Abstract:
BACKGROUND:Asthma is a chronic lower airway inflammatory disease. Nitric oxide is an inflammatory mediator produced endogenously in the airway. Previous studies have demonstrated that the fractional concentration of exhaled nitric oxide (FeNO) is increased in asthma. OBJECTIVES:To investigate if FeNO concentrations were correlated with wheezing phenotypes in preschool children and to compare the FeNO results with airway hyperresponsiveness (AHR) and pulmonary function test (PFT) results. METHODS:We performed skin prick tests, methacholine provocation tests, PFT, impulse oscillometry bronchodilator response (IOS BDR) tests, and FeNO measurements in 372 preschool children between the ages of 4 and 6 years. Wheezing phenotypes were defined according to the age of onset and persistency. RESULTS:Persistent wheezers had higher FeNO levels than transient wheezers and non-wheezers. Among persistent wheezers, those with atopy and AHR had significantly higher FeNO levels than those without atopy or AHR. FeNO levels were significantly higher in late-onset wheezers than early-onset wheezers and non-wheezers. Among late-onset wheezers, those with atopy and AHR had a significantly higher FeNO concentration than those without atopy or AHR as well as those with either atopy or AHR. However, there were no significant differences in AHR, PFT, or IOS BDR between persistent and transient wheezers or between late-onset wheezers and early-onset wheezers. CONCLUSION:FeNO may be a better marker for asthma phenotypes in preschool children than AHR and PFT results.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Oh MA,Shim JY,Jung YH,Seo JH,Young Kim H,Kwon JW,Kim BJ,Kim HB,Kim WK,Lee SY,Jang GC,Song DJ,Kim HJ,Shin YJ,Park JW,Cho SH,Lee JS,Hong SJdoi
10.1002/ppul.22705subject
Has Abstractpub_date
2013-06-01 00:00:00pages
563-70issue
6eissn
8755-6863issn
1099-0496journal_volume
48pub_type
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