Is a longer time interval between recombinant human deoxyribonuclease (dornase alfa) and chest physiotherapy better? A multi-center, randomized crossover trial.

abstract：BACKGROUND:Variation of lung function is considered to be a hallmark of asthma. Although guidelines recommend measuring it as a diagnostic tool for asthma, the usefulness of this approach has not been studied in children. AIM:To assess the usefulness of home spirometry in children with nonspecific lower respiratory tr...

journal_title：Pediatric pulmonology

authors： Brouwer AF,Visser CA,Duiverman EJ,Roorda RJ,Brand PL

更新日期：2010-04-01 00:00:00

abstract：:Bronchial reactivity was assessed in 66 children with bronchial asthma (aged 8-15 years) by provocation with histamine-HCl during a symptom-free period. A significant bronchial reaction to histamine was defined as a 50% increase in the resistance of the respiratory system (Rrs) determined by the forced oscillation tec...

journal_title：Pediatric pulmonology

authors： Holmgren D,Engström I,Bjure J,Sixt R,Aberg N

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Interferon-gamma (IFN-γ) and interferon-inducible protein of 10 kDa (IP-10) are potent inflammatory mediators and contribute to acute lung injury in adults. Recently, a potential role for IFN-γ and IP-10 in the pathogenesis of bronchopulmonary dysplasia (BPD) has been reported in animal models. OBJECTIVE:To...

journal_title：Pediatric pulmonology

authors： Aghai ZH,Saslow JG,Mody K,Eydelman R,Bhat V,Stahl G,Pyon K,Bhandari V

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Evidence from recent studies suggests that IRT/PAP protocols may be successfully used as a purely biochemical newborn screening (NBS) for cystic fibrosis (CF) that does not require genetic screening. However, the experience with the performance of different IRT/PAP protocols remains limited. In this study, w...

journal_title：Pediatric pulmonology

authors： Sommerburg O,Hammermann J,Lindner M,Stahl M,Muckenthaler M,Kohlmueller D,Happich M,Kulozik AE,Stopsack M,Gahr M,Hoffmann GF,Mall MA

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVES:To determine 1) what proportion of abstracts of randomized controlled trials (RCTs) presented at international conferences on cystic fibrosis (CF) are published as full reports, 2) time to publication, and 3) factors that might delay or prevent publication. METHODS:At the end of 1995, the Cochrane CF Group'...

journal_title：Pediatric pulmonology

authors： Cheng K,Preston C,Ashby D,O'Hea U,Smyth RL

更新日期：1998-08-01 00:00:00

abstract：:Pulmonary surfactant, a unique developmentally regulated, phospholipid-rich lipoprotein, is synthesized by the type II epithelial cells (AECII) of the pulmonary alveolus, where it is stored in organelles termed lamellar bodies. The synthesis of pulmonary surfactant is under multifactorial control and is regulated by a...

journal_title：Pediatric pulmonology

authors： Zhang XQ,Zhang P,Yang Y,Qiu J,Kan Q,Liang HL,Zhou XY,Zhou XG

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Asthma is the most common chronic disease of childhood. Although asthma admissions to the pediatric intensive care unit (PICU) are increasing, there are no evidence-based guidelines on preferred escalation of therapies for patients with status asthmaticus who fail to respond to inhaled bronchodilators and sys...

journal_title：Pediatric pulmonology

authors： Stulce C,Gouda S,Said SJ,Kane JM

更新日期：2020-07-01 00:00:00

abstract：:Pulmonary function testing and monitoring plays an important role in the respiratory management of neonates. A noninvasive and complete bedside evaluation of the respiratory status is especially useful in critically ill neonates to assess disease severity and resolution and the response to pharmacological intervention...

journal_title：Pediatric pulmonology

authors： Reiterer F,Sivieri E,Abbasi S

更新日期：2015-10-01 00:00:00

abstract：:The value of exercise testing as an objective measure of disease severity in patients with chronic chest diseases (CCD) is becoming increasingly recognized. The aim of this study was to investigate changes in oxygen uptake (VO2) during early recovery following maximal cardiopulmonary exercise testing (CPXT) in relatio...

journal_title：Pediatric pulmonology

authors： Stevens D,Oades PJ,Armstrong N,Williams CA

更新日期：2009-05-01 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD) is a chronic obstructive pulmonary disease of prematurely born infants following prolonged mechanical ventilation and oxygen therapy. Developmental changes in pulmonary function of children with BPD during their early years have been difficult to study. We longitudinally studied maxima...

journal_title：Pediatric pulmonology

authors： Mallory GB Jr,Chaney H,Mutich RL,Motoyama EK

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To describe and analyze the characteristics and the early risk factors for mortality of noninvasive ventilation (NIV) in critically ill children. STUDY DESIGN:A multicenter, prospective, observational 2-year study carried out with critically ill patients (1 month - 18 years of age) who needed NIV. Clinical d...

journal_title：Pediatric pulmonology

authors： López J,Pons-Òdena M,Medina A,Molinos-Norniella C,Palanca-Arias D,Demirkol D,León-González JS,López-Fernández YM,Perez-Baena L,López-Herce J,NIV Research Group.

更新日期：2020-12-31 00:00:00

abstract：:Our objective was to study meconium-induced lung injury in isolated perfused rat lungs exposed to anoxia. Our working hypothesis was that meconium-induced lung injury is independent of preexisting hypoxia, and that hypoxia will increase severity of lung injury observed after meconium aspiration. We compared five diffe...

journal_title：Pediatric pulmonology

authors： Wisniewski WM,Zagariya AM,Pavuluri N,Srinivasan H,Shankarao S,Vidyasagar D

更新日期：2005-04-01 00:00:00

abstract：:In contrast to its effect on airway smooth muscle in the adult, in vitro studies have shown that caffeine significantly increases active tension in airway smooth muscle in the neonatal lamb. To determine if caffeine has a physiological effect on airway function during early development, we studied the effect of caffei...

journal_title：Pediatric pulmonology

authors： Keklikian EN,Wolfson MR,Shaffer TH

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Severe inflammation plays a vital role in the pathogenesis of meconium aspiration syndrome (MAS). Intratracheal (IT) instillation of corticosteroids may be beneficial for MAS in optimizing local effect and reducing systemic adverse effects, but the optimum dosing course remains open to question. METHODS:Thi...

journal_title：Pediatric pulmonology

authors： Lin CH,Jeng MJ,Yang YC,Hsiao YH,Kou YR

更新日期：2017-07-01 00:00:00

abstract：:Nitric oxide (NO) that is produced within the airways can be measured in the exhaled air. Concentrations of exhaled NO (FENO) are decreased in cystic fibrosis (CF) and, in cross sectional studies, have been shown to be even lower in patients with more advanced pulmonary disease. This may result from retention and meta...

journal_title：Pediatric pulmonology

authors： Grasemann H,Lax H,Treseler JW,Colin AA

更新日期：2004-11-01 00:00:00

abstract：:The current bronchopulmonary dysplasia (BPD) is seen in infants born extremely premature, with less severe respiratory distress syndrome (RDS) and who received prenatal steroids-"new BPD". The pathophysiology of BPD is based on an impairment of lung maturation with prenatal and postnatal multi-hit insults and genetic ...

journal_title：Pediatric pulmonology

authors： Kugelman A,Durand M

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Asthma is the most common chronic inflammatory disease in childhood and some reports have demonstrated systemic inflammation. The relevance of high-sensitivity assays for C-reactive protein (hs-CRP), which are known to be a sensitive marker of low-grade systemic inflammation, has not been fully studied in ch...

journal_title：Pediatric pulmonology

authors： Deraz TE,Kamel TB,El-Kerdany TA,El-Ghazoly HM

更新日期：2012-03-01 00:00:00

abstract：:Respiration rate is an important indicator of a person's health, and thus it is monitored when performing clinical evaluations. There are different approaches for respiration monitoring, but generally they can be classed as contact or noncontact. For contact methods, the sensing device (or part of the instrument conta...

journal_title：Pediatric pulmonology

authors： Al-Khalidi FQ,Saatchi R,Burke D,Elphick H,Tan S

更新日期：2011-06-01 00:00:00

abstract：:Assessment of dynamic inspiratory function may provide valuable information about the degree and progression of pulmonary involvement in patients with Duchenne muscular dystrophy (DMD). The aims of this study were to characterize inspiratory function and to assess the efficacy of idebenone on this pulmonary function o...

journal_title：Pediatric pulmonology

authors： Buyse GM,Voit T,Schara U,Straathof CS,D'Angelo MG,Bernert G,Cuisset JM,Finkel RS,Goemans N,Rummey C,Leinonen M,Mayer OH,Spagnolo P,Meier T,McDonald CM,DELOS Study Group.

更新日期：2017-04-01 00:00:00

abstract：:This study sought to determine if a clinical pathway developed and executed by specialists in pediatric asthma would reduce hospital costs and length of stay (LOS). The study design was a retrospective, nonrandomized, controlled trial. Subjects were children aged 2-18 years (N = 1,004) with a history of recurrent whee...

journal_title：Pediatric pulmonology

authors： Wazeka A,Valacer DJ,Cooper M,Caplan DW,DiMaio M

更新日期：2001-09-01 00:00:00

abstract：:This report describes a patient with biliary atresia (BA) associated with polysplenia syndrome who showed a rapid progression of intrapulmonary arteriovenous shunting (IPS), resulting in a fatal outcome. Intrauterine ultrasonography at 36 weeks of gestation revealed fetal abnormalities, including situs inversus, absen...

journal_title：Pediatric pulmonology

authors： Kimura T,Hasegawa T,Sasaki T,Okada A,Mushiake S

更新日期：2003-06-01 00:00:00

abstract：:Four patients with generalized lymphangiomatosis presenting with chylothoraces are described. All four had bone involvement, two had involvement of the spleen, and one of the pericardium. The diagnosis was confirmed by typical radiology, histology, and in three patients by immunohistochemistry. Treatment was mainly pa...

journal_title：Pediatric pulmonology

authors： Shah AR,Dinwiddie R,Woolf D,Ramani R,Higgins JN,Matthew DJ

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Gastro-esophageal reflux (GOR) may contribute to lung disease in children with cystic fibrosis (CF). There is conflicting evidence regarding the effect of chest physiotherapy (CPT) in the head-down position on GOR. Furthermore, there is currently no evidence on the impact of physiotherapy on GOR as assessed ...

journal_title：Pediatric pulmonology

authors： Doumit M,Krishnan U,Jaffé A,Belessis Y

更新日期：2012-02-01 00:00:00

abstract：:There is a need to judge general exercise tolerance in children with cystic fibrosis (CF) under normal daily activity conditions and -when more extensive testing is required-in an exercise laboratory in a specialized center. We investigated the reproducibility, validity, and criterion for a 6-minute walking test, whic...

journal_title：Pediatric pulmonology

authors： Gulmans VA,van Veldhoven NH,de Meer K,Helders PJ

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Pulmonary function testing is commonly performed for diagnosis and clinical management of respiratory diseases. It is important to use appropriate reference equations from healthy subjects for interpretation of data from infants with lung disease. This study aimed to determine if published reference equation...

journal_title：Pediatric pulmonology

authors： Lu Z,Foong RE,Kowalik K,Moraes TJ,Dubeau A,Lefebvre D,Davis SD,Balkovec S,Becker A,Mandhane P,Turvey SE,Lou W,Sears MR,Ratjen F,Subbarao P

更新日期：2018-07-01 00:00:00

abstract：:Pulmonary sequestration is a rare anomaly and is conventionally treated with surgical excision. This report describes the successful occlusion of a large aberrant artery to an intralobar pulmonary sequestration using an Amplatzer Vascular Plug. ...

journal_title：Pediatric pulmonology

authors： Hwang HK,Tsai YS,Lin SM,Chen MR

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the association among a validated symptom-based questionnaire for asthma control in children (CAN), forced expiratory volume in 1 sec (FEV(1)), and fractional exhaled nitric oxide (FE(NO)). METHODS:Observational cross-sectional study was performed in a consecutive sa...

journal_title：Pediatric pulmonology

authors： Sardón-Prado O,Korta-Murua J,Valverde-Molina J,Fernández-Paredes JJ,Mintegui J,Corcuera-Elosegui P,Emparanza JI,Pérez-Yarza EG

更新日期：2010-05-01 00:00:00

abstract：:"Pulmonary Interstitial Glycogenosis: Diagnostic Evaluation and Clinical Course," written by Liptzin et al is a timely and insightful phenotypic summary of a rare pediatric interstitial lung disease. Twenty-four infants with biopsy-proven pulmonary interstitial glycogenosis (PIG) were reviewed at their center. Genetic...

journal_title：Pediatric pulmonology

authors： Yonker LM,Kinane TB

更新日期：2018-12-01 00:00:00

abstract：:Inadequate intake and suboptimal growth are common problems for patients with CF and a critical target for intervention. The purpose of this study was to compare the growth outcomes of children with CF who participated in a randomized clinical trial to improve energy intake and weight to children with CF receiving sta...

journal_title：Pediatric pulmonology

authors： Stark LJ,Opipari-Arrigan L,Quittner AL,Bean J,Powers SW

更新日期：2011-01-01 00:00:00

abstract：:The fixed-combination metered aerosol lK6 (fenoterol 0.05 mg/puff, ipratropium bromide 0.02 mg/puff--Berodual, Boehringer-Ingelheim Ltd., Ridgefield, Conn.) was administered to 12 children (8 boys, 4 girls) aged 3 1/2 to 6 2/12 years who had extrinsic bronchial asthma. Three forms of administration, each with a differ...

journal_title：Pediatric pulmonology

authors： Berdel D,Kellersmann U

更新日期：1985-11-01 00:00:00