Adult-type pulmonary function tests in infants without respiratory disease.

Abstract:

:A new method that permits the measurement of adult-type maximal expiratory flow-volume curves and fractional lung volumes in sedated infants was recently described. The purpose of this study was to define the normal range for these new measures of pulmonary function in infants and young children. Measurements of forced expiratory flows and fractional lung volume were made on 35 occasions in 22 children (ages 3-120 weeks) without respiratory disease. Maximal expiratory flow-volume curves were measured by the raised lung volume, thoracoabdominal compression technique. Functional residual capacity (FRC) was measured plethysmographically. Measurements of total lung capacity (TLC), residual volume (RV), FRC, forced vital capacity (FVC), and forced expiratory flows at 25, 50, 75, 85, and between 25% and 75% of expired FVC (FEF(25), FEF(50), FEF(75), FEF(85), and FEF(25-75), respectively) all increased in relation to infant length (P<0.001). RV/TLC, FRC/TLC, and FEF(25-75)/FVC declined in relation to increasing length (P<0.001). The forced expiratory flow and fractional lung volume measurements using this method were similar to previously reported estimates using other methods. These estimates represent a reasonable reference standard for infants and young children with respiratory problems.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Castile R,Filbrun D,Flucke R,Franklin W,McCoy K

doi

10.1002/1099-0496(200009)30:3<215::aid-ppul6>3.0.c

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

215-27

issue

3

eissn

8755-6863

issn

1099-0496

pii

10.1002/1099-0496(200009)30:3<215::AID-PPUL6>3.0.C

journal_volume

30

pub_type

临床试验,杂志文章
  • Variability and accuracy in interpretation of consolidation on chest radiography for diagnosing pneumonia in children under 5 years of age.

    abstract:BACKGROUND:Consolidation on chest radiography is widely used as the reference standard for defining pneumonia and variability in interpretation is well known but not well explored or explained. METHODS:Three pediatric sub-specialists (infectious diseases, radiology and respiratory medicine) viewed 3,033 chest radiogra...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22806

    authors: Williams GJ,Macaskill P,Kerr M,Fitzgerald DA,Isaacs D,Codarini M,McCaskill M,Prelog K,Craig JC

    更新日期:2013-12-01 00:00:00

  • Greater length of stay and hospital charges for severe asthma in children with depression or anxiety.

    abstract:RATIONALE:Asthma is one of the most common chronic disorders of childhood and is associated with significant healthcare utilization and costs. Comorbid psychiatric illnesses, specifically depression and anxiety, are more prevalent in patients with asthma and associated with worse asthma control, more emergency departme...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25061

    authors: Munoz FA,Benton LD,Kops SA,Kowalek KA,Seckeler MD

    更新日期:2020-11-01 00:00:00

  • Tuberculosis of the endothoracic fascia.

    abstract::A 13-year-old boy presented with a history of respiratory infection that had progressed for 3 months. A chest X-ray showed pathological findings that suggested endothoracic fascia compromise (Skarby sign). The thorax computerized axial tomography scan revealed multiple opacities in the fascia. A biopsy was performed, ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20379

    authors: Broglia B,Bisero E,Sclavo L,Andreozzi P

    更新日期:2006-05-01 00:00:00

  • Pulmonary hypertension in the premature infant population: Analysis of echocardiographic findings and biomarkers.

    abstract:OBJECTIVE:Extremely low gestational age neonates (ELGANs) are at risk for pulmonary hypertension (PH). We hypothesized that PH, defined by echocardiogram at 36 weeks gestational age (GA), would associate with respiratory morbidity, increased oxidant stress, and reduced nitric oxide production. STUDY DESIGN:ELGANs in t...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23913

    authors: O'Connor MG,Suthar D,Vera K,Slaughter JC,Maitre NL,Steele S,Beller A,Fike CD,Aschner JL,Moore PE,Austin ED

    更新日期:2018-03-01 00:00:00

  • Data that empower: The success and promise of CF patient registries.

    abstract::In this article, we describe existing CF registries with a focus on US registry data collected through the CF Foundation Patient Registry (CFFPR) and the Epidemiologic Study of CF (ESCF); highlight what registries have taught us regarding epidemiology of CF; showcase the impact of registries on research and clinical c...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.23790

    authors: Fink AK,Loeffler DR,Marshall BC,Goss CH,Morgan WJ

    更新日期:2017-11-01 00:00:00

  • Electrical activity of the diaphragm during neurally adjusted ventilatory assist in pediatric patients.

    abstract:BACKGROUND:Neurally adjusted ventilatory assist (NAVA) is a ventilation mode which provides respiratory support proportional to the electrical activity of the diaphragm (Edi). The aims of this trial were to assess the feasibility of aiming at peak Edi between 5 and 15 µV during NAVA in clinical practice, to study the e...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ppul.23084

    authors: Kallio M,Peltoniemi O,Anttila E,Jounio U,Pokka T,Kontiokari T

    更新日期:2015-09-01 00:00:00

  • Ultrastructural ciliary defects in children with recurrent infections of the lower respiratory tract.

    abstract::One hundred fifty-four children with recurrent or chronic infections of the lower respiratory tract compatible with the diagnosis of primary ciliary dyskinesia (PCD) were evaluated for the presence of ultrastructural ciliary abnormalities. Studies were performed on multiple samples of respiratory mucosa obtained by na...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950100104

    authors: Barlocco EG,Valletta EA,Canciani M,Lungarella G,Gardi C,De Santi MM,Mastella G

    更新日期:1991-01-01 00:00:00

  • Nonsurgical management of an enlarging pneumatocele by fibrin sealant injection via pigtail catheter.

    abstract::Most pneumatoceles disappear spontaneously and do not cause severe symptoms. Treatment alternatives include various conventional or surgical methods. However, an enlarging, complicated pneumatocele with cardiorespiratory instability requires imaging-guided catheter drainage or surgery. Here, we report the case of a ne...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23311

    authors: Park TH,Kim JK

    更新日期:2016-02-01 00:00:00

  • Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR.

    abstract::The gasdermin A (GSDMA) and gasdermin B (GSDMB) genes are located at 17q21.2. The GSDM family genes have been studied in the gastrointestinal tract but recent reports suggest that GSDMB is associated with childhood asthma in several populations. We investigated the association of the GSDMA and GSDMB variants with asth...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21424

    authors: Yu J,Kang MJ,Kim BJ,Kwon JW,Song YH,Choi WA,Shin YJ,Hong SJ

    更新日期:2011-07-01 00:00:00

  • The ontogeny of human pulmonary angiotensin-converting enzyme and its aberrant expression may contribute to the pathobiology of bronchopulmonary dysplasia (BPD).

    abstract:INTRODUCTION:The mammalian lung possesses the highest level of angiotensin converting enzyme (ACE) amongst all the organs. ACE is known to generate angiotensin (AT)-II from AT-I and to regulate serum bradykinin level, thereby controlling blood pressure. Recent data, however, indicate a role for ACE derived AT-II in ang...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22911

    authors: Castro EC,Parks WT,Galambos C

    更新日期:2014-10-01 00:00:00

  • Infection and inflammation in induced sputum from preschool children with chronic airways diseases.

    abstract:BACKGROUND:We hypothesized airway inflammation can be detected non-invasively by induced sputum (IS) or peripheral blood eosinophilia, and IS can detect bacterial and viral infection in preschool children with airway disease, with results comparable to broncho-alveolar lavage (BAL). METHODS:Preschool children with cys...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23366

    authors: Jochmann A,Artusio L,Robson K,Nagakumar P,Collins N,Fleming L,Bush A,Saglani S

    更新日期:2016-08-01 00:00:00

  • Maturity-onset diabetes of the young: Different diabetes in an infant with cystic fibrosis.

    abstract::Cystic fibrosis (CF) is one of the most common autosomal recessive and multisystemic diseases. CF affects many systems. One of these systems is the endocrine and exocrine functions of the pancreas, causing cystic fibrosis-related diabetes, which is extremely complex and has unique pathogenesis. Maturity-onset diabetes...

    journal_title:Pediatric pulmonology

    pub_type:

    doi:10.1002/ppul.24746

    authors: Hangül M,Erdoğan M,Hatipoğlu N,Köse M

    更新日期:2020-05-01 00:00:00

  • Longitudinal assessment of health-related quality of life in an observational cohort of patients with cystic fibrosis.

    abstract:BACKGROUND:Patient-reported outcomes (PROs) are increasingly used to evaluate the efficacy of new treatments and the progression of chronic diseases. The Cystic Fibrosis Questionnaire-Revised (CFQ-R) is a disease-specific, PRO measure of health-related quality of life (HRQOL). We evaluated associations between changes ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21325

    authors: Sawicki GS,Rasouliyan L,McMullen AH,Wagener JS,McColley SA,Pasta DJ,Quittner AL

    更新日期:2011-01-01 00:00:00

  • New indicators for optimal lung recruitment during high frequency oscillator ventilation.

    abstract::Previous research has demonstrated the potential benefit derived from the combination of high frequency oscillatory ventilation and volume guarantee mode (HFOV-VG), a procedure that allows us to explore and control very low tidal volumes. We hypothesized that secondary spontaneous change in oscillation pressure amplit...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25084

    authors: Rodríguez Sánchez de la Blanca A,Sánchez Luna M,González Pacheco N,Ramos Navarro C,Santos González M,Tendillo Cortijo F

    更新日期:2020-12-01 00:00:00

  • Cerebral abscess as a complication of cystic fibrosis.

    abstract::Two male patients with cystic fibrosis (CF), both 18 years old, developed frontal lobe brain abscesses. Both patients presented with histories of intermittent headache over several days and occasional vomiting. Headache was not more evident in the mornings and not associated with visual disturbance in either patient. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950170609

    authors: Cooper DM,Russell LE,Henry RL

    更新日期:1994-06-01 00:00:00

  • Preserved diffusion capacity in children with cystic fibrosis.

    abstract::Early detection of progressive lung disease in cystic fibrosis (CF) may lead to better treatment and prognosis. Routine lung function indices may be relatively insensitive markers of peripheral airway obstruction and alveolar collapse. We hypothesized that the single-breath diffusion capacity of the lung for carbon mo...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10357

    authors: Merkus PJ,Govaere ES,Hop WH,Stam H,Tiddens HA,de Jongste JC

    更新日期:2004-01-01 00:00:00

  • Nebulized therapies for childhood pulmonary hypertension: an in vitro model.

    abstract:OBJECTIVES:Sildenafil, tezosentan, and prostacyclin reduce pulmonary vascular pressures in pulmonary hypertension, but have potential to vasodilate the systemic circulation. Nebulized vasodilators allow targeted drug delivery, high local drug concentrations, less systemic hypotension, and better matching of the lung's ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20431

    authors: Katz SL,Adatia I,Louca E,Leung K,Humpl T,Reyes JT,Coates AL

    更新日期:2006-07-01 00:00:00

  • Evaluation of the multiple linear regression method to monitor respiratory mechanics in ventilated neonates and young children.

    abstract::A potentially useful method to monitor respiratory mechanics in artificially ventilated patients consists of analyzing the relationship between tracheal pressure (P), lung volume (V), and gas flow (V) by multiple linear regression (MLR) using a suitable model. Contrary to other methods, it does not require any particu...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950130307

    authors: Rousselot JM,Peslin R,Duvivier C

    更新日期:1992-07-01 00:00:00

  • Use of exercise in the management of cystic fibrosis: short communication about a survey of cystic fibrosis referral centers.

    abstract::A survey of 47 cystic fibrosis referral centers was conducted to study the use of exercise in the management of patients with cystic fibrosis (CF). A questionnaire with 5 brief questions concerning the prescription and application of exercise therapy was sent to the first 47 centers (38.5%) listed in the 1988 CF Found...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950100313

    authors: Kaplan TA,ZeBranek JD,McKey RM Jr

    更新日期:1991-01-01 00:00:00

  • Ten-year follow up of hydroxychloroquine treatment for ABCA3 deficiency.

    abstract::We present a child with interstitial lung disease (ILD) who was diagnosed with desquamative interstitial pneumonitis following CT thorax and open lung biopsy aged 2 years. Subsequently, surfactant protein gene analysis revealed mutations in the ABCA3 gene. This case of ABCA3 deficient ILD describes a stable clinical c...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22811

    authors: Williamson M,Wallis C

    更新日期:2014-03-01 00:00:00

  • Comparative study using oral solutions of bambuterol once daily or terbutaline three times daily in 2-5-year-old children with asthma. Bambuterol Multicentre Study Group.

    abstract::The aim of this study was to compare safety and efficacy of bambuterol hydrochloride (10 mg) oral solution administered once daily in the evening with terbutaline sulphate (0.075 mg/kg body weight) oral solution administered three times daily in 2-5-year-old children with asthma. There were two treatment groups: (2/3)...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/(sici)1099-0496(200003)29:3<194::aid-ppul7

    authors: Kuusela AL,Marenk M,Sandahl G,Sanderud J,Nikolajev K,Persson B

    更新日期:2000-03-01 00:00:00

  • Efficacy of mycophenolate on lung disease and autoimmunity in children with immunodeficiency.

    abstract::The autoimmune manifestations of primary immunodeficiencies, such as autoimmune lymphoproliferative syndrome (ALPS) and common variable immunodeficiency (CVID), often constitute a great therapeutic challenge and have a significant impact on patients' morbidity and mortality. The most common autoimmune presentations ar...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23757

    authors: Bucciol G,Petrone A,Putti MC

    更新日期:2017-10-01 00:00:00

  • Benzyl-benzoate foam: effects on mite allergens in mattress, serum and nasal secretory IgE to Dermatophagoides pteronyssinus, and bronchial hyperreactivity in children with allergic asthma.

    abstract::Home mattresses of 24 asthmatic children with house dust mite allergy were sprayed with either benzyl-benzoate foam or placebo in a double blind fashion, 10 days before the children left the residential house for asthmatic children Istituto Pio XII (located in the Italian Alps in an environment free of mites) and went...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/ppul.1950180405

    authors: Sette L,Comis A,Marcucci F,Sensi L,Piacentini GL,Boner AL

    更新日期:1994-10-01 00:00:00

  • Early factors related to mortality in children treated with bi-level noninvasive ventilation and CPAP.

    abstract:OBJECTIVE:To describe and analyze the characteristics and the early risk factors for mortality of noninvasive ventilation (NIV) in critically ill children. STUDY DESIGN:A multicenter, prospective, observational 2-year study carried out with critically ill patients (1 month - 18 years of age) who needed NIV. Clinical d...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25246

    authors: López J,Pons-Òdena M,Medina A,Molinos-Norniella C,Palanca-Arias D,Demirkol D,León-González JS,López-Fernández YM,Perez-Baena L,López-Herce J,NIV Research Group.

    更新日期:2020-12-31 00:00:00

  • Reference values of sniff nasal inspiratory pressure in healthy children.

    abstract:OBJECTIVE:To determine reference values of sniff nasal inspiratory pressure (SNIP) in healthy children. METHODS:This cross-sectional observational study included healthy children aged 6 to 11 years of both sexes. The volunteers underwent a pulmonary function test to rule out respiratory disorders. Respiratory muscle s...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24591

    authors: Marcelino AA,Fregonezi GA,Lira MGA,de Oliveira LM,Araújo PRS,Parreira VF,de Andrade AD,Resqueti V

    更新日期:2020-02-01 00:00:00

  • Standardized procedure for measurement of nasal potential difference: an outcome measure in multicenter cystic fibrosis clinical trials.

    abstract::Patients with cystic fibrosis (CF) can be discriminated from healthy subjects by measurement of the nasal potential difference, which has become a useful outcome measure for therapies directed toward correcting defective electrolyte transport in CF. A standard operating procedure was developed by a CF Foundation clini...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ppul.10448

    authors: Standaert TA,Boitano L,Emerson J,Milgram LJ,Konstan MW,Hunter J,Berclaz PY,Brass L,Zeitlin PL,Hammond K,Davies Z,Foy C,Noone PG,Knowles MR

    更新日期:2004-05-01 00:00:00

  • Fraction of exhaled nitric oxide and wheezing phenotypes in preschool children.

    abstract:BACKGROUND:Asthma is a chronic lower airway inflammatory disease. Nitric oxide is an inflammatory mediator produced endogenously in the airway. Previous studies have demonstrated that the fractional concentration of exhaled nitric oxide (FeNO) is increased in asthma. OBJECTIVES:To investigate if FeNO concentrations we...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22705

    authors: Oh MA,Shim JY,Jung YH,Seo JH,Young Kim H,Kwon JW,Kim BJ,Kim HB,Kim WK,Lee SY,Jang GC,Song DJ,Kim HJ,Shin YJ,Park JW,Cho SH,Lee JS,Hong SJ

    更新日期:2013-06-01 00:00:00

  • Preservation of pulmonary function in the ventilated neonatal piglet with normal lungs.

    abstract::Little attention has been focused on the progressive pulmonary deterioration which occurs in mechanically ventilated infants with normal or mildly abnormal lungs. We hypothesized that lung function would deteriorate over a 24-hr period in anesthetized neonatal piglets with normal lungs mechanically ventilated at 2 cm ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950190306

    authors: Easa D,Finn KC,Balaraman V,Sood S,Wilkerson S,Takenaka W,Mundie TG

    更新日期:1995-03-01 00:00:00

  • Long-term outcome of parapneumonic effusions in children: Lung function and exercise tolerance.

    abstract:OBJECTIVES:a: To evaluate the long-term outcome of parapneumonic effusions (PPE) in children regarding lung function and exercise tolerance, (b) to investigate the role of bronchial asthma in the outcome of PPE. METHODS:The design of the study included 51 children with PPE, at least 2 years after the initial infection...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23054

    authors: Kontouli K,Hatziagorou E,Kyrvasilis F,Roilides E,Emporiadou M,Tsanakas J

    更新日期:2015-06-01 00:00:00

  • Diagnostic value of sputum cultures in children under 2 years of age with chronic suppurative lung diseases.

    abstract:BACKGROUND:Acquiring sputum cultures from infants is considered challenging. We describe their yield in infants with cystic fibrosis (CF) and other chronic suppurative lung diseases (CSLDs). METHODS:Retrospective medical record review over a 4-year period, for infants aged 0-2 years with ≥2 airway bacterial cultures a...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25103

    authors: Stafler P,Zaks-Hoffer G,Scheuerman O,Ben-Zvi H,Mussaffi H,Mei-Zahav M,Steuer G,Levine H,Bar-On O,Mantin H,Prais D,Blau H

    更新日期:2020-12-01 00:00:00