Abstract:
:Environmental tobacco smoke, also called passive smoking, was shown to have adverse effects on the health of children. Hydrogen peroxide (H2O2) is proposed as a sensitive marker of oxidative injury and inflammatory processes in the airways, being increased in adult active cigarette smokers. We tested whether passive smoking had an influence on H2O2 exhalation in healthy children. Thirty healthy passive smoking and 24 nonexposed healthy children aged 9 years were included in the study. Exhaled breath condensate (EBC) was obtained by spontaneous tidal volume breathing with EcoScreen (Jaeger, Germany). All subjects underwent flow-volume measurements immediately after EBC collection. Levels of H2O2 were measured fluorimetrically with the homovanillic acid method. Lung function did not differ between the passive smoking and nonexposed children groups. In the passive smoking group, EBC H2O2 concentration (median and range) was 0.32 (0.00-1.20) microM, and did not differ significantly (P >0.05) from that found in the nonexposed group, i.e., 0,22 (0.00-0.68) microM. Exhaled H2O2 did not correlate with spirometric parameters (FEV1, FEV1%FVC, and MEF50%FVC) in either group. We conclude that passive smoking does not increase H2O2 exhalation in healthy children.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Doniec Z,Nowak D,Tomalak W,Pisiewicz K,Kurzawa Rdoi
10.1002/ppul.20129subject
Has Abstractpub_date
2005-01-01 00:00:00pages
41-5issue
1eissn
8755-6863issn
1099-0496journal_volume
39pub_type
临床试验,杂志文章abstract::There is a subpopulation of asthmatic patients with a history of life-threatening asthma (LTA) who have a reduced perception of respiratory loads. The aim of this study was to determine if these patients have a reduced perception of both intrinsic and extrinsic loads. Children with asthma were classified into life-thr...
journal_title:Pediatric pulmonology
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doi:10.1002/ppul.10199
更新日期:2002-12-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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abstract::Neutrophil elastase is present at high levels in airway fluid of patients with cystic fibrosis (CF), and is responsible for considerable inflammatory damage. Human monocyte/neutrophil elastase inhibitor (MNEI), a 42-kDa serpin protein, is an effective inhibitor of neutrophil elastase, cathepsin G, and proteinase-3, re...
journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20725
更新日期:2007-12-01 00:00:00
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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更新日期:2015-12-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950030207
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950190306
更新日期:1995-03-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
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更新日期:2012-10-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1099-0496(199903)27:3<203::aid-ppul9
更新日期:1999-03-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
doi:10.1002/ppul.20520
更新日期:2007-01-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22891
更新日期:2014-05-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2016-07-01 00:00:00
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更新日期:2010-04-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2008-01-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:1990-01-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2020-12-09 00:00:00
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更新日期:1991-01-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2012-11-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2019-06-01 00:00:00