giebels K,Marcotte JE,Podoba J,Rousseau C,Denis MH,Fauvel V,Laberge S

    更新日期:2008-02-01 00:00:00

  • Rapid progression of intrapulmonary arteriovenous shunting in polysplenia syndrome associated with biliary atresia.

    abstract::This report describes a patient with biliary atresia (BA) associated with polysplenia syndrome who showed a rapid progression of intrapulmonary arteriovenous shunting (IPS), resulting in a fatal outcome. Intrauterine ultrasonography at 36 weeks of gestation revealed fetal abnormalities, including situs inversus, absen...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10285

    authors: Kimura T,Hasegawa T,Sasaki T,Okada A,Mushiake S

    更新日期:2003-06-01 00:00:00

  • Prenatal exposure to VOCs and NOx and lung function in preschoolers.

    abstract:BACKGROUND:Several studies have shown that exposure to air pollutants affects lung growth and development and can result in poor respiratory health in early life. METHODS:We included a subsample of 772 Mexican preschoolers whose mothers participated in a Prenatal Omega-3 fatty acid Supplements, GRowth, And Development...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24889

    authors: Gutiérrez-Delgado RI,Barraza-Villarreal A,Escamilla-Núñez MC,Hernández-Cadena L,Cortez-Lugo M,Sly P,Romieu I

    更新日期:2020-08-01 00:00:00

  • Neonatal screening programme for CF: Results from the Irish Comparative Outcomes Study (ICOS).

    abstract::The introduction of NBS in Ireland in July 2011, provided a unique opportunity to investigate clinical outcomes using a comparative historical cohort study. Clinical cohort: children clinically diagnosed with CF born 1 July 2008 to 30 June 2011, and NBS cohort: children diagnosed with CF through NBS born 1 July 2011 t...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24876

    authors: Fitzgerald C,Linnane B,George S,Ni Chroinin M,Mullane D,Herzig M,Greally P,Elnazir B,Healy F,Mc Nally P,Javadpour S,Cox D,Fitzpatrick P

    更新日期:2020-09-01 00:00:00

  • Occlusion of an aberrant artery to an intralobar pulmonary sequestration using an Amplatzer Vascular Plug.

    abstract::Pulmonary sequestration is a rare anomaly and is conventionally treated with surgical excision. This report describes the successful occlusion of a large aberrant artery to an intralobar pulmonary sequestration using an Amplatzer Vascular Plug. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20882

    authors: Hwang HK,Tsai YS,Lin SM,Chen MR

    更新日期:2008-09-01 00:00:00

  • Flexible bronchoscopy in pediatric intensive care.

    abstract:OBJECTIVE:To define the benefits of a flexible bronchoscopy (FB) service in a Paediatric Intensive Care Unit (PICU). DESIGN:Review of the first 200 FBs undertaken in a large PICU. SETTING:Large cardiac and medical PICU in the United Kingdom, also providing extra-corporeal life support. PATIENTS:129 patients (78 male...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20910

    authors: Davidson MG,Coutts J,Bell G

    更新日期:2008-12-01 00:00:00

  • Increased serum interleukin-5 and vascular endothelial growth factor in children with acute mycoplasma pneumonia and wheeze.

    abstract::Acute mycoplasma pneumonia may be accompanied by wheeze in some children considered not to have asthma. The aim of the present study was to evaluate cytokine secretion in children with acute mycoplasma pneumonia and wheeze. We studied 58 patients with mycoplasma pneumonia (12 with wheeze, Group 1; 46 without wheeze, G...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20961

    authors: Choi IS,Byeon JH,Yoo Y,Lee KC,Choung JT

    更新日期:2009-05-01 00:00:00

  • Asthma and COVID-19 in children: A systematic review and call for data.

    abstract:RATIONALE:Whether asthma constitutes a risk factor for coronavirus disease-2019 (COVID-19) is unclear. Here, we aimed to assess whether asthma, the most common chronic disease in children, is associated with higher COVID-19 risk or severity in pediatric populations. METHODS:We performed a systematic literature search ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,meta分析

    doi:10.1002/ppul.24909

    authors: Castro-Rodriguez JA,Forno E

    更新日期:2020-09-01 00:00:00

  • Nonsurgical management of an enlarging pneumatocele by fibrin sealant injection via pigtail catheter.

    abstract::Most pneumatoceles disappear spontaneously and do not cause severe symptoms. Treatment alternatives include various conventional or surgical methods. However, an enlarging, complicated pneumatocele with cardiorespiratory instability requires imaging-guided catheter drainage or surgery. Here, we report the case of a ne...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23311

    authors: Park TH,Kim JK

    更新日期:2016-02-01 00:00:00

  • Tracking of lung function in healthy children and adolescents.

    abstract::Two hundred twenty-six healthy school children, with a mean age of 8.8 years; 62 girls mean age 8.8, 48 boys mean age 12.6 and 51 girls mean age 12.6 years at the start, were enrolled in a longitudinal study of lung function and tested annually for 5 years. All were free of respiratory symptoms, and none smoked more t...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950080308

    authors: Hibbert ME,Hudson IL,Lanigan A,Landau LI,Phelan PD

    更新日期:1990-01-01 00:00:00

  • The use of biologic therapies for the management of pediatric asthma.

    abstract::With better understanding of the role of type 2 inflammation in allergic asthma, there has been progress made in the development of new biologic therapies targeting these specific pathways. This review will consider diagnostic criteria for using biologic therapies for pediatric asthma with special emphasis on populati...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.24613

    authors: Lovinsky-Desir S

    更新日期:2020-03-01 00:00:00

  • Long-term effects of prednisolone in the acute phase of bronchiolitis caused by respiratory syncytial virus.

    abstract::Follow-up studies have demonstrated that bronchiolitis caused by respiratory syncytial virus (RSV) is strongly associated with wheezing in the ensuing years. During the acute infection the immune response may induce long-lasting detrimental effects, thereby contributing to post-bronchiolitis wheezing (PBW). Therefore,...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1099-0496(200008)30:2<92::aid-ppul3>3.0.co

    authors: van Woensel JB,Kimpen JL,Sprikkelman AB,Ouwehand A,van Aalderen WM

    更新日期:2000-08-01 00:00:00

  • Nocturnal dry cough in the first 7 years of life is associated with asthma at school age.

    abstract:BACKGROUND:Childhood wheeze is an important, well-known risk factor for asthma, yet little is known about the contribution of nocturnal dry cough. We investigated the association of nocturnal dry cough at ages 1-7 years with doctor-diagnosed asthma at 8 years of age, both in the presence and absence of wheeze. METHODS...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23092

    authors: Boudewijn IM,Savenije OE,Koppelman GH,Wijga AH,Smit HA,de Jongste JC,Gehring U,Postma DS,Kerkhof M

    更新日期:2015-09-01 00:00:00

  • Outcome of idiopathic apparent life-threatening events: infant and mother perspectives.

    abstract::The objective of this study was to determine the neurodevelopmental and temperamental outcome of infants who suffered an idiopathic apparent life-threatening event (IALTE) and their mothers' perceptions of such an event, and to compare such infants with a matched group of babies hospitalized for nonthreatening events....

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/(sici)1099-0496(199907)28:1<47::aid-ppul8>

    authors: Tirosh E,Kessel A,Jaffe M,Cohen A

    更新日期:1999-07-01 00:00:00

  • Reference values of sniff nasal inspiratory pressure in healthy children.

    abstract:OBJECTIVE:To determine reference values of sniff nasal inspiratory pressure (SNIP) in healthy children. METHODS:This cross-sectional observational study included healthy children aged 6 to 11 years of both sexes. The volunteers underwent a pulmonary function test to rule out respiratory disorders. Respiratory muscle s...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24591

    authors: Marcelino AA,Fregonezi GA,Lira MGA,de Oliveira LM,Araújo PRS,Parreira VF,de Andrade AD,Resqueti V

    更新日期:2020-02-01 00:00:00

  • Effects of different modes of delivery on lung volumes of newborn infants.

    abstract::The aim of our study was to examine the effect of labor and birth canal compression on the rate of clearance of lung fluid. We recruited 10 babies born by vaginal delivery and 10 born by elective cesarean section (ECS). Thoracic gas volume (TGV) was measured using total body plethysmography, and functional residual ca...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-0496(199905)27:5<318::aid-ppul4

    authors: Lee S,Hassan A,Ingram D,Milner AD

    更新日期:1999-05-01 00:00:00

  • An apple a day won't keep the doctor away: presentation, treatment, and outcome in pediatric apple aspirations.

    abstract:INTRODUCTION:Foreign body (FB) aspiration is a frequent and preventable source of morbidity and mortality, especially in children under 4 years of age. Few comprehensive studies exist on presentation and outcome of apple aspirations in children. METHODS:In a retrospective analysis of bronchoscopy records of a tertiary...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24768

    authors: Zychlinsky Scharff A,Schwerk N,Baumann U,Burmester H,Carlens J,Dopfer C,Grewendorf S,Mueller C,Schütz K,Voelker M,Hansen G,Happle C,Wetzke M

    更新日期:2020-07-01 00:00:00

  • Respiration rate monitoring methods: a review.

    abstract::Respiration rate is an important indicator of a person's health, and thus it is monitored when performing clinical evaluations. There are different approaches for respiration monitoring, but generally they can be classed as contact or noncontact. For contact methods, the sensing device (or part of the instrument conta...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.21416

    authors: Al-Khalidi FQ,Saatchi R,Burke D,Elphick H,Tan S

    更新日期:2011-06-01 00:00:00

  • CF: an X-ray database to assess effect of aerosolized tobramycin.

    abstract::This paper assesses the effectiveness of aerosolized tobramycin (TOBI) on cystic fibrosis (CF) lung disease, using a radiologic tool. The published tool, the age-based severity curve (ABS), is derived from Brasfield scoring of chest X-rays (CXR). This study evaluates both the usefulness of the ABS as an assessment too...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20032

    authors: Slattery DM,Zurakowski D,Colin AA,Cleveland RH

    更新日期:2004-07-01 00:00:00

  • Recruitment of intercostal muscle activity during hypercapnia in kittens.

    abstract::Little is known about the respiratory behavior of the intercostal muscles within a neonatal and developmental context. We, therefore, examined intercostal muscle electromyographic (EMG) activity in kittens (1 month old, n = 8; 2 months old, n = 7) during eupnea and heightened respiratory drive induced by hypercapnia. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950050407

    authors: Watchko JF,Klesh KW,O'Day TL,Guthrie RD

    更新日期:1988-01-01 00:00:00

  • Connective tissue, mechanical, and morphometric changes in the lungs of weanling rats fed a low protein diet.

    abstract::We studied the effect of low-protein diet (8% casein) on lung growth in rats from 3 to 7 weeks of age. Their diet was isocaloric with that of control animals fed a diet of 20% casein. The calorie intake of experimental animals was increased during the first 3 weeks of the experiment, but they increased less (about 10%...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950070308

    authors: Matsui R,Thurlbeck WM,Fujita Y,Yu SY,Kida K

    更新日期:1989-01-01 00:00:00