Abstract:
:Follow-up studies have demonstrated that bronchiolitis caused by respiratory syncytial virus (RSV) is strongly associated with wheezing in the ensuing years. During the acute infection the immune response may induce long-lasting detrimental effects, thereby contributing to post-bronchiolitis wheezing (PBW). Therefore, immune-modulating drugs like corticosteroids, administered in the acute phase of RSV bronchiolitis, may prevent PBW and asthma. To evaluate this, we performed a controlled prospective follow-up study after a randomized double-blind placebo-controlled intervention in the acute phase with oral prednisolone. Fifty-four patients under 2 years of age and hospitalized for RSV bronchiolitis between 1992 and 1995 were randomly assigned to prednisolone 1 mg/kg/day for 7 days or placebo. At the mean age of 5 years, 47 patients had completed their follow-up. Patients were divided into four groups: no wheezing, transient wheezing (wheezing during the first year of life); persistent wheezing (wheezing during the first year of life and asthma at the age of 5); and late-onset wheezing (no wheezing during the first year of life but asthma at the age of 5). Prevalence of wheezing and asthma were investigated through an interview by telephone, using a standardized questionnaire. We found no significant differences between the prednisolone- and the placebo-treated group in the number of patients with transient wheezing (8% vs. 17%), persistent wheezing (42% vs. 31%), or late-onset wheezing (17% vs. 13%). We conclude that oral prednisolone during the acute phase of RSV bronchiolitis is not effective in preventing PBW or asthma at the mean age of 5 years. Pediatr Pulmonol. 2000; 30: 92-96.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
van Woensel JB,Kimpen JL,Sprikkelman AB,Ouwehand A,van Aalderen WMdoi
10.1002/1099-0496(200008)30:2<92::aid-ppul3>3.0.cosubject
Has Abstractpub_date
2000-08-01 00:00:00pages
92-6issue
2eissn
8755-6863issn
1099-0496pii
10.1002/1099-0496(200008)30:2<92::AID-PPUL3>3.0.COjournal_volume
30pub_type
临床试验,杂志文章,随机对照试验abstract::A new method that permits the measurement of adult-type maximal expiratory flow-volume curves and fractional lung volumes in sedated infants was recently described. The purpose of this study was to define the normal range for these new measures of pulmonary function in infants and young children. Measurements of force...
journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章
doi:10.1002/1099-0496(200009)30:3<215::aid-ppul6>3.0.c
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:Magnetic Resonance Imaging (MRI) techniques to image the larynx have evolved rapidly into a promising and safe imaging modality, without need for sedation or ionizing radiation. MRI is therefore of great interest to image pediatric laryngeal diseases. Our aim was to review MRI developments relevant for the p...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24250
更新日期:2019-04-01 00:00:00
abstract::SUMMARY. Patients with idiopathic scoliosis are reported to have a restrictive pattern on pulmonary function tests. A case is presented of a teenage girl with juvenile idiopathic scoliosis who had evidence of airways obstruction in addition to restriction on pulmonary function tests (PFT). Examination of flow-volume l...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
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abstract:BACKGROUND:Ivacaftor is a significant innovation in the treatment of cystic fibrosis (CF) with gating mutations. A substantial percentage of patients with CF have severe lung involvement, but these patients are usually excluded from phase III clinical trials. Thus, the effectiveness of ivacaftor in this population has ...
journal_title:Pediatric pulmonology
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doi:10.1002/ppul.24424
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/1099-0496(200007)30:1<32::aid-ppul6>3.0.co
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22723
更新日期:2013-10-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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journal_title:Pediatric pulmonology
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pub_type: 杂志文章
doi:10.1002/ppul.1950100214
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23176
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2011-03-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:1996-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ppul.10090
更新日期:2002-04-01 00:00:00
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journal_title:Pediatric pulmonology
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doi:10.1002/(SICI)1099-0496(199608)22:2<85::AID-PPUL1>
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,meta分析
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:
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pub_type: 杂志文章,评审
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更新日期:2002-09-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1985-11-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2008-09-01 00:00:00
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更新日期:2017-04-01 00:00:00
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更新日期:2008-12-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23886
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